1MJ1,1FJG,1JGO,1QZC,2AW7


Conserved Protein Domain Family
Ribosomal_S12

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cd03368: Ribosomal_S12 
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S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit interactions. S12 is essential for maintenance of a pretranslocation state and, together with S13, functions as a control element for the rRNA- and tRNA-driven movements of translocation. Antibiotics such as streptomycin bind S12 and cause the ribosome to misread the genetic code.
Statistics
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PSSM-Id: 239466
Aligned: 63 rows
Threshold Bit Score: 134.568
Created: 5-Jan-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1:aminoacyl-tRNA interaction site (A-site) [nucleic acid binding site]
Evidence:
  • Comment:The A (acceptor)-site is the attachment site for an incoming aminoacyl-tRNA.
  • Structure:1MJ1_O; Escherichia coli S12 binds aminoacyl-tRNA at the A-site

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                       ######                   ## ##
1MJ1_O      6 TINQLVr----kGREKVRKKSKVPALk----GAPFRRGVCTVVRTVTPKKPNSALRKVAKVRLTSGYEVTAYIPGEG-HN 76  Escherichia coli
XP_795803  21 TINQLH------RRGPFRRKPNPNMTfa-mdKRPQMKGVVLKTIIRKPKKPNSANRKCAKVRLSNGREVVAFIPGEG-HN 92  purple urchin
AAO40235    3 TFNQLIk----nSRKKKNKFKNSILN-----RCPQKKGICLKVFTKSPKKPNSALRKVVKIRLSNNKEIIAYIPGEG-YA 72  Eimeria tenella
CAA64591    3 TINKLLy-----KKKYKKTKKITNYLl---nKCPQKKGIVLKILIKTPKKPNSALRKVAKIRLSNNKELLAYIPGEG-KS 73  malaria parasite P...
NP_696970   3 TINQLSkk--niRKRKTRITAGSKFLknqglINPQLKGVCIRVLTRKPKKPNSAQRKIAKVKLTNGLIVDAFIPGEG-HS 79  Monosiga brevicollis
AAW25012   63 TLVQMAi----sGPYQKKRPPNKAMN-----GKPFIKGIVLKTIIRKPKKPNSANRKCVRVRLTDGREITAHIPGEG-HN 132 Schistosoma japonicum
NP_044557   3 TNNQLL------KHSRIKKKKQSYNFy----TKPQIKGLCIKVFTRTPKKPNSALRKIAKIKLKNKKEILAYIPGEG-HA 71  Toxoplasma gondii
NP_051137   3 TRSQLIe----nQRKKKFRSARKAALq----GNPQKKGTIVKLIVRSPKKPNSANRKLAYVRLVTGKKVYGYIGGMGkHG 74  Cafeteria roenberg...
P10735     32 SLQQMHr----sGPHIKTRPPRQPLD-----GKPFAKGVVLKTLIKKPKKPNSANRKCVLVRLSTGKEMVAYIPGIG-HN 101 fruit fly
NP_508023  46 NFLQFIhyrngpPKRRARSKDKSAIS-----GYSHYKGIVLKTVIRHPKKPNSGNRKCAIVRLSTGAEVCAYIPNVG-HN 119 Caenorhabditis ele...
Feature 1     #####                                
1MJ1_O     77 LQEHSVVLIRGGRVKDLPGVRYHIVRGVYDAAGVKDR 113 Escherichia coli
XP_795803  93 LQEHNIVLVEGGRTQDLPGVKHTVIRGKYDCGHVIKK 129 purple urchin
AAO40235   73 IQEHNYALIKGGKVQDLPGIRYKIIRGALNVSGVKNR 109 Eimeria tenella
CAA64591   74 IQEHNFVLIKGGRVKDLPGIKYKIIRGSLDSTGVLNR 110 malaria parasite P. falciparum
NP_696970  80 LQEHGIVLIRGGRVKDLPGIKLKCVRGKYDLAGVIGR 116 Monosiga brevicollis
AAW25012  133 LQEHNIVLVRGGRTQDLIGVKHKVVRGVYDCAPVQKP 169 Schistosoma japonicum
NP_044557  72 LQDHNFVLIKKGRVQDLPGIKYKVIRGVLDTIGVLNR 108 Toxoplasma gondii
NP_051137  75 LQEHSVVLIRGGRIKDLPGVKYRLIHGVYDFPGTSGR 111 Cafeteria roenbergensis
P10735    102 LQEHNIVLCRVGRLQDVPGVKLKAVRGVYDLAHVVKK 138 fruit fly
NP_508023 120 LQEHSQVLVKGGRRRDLISVKANIVRGKYDCAPAGGR 156 Caenorhabditis elegans

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