Conserved Protein Domain Family
DMP1

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pfam07263: DMP1 
Dentin matrix protein 1 (DMP1)
This family consists of several mammalian dentin matrix protein 1 (DMP1) sequences. The dentin matrix acidic phosphoprotein 1 (DMP1) gene has been mapped to human chromosome 4q21. DMP1 is a bone and teeth specific protein initially identified from mineralized dentin. DMP1 is primarily localized in the nuclear compartment of undifferentiated osteoblasts. In the nucleus, DMP1 acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the early phase of osteoblast maturation, Ca(2+) surges into the nucleus from the cytoplasm, triggering the phosphorylation of DMP1 by a nuclear isoform of casein kinase II. This phosphorylated DMP1 is then exported out into the extracellular matrix, where it regulates nucleation of hydroxyapatite. DMP1 is a unique molecule that initiates osteoblast differentiation by transcription in the nucleus and orchestrates mineralized matrix formation extracellularly, at later stages of osteoblast maturation. The DMP1 gene has been found to be ectopically expressed in lung cancer although the reason for this is unknown.
Statistics
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PSSM-Id: 462128
Aligned: 13 rows
Threshold Bit Score: 254.081
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q13316         1 MKISILLMFLWGLSCALPVTRYQNNESEDSEEWKGHLAQAPTPPLeSSESSEGSKVSSEEQANEDPSDSTQSEEGLGSDD 80  human
DAA28467       1 MKTTILLMFLWGLSCALPVARYQNTESKSSEEWKGHLAQTPTPPLeSSESSEESKLSSEEQANEDPSDSTESEEVLGLDD 80 
XP_003469412   1 MKTVILLALLWGLACALPVARYQDTASESSEEWTGHLVSSPTPSV-GNESSQESKVSSEEQANEDLSDSPETAEDLTSDD 79 
EHB12356       1 MKTSILLMLLWGLSCALPVARYQNTESESSDEWKGHLAPSPAPPVeNSESSEESKVSSEEQANEDPSDSTETEEDLTSDD 80 
O55188         1 MKTVILLVFLWGLSCALPVARYHNTESESSEERTGDLAGSPPPPT-NSESSEESQASPEGQANSDHTDSSESGEELGYDR 79  house mouse
XP_016849658  89 eisgddsfnehneedlghtvlpseggnpqtavdnggqeednaisrhprdssssssssesrsldkednhiadyrrrhrads 168 green anole
XP_028932379  65 tesgtiilvlpqspvyclvaryqntesesseewkghlqrvrdrttessesseeskdsseeqVSEDNSDSTESEEDL---- 140 platypus
XP_021576845   1 MKTSILLICFWGLSCALPVARYQNTETESSEEWKgylaqsptpptensesseeskvsseeqANVDPSDSAELEDDLGSDD 80  thirteen-lined ...
XP_017202907   1 MKTSILFMFLWGLTCALPVTRYENTETESSEEWKDPLAPPPTPPL----------------VSKDSRDTTDSEEALISDD 64  rabbit
XP_023369186   1 MKTSILLMFLLGLSSAFPVTRYQNNESESSEEWKGHLAQVSTPPL----------------ANEDPSDSTESEEELASDD 64  small-eared galago
XP_023408999   1 MKTSILLVFLWGLSCALPVARYQNTESKSSEEWKGRLAKTPTLPSeSSESSEESKDSSEEQENEDPSESSESEEGRGHDD 80  African savanna...
XP_011230561   1 MKTSILLMFLWGLSCALPVTRYQNTESESSEEWKGHLAQTPTPPLeSSESSEESKVSSEEQASEDPSDSAESKEGL--ND 78  giant panda
XP_023606060   1 MKTSILLMFLWGLSCALPVTRYQHTESESSEEWKGHLAQTPTPPLeSSESSEESKVSSEEQVNEDPSDSAESEEGLSLAD 80  little brown bat
Q13316        81 HQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSG---------------------PGPKDRQEGGNSRLGSDED 139 human
DAA28467      81 QQHVHRPAGGLSRRGGSEGDNKDDDEDESGDDTFGDDDGG---------------------PGPEERRSGGDSRLGSDED 139
XP_003469412  80 DHYVSRPAGGLARSAGREGDDKEDDEDDSGDDTFGDEDNS---------------------LGPRKDREGGISRLDSGED 138
EHB12356      81 GHYVSGSDGGLSRSAGKEEDDKEDDEDDSGDDTFGDEDNG---------------------LGPKEGQEGGISRLGSEKD 139
O55188        80 GQY--RPAGGLSKSTGT-GADKEDDEDDSGDDTFGDEDND---------------------LGPEEGQWGGPSKLDSDED 135 house mouse
XP_016849658 169 ysssqedryyfddegmqgddatffeshdadsdmlhgdfnskessqessrgkakhhsktierfarkvyhyvdadseedqsp 248 green anole
XP_028932379 141 -HRLYKPAMGPTKSIMKEADGKDDDEDDSGDDTFGDEENG---------------------QASIQRQEEESPFVGAGDD 198 platypus
XP_021576845  81 RQYVYRPAGGLSRSTGKE-EDKDDDEDDSGDDTFADEDNG---------------------PWPEERTGGGISR-ADGDD 137 thirteen-lined ...
