Conserved Protein Domain Family
Rad51B
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cd19493: Rad51B 
RAD51B recombinase
RAD51B recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. RAD51B, together with the other RAD51 paralogs, RAD51C, RAD51D, XRCC3, and XRCC2, helps recruit RAD51 to the break site.
Links
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Statistics
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PSSM-Id: 410901
Aligned: 16 rows
Threshold Bit Score: 223.351
Created: 16-May-2012
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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ATP binding
Feature 1:ATP binding site [chemical binding site]
Evidence:
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                             ######                              #                       
CAD66573      101 DEALHGGVacGSLTEITGPPGCGKTQFCIMMSILatlptn---mggleGAVVYIDTESAFSAERLveiaesrfpryf--- 174  human
CCA24579      101 DTALGGGLhlGAITEIAGIAGVGKTQFAMTVALQilsdeillakdertSTVIYFDAEATLNVERLkldqiatamlntrk- 179  Albugo laibac...
XP_002905231   89 DQALNGGLhcRALSEFVGTAGIGKSQVAMTLAVVcamd-------ypnNGVVFFDVEHNFSAKRLlqitiarikvtqag- 160  Phytophthora ...
XP_764088      36 DQALNGGLllGKVCEIYGPSGSGKTQFALSLTSEvlinnl---ihskdYVVLYIYTNGTFPIERLneilrskyedakgl- 111  Theileria par...
XP_002672376  797 NTLFHGGIplNMITEIVGATTSGKSEFCLSAVSDllme-------fdkFGCVIFDTEVKQANIFQriyfmmknrnpd--- 866  Naegleria gru...
XP_001609660   21 DDALGDCLllGMLTEIYGESGSGKTQVALTLVAEelvrmq---eadsnDVMLYFQTSRAFPMQRFcdiiehkrksknsr- 96   Babesia bovis...
AAS75434       91 DGALRLGVpvGSITELVGPGGVGKSQLSHMLALAvampea---lgglgAGVVYIDTERKFSAPRLqemvharvaeaaaaa 167  Chlamydomonas...
CCD14008      131 DTAIAGGVgrGSVTEITGASGSGKTVFALHLMKGaarlss---gegtpYHTLWITSDGYSSFPVKaasnvlgsgldgcvs 207  Trypanosoma c...
CCC53249      230 DRALAGGLacGTITEVTGASGSGKTALALHLAMRlacend---tmpgpHRTLWITTDYLAFPSAAlrdlarlhmktr--- 303  Trypanosoma v...
CBH17677      141 DDVLAGGVkcGLVTEITGASGTGKTALALNLAGRaatlare-grgngkYHTLWISSNQHPFSTRAtagylrstlgtyrgd 219  Trypanosoma b...

Feature 1                                                                 #                       
CAD66573      175 ----------nteekllltssKVHLYRELtcDEVLQRIESLEEEii-skGIKLVILDSVASVvrkefdaqlq-------- 235  human
CCA24579      180 --------gfcrdyraedlldRLLIIKVDtlAQFLTKLLKLGQNlrmmsGTKLLIVDSIAALyvhsiges---------- 241  Albugo laibac...
XP_002905231  161 --------qedinelaaavikRIRVVKVNsiAAFLSKFKEMEDAmh-slKAKLLIIDCVTTLflkaddlt---------- 221  Phytophthora ...
XP_764088     112 -------ikadenfntsqllkNLYVEKVTdnDELYFTFTSKLEEml-qhNVKLIVIDSIAALfrtvqnes---------- 173  Theileria par...
XP_002672376  867 ---------mseseieerilkKCTIIHVAssKELIDSLDNLEEFif-ekNIKLIVIDSLATLstkefqgke--------- 927  Naegleria gru...
XP_001609660   97 --------fkgaplgpreiakHLRIYRPSepTLFLEELRNLHADvgasyHIRLIVIDSIACLfgdcmedkd--------- 159  Babesia bovis...
AAS75434      168 gp--qaahvlqplavqgevlrRVAVSTPGstEQLMQTVENLQHTvl-qyRARLVVVDSIAALarteygnpsssgasgsva 244  Chlamydomonas...
CCD14008      208 ntscfagssreaagralkmaqGLSVVVVStiTQLLECLPKLREHvsfssGVRLVVVDDLNTMvrrsysgvd--------- 278  Trypanosoma c...
CCC53249      304 ----------wsreleevalcRVSVTAINtfSELRAQFPALREHllretGTGLLVVDGLNTLvrrtfpgvd--------- 364  Trypanosoma v...
CBH17677      220 nngsnaaepdrfggdaetalqQLAIVTIPtlGQLLEHMPVLRENimlndGVRLVVVDDFSAMvrrtftgmd--------- 290  Trypanosoma b...

