3I6D,2IVD


Conserved Protein Domain Family
HemY

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COG1232: HemY 
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]
Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis
Statistics
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PSSM-Id: 440845
Aligned: 480 rows
Threshold Bit Score: 116.47
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3I6D_A         5 KKHVVIIGGGITGLAAAFYMEKeikeknlpLELTLVEASPRVGGKIQTVKKDGYIIERGPDSFLERKKSAPQLVKDLGLE 84 
WP_014051308   1 --MYHVVGGGIAGLAAAYRLQGq------gHEVEIFEGSETLGGLAASYDTAGDPIEVFYHHLSKSEETIVELADELGVG 72 
WP_014556924   1 --MIGVVGGGIAGLAAAYRLQQa------gHEVQVFEATETVGGLAAVYETAGDDIERFYHHLSKSEETIVALAEELGLG 72 
WP_015076950   5 KKRIAIVGGGITGLTAAYEIKKfiekeqlpFELILLEGSTRVGGKIHTLQIGTRFFDTGAESIDVRYSGAMTLIKELGLE 84 
WP_072694504   5 KKRIAVIGTGITGLTAAYRLKKiikeenlpLELLVLEGSIRSGGKIHTMKMGEDFVDIGAESIDIRTDHTLDLIKELDLQ 84 
WP_103426759   1 --MKHVVGGGIAGLAAAYRLQRq------gHDVHVFEASHDLGGLAATYETAGDRIEQFYHHLSKSEETIVDLAAELGVD 72 
WP_119818289   1 --MITVVGGGIAGLAAAYRLQEh------gFDVRVYEAADEVGGLAALYDTAGDPIERYYHHLSKSEETIVELAEELGVD 72 
WP_108381073   1 --MIAIVGGGIAGLAAARRLQAa------gREVTVFEAAEQIGGLAATVETGGDPIEQYYHHLSKSEERIVEVIEEVGLG 72 
WP_121921492   1 --MIHVVGGGIAGLAAAYRLQQh------gHEATVLEASDDLGGLAATYPTAGDDIEQFYHHLSKSEETIVELAEDLGLG 72 
WP_128476414   1 --MKGVVGGGIAGLAAAYRLQQh------gHDVQVFEASDQIGGLAAVYETAGDPVEKFYHHLSASEETIIDLIEELGLG 72 
3I6D_A        85 HLLVNNATGQSYVLVNRTLHPM--PkgAvmgiptkiAPFVSTGLFSLSGKARAAMDFI-LPAS-------------KTKD 148
WP_014051308  73 DRIEWLVGKNAYYV-DGVVHPLdtP-----------WEILAYPHMSVYDKFRLGMlTMeI-DVrggipsfdtyddlEDfE 139
WP_014556924  73 DRVEWRIGTNGYYV-DGTAHPLntP-----------LDIITYPHLSLYDTFRLGLlTLgV-DIrdgipdldayddlAAyE 139
WP_015076950  85 EELVYSSGDKPDVYFYNQLHQLtyP--TykgipihrTDIWKNKLLTFHGKLASYKDLV-VPKT-------------KIEE 148
WP_072694504  85 KEMTHSQNGKQDIYAFNKLYHIdnP--SyngipskrSDIWKYDILSFQGKITYLKDTY-LSDT-------------EVHD 148
WP_103426759  73 DRLEWLVGKNAYYV-DGVVHPLdtP-----------WEILAYPHLSLYDKFRLGMlTLgA-DFrelpprfdsyeslEAyE 139
WP_119818289  73 DRLEWSIGKNAYYV-DGVVHPLdtA-----------TQIAAYPHLSLYDKFRLGMlTLgV-DVrggrprfdsyddlTEyE 139
WP_108381073  73 EDLHWPVGETANYV-DSTVWPLdkP-----------WEILAYPYLSLYDTFRLGMlVKgV-DLrggipsfdsydslDAyD 139
WP_121921492  73 DRVEWLVGRNAYYV-DGVVHPLdtL-----------PQIAAYPHLSFYDTFRLGMlTLeI-DVrggrprfdtyddlSDfE 139
WP_128476414  73 EDVTWPIGKNAYYW-DGTVYPMdkP-----------WEILAYPHMSVYDKFRLTMlTQeI-DVrggiptfdtyenlEDfE 139