XP_017202907  65 GQYLYRTAGGFSKS------DKEDDEDDSGDDTFGDEDNG---------------------PGPKERQGGGNSELGSEED 117 rabbit
XP_023369186  65 RQDVHRPAGSLSSSAGIQGDDKDDDEDDSGDDTFGDDDNG---------------------PLSEERQ-GGNSRLGSDED 122 small-eared galago
XP_023408999  81 RQYIYRPADGLSRRGGK------------G---------GddkdddeddsgddtfgdedngLGPEEGHEGGNVRLQSDED 139 African savanna...
XP_011230561  79 HQYMHRPADGLPRNGGKGGDDKDDDEDDSGDDTFGNDDNG---------------------PGPEKRQ-GGNSRHKSNED 136 giant panda
XP_023606060  81 HPYAHRPAGGFSRNGGKEGDDRDDDEDDSGDDTFGDDDNG---------------------PGPEETQ-GGNSRLSSNED 138 little brown bat
Q13316       140 SDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDS------------------------------------------- 176 human
DAA28467     140 SADTTRSREDSTPQGDEGARDTTSESRDLDREDEGNS------------------------------------------- 176
XP_003469412 139 SADTTQSREDSASR-EDSTEHLASDSRELDGEDGV--------------------------------------------- 172
EHB12356     140 SAGTTQSREDSASR-EDSIQYPASDSRDLDGEDRV--------------------------------------------- 173
O55188       136 STDTTQSSEDSTSQ-ENSAQDTPSDSKDHDSEDEADS------------------------------------------- 171 house mouse
XP_016849658 249 eqeesksqqeddvvSQESSQSVEETSQSTENVLSRSGedansqskemvkgssrghshsrsketfkshsrenghshsredd 328 green anole
XP_028932379 199 NT-VGDDSEDYA----DTQRDYS--SQNLDEGEDVSH------------------------------------------- 228 platypus
XP_021576845 138 SADATRSSEDSTSP-EDSAQDTTSDSRDLDHEDDVGS------------------------------------------- 173 thirteen-lined ...
XP_017202907 118 SADNTQSREDSA-------QDTTSDSRDLDHEGVVHS------------------------------------------- 147 rabbit
XP_023369186 123 SGDTTQSSEESVPQAEDSAQDVTSESRDLDNE--VDS------------------------------------------- 157 small-eared galago
XP_023408999 140 SADTTQSREDSTPQGEDSDQDTTIESREVDNEGEVNS------------------------------------------- 176 African savanna...
XP_011230561 137 SADTTQSGEDSALQGEDSAQDTTSESRDLDHEDEVNS------------------------------------------- 173 giant panda
XP_023606060 139 SADATESREDSASHGEDSGQDTTSESRDLDKE------------------------------------------------ 170 little brown bat
Q13316       177 -KPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKES-GeNSEQ-ANTQD 253 human
DAA28467     177 -RPEGGDSTPDSDSEEHWVGGGSEGDSSHGDGSEFDDEGMQSDDPGAYRSERGNSRISDAGLKSRESkGdDEEQ-ASTQD 254
XP_003469412 173 ----------DSKSEEHWEGGDSEGDSSHGTGLEFHDNGMQNDDPDSTRREGGSSRMDSTSVKSKESqG-VLKQ-EGTQD 240
EHB12356     174 ----------DSESEEHWVGGGREGDSSHGDASEFHDDGMQSDDPDSTRSEGGSSRMDNVSVKSKEFqGdSKKE--GTED 241
O55188       172 -RPEAGDSTQDSESEEQRVGGGSEGESSHGDGSEFDDEGMQSDDPESTRSDRGHARMSSAGIRSEESkG-DHEP-TSTQD 248 house mouse
XP_016849658 329 rHSQSREDDRHSHSQEDDRHSRSREDDRHSRSREDDRHSRSRED-----GRHSRSREDGRHSRSRE----DGRHsRSRED 399 green anole
XP_028932379 229 -AADSGASDGDGQSRE-------NGEEHDSDSQEFDDDEMQGDDPDSFGSDNSNSSMSSDSLNSKESsQeNSEQ-GSRQD 299 platypus
XP_021576845 174 -RVEGRDFAQESESEEDWVGGGSEGESSHGDGSEFDDEGMQSDDPDSTRRDRGNSRMSSAGVKSKESkR-DNEQ-VSAQD 250 thirteen-lined ...
