1ACA,1HB8,1HBK


Conserved Protein Domain Family
ACBP
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cd00435: ACBP 
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Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a role in regulation of intermediary metabolism and gene regulation. The suggested role of ACBP is to act as a intracellular acyl-CoA transporter and pool former. ACBPs are present in a large group of eukaryotic species and several tissue-specific isoforms have been detected.
Links
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Statistics
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PSSM-Id: 238248
Aligned: 15 rows
Threshold Bit Score: 122.434
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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acyl-CoACoA binding
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:acyl-CoA binding pocket [chemical binding site]
Evidence:
  • Structure:1ACA; bovine ACBP with bound palmitoyl-CoA
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             #  ## #      ## #  ## ##  ##                 ##  ##                  #  
1ACA        1 SQAEFDKAAEEVKHLK----TKPADEEMLFIYSHYKQATVGDIN-TERPGMLDFKGKAKWDAWNELKGTSKEDAMKAYID 75  cow
1HBK_A      2 MAQVFEECVSFINGLPr--tINLPNELKLDLYKYYKQSTIGNCN-IKEPSAHKYIDRKKYEAWKSVENLNREDAQKRYVD 78  malaria parasite P...
5902716     1 MTLSFDDAAATVKTLK----TSPSNDELLKLYALFKQGTVGDNT-TDKPGMFDLKGKAKWSAWDEKKGLAKDDAQKAYVA 75  Caenorhabditis ele...
5902715     3 LKEDFEEHAEKVKKLT----ASPSNEDLLILYGLYKQATVGPVT-TSRPGMFSMKERAKWDAWKAVEGKSTDEAMSDYIT 77  rape
13324982    5 LDEQFEAAVWIINALPkngpIKTSINDQLQMYSLYKQATSGKCD-TIQPYFFQIEQRMKWNAWNQLGNMDEAEAKAQYVE 83  Caenorhabditis ele...
2226378     4 SVEEFNAAKEKLGALK----KDPGNEVKLKVYALFKQATQGPCN-TPKPSMLDFVNKAKWDAWKSLGSVSQEEARQQYVD 78  common carp
3878905    25 AQADFEKAQKNLKTLK----EEPDNDVKLQLYGLFKQATAGDVQ-GKRPGMMDFVGRAKYDAWNTLKGQTQDEARANYAK 99  Caenorhabditis ele...
1168273     2 VSEQFNAAAEKVKSLT----KRPSDDEFLQLYALFKQASVGDND-TAKPGLLDLKGKAKWEAWNKQKGKSSEAAQQEYIT 76  fruit fly
119335     42 HETRFEAAVKVIQSLPkngsFQPTNEMMLKFYSFYKQATEGPCK-LSKPGFWDPVGRYKWDAWSSLGDMTKEEAMIAYVE 120 cow
398989      3 LQEQFDQAASNVRNLK----SLPSDNDLLELYALFKQASAGDADpANRPGLLDLKGKAKFDAWHKKAGLSKEDAQKAYIA 78  tobacco hornworm

Feature 1               
1ACA       76 KVEELKKKYG 85  cow
1HBK_A     79 IVSEIFPYWQ 88  malaria parasite P. falciparum
5902716    76 LVEELIAKYG 85  Caenorhabditis elegans
5902715    78 KVKQLLEAEA 87  rape
13324982   84 KMLKLCNQAE 93  Caenorhabditis elegans
2226378    79 LISSLVGTEA 88  common carp
3878905   100 LVGGLISEEA 109 Caenorhabditis elegans
1168273    77 FVEGLVAKYA 86  fruit fly
119335    121 EMKKILETMP 130 cow
398989     79 KVESLIASLG 88  tobacco hornworm

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