3I6D_A       149 DQSLGEFFRRRVGDEVVENLIEPLLSGIYAGDIDKLSLMSTFPQFYQTEQKHRSLILGMkKTRPqgsgqqltaKKQGQFQ 228
WP_014051308 140 DVPIKQFLLEHTSRGVYENFFEPLLDAKFGDRKEDVSAAWLLGRIKFRGE-RDLL-------------------RGEILG 199
WP_014556924 140 HMTVREFVEKHTTTGVYESFVDPLLDGKYGDRKHDVSAAWFLGRVRFRGE-RDPL-------------------RGEVLG 199
WP_015076950 149 DLTVSSFLKRRLGEEQVEHVVEPFFSKIYAGDLDEMGVRSSNEFIYDVEQNHRRLSKGLsNYPEf-------fDGDGNYV 221
WP_072694504 149 KTSVMEYLTKRIGTELTEYVAEPYFSKIYVTDMESTSIEVLNKQIVELEQEYGDLTKAIeANPNl-------lDGTGNQI 221
WP_103426759 140 DVPIREFVVDHTTEGVYENFFEPLLDAKFGSRKEEVSAAWLLGRIKFRGE-RDLL-------------------RGEILG 199
WP_119818289 140 DVPVREFVEEHTTRGVYERFFDPLLDAKFGDRKEDVSAAWLLGRIRFRGE-RDLR-------------------RGEILG 199
WP_108381073 140 DVPIEQFVTEHTTRGVYEHFFEPLIEAKFGDRADEVSAAWLLGRVQFRGE-RDPI-------------------RGEYLG 199
WP_121921492 140 DVPIKEFLLEHTTRGVYENFFEPLLDAKFGDRKDDVSAAWLLGRIKFRGE-RDLL-------------------RGEILG 199
WP_128476414 140 DVPIEQFLREHTSNGVYEGFFEPLLDAKFGDRKGDVSAAWLLGRIKFRGE-RDLL-------------------RGEPLG 199
3I6D_A       229 TLSTGLQTLVEEIEKQLKltKVYKGTKVTKLSHS--------GS--C-YSLELD--------------N----------G 273
WP_014051308 200 YPNGGFDALLDPLVESVGheTITTNTRVTDLGIE--------DGelTtITTESGg-------------H----------A 248
WP_014556924 200 YFDGGFGVLLDALIDAVGreNIMTNASVTDITIDs------eTNavSsLTVTDTt-------------Gskd-----dtD 255
WP_015076950 222 TFEKGLEVLPKKLAETIEp-HIQYGKKVFEISKG--------QE--GtYVIDIN--------------R----------K 266
WP_072694504 222 SFKQGLETLTTALLEEVNe-HVLFSKKVTEIKKS--------IE--GtYILDIN--------------H----------K 266
WP_103426759 200 YFDGGFAPFIDALVDAVGreNITTGARVTDLALD--------DGavStLTAERGg-------------A----------S 248
WP_119818289 200 YFDGSFGVLIDALVDGVGrdRITTGARVVDVGFStaggesaaDRgvEtVTVEAGs-------------G----------T 256
WP_108381073 200 YLDGGFGRLIDALIEDVGrdAIQTGARVTDLELA--------DGavDrITVETSgdssgp--daegsdDgeqt---artT 266
WP_121921492 200 YFDGGFAVLIDALVDAVGreHVVTGARATDLTVE--------DGavDsITVETEs-------------G----------V 248
WP_128476414 200 YLEGGFGRLLDALVAAVGreNITTNARVTDLNLD--------DGrvSeMTVETKpaasaevgeaaetdGgveaadpgvaT 271
3I6D_A       274 VTLDADSVIVTAPHKAAAGMLSElpAIsHLKNMHSTSVANVALGFPEGSVQmEH-EGTGFV-ISRNSDFAITACTWTNKK 351
WP_014051308 249 TTQETDGVIVAAMPNVLEELAg---YE---CEIDFQGAVCAVATMDRS-LT-Dt----yWLnIA-DD-APFGALIEHTNF 314
WP_014556924 256 TMYSVDSAIVATMPNVLESLTg---YT---CDIDFQGAVCGLMSMDES-VL-Dt----yWLnIA-HD-APFGALIEHTNF 321
WP_015076950 267 EQMRAGAVIVATPATEYSRLFKDekLTsFFNKTVTTSIGFILLSFPKGAIK-NEpKGFGFV-TPRRNDSHVTSVILLDKK 344