XP_017202907 148 -RP-------DSESEEHWVGGGSDGESSHGDGSEFDDEGMQSDDPDSIMSERVKARISSAGVRSKESnG-DSRQ-ASTPD 217 rabbit
XP_023369186 158 -RPEGGDSTPDSESEEHWLGVGSDGGRSHGDGSEFDDEGMQSDDPDSIRSERGSSRIKGSTA--------NSEQ-PSPED 227 small-eared galago
XP_023408999 177 -RPEAGDFTHESESEERWVGGGSEGDSSHGDGFEFDDEEMQSDDPDSVRSDRNNSRMSSASIKSEESkGkSDEQ-ASTQD 254 African savanna...
XP_011230561 174 -RPERGDSAQESDSEELWVGGGSEGDSSHGDGSEFGDEEMQNDDPDIIRSDRGNSRMNSASVKSEESkGnSDEQ-ASTQD 251 giant panda
XP_023606060 171 -----------SESKERWVGGGSEGDSSHGDGSEFDDEGMQSDDPDTIRSERSHSRMNSASVKSKESrGnSDGQ-ANTQD 238 little brown bat
Q13316       254 SGGSQLLEHPSRKIFRKSRIS--EEDDRS----ELDDNNTMeEVKSDSTE----NSNSRDTGLSQPR--------RDSKG 315 human
DAA28467     255 SHESPAAAYPRRKFFRKSRLP--EEDGRG----ELDDSRTI-EVMSDSTE----NPDSKEAGLGQSR--------EHSKS 315
XP_003469412 241 SGDKQSVGSPSRKFFRKSRIS--EEDDRD----DLEDSNTVeDLRSDLTD----STDSQEDSPGQ----------EDSKS 300
EHB12356     242 SGDKQSAESPSRKFFRKSRIS--QEDDRG----DLEDSDTMeDLKSGSTE----STNSQEDSPDQSR--------EDSKS 303
O55188       249 SDDSQSVEFSSRKSFRRSHVS--EEDYRG----ELTDSNSR-ETQSDSTE----DTASK----------------EESRS 301 house mouse
XP_016849658 400 GRHSRS-----REDGRHSR-S--REDGRHsqsqEYIQSHSReDVHSHSKEghkhSRSREENKHSWSS--------EDKHS 463 green anole
XP_028932379 300 SNDSQSVGQSSRKWLKKAGISeeEEDDSG----EQNDSNSMeERDSHSTE----DSSSREASPGQSE--------ENSKS 363 platypus
XP_021576845 251 SGESPLVEHSSRKFSRKSRIS--EEDGGG----ELNGGYTTeEVKSDS----------------NSKeadlgqsrEDSKS 308 thirteen-lined ...
XP_017202907 218 AGQSRSVEYPRRRFFWKSRIS--QEDDRH----ELEDSNTQeEVE-DSTE----SPDSRDAGLSRSR--------E---- 274 rabbit
XP_023369186 228 SGESQAGPRPGRTAFRKSRLS--PE------------AAAPeEMQSDSAE----DADAGEAGLRRSR--------EDSRH 281 small-eared galago
XP_023408999 255 SDGSQSAENPRRKFFRKSRLS--DEDDRS----ELVDSNTMeEFKSDSSE----NSSSKEIGLSQSR--------EN-KS 315 African savanna...
