Conserved Protein Domain Family
DLC-like_TCTEX1D2
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cd21459: DLC-like_TCTEX1D2 
dynein light chain (DLC)-like domain found in Tctex1 domain-containing protein 2 (TCTEX1D2) and similar proteins
Tctex1 domain-containing protein 2 (TCTEX1D2) is required for proper retrograde ciliary transport. It associates with short-rib polydactyly syndrome proteins, such as Wdr34, Wdr60, and other dynein complex 1 and 2 subunits, and is required for ciliogenesis. TCTEX1D2 is a negative regulator of GLUT4 translocation and glucose uptake. The model corresponds to the dynein light chain (DLC)-like domain of TCTEX1D2.
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Statistics
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PSSM-Id: 412007
Aligned: 148 rows
Threshold Bit Score: 72.5141
Created: 28-Jan-2020
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q8WW35        38 RFRPSVVKDCIHAVLKEELANAEYSPEem--------pqLTKHLSENIKDKLKEMgf----------------------- 86  human
RZF43015      42 RFNTDKVKRIVENAIRDEMMFDEYDENha--------stACAKIANHVREEVKRLvh----------------------- 90  small brown pla...
EPT02886      24 TFDAELLKAYMKKLLQTTLQNATWPEQkdhe----rlkaWNKEIGERVKERAIEIqp----------------------- 76  Fomitopsis pini...
XP_006958842  16 KFDVEKLRPIMRRVLNAELTNASYEDLdk---------eSTTRIAHKIKQAMLEIsp----------------------- 63  Wallemia sebi C...
XP_008488062  38 KFKPGKAKEIIRAVLEEEFKDKPYDGKqs--------nqIVQKLSKIIKSKVEAVth----------------------- 86  Asian citrus ps...
XP_009492488   8 DAFIELSRHIVRASLRSQSIVSSGDEQpavs-----eegLSRRISSEVLEQLKEHss----------------------- 59  Fonticula alba
OQR77818      25 RFKPDEAKQVMKEIVNPLLDSVERYDAerv-------skLTRKISEKVVEKLKELserakedealrpttaasnrslsdaa 97  Tropilaelaps me...
POV94629      29 HTIQSKIQYILSSKLGITNDLSNEKESfshsnnqlrlkeLNQTIGESIQNLLLEFyp----------------------- 85  Puccinia striif...
PRQ71297      45 RFNPDLLRPYLKRLLAAPEITGAVWDRdaek-----lvkRAEEISGEVKRRMVDLep----------------------- 96  Rhodotorula tor...
XP_025425673  44 MISKPLIKEIIQNVYGKHLKGKTWKDLdp--------kiTCTNISRDIEYGVVEVyrci--------------------r 95  yellow sugarcan...

Q8WW35        87 --dRYKMVVQVVIGEq----------------RGEGVFMASRCFWDaDTDNYTHDVFMNDsLFCVVAAFGCFY 141 human
RZF43015      91 --pKFRIVVQVVIGGl---------------mNGLGTSGAVRCLWDpKTDSMATDTLQTDnFFCCVSVFGIYT 146 small brown planthopper
EPT02886      77 --kGFKYIVMTQIHEn----------------LGQGGRADMACHWE-DSDAAAREMFVNNsIVCTCVAFAIRT 130 Fomitopsis pinicola FP...
XP_006958842  64 --sDYKYIVLVNASKn----------------NNQGGRVDASMHWEmDADTFVQDIYQSDlLICSSIAFAIRL 118 Wallemia sebi CBS 633.66
XP_008488062  87 --qNYKIVVEVTLVEq----------------RGAGIRSDLKCIWDsDADGLASEVFISEhLVCHASVIALYY 141 Asian citrus psyllid
XP_009492488  60 --tKYKFIVNTFSVKrs-------------knSTNGINAQALCYWDaSQDAHVEELFENEnFIIHCSVFILTH 117 Fonticula alba
OQR77818      98 tggRYKIICHTVIVEn----------------RGAGIRVSYGQQWDvDSDGATSHFYASScLQCTCTVLALFY 154 Tropilaelaps mercedesae
POV94629      86 --tGYKIMICTQVIEn----------------KGQAGRAGLVSHWDeVSDKVFKEVWSNDsVIGTVTAFIIKV 140 Puccinia striiformis
PRQ71297      97 --sGYKYLCQVSVSErprgtlsstssstsssaGPGAGKAFLSCFWDpTSDSILSEVYQNEtVVVTVLAVAVRI 167 Rhodotorula toruloides
XP_025425673  96 ednKYKLVVQTMICEy----------------NSQSVNIDALCFWDkNTDGLVYDSYINGyVVCYSQVYFSYL 152 yellow sugarcane aphid
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