Conserved Protein Domain Family
GpcrRhopsn4

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pfam10192: GpcrRhopsn4 
Rhodopsin-like GPCR transmembrane domain
This region of 270 amino acids is the seven transmembrane alpha-helical domains included within five GPCRRHODOPSN4 motifs of a G-protein-coupled-receptor (GPCR) protein, conserved from nematodes to humans. GPCRs are integral membrane receptors whose intracellular actions are mediated by signalling pathways involving G proteins and downstream secondary messengers.
Statistics
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PSSM-Id: 462989
Aligned: 21 rows
Threshold Bit Score: 168.198
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
AAH83689      40 EEDIPFEMVLLNPDaeg-------npLDHFSARESGLHEFFFLLVLVYFVTACIYAQSLwQAMRKGGPMHTILKVLTTAL 112
XP_002643928 183 NVPINYDIWLTNGRpnsaa---vsffTFNFSFDEQNTVQLFLLTVCMYAILSIIQS----GANFKNRQIPPRSIILSRII 255
Q9W2B3       282 LNTLHYDIHLVNLHpnnsa---ahplTYQYSYDQQNLLEMYLVFLLVYIVLLPM------QIYAVRRQKHPVTKLFTVSL 352 fruit fly
Q7PZ34       178 PPAINYDITLVNGNpnrqtlsffnplLFHFSFDQQNTLEMYLIFFVVYLLMVPL------QIYAVRLQKHPVTRLFTVSL 251 Anopheles gambi...
Q54EU0       131 VGEVDFTLTLLNGGgl---------wSAQFSYDEQGLEALYLVYFFVFLVLTGYTAFTAfKLY-KANAFHPMIKILSGVI 200 Dictyostelium d...
EDO35391       1 GLKLKYELNLTNGDdf---------wTMHFSADERHILKMDIFFVVTFLIVIVLAIHVT-YVLISRRLFHYTYKLFIWSL 70 
Q8NBT3       143 GLQLEYEMVLTNGKsf---------wTRHFSADEFGILETDVTFLLIFILIFFLSCYFG-YLLKGRQLLHTTYKMFMAAA 212 human
EDO35662     108 VLDMDYKITVTNGdd----------wQSHLSADETHMLEIVSSFFLIMILTLIVGLVFA-KTLWIEHMLHRPYEIFLVSL 176
Q54MH1       156 KYFAEYVFSLSNNGdh---------iDSVLSADQQSIPQSQMFYFLLYIIMFVITIVFI-IILKKKQLESKVLQFFIVIL 225 Dictyostelium d...
Q54YJ2       143 PFVSTYTFEVQNSGds---------fDSQLSAEQQSIPQGQIFFFLLYTAFLIISIIYS-VALKKKGLEGKAIHFFIAIL 212 Dictyostelium d...
AAH83689     113 LLQAASALANYIHFSRYS-RDGIGLPLMGSLAEVFDIASQIQMLYLLLSLCMGWTIVR-MKKSqsrplqwdSTPASTGMA 190
XP_002643928 256 TMKLIGYSLQCFNVLLFA-YDGQGFFIARIAGEVLRNTSVQVHCLLLILLAKGWDISY-PGTE--------YPRRTIIMW 325
Q9W2B3       353 LSEFVSLALITAHLIHYA-ANGVGEPRLQAAGDVLDILSRTTFMLILLLLAKGWAVTR-QQISr------tGWIILMSIW 424 fruit fly
Q7PZ34       252 VLEFVSVCLLLTHTVRYA-MNGVGDEKLAIMGDIFDIFSRTSFMLILLLLAKGWAVTR-LQISv------sSWILLMVIW 323 Anopheles gambi...
Q54EU0       201 VLEFLSVFVLLCNYGSYS-HNGTGGKGAQGFGELLDLAAQLLFILLLILIAKGWAISR-VTID--------EKRIVLGAM 270 Dictyostelium d...
