Conserved Protein Domain Family
GAGE

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pfam05831: GAGE 
GAGE protein
This family consists of several GAGE and XAGE proteins which are found exclusively in humans. The function of this family is unknown although they have been implicated in human cancers.
Statistics
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PSSM-Id: 461753
Aligned: 23 rows
Threshold Bit Score: 84.7394
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_005641427   1 MSGRVRSRSRSKQGREDRGSAQPAARVVTPPPTQaE----QLKPKEKPTKTQDIIPDQGKEv-EGAPVIQGPEMKSELQE 75 
Q5JUK9         1 MSGHQRTRSRSRERRDDQDSNHPVGAVVAQELPSnD----QLQQEEPPIESQDYTPGQERD--EGALDFQVLGLAAYLWE 74  human
XP_017824162   1 MSGHQRTRSTSRERRDDQESNHPVGAVVAQEPPSdD----QPQQEEPPTENQDYTPDRERH--GGRPEFQVLGLAAYIRE 74 
XP_003435563   1 MNWQVRSTFRPRARRDDEKYLKPFGPVVAQQPSA-E----Q-QGEEPPTERQDVIPDQEKRd-EGAPVAQGPALEPNQEE 73 
2_pfamImport   1 MSRRIKSTYRPKGRGYGQEYCRALGPVV---PSG-K----QPQQMEPPTLSEDIPPGQEKKt-EGASAIQGAVLEANQQE 71 
XP_002831719   1 MIWRGRSTYRPRPRRS-VPPPELIGPML--EPSD-E----EPQQEEPPTESQDPAPGQEREedQGAAEIQVPDLEADLQE 72 
XP_018874574   1 MSWRGRSTYRPRPRRS-LQPPELIGAML--EPSD-E----EPKEEKPPTKSQNPTPDQKREddQGAAEIQVPDLEADLQE 72 
Q8WWM1         1 MSWRGR---RYRPRRC-LRLAQLVGPML--EPSV-P----EPQQEEPPTESQDHTPGQKREddQGAAEIQVPNLEADLQE 69  human
A6NGK3         1 MSWRGRSTYRPRPRRY-VEPPEMIGPMLPEQFSD-EvepaTPEEGEPATQRQDPAAAQEGEd-EGASAGQGPKPEADSQE 77  human
PNJ15012       1 MGFQRRLIYRRRPIIY-IESSE--------ESSD-E----QPDEEESPTQSQDSTPAEEREd-EGASAAQGQEPEADSQE 65  Sumatran orangutan
XP_005641427  76 VAQPMTGDKSEDGPDVKGLKIPNLEPIKMPEAG 108
Q5JUK9        75 LTRSKTGGERGDGPNVKGEFLPNLEPVKIPEAG 107 human
XP_017824162  75 LIQSKTGGERGDGLNVVGEFLPNREPVTIPEAG 107
XP_003435563  74 LTLPKTEREHGDGPDVKGKRLADLEPLKMLEAG 106
2_pfamImport  72 LAEAKTGYEHEDGADVK-KILPNPEPDEMPEGG 103
XP_002831719  73 LSQSKTGDECGNGPDDQGKILPKSEQFKMPEGG 105
XP_018874574  73 LCQTKTGDGCEDGTDVKGKILPKAEHFKMPEAG 105
Q8WWM1        70 LSQSKTGDECGDSPDVQGKILPKSEQFKMPEGG 102 human
A6NGK3        78 QVHPKTGCECGDGPDGQEMGLPNPEEVKRPEEG 110 human
PNJ15012      66 LVQPQIGYELGDGPDAKRVCLRNEEQMKLPAE- 97  Sumatran orangutan
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