Conserved Protein Domain Family
CobB

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COG1797: CobB 
Cobyrinic acid a,c-diamide synthase [Coenzyme transport and metabolism]
Cobyrinic acid a,c-diamide synthase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis
Statistics
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PSSM-Id: 441402
Aligned: 377 rows
Threshold Bit Score: 407.573
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_015204530   1 M-----------------------ALVIAGERSGVGKTTITLAMLACLQRRGLQVQSFKVGPDYIDPMFHQYVTGGASRN 57 
WP_012799229   1 Mias------------------ipRIVIGAASSGSGKTTVACALMRALVRRGLDVRAGKCGPDYIDPMYHTRVVGAPSRN 62 
WP_013625973   1 Mkak------------------ipRLMFSAFNSGGGKTTITCAILQALLTKGLTPAAFKCGPDYIDPMFHSEVTGVKARN 62 
WP_015042820   1 MstdhlsfdsfdrngeqvmkavipRIMFAAAGSSSGKTTITCAVLQALLEQGVNPAAFKCGPDYIDPMFHTEVIGTKSRN 80 
WP_065534127   1 Msa--------------------pRLLLCAPASGGGKTTVTCALLQALVNRGAGPVAFKCGPDYIDPMFHSEIIGAKSRN 60 
WP_005934995   1 ----------------------miQFLVAAPCSGSGKTTLTCALLAALKRRGQDPCSFKSGPDYIDPMFHRAVLGVESHN 58 
WP_041647546   1 ---------------------------MAAPRSGSGKTTVVCALLQALKDRGLSPAAFKSGPDYIDPMFHRRVLDTPSYN 53 
WP_124786710   1 --------------------------MVAAPSSGSGKTVVTCALLRALAHRGIACAAFKCGPDYIDPLFHRRVVGARSGN 54 
WP_021718585   1 Msem-----------------flpRFMIAAPNSGSGKTTVVCALLKALLDQEYKVAAFKSGPDYIDPMFHSRVIGAKSRN 63 
WP_128745563   1 Metk-----------------nlpRILIGAPSSGSGKTTVVCAILQALINRGCPIASFKCGPDYIDPMFHKEALGLASRN 63 
WP_015204530  58 LDPVLTSED-----YVQQCFTRHIQSVDYALVEGVMGLFDGVKVtgdwrlgtgknnfelnldndgatnqinshpianhqi 132
WP_012799229  63 LDLFLAGKN-----TAKALFAEANEGADIAVVEGVMGYYDGVAL------------------------------------ 101
WP_013625973  63 LDVFLLPEG-----VCRYLLVRNSRTADLAILEGAMGYYDGLGA------------------------------------ 101
WP_015042820  81 LDLFMLSEE-----VCRYLLVKNSEQSQIAVLEGVMGYYDGLGI------------------------------------ 119
WP_065534127  61 LDLFFLGRD-----TARYLLEKNSRGSGLALIEGVMGYYDGIGL------------------------------------ 99 
WP_005934995  59 LDLFFSAPE-----TVRALYAQAAAGHGAAVCEGAMGFYDGLGG------------------------------------ 97 
WP_041647546  54 LDLFLFGRHeqgaaAAREVLMNHGAAADISILEGAMGYYDGVGT------------------------------------ 97 
WP_124786710  55 LDGFFTDAS-----TLRALLARGAAGADVAVLEGVMGFYDGMAP------------------------------------ 93 
WP_021718585  64 LDLFMLGRE-----TTKYLLAKNACDCDIAVLEGAMGFYDGMGK------------------------------------ 102
WP_128745563  64 LDLFFNDAD-----TIQYLLAKNSRHADIAIIEGVMGYYDGITG------------------------------------ 102