EDO35391      71 LLEFVSICVNIGYYVHYG-NTGFAVYSAQIAARAIHYIAHIMFLVLLILLAKGWTVTSlFSITs------aSSVLLYKYG 143
Q8NBT3       213 GVEVLSLLFFCIYWGQYA-TDGIGNESVKILAKLLFSSSFLIFLLMLILLGKGFTVTR-GRISh------aGSVKLSVYM 284 human
EDO35662     177 GYELFGLLLSVVYYIEYV-SYGTLRTPIHTTSGLLHAVSEIIFVCLLILLSKGYTITR-ARLSs------rGQIKLSVFI 248
Q54MH1       226 GVQLISLVLFLANWSTIIkYDGPELKYANLFGNIFSILANSLFVLLILMVGQGWTTSL-YYGSm------iKRMVNLSVS 298 Dictyostelium d...
Q54YJ2       213 LIFLISLALYISNWAHILkYHKYELRYLNLFGNIFEILGNGLFVALILMIGQGWTTSI-YFGSl------vKQMINILVS 285 Dictyostelium d...
AAH83689     191 AFIVITQSVLLLW-EQFEDTSHHSSHSHLSLAGVLLIILRICLALSLGCGLYQ-IITMERSTLKREFYITFAKGCILWFL 268
XP_002643928 326 GILAGLDTILFFYnCTFVYDVLHDVDIYSAWPGHGMILIRIVYAIWFLIEIRK-LIDSEQNRHKAEFLAHFGAGFLVWFV 404
Q9W2B3       425 VPYCAFHVFLYIW-DRTEVDVVSDIDEYQTWPGWIVLILRTSFMMWFLYELRN-TMKYEHSTKKLDFLLHLGASSLVWFI 502 fruit fly
Q7PZ34       324 IPYCAIHVLLYIW-NRTEVDIISDIDEYQTWPGWLVLACRSTMMLWFLWELRT-TMKYEHSSQKLDFLLHFGASSLVWFI 401 Anopheles gambi...
Q54EU0       271 GVLTVLYFIMFVW-IKAGENPAATTYMYDTVPGIILLVARSLAMLWFMWCGYN-TYLEETHPAKRNFYTVFGIAFVAWFL 348 Dictyostelium d...
EDO35391     144 TNGCCTYQLLVLLkGKHIFDPADVLYVYESPAGIGICILRVIAWLWFCYGPFIfTL--KHFPSKATFYYPFWFFYTGWFL 221
Q8NBT3       285 TLYTLTHVVLLIYeAE-FFDPGQVLYTYESPAGYGLIGLQVAAYVWFCYAVLV-SL--RHFPEKQPFYVPFFAAYTLWFF 360 human
EDO35662     249 GLYSVTFSILFFIqAN-MFDPGLVKYLYDSAAGTGIVALRIVAWCWFSLSVHH-TV--KRYPEKRVFYGWFFVLFSVWFL 324
Q54MH1       299 GLLFVFGVIVYIFvCFKAPEFNNYIYFYDTYPGYALLAIYVFIIFFFTIGNTL-SRRKQNDEMKKKFILIFTIIFTLWFI 377 Dictyostelium d...
Q54YJ2       286 IALIVIGWVAYVYyVYHSKEQNSYIYFMDTCPGYFLLALYVVIIGYFCWANYV-NRNKQNESIKKNFILIFTIIFVFWLI 364 Dictyostelium d...
AAH83689     269 CQPALACIAVF-FNDYQRDKVITVGVILCQAVAMVIL 304
XP_002643928 405 SLPMIGIVASF-VSQLWRFSLILALTTFANFVALSCL 440
Q9W2B3       503 YLPIVAIVALQ-VSPMWRYKLLQGITNSADCMAYCVM 538 fruit fly
Q7PZ34       402 YLPIVAIIAVN-VSPLWRYKLLLGITNSADCLAYCVM 437 Anopheles gambiae str. PEST
Q54EU0       349 ILPIICIIAAA-VEPWVREKTVLAFYVTTNALALIGV 384 Dictyostelium discoideum AX4
EDO35391     222 AGPVIVLISAYvIQKWARSQIVHGIEWSVSLLAHVFF 258
Q8NBT3       361 AVPVMALIANFgIPKWAREKIVNGIQLGIHLYAHGVF 397 human
EDO35662     325 AKPSLVLLGYYhIEEWERTKIFSGVDFAISAIGFLVF 361
Q54MH1       378 AQPMIVVCAHF-TEPWVKFKVISILYQTINAIFYIVL 413 Dictyostelium discoideum AX4
Q54YJ2       365 SHPLVVIVAHF-MDPWVKYKVIALLNLTINAIFFIIL 400 Dictyostelium discoideum AX4
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