1JNP


Conserved Protein Domain Family
TCL1_MTCP1
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pfam01840: TCL1_MTCP1 
TCL1/MTCP1 family
Two related oncogenes, TCL-1 and MTCP-1, are overexpressed in T cell prolymphocytic leukaemias as a result of chromosomal rearrangements that involve the translocation of one T cell receptor gene to either chromosome 14q32 or Xq28. This family contains two repeated motifs that form a single globular domain.
Links
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Statistics
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PSSM-Id: 460358
Aligned: 17 rows
Threshold Bit Score: 127.51
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1JNP_B         1 MATQRAhrAETPAHPNRLWIWEKHVYLDEFRRSWLPVVIKSNEK--------------------------FQ--VILRQE 52  house mouse
XP_003128758   1 MAAEAS--PPLGSPPSCLSFQRPGIYEDEKGRTWMTVVLRINPShqvlgrn------------spgstrdTSvtVHMWQM 66 
P56844         1 MADSVRf-PCMPFPPCFLVCTRDDIYEDEHGRQWVAAKVETSSHspyc------------------skieTCvtVHLWQM 61  house mouse
P56842         1 MADSVHf-PWMPFPPRFLVCTRDDIYEDENGRQWVVAKVETSRSpygs-------------------rieTCitVHLQHM 60  house mouse
P56845         1 MAAVSVd-PQRPL-PVLLVSVSLGIYEDEHHRVWIAVNVETSHSshgn-------------------rieTCvtVHLQHM 59  house mouse
P56840         1 MAAAAFd-PLGPL-PVYLVSVRLGIYEDEHHRVWIVANVETSHSshgn-------------------rrrTHvtVHLWKL 59  house mouse
VFV18119       1 MASGAS--PILGVPPHRLWARRPGIYEDEKGRTWVTVVVRLSPSqrarsras----------pggthepePSvtVHMWQM 68  Spanish lynx
EPQ06459       1 MSELPSn-VHLTSHPIYLSIRGPLLYEDENQRMWLNLLMDTVGV--------------------------LQ--VRFLQV 51  Brandt's bat
XP_017832969   1 MASEAS--LHPGAPPTRLWIQSPGIYEDESGRNWVTVVVRFSPSrrewarlsssqggasqdsasqsstyePSitVHLWQM 78  white-tufted-ea...
XP_004055705   1 MASKAS--VRLGVPPGRLWIQRPGIYEDEEGRTWVTVVVRFNPShrewarasssq-----gsasqgsryePSitVHLWQM 73  western lowland...

1JNP_B        53 DVTLG-EAMSPSQLVPYELPLMWQLYPKDRYRSADSMYWQILYHIKFRDVEDMLLELID 110 house mouse
XP_003128758  67 AVHPQ-TPRFSIHLPVTGLPLKWELCPGRRYRAADSRLWQIVDHGLINSREQLILRLRP 124
P56844        62 TTLFQ-EPSPDSLKTFNFLPRTWRLESRNTYRGADAMHWRLVNHSQFYGTEELVLMLDS 119 house mouse
P56842        61 TTIPQ-EPTPQQPINNNSLPTMWRLESMNTYTGTDGTYWRLLDHSQMGDTLQLILDIVI 118 house mouse
P56845        60 TTLPQ-EPTPQQPINNNSLPTMWRLESRNTYTGTDGTYWRLLDHSQMGDTVQLTLDIII 117 house mouse
P56840        60 --IPQ-QVIPFNPLNYDFLPTTWKLESRNIYWATDGTHWRLLDHSQLGDTEQLILMLVl 115 house mouse
VFV18119      69 PVHPQ-EPVSPSQLTLSRLPLVWQLYSGRRYRAMDSRLWEIVSHGQIDSTEELVLTelp 126 Spanish lynx
EPQ06459      52 DTPSGhIALTTSSLTSSTIPLLWTLYPGDQYLDSMCRFWHIVHHVKKNGVEEMILELME 110 Brandt's bat
XP_017832969  79 AVHRR-DPLSPNQMPFSRLPTVWQLYPGNKYRASDSSFWEIVNHGQIDSFEELVLTYEt 136 white-tufted-ear marmoset
XP_004055705  74 AVHTR-ELLSSGQMPFSQLPAMWQLYPGRKYRAADSSFWEIADHGQIDSMEQLVLTYQP 131 western lowland gorilla
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