WP_015204530 133 LTDFASTAHIARLLSLPVVLVIDCSRLSGSVAAIAHGYLSFDPRLKIAGVVLNRVGSDRHlELLQDALEP-SHLPILGTF 211
WP_012799229 102 -SSDASAWDVACTLEAPALLVVDGRSRARSIAAEVQGFVNFRTPSMVAGIILNRTSEAMY-VRLKQVIEEeCGVAVFGYL 179
WP_013625973 102 DSTTASSYHLARVTGTPVVLIVDGKGSSLSLAALIQGFIRFRPESNIRGIILNRLSPGMF-PLYRKMIEKeTGIPVLGYF 180
WP_015042820 120 GSTVASSYHLAAVTQTPVILIVNCAGSAISIAALIQGFCHFRPDNGIKGVILNNLTPSLY-PQYKEMIEKeTDIQAVGYF 198
WP_065534127 100 -SADASAYDLARATGTPAVLVLDGRGRALTAAAAVKGMRDFRPDSGIRGVILNRVSPMLY-PRLKEAIEGeTGVTVYGYL 177
WP_005934995  98 VSDTASAWHLADTLGLPVLLVVQPRGASLTLAAQINGLKQFRTPSHLAGILLNDCAPHLY-ALLAPMLEReTGLPVLGYL 176
WP_041647546  98 -GREASAYELAVATDTPVVLVVDGRGAGLSLAAVLQGLAAFRPDSHVAGFIVNRIKPMVY-EHFKSSWEAaSGLKAFGCF 175
WP_124786710  94 GVADASSYQVARDTETPVVLVVNGRGASLSLAAVIRGIAEFLPCANVRGVVLNKTSAAAC-AYAAPAIEKhTGVAVLGNI 172
WP_021718585 103 -TEQCSAYDLARVTKTPVILVINGKGAALSLAALIKGFKEFRPDANVRGAILNNVTAMSY-KFYKEVIELeTGVKLVGYL 180
WP_128745563 103 KSYEASSYDLARKTKTPSVLIIDCKAKAVSILAEIKGFKELESDSNIKGVILNRISPQIY-EEIKPLIEEkLGITVLGYM 181
WP_015204530 212 RRQDNINIPDRHLGLVPTGEIAELDSLIDKLAYLGETCFNWELLLPLLKAETNSPQNqdeipsiapprisgrgwggvnpd 291
WP_012799229 180 PDVENASLESRHLGLVLADEVSDLQRKLDGLADAVEACIDLDAVLRLAASAQPLAFEp---------------------- 237
WP_013625973 181 PYHKELSLASRHLGLITAAEVEDLREKTVRLGQQAAGTIDLAALLEIAAGAEDIRYEd---------------------- 238
WP_015042820 199 PKLKECALESRHLGLITASEVEDLQQKMKLLAIQARESIDLKQLLRIAGRAAEIDYHe---------------------- 256
WP_065534127 178 PNLPGCALESRHLGLVTAAEVAGLREKLSALAAQAEKSVDIDGLLALAASAPALDAAa---------------------- 235
WP_005934995 177 PHLPDAALESRHLGLKTAGEIADLQQKISRMADALV--VDWEKLFALTEGAAPLAYTdr--------------------- 233
WP_041647546 176 PDMPDCTFSSRHLGLVTAGEIADLQETMRKLALQAEKSLDMDGLLACARQAAPLSRVs---------------------- 233
WP_124786710 173 PADEAFSLESRHLGLVTADEVEQLSARIDKMAELVEKSIDVDRLLEIAATAPDIREEpy--------------------- 231
WP_021718585 181 PHMDDCNFESRHLGLVTAEEIGDLQEIISRLAEQAAKTIDFDELLGIANSAEDLVYEe---------------------- 238
WP_128745563 182 PFLKECSLESRHLGLVTAQEVGNLKKILDRLAAQAAESIDLDKLVKLAQTAPEIGFTk---------------------- 239
WP_015204530 292 khnRilqPlq-----nSLKNMEGVRIAVARDRAFNFYYQDNLDQLKNlGAELIFWSPLTDtELPeNVQGMYFGGGFPEVF 366
WP_012799229 238 ---Mg-lP---------AKADGNPTIAVAYDEAFCFYYEDALRLLEKlGARLVRFSPLRDaQLPa-CDGLYLGGGYPELH 303
WP_013625973 239 ---Q---P---------VLRKGEVTVAVARDKAFCFYYQDSLELLEEmGAKIRYFSPLQDtALPe-CDGLILGGGYPEVF 302
WP_015042820 257 ---A------------GIERISAVKVAVARDKAFCFYYQDSLDLLETlGAELQYFSPLDDqAVPe-CDGLILGGGYPELY 320
WP_065534127 236 ---P---Al-------PPPVEGRPRIAVARDKAFCFYYADGLELLETlGAELAEFSPLADeSLPeGACGLYLGGGYPELF 302