Feature 1                                                #                                        
CAD66573      236 -------gnlkernkfLAREASSLKYLAEefSIPVILTNQItthlsgalasqadlvspaddlslsegtsgsscvIAALGN 308  human
CCA24579      242 ---------ltkkefwLTRIARELKFLSDnfQICALLTNRAvssfne---------------------hglrgsKPSLGD 291  Albugo laibac...
XP_002905231  222 ---------hsqrqheMLRMARDLKLFADtyQAFVVVTNRAttvdge----------------------dglytKPQLGD 270  Phytophthora ...
XP_764088     174 --------yhgqrinsITKVGLIMKRISHeyNLLILAINQAsgvfnlsni---------------pflnprsgiKPALGE 230  Theileria par...
XP_002672376  928 -------ggaferasiLQTEATLLKQLNEkfKVGVLVTNSLss-----------------------------sdEAQLGI 971  Naegleria gru...
XP_001609660  160 --------adnasmntLLNVASILKRLAHqkNALILLINEAiagnldasa---------------gtgmthtlvTPALGD 216  Babesia bovis...
AAS75434      245 ggggglvgsimdrqqvLGRIAASLKALAEslRIPVLVTNQVttrigggggggp----------gppgsaangtlTAALGA 314  Chlamydomonas...
CCD14008      279 -------eevlerhnaVASLMQSFKIIAQefSVAIVVLTQS---------------------------------VGDLGH 318  Trypanosoma c...
CCC53249      365 -------gevaerheaVTEFMCALKSMAHefHLTVIVTTVA---------------------------------GKDLGQ 404  Trypanosoma v...
CBH17677      291 -------gevierhnaVAALMNAMKSVAQdlRVAVVIITQS---------------------------------EVDLGH 330  Trypanosoma b...

Feature 1                      #                                     
CAD66573      309 TWSHSVNTRLILQYlds----------------------errQILIAKSPL 337  human
CCA24579      292 LWSHYVTYRLSLDWdre-----------------------frVLSITKSPS 319  Albugo laibachii Nc14
XP_002905231  271 NWAHCVTTRFIMERhsl-----------------------yhAMTIVKSSV 298  Phytophthora infestans T30-4
XP_764088     231 AWERCINSRILVTRrrdqrf-----------------nreirHFQVIFSSN 264  Theileria parva strain Muguga
XP_002672376  972 NWYHFVNHRLKIYKige----------------------skaIINIVKSSI 1000 Naegleria gruberi strain NEG-M
XP_001609660  217 LWSQAINCRILIEAirsss-------------------strrFLRILFNCN 248  Babesia bovis T2Bo
AAS75434      315 KWAHCVNLRLVLQRlqe-----------------------rrFLKVAKSPS 342  Chlamydomonas reinhardtii
CCD14008      319 AFLYGVNTRLRLSKcllrhrrdae--------ptegelrlghVLNVVKSSA 361  Trypanosoma congolense IL3000
CCC53249      405 AFPHAVNTRLRLSQclvrhrvdsakfcsndivghrfgarlayVLELAKSCA 455  Trypanosoma vivax Y486
CBH17677      331 AFLYAVNTRLRLSRcllqpndaaa--------dvagnvrlvhLLELVKSCM 373  Trypanosoma brucei gambiense DAL972

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