Conserved Protein Domain Family
ThiC

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COG0422: ThiC 
4-amino-2-methyl-5-hydroxymethylpyrimidine (HMP) synthase ThiC [Coenzyme transport and metabolism]
4-amino-2-methyl-5-hydroxymethylpyrimidine (HMP) synthase ThiC is part of the Pathway/BioSystem: Thiamine biosynthesis
Statistics
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PSSM-Id: 440191
Aligned: 435 rows
Threshold Bit Score: 553.894
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_045361759 141 VSQMHYARQgIITAEMEFVALRENqcraeylaslrasgpqgerlvellsrqhpgqafgaalssqpgaqhnayeITPEFVR 220
NP_228597      1 MTQMEMARKgVVSDEMKKVAEYEG-------------------------------------------------VDVEIVR 31 
WP_011343677   1 MTQLLKAKEgVITREMEVVAAEER-------------------------------------------------KSPEEIR 31 
WP_011915868   2 KTQMTYAKEgIFTREMELAIQNEE-------------------------------------------------IDKEEFL 32 
WP_012580424   1 MTLIEKVKNgEKCSEIEKIAEHEN-------------------------------------------------VSVNKII 31 
WP_013387629   4 MTQMEAARKgIFTKEMEIVLKEES-------------------------------------------------ISKKDLM 34 
WP_014451234   1 MTQLELARAgLITKEMKYCAEFEG-------------------------------------------------IEFERLR 31 
WP_014296378   1 MTQLEFAKAgIITEEMVIAAEYEG-------------------------------------------------ISPEELR 31 
WP_014955584   6 TTQMDAARKgILTPQMKQVLENEA-------------------------------------------------ISQTDLM 36 
WP_066747206   4 RTQMEAARRgIITSEMKAVAEKEH-------------------------------------------------IEAEKLM 34 
WP_045361759 221 DEIARGRAIIPANINHPEIEP-MIIGRNFLVKVNANIGNSALGSSIGEEVDKMTWATRWGADTVMDLSTGKNIHETREWI 299
NP_228597     32 QKLAEGRAVLPKNKLHRIERP-MIVGEGFSVKVNANIGTSQGFSSLEEEKEKARVAIEYGADSLMVLSTWGDLREIRRAI 110
WP_011343677  32 QKVALGEVVIPANVNHQNLHP-KGIGAGLKVKVNANLGTSENRCFYEDELKKVKVAIKAGADAIMDLSTGGNLDEIRRAI 110
WP_011915868  33 QKVAEGKIVIPANKNRKRNKY-FAIGDGTYVKINVNIGVSEACPNFDIEVQKLEVAKKFDVESVMDLSSGLDASNFRKYI 111
WP_012580424  32 EGLLNGKIVIPHNKNHTSLKKfIGIGEGLTVKVNANIGTSFGYDDFEYEKEKFNTAKAVGANSVMLLSTWGNLDEQREFI 111
WP_013387629  35 EKMAQGKIVIPANKNHKSLSP-KGIGEGLKTKINVNLGVSEDCCDQELELEKVMNSIKLGADAIMDLSTFGDTRGFRRKL 113
WP_014451234  32 ALVADGKVVIPRNKLHSLERP-VAIGEQMTVKVNANIGTSVGYSSLEEELGKLEVALNAGADAVMVLSTWGNLSEMRREI 110
WP_014296378  32 NKIEKGYAVLPVNKNHKFDNI-RAIGEGLKTKVNINLGTSQGYSSVKEEIEKLKIAEKFGADSIMDLSTWGNLSYIRDEI 110