WP_005934995 234 --lP---PagelppqgAEEQRPRVPIAVARDAAFCFTYAETLEALEWaGAELCWFSPLQDpALPeQIGGLYLPGGYPELY 308
WP_041647546 234 ---Pi--P--------APPAAGQAIIAVAQDEAFCFYYEDSLQVLREaGADLTFFSPLHDrELPp-CDGIYLGGGYPELY 299
WP_124786710 232 -rlE---P----------IAGARPIVAVARDEAFSFYYEENLRALEDlGCELAFFSPLCDgELPrGTSALYLGGGYPELH 297
WP_021718585 239 ---Q---P---------VASVAKVKIAIAQDKAFCFYYQDALDLLQEfGAELITFSPLVDkELPe-CDGIILGGGYPELY 302
WP_128745563 240 -------P--------EIVCGKKVRIGVAKDKAFCFYYQDNLDLLTElGADLCYFSPLEDqKLPeDLQGLYFGGGYPELY 304
WP_015204530 367 AQELsnNTSAKDTVKKAILAGMPTYAECGGLMYLCEDIVNFEQQSYPMVGVLPTTAVMSCRL-SLGYRIAIALQDSPLLS 445
WP_012799229 304 AKILseNTGMLESIRRAVAAGMPTVAECGGFLYLQQQLEDAEGEAWPMVGALDGRGFKTGRLqRFGYVTLSARRDGLLAC 383
WP_013625973 303 ARELaeNTRMKASLKAALKRRTPCLAECGGFMYLLEEITDQEGKHHEMTGAIRGKAFMTEKLnRFGYITLTSGNHNLLSE 382
WP_015042820 321 TGQLarNTSMLASIRHVLSNNTPCIAECGGFMYLLERIADKDGKPYPMAGYLEGDAVLTDKLnRFGYITLTAQKDNLLCD 400
WP_065534127 303 AGALaaNAPMREAVRAAVAGGLPTVAECGGFLYLNRLLSDGEGRDWPMAGALPGRAANTGKLgRFGYVTLTAKKDGLLGP 382
WP_005934995 309 AGQLsaNRSMLASVRRAVERGLPTVAECGGFLYLGQSLEDANGERWPMAGVLPGQGFRVGRLvRFGYAALTAHADSMLFR 388
WP_041647546 300 AQALsqNESMRASLRRALAAHVPCFAECGGFMYLHESFRDSQDHSWPWVGAVPGETFMTPSLkRFGYVTLQAEKDNLFCQ 379
WP_124786710 298 ARQLseNVSMRGAVRRAVESGMPTVAECGGFLYLQREIADSEGWRWPVAGALEGASENGGRLsHFGYVELTSQRDGLYGP 377
WP_021718585 303 AKELaeNISMRTSIKTALKIGKPCFAECGGFMYLLERFQAASGEIYEWTGAISGETFMTAKLnRFGYITLTAESDNVFCK 382
WP_128745563 305 LKELeaNRSMRQSIKKALEENVPCLAECGGFMYLHETVQDKLGHSYKMVGAVRGECTYAGKLvRFGYIDMRAEKANLLCT 384
WP_015204530 446 KSATVWGHEFHRSFLSKTPTqpLYNLHSYSAHtSATIEGWSLHQLHASYVHLHFGANPQIPLRFWQ 511
WP_012799229 384 EGDTLPAHEFHYWDCDACGD--AFAARKPQSA-RHWDCCMCTPTLHAGFPHLYLPGAPSAAARFVR 446
WP_013625973 383 KGGQINAHEFHYSDSTANGS--AFQARKPTRN-MEWDCIQADANLFAGYPHLHLWGNIRFAVSFVE 445
WP_015042820 401 KGGKINAHEFHYSDSTANGS--SFTAVNSSGS-KTWDCIHADENLVAGYPHLHLWGNPEFARSFIR 463
WP_065534127 383 AGTRLPAHEFHYWDSDAPGS--GFRADKPQSS-RGWDCAFHTPTLYAGFPHFHFWAAPSAARNFVA 445
WP_005934995 389 AGERLPVHEFHHWDSTDNGT--GFTAAKPNG--KQWDCGFANEHFYAGFPHLYWAGt-aLPRRFVD 449
WP_041647546 380 AGDTVTAHEFHYSDSTDRGS--DFTAYKAGSQ-RHWPCIIADDHFVGGYPHIHFLGKRDWAARFVA 442
WP_124786710 378 RGTRIRAHEFHYWQSTCPGG--DFWAQKPRRD-KGWPCMTTTPSLVAGFPHVYYPANPDVARAFAS 440
WP_021718585 383 IGEKINGHEFHYSDSNNNGH--DFLALKASGI-SEWSCSHANKVLYAGYPHIHLWGNINFARNFIR 445
WP_128745563 385 EGMHIKGHEFHYWDSNNSGE--CFHAQKPYRS-KSWKCVIGNEQLYAGYPHIHFYSNIKAAERFVN 447
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