XP_011230561 252 SGDSQSVEYPRRKIFRKSRIS--EEDDIG----ELDDNNTMeEIKSDSTE----NTNSKETGLSQSR--------ENSES 313 giant panda
XP_023606060 239 SGESQSVENPGRKFFRKSRIS--VEDDTG------DRGNSQeEVKSDSTE------NTKEAGLSQSR--------ENSKS 296 little brown bat
Q13316       316 DSQEDSKENLSQE--ESQNVDGPS----SESSQEANLSSQEN---------SSESQEEV-VSESRGDNPD-PTTS---YV 375 human
DAA28467     316 ESRQESEENRSPE--DSQDVQDPS----SESSQEVDLPSQEN---------SSESQEEA-LHESRGDNPD-NATS---HS 375
XP_003469412 301 DSQEDTSESQSHE--D-EDEQDTS----SESSQEVDTPSQES---------SSESQEEVmAAESRGDNPD-ATS------ 357
EHB12356     304 DSQVDSSESQSQE--DGEDLQEPS----SESSQEVDLPSQES---------SSESQEGV-VGESRGDNPD-ATS------ 360
O55188       302 ESQEDTAESQSQE--DSPEGQDPS----SESSEEAGEPSQES---------SSESQEGV-TSESRGDNPD-NTSQ---AG 361 house mouse
XP_016849658 464 QSREDDHHSWSRE--DDAHSQSREtslvSQSREDENSPSREDdntvsiediKSESTED-----SRGSYKKaVKKSkeiSE 536 green anole
XP_028932379 364 KSHEDS-GSRSREgaDSRGSRDL-----SSSKDHSKGSSQETvlk----qkSSKSHEDS-EVTSRGDNPEpN-------E 425 platypus
XP_021576845 309 ESQEDSKESRSQE--DSENAQDPS----SESSQEADLASQES---------SSESEEEV-ASESRGDNPD-NVSR---AS 368 thirteen-lined ...
XP_017202907 275 ----DSRESQSQE--DSNNEQDPS----SESSQEADLPSQES---------SSESQEEG-LSESRGDNPD-ATTS---ST 330 rabbit
XP_023369186 282 ESQEDREENESWE--DSRNEPEPS----SESSQEADLPSEES---------SSESREEA-AGESRGDNPD---------- 335 small-eared galago
XP_023408999 316 DSREDSKENQSQE--DNQNVQDLS----SESSQEADLPPQEN---------SSESQEEV-VSESRGDNPDqNTTN---HS 376 African savanna...
XP_011230561 314 ESLEESEEKQSPE--DSQNVQDPS----SESSQEIDQPSQEN---------SSESQEEV-VSESRGDNPD-NTTS---HS 373 giant panda
XP_023606060 297 ESQEDSEENQVQA--DSQNEQDPS----SESSQEVDLPSQET---------SSESQEEV-LSKSRGDNPD-NTST---HS 356 little brown bat
Q13316       376 -EDQEDSDSSEE------DSSHTLSHSKSESRE-EQADSESSESLNFSEESPESPEDENSSSQ-EGLQSHSSSAESQ--S 444 human
DAA28467     376 rEHQADSESSEE------DVLDKPSDSESTSTE-EQADSESHESLRSSEESPESTEEQNSSSQ-EGAQTQSRSQESL--S 445
XP_003469412 358 ---QPDSDSSEE------DSLNTFSSSESESRE-QQADSESNESLRLSEESQESSEDDHSSSQ-EDLQSWSTSTESQ--S 424
EHB12356     361 ---QEDSDSSEE------DSLNTFSSSESESRE-QQADSESNESLRFSEESQESPEDDSSSSQ-EGLQSQSRSTESH--S 427
O55188       362 --DQEDSESSEE------DSLNTFSSSESQSTE-EQADSESNESLSLSEESQESAQDGDSSSQ-EGLQSQSASTESR--S 429 house mouse
XP_016849658 537 rSGEHSTGKSKQqrsysvEDVSNRAPRGSESREvKREHSSSSEKSVSTEESEESSEDTDESLQtDSRLSHSTSSESSkaS 616 green anole
XP_028932379 426 dGDEVDSDSSQE------SSLSKSSQSESESRE-SQEHSKSSESSRQSEESRESSEEKSSSSH-EGLLSHSRSSSKEd-S 496 platypus
XP_021576845 369 --DQEDSDSSQE------DSLNTFSSSESESRE-EQADSESNESLKLSEESPESTEDENSSSQ-EGLQSQSTSAESQ--S 436 thirteen-lined ...