WP_014955584  37 EKVALGHIAIPANRNHLNIAA-AGVGQGLKTKINVNLGVSKDVCSFDAEMKKAKMAIEYKADAVMDLSVSGDTEGFRKRL 115
WP_066747206  35 GLLAEGRAIIPCNRLHTAISP-NGLGSMLRTKINVNLGTSRDMTDLEMEFQKVRSAVEMGAEAIMDLSSFGDTRKFRRCL 113
WP_045361759 300 LRNSPVPIGTVPIYQALEKV---NGKAEDLTWEIFRDTLIEQAEQGVDYFTIHAGVLLRYVPMTA--KRMTGIVSRGGSI 374
NP_228597    111 VEMSPVPVGSVPIYDSAVRSyqmKKNVVDFSEKDFFDMVIAHAEDGIDFMTIHVGVTRRVLDRIKssRRVLKIVSRGGAI 190
WP_011343677 111 IKESSVPVGTVPLYQAAAETlnkYGDISRLDPELLFDVIEKQAADGVDFMTVHVGVTREILKVLDrfPRVTEVVSRGGSL 190
WP_011915868 112 LQNYDFIVGTVPVYQVASR----HDDITKVDSKEFIEEIERQAEEGVDFFTIHAGITRRTLERFEknDRLLKIVSRGGAL 187
WP_012580424 112 IKNSDIPVGTVPIYDAAVISyqkKKNVVDFSEKDFLKIFEKHAKQGVDFVTLHISITKDIVKKLKssKRIMKIVSRGGSI 191
WP_013387629 114 ADMSPAALGTVPMYDAVAKY---GKDIASMTVEDLFKVVEEHCEDGMDFLTIHAGLNLTCVERLQknNRLTKIVSRGGSI 190
WP_014451234 111 VKRSPAPVGSVPIYDSAVKAyaeKRNVVDFSEKDFINMVLQHAEDGIDFMTIHVGITKRVLEKLKnsKRILKIVSRGGSI 190
WP_014296378 111 IRNSNIMVGTVPVYDAATKAvqnKKRVIDFDADDFIQMVRDHAKAGVDFMTIHAGITRTTIEKLRnsRRITKIVSRGGSI 190
WP_014955584 116 VSEIPVMIGTVPIYDTLTRT---GKPTQDITIEDWFETVDIHARNGIDFITIHAGLTRKCATSIRtnPRLCGIVSRGGAI 192
WP_066747206 114 TEKCPAMIGTVPIYDAVVYY---NKPLAQITAAEWIDIARMHAIDGVDFMTVHCGINRETAEKFKknKRLTNIVSRGGSI 190
WP_045361759 375 IAKWCLSHHRESFIYEHFEEICEIMKAYDVSFSLGDGLRPGSIYDANDEAQLAELKTLGELTQIAWKHDVQVMIEGPGHV 454
NP_228597    191 IAGWMIKNNKENPFYEHFDELLDIAKDYDITLSLGDGMRPGAVVDASDAQQFEELFVMGELVERAREKGVQVMLEGPGHV 270
WP_011343677 191 TIAWMEKNGRENPLYEQFDRLLAICRKYDVTLSLGDGLRPGSIADATDQLQIMELMKLGELVKYAQNQGVQVMVEGPGHV 270
WP_011915868 188 LYKWMMANGKENPLYEHFDEILKICKKHDVTISLGDSLRPGAVYDATDALQIEELINLGELTKMAWKEDVQVMIEGPGHM 267
WP_012580424 192 IAGWIIKNNLENPFYKYFDEVLDIAREYDVTLSLGDSLRPGNLFDSLDRLQLEEWFIFEELVEKARKKNVQVMLEGPGHV 271
WP_013387629 191 LYEWMIKNNKENPFYEHYDRLLDICRKYDVTLSLGDGLRPGSLKDATDAPQIQELIILGELTKAAWEKDVQVMIEGPGHV 270
WP_014451234 191 IAGWMIKNNKENPFYEHFDEILQIAREYDITLSLGDGMRPGAIVDSTDPQQLEELFFMQELVLKAYDAGVQVMLEGPGHV 270
WP_014296378 191 IVGWMIKNHKENPFYEYFDEVLEICREYDVTISLGDGMRPGSLHDATDDLQFEELLRLGELVKRARNAGVQVMVEGPGHM 270
WP_014955584 193 LFEWMEKTGNENPFYEHFDRLLDVCEAHDVCISLGDGLRPGAIKDSTDAPQIEELITLGELTKRAWEKNVQVMIEGPGHV 272
WP_066747206 191 IFAWMEMTGNENPFYERFDELLDICREYDVTLSLGDACRPGCIADATDASQIGELITLGELTKRAWARDVQVMIEGPGHM 270
