Conserved Protein Domain Family
Vezatin

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pfam12632: Vezatin 
Mysoin-binding motif of peroxisomes
Vezatin is a peroxisome transmembrane receptor that is involved in membrane-membrane and cell-cell adhesions. In the movement of peroxisomes it binds to class V and class VIIa myosins to guide the organelle through the microtubules and allow pathogens to internalize themselves into host cells. Vezatin is crucial for spermatozoan production. In mouse cells it interacts with the cadherin-catenin complex bridging it to the C-terminal FERM domain of myosin VIIA.
Statistics
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PSSM-Id: 463650
Aligned: 29 rows
Threshold Bit Score: 130.206
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_011489592  150 LLGLAAVLLGLCSssss--segPW-LLALAPWGLTLLGWV---GLRG--AALWRRGRMQRAVHSRATQLQALLHDSKTLT 221 
XP_007677613  151 LAFALVCVLSWAT----------SeRSGSVSKGRIALALItfaLAALlgYAYVRRQWLKSIRLQAVTAVSELTASWQGFE 220 
CCU76264      143 sAFSLAWLIHWAR----------TsARSAAGRGRLAVMLTvlgIAGMisYAYFRRQWLQNLRQETVTELSNLIVSAYELD 212 
XP_011275534  231 ILGVLSHLQKHKG--------------NYQNSQIRLVIIIsliILNA--HTISHTQSLDLIQHKTLNQLKRFIKIQQKFD 294 
EEQ39047      183 TVLLIVYLLKQRLlp------rQTlDSSQHYQLFKLLLIMatkIVKF------QRAAILIYSSKTLRSLDDFMLSNCQIN 250 
Q59N02        327 VILMIIYLLKQQQlmsyqhhhnYGlSIKIQFKLFKIIIYIsmkLIKV------KKFKLIIESNQILLNLQKFLILNYKIN 400  Candida albicans
ABN64437      296 IINLIIFLMKQEQrrhl--nysATmSYSNRMKMFKILLIIstkLIKF------NRFKLLVMSQSNLSYLNSFLLSNYSIN 367 
EGW34170      183 IINLIIYLLKQRKt-------nEHtNQSNQLKFFKIILIIstkLIKV------KKFRTLVQTSQILNLLNEFLMSNYIVN 249 
XP_001486211  164 VIHLIIFLIKQSLke------dSHlLSHSKHKLFRILLVVstrMIQF------KRIGLRIKANKILNYTEEFLKLNYKIN 231 
Q6BGY9        189 TIYMIIFLLKQSLkg-----vkSKmSTQNKFKMFKILLIIsvkLIQF------KRINLKIQSTKVLNMLNDFLVNNYKVN 257  Debaryomyces ...
XP_011489592  222 GLSRKALRLVQE--TEVISRGFTLlldrVSAASSFSRAgpGAMPRGQQLIGLRKALYRALRSAFRASRRATCHMLKafpl 299 
XP_007677613  221 ASTSSALSLIQE--VELVSKGYKL----GTPLPPASRI--EENGTSRRCGRLRKALHNAYTTAIPTCVKACTTLRR---- 288 
CCU76264      213 RAAANAISLVQE--VELVSRGYRI----SSPLPPISRI--EDRSQSRRCIRLRKQIRKSFVDVTTKYVEAVSQLQP---- 280 
XP_011275534  295 LQEQKLITKYKE--LKLYNNILPI----------------QQQHSSEDPSQLFDLVSSTIIVASTSVINSIHKILP---- 352 
EEQ39047      251 KDIITSIITLKE--FQMFSFLDRP------------K---QEQISSGYPKDLAKHLNTTLRLLSLNMKHSISALLP---- 309 
Q59N02        401 KKLIIQLINLKGdqLNLISNS-------------------SGGGGDGFEQQLKQYLFNILSLLNLNLQNSIIKLLP---- 457  Candida albicans
ABN64437      368 KKLIQKLIILKE--LDVYYYVNRNkdeaNH----------DSKSREVYKSSLREHLANTLHFLNLNLRTSIARLLP---- 431 
EGW34170      250 KKIILQMIRLKE--LHTYNFLP------------------GQGDNVSYKSHLHSHLLSSLSFLNLNLKSSIMDLLP---- 305 
XP_001486211  232 KKLISHMIRAKE--MAIFTGTS------------------LSSSGSNDPTSLMKTLDETLSFLIFNLKSSIVRLLP---- 287 
Q6BGY9        258 KKLIMNLINLKE--MEIFGFMK------------------NSAISKNKVHDLKENLDNTLNFLNFNLKSSIIKLLP---- 313  Debaryomyces ...