WP_072694504 267 EQVRVGAVVVATDPSVYKELFNDpeLIdYFKDIKTTSVGFSMFSFPKGAIK-DEpQGNGVL-CSRRNDSHISSIVWLNKK 344
WP_103426759 249 ETHDTEGVVVAAMPNVLEALCg---YE---CDIDFQGAVCAVVTMDAP-LT-Dt----yWLnIA-HD-APFGALIEHTNF 314
WP_119818289 257 ETHETDGVVVAAMPNVLEALTg---YE---CDIDFQGAVCAVVTMDRQ-LL-Dt----yWLnIA-EE-APFGALIEHTNF 322
WP_108381073 267 TAHPVDAVIVAAMPSVLESLTd---YS---CPIEFQGTVCSIIAMDEQ-LT-Dt----yWLnVV-DD-APFGALIEHTNF 332
WP_121921492 249 ETHPTDGVVVATMPNVLESLTg---YP---CDIDFQGAVCAVVTMDDP-LT-Et----yWLnVA-HD-APFGALIEHTNF 314
WP_128476414 272 ETHAVDDVVVAAMPNVLEDLCg---YE---CDIDFQGAVCALVTMDEA-LT-Dt----yWLnVA-HD-APFGALIEHTNY 337
3I6D_A       352 WPHAAp-EGK--TLLRAYVGKAGDE-SIVDLSDNDIINIVLEDLKKVMNINGEP-------EMTCVTRWHESMPQYHVGH 420
WP_014051308 315 VSPERy-GGDhlLYVASYVQ--SEEeWLATAEEDAIEDRWLDAVGDLf-----PafdrshvEEFRLARAPRAAPVYERGY 386
WP_014556924 322 VDPERy-GGDhlMYIAAYVQ--DQTeDLWQADDESVQKQWLTEIESMf-----PefsreniNDIRISRNPRAAPIYERGY 393
WP_015076950 345 WPTLKqnDEE--VLIGANFGRRGEE-SLVSLSNLEIEEYILKDLNQILGIEVPP-------NYSKIARWPNAIPQYTIHH 414
WP_072694504 345 WKSLe-nKEE--ELIGVYFGRGNEE-IMLSLSNKQIEELLLKDLERILGISAEP-------IFHVVKRWTNSYLKSSFKF 413
WP_103426759 315 VSPDRy-GGQhlLYVASYIQ--SSDePLWQASDEEIEEQWLSHLEEMf-----PdfsrdsvTRFRLARNPRAAPVYERGY 386
WP_119818289 323 VPPDRy-GGQhlLYVASYVQ--SSDdWRWQADDATLEERWLDGIAELf-----PsfsrehvASVRISRNPRAAPVYERGY 394
WP_108381073 333 VPPERy-GGEhlLYAVKYVD--GPEdPFFQRSDDDIEAAWLDGLDDLf-----EqfdrsavEWIETARNPRTAPVYERGY 404
WP_121921492 315 VSPERy-GGDhlLYIASYVQ--DPSeAVWQMDDAALRETWLGHVAEMf-----PefdqstvSEFRVARNPRAAPVYERGY 386
WP_128476414 338 MPPENy-GGDhlLYVASYIQ--DYEeDLWQMDETEIEDLWLGHIEEMf-----PdwdrshvEEFRLGKNPRAAPIYERGY 409
3I6D_A       421 KQRIKELREALasayPGVYMTGAS-----FEGVGIPDCIDQGKAAVSDAlTYL 468
WP_014051308 387 LDMVVPYDLGDdv-aEGLYYAGMAseaqyP-ERSLDGGVEAGFECADRIvEKT 437
WP_014556924 394 LDLVIPYDIGEtv-gDGIYYAGMAsaaqyP-ERSLNGGVVAGYEAADRIiKTF 444
WP_015076950 415 EERKQKLVAILradfPGIYIGGNG-----FGGFGINQCVAQANRISKATiEYM 462
WP_072694504 414 QDERPRLLDAIrtdyPGIYLAGNG-----VNGFGINSCIEQGNEVSEKViAHL 461
WP_103426759 387 LEKVVPYDLSEv--aEGLYYAGMAsraqyP-ERSLNGGIVAGFECADRIdTKG 436
WP_119818289 395 LETVIPYHLHEav-gDGVYYAGMAsraqyP-ERSLNGGIVAGFECADRIaDGE 445
WP_108381073 405 LDKIVPTDLSEi--aDGLYYAGMGsrtqyP-ERSLDGGIRAGERAADLIcD-- 452
WP_121921492 387 LDMVVPYDLGDav-gEGIYYAGMAsraqyP-ERSLNGGIVAGFECADRIaEN- 436
WP_128476414 410 LDTVIPYDLSAev-aDGLYYAGMAsraqyP-ERSLNGGIVAGYECADRIaGRK 460
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