WP_045361759 455 PMQLIKENMELQLDWCREAPFYTLGPLTTDIAPGYDHITSGIGAAMIGWFGTALLCYVTPKEHLGLPNKDDVKEGIITYK 534
NP_228597    271 PLNEVEMNVRLMKKIGKGAPIFLLGPLPTDRAMGYDHIACAIGGALAGYYGADFLCYVTPSEHISLPDVEDVREGVIASK 350
WP_011343677 271 PINQIEMNVKLMKRLCANAPFYVLGPLVTDIAPGYDHITAAIGGAWAAYFGADFLCYVTPAEHLGLPTVEDVEEGVIALK 350
WP_011915868 268 RANEIAANMVIQKRLCHGAPFYVLGPLTTDIAAGYDHISGAMGALIAALNGADFLCYVTPAEHLRLPSADDVKEGIVAFK 347
WP_012580424 272 PLDQIETTVNLMKKYGKNSPVFLLGPIVLDIAPGYDHITSAIGAAIAARSGADFICYVTPSEHLSLPNVEDVKKGVIAAK 351
WP_013387629 271 PLNEIATNMQLEKKLCHGAPFYVLGPIVTDIAPGYDHITSAIGGAIAASNGADFLCYVTPAEHLRLPTAEDVKEGIIASK 350
WP_014451234 271 PLNEIELNVKLMKKIGLGRPIFLLGPLPTDRGVGYDHIVSAIGGALAGYYGCDFLCYVTPAEHVGLPDAEEVKEGVISAK 350
WP_014296378 271 PIDEIEANVILQKKICDRAPFYVLGPITTDIAPGYDHITSAIGGAIAAAKGADFLCAVTPAEHLRLPTLEDIKEGVIATK 350
WP_014955584 273 PLHEIEMNMKLQKKLCHNAPFYVLGPLVTDIAPGYDHITSAIGGALAAMHGADFLCYVTPAEHLRLPTADDVKEGIMASK 352
WP_066747206 271 PLNQIAANMEIEKTLCHGAPFYVLGPIVTDIAPGYDHITSAIGGALAAANGAAFLCYVTPAEHLRLPDVDDVKEGIIAAR 350
WP_045361759 535 LAAHAADLAKGHPGAQIRDNALSKARFEFRWEDQFNLGLDPDKAREFHDETLPkdsaKVAHFCSMCGPhFCSMKITQDVR 614
NP_228597    351 IAAIVADVARGNKKAWELEKKMALARKNFDWETMFSLSLGKDVAKKKYEERP-----YPDKGCSMCGP-FCAIKIAEEFS 424
WP_011343677 351 IAAHAADLARGNREAWNRDYEMSVARKELNWERQFELAINPERARKMRIERGS----QDIKSCSMCGE-LCAMKIMNERG 425
WP_011915868 348 IAAHSANIAKGFKKPLEKDIEMSIARRDLDWQKMISLSIDPQKAREYRSTY-------PSDTCSMCGR-LCAVKNSRDEA 419
WP_012580424 352 IAAMAADFSRG--KFIDENYKLAISRKNLDWQGIKEVSLDKEIVERYLSARP-----YSGKGCSMCGP-FCALKVVEEYL 423
WP_013387629 351 IAAHVGDIAKGIKGAIDWDHAMSEARGTLNWQKMFDLCIDREKAIEYRRSVIEs---SKGEACTMCGD-LCPIKRCNEIA 426
WP_014451234 351 IAAVVADVARGNRKAMKLEEEMAIARRDFDWNKMFKLAIHAERAQRKFEKMK-----YTDDGCSMCGP-FCAIKITKDFA 424
WP_014296378 351 IAAHSADIAK-NRKHMNIDNQMSHARKEFNWEKQFEIAIDKEKALNFYSSRKG----MENNMCSMCGP-LCAMRITEEFL 424
WP_014955584 353 IAAHAGDLAKGIKGVEELDHKMSKARGKLDWDGQFDCAIDPEKAREYRKSSQPs--gSDKDVCTMCGD-FCAVKRVENLL 429
WP_066747206 351 IAAHAADIAKGVPGAADWDRDMSLARKKLDWEKMFTLAIDPEKARRYRAESKP----EREDTCSMCGN-FCAVRNMNRIL 425
WP_045361759 615 DFAA 618
NP_228597        ----    
WP_011343677 426 GKNA 429
WP_011915868 420 Vl-- 421
WP_012580424 424 EE-- 425
WP_013387629     ----    
WP_014451234 425 EEK- 427
WP_014296378 425 EKEE 428
WP_014955584     ----    
WP_066747206 426 DGEI 429
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