XP_011489592  300 SSEIDNVTNYVCAVPLKELglGLGIEhlgdeq---------aqeltDDYSLPALKMLFQLWVGQSSECFRRLALLLSPYR 370 
XP_007677613  289 LSDEDDFEKFLEVYDVNPQ--DAKQAsgddpl---------lpledDAESLKSLRVMSYRAGILRRIVLCALMALEADGG 357 
CCU76264      281 LAEELDLEKYYDIYDITEN--DLTEAslgys----------eieaeDQESVRTLKLLAARYNTLRRIFLCSLMALNADGN 348 
XP_011275534  353 YVNGYELENYCELYNIELTqlGFETEnlkpf-----------niseSESSIDQLVNKFRRFQYLRRFLIVLFLAMNHQFS 421 
EEQ39047      310 FSNGEILEKYCQINNVQMS--WIFEEhde--------------sieEVSSLEILTSKLGHFNNLRRFFICQLLTIHDPPS 373 
Q59N02        458 FMNGELLEQYCLMNNIKID--ILNQDneiistvgrg-ytlgsnsnsNSSCLDNVKFHFKKFDNLRKLFICQLLIINQ-PS 533  Candida albicans
ABN64437      432 NLNGDLFEQYCNLNNIDIL--LLQEDyrdgdeeelngmdspvssskEKNSLDEIVFNMNKFNQLRKLFICQLLTINESSV 509 
EGW34170      306 VLNGDLLQQYCNINSIDLE--ILTQEytp--------------ddnQDEYINEIIFNITKFNQLRRLFICQLLAINQTPV 369 
XP_001486211  288 FLNGPTFEQYCHINNINID--ILGKSld-----------------eTELTIDTLRSKLDKFHKLRKMFLCQLLTISERQS 348 
Q6BGY9        314 FLNGPMFEKYCNINNINVC--TLNSKydadgti-------einrssEKITIDELTFKLNKFNQLRKFLVCQLLTVNESPI 384  Debaryomyces ...
XP_011489592  371 TDEPEEGKSKavgsppl-------pmhrsiAAMTEPLHHALTSCLAEVqrsydfHRHFETQPRT---------ASSDRTG 434 
XP_007677613  358 KPDFARWRVA--------------------TETMRALSANLGGPAEKL------RLIMTEMESLtipatpltppksgghg 411 
CCU76264      349 KNDFHVWKIA--------------------LERIRDTRVATASAGARL------ATLLNTEESFpvpptpklpLTP-GRE 401 
XP_011275534  422 THSPFLMKVFgifqiksrltcsilkssvlvSQ------------------------------------------------ 453 
EEQ39047      374 H-NFFISKIRdy------------------------------------------------------------lPTPIKTS 392 
Q59N02        534 KPNFFLFKLMdqfnid---------dsnssSSFSENFFNNSVPIFDSL-------------------------------- 572  Candida albicans
ABN64437      510 KKNFFIYKLMdqfpp-----------------------------------------------------iktedWERDDDI 536 
EGW34170      370 RYNFFIYKLMdq-------------------------------------------------------------fNLDSRE 388 
XP_001486211  349 Y-NFFLSKAWdlfnlp---------qaetrELCSTPISVLE--------------------------------------- 379 
Q6BGY9        385 R-SFFLFQVWdqfnit---------eyevdEVLQNDFLFFE--------------------------------------- 415  Debaryomyces ...
XP_011489592  435 RAREKCRELNTLHTSIRSLQLHLK 458 
XP_007677613  412 qarqrmrgqvrkismlssgiralq 435 
CCU76264      402 RWRAQSRQLNSLSTGIRGLQAKLQ 425 
XP_011275534  454 -------SLESLQELISGLVESLS 470 
EEQ39047      393 TYTSTIDKLKSLQLVFQEHTAALE 416 
Q59N02        573 -------RLKIIHDLLIDHNLTLS 589  Candida albicans
ABN64437      537 TAFNNIAKLGFIRQVLHDHNKITN 560 
EGW34170      389 VQISDYNRLNLIKRVMTNHNQTSS 412 
XP_001486211  380 -------KFIILEDIFHEHNQTVS 396 
Q6BGY9        416 -------KLLVVEELFEEHTNIVK 432  Debaryomyces hansenii
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