Conserved Protein Domain Family
HTH_MerR-SF

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cl02600: HTH_MerR-SF Superfamily 
Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily
Helix-turn-helix (HTH) transcription regulator MerR superfamily, N-terminal domain. The MerR family transcription regulators have been shown to mediate responses to stress including exposure to heavy metals, drugs, or oxygen radicals in eubacterial and some archaeal species. They regulate transcription of multidrug/metal ion transporter genes and oxidative stress regulons by reconfiguring the spacer between the -35 and -10 promoter elements. A typical MerR regulator is comprised of two distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their N-terminal domains are homologous and contain a DNA-binding winged HTH motif, while the C-terminal domains are often dissimilar and bind specific coactivator molecules such as metal ions, drugs, and organic substrates.
Links
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Taxonomy: root
PubMed: 79 links
Protein: Related Protein
Related Structure
Statistics
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Accession: cl02600
PSSM Id: 470628
Name: HTH_MerR-SF
Created: 8-Feb-2008
Updated: 4-Oct-2023
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