XP_017202907 331 ---EEDSDSSQE------DNLSVPSSSESQSRE-EQADSDSNESLKSSEESPETTEEENSSSQ-EGLQSQSESAESP--S 397 rabbit
XP_023369186 336 --DVANRDSSEE------GGLTASSSSESESGE-DQADGESSESLQSSEESPESAEEGNSSSQ-EGFRSHSASAESQ--S 403 small-eared galago
XP_023408999 377 eEDQEDSDSSEE------DNVSKPSNSESESRE-EQADSDSNESLKSSEESPESVEDENSSSQ-ESLQSQSASTESQ--S 446 African savanna...
XP_011230561 374 -EDQEDSDSSEE------NSLNKTSSSESESTE-EQADSESNESLKDSEESPEFTEE-NSSSQ-EGLQSHSASAESQ--S 441 giant panda
XP_023606060 357 -EDQDSSDSSEE------DSLSTPSSSESTSRE-EQADSESNESLKFSEESPESPED-NSSSQ-EGLQSHSASTESQ--S 424 little brown bat
Q13316       445 EEshs------------eeD-D-SDSQDSSRSKE-DSNSTESKSSSEED-GQLKNIEIESRKLTVDAYHNKPIGDQDDND 508 human
DAA28467     446 EE-----------------D-DgSDSQDSSRSKE-DSNSTESVSSSEEE-AQTKNTEVESRKLTVDAYHNKPIGDQDDND 505
XP_003469412 425 QEsss------------reD-TdSNSQDASWSKE-DSNSTESTSSSEED-WLPKNMEAESRKLTVDLYHNKPIGDQDDND 489
EHB12356     428 QEshs------------geD-TnSDSQDSSQSKE-DSNSTESTSSSEEN-GQPKNMEVENRKLTVDSFHNKPIGDQDDND 492
O55188       430 QEsqseqd------srseeD---SDSQDSSRSKE-ESNSTGSASSSEED-IRPKNMEADSRKLIVDAYHNKPIGDQDDND 498 house mouse
XP_016849658 617 HEstssedsdshdkdlksaEtSeSTEEDNSHSIErDSHSREDTASIEDD-SWSRSMELESRKLMFDIDHNKPLSDYDDND 695 green anole
XP_028932379 497 AEssseqv------gtkesDsEeSESQENSTSKR-DSKSTESQSSSEEDaSLSKSIELESRKLMLDAYHNKPIGDHDDND 569 platypus
XP_021576845 437 DEsrseqd------sqseeE-PdSDSQDSSRSKE-DSNSTESTSSSEED-GQPKNMEMDSRKLTVDAYHNKPIGDQDDND 507 thirteen-lined ...
XP_017202907 398 EEsqseqd------sqsdeG-AgSDSQENSKSKE-DSNSTESMSSSEED-GQARGMDMESRKLTVDTYNNKPIGDQDDND 468 rabbit
XP_023369186 404 EE-----------------D-RsSDSQDSSRSKE-DSDSTESTSSSEEH-GQSKTVEIESRKLTVDAYHNKPIGDQDDND 463 small-eared galago
XP_023408999 447 EEsqseqd------sqsveD-DdSDSQDSSRSKE-DSNSTESKSSSEED-GQSKNTEIESRKLTVDIYHNKPIGDQDDND 517 African savanna...
XP_011230561 442 EEsqseqd------sqseeD-DaSDSQDSSKSKE-DSNSTESKSSSEED-GQSKNTEIESRKLTVDTYHNKPIGDQDDND 512 giant panda
XP_023606060 425 QEsqspe-------sqseeD-DgSDSQDSSKSQE-DSNSTESNSSSEEA-GQSKNTEIESRKLTVDAYHNKPVGDQDDND 494 little brown bat
Q13316       509 CQDGY 513 human
DAA28467     506 CQDGY 510
XP_003469412 490 CQDGY 494
EHB12356     493 CQDGY 497
O55188       499 CQDGY 503 house mouse
XP_016849658 696 CQDGY 700 green anole
XP_028932379 570 CQDGY 574 platypus
XP_021576845 508 CQDGY 512 thirteen-lined ground squirrel
XP_017202907 469 CQDGY 473 rabbit
XP_023369186 464 CQDGY 468 small-eared galago
XP_023408999 518 CQDGY 522 African savanna elephant
XP_011230561 513 CQDGY 517 giant panda
XP_023606060 495 CQDGY 499 little brown bat
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