7AJK


Conserved Protein Domain Family
CYRIA-B_Rac1-bd

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pfam07159: CYRIA-B_Rac1-bd 
CYRIA/CYRIB Rac1 binding domain
This domain has been annotated as Rac1-binding domain. It can be found in human CYRIA/CYRIB and at the N terminus of CYFIP1/2. CYFIP proteins are known RAC1 effectors that stimulate actin polymerization. In mice, CYRIB (also known as CYRI or FAM49B) negatively regulates RAC1-driven cytoskeletal remodelling and plays a role in restricting infection mediated by Mycobacterium tuberculosis and Listeria monocytogenes.
Statistics
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PSSM-Id: 462106
Aligned: 32 rows
Threshold Bit Score: 337.677
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7AJK_CCC                  18 NFFLDFENAQPTES-EKEIYNQVNVVL-KDAEGILEDLQSYRGAGHEIREAIQHPA--------DEkLQEKAWGAVVPLV 87 
EGF81405                  19 DIPIDF-NAQPTPE-EQQIYNSASEIL-SFAPNILQDLRNYTGCGEAIRQAISTPG--------RA-TEDAAWAVVCPAV 86 
EPB90899                  19 ELGFDLENATPSSD-ELQLYNKLSSLLvKPGPALLHLLKSYVPASDQIRDAIAKPT--------PE-NESRAWDAVSPTV 88 
EIE80432                  19 EIGFDIENAAPTTE-ESEIHDELYNLLiQPTTELLQSFRQYEPASDMIREAIASPT--------TE-NEDKAWEAVTPTV 88 
Q8T2H0                    16 QIFIDFEHAQPSDD-ERELHKTVNEVL-IRGPAIIDKLLAYAGCNEFIRRAITNPG--------PE-TEDAAWEAVLPSV 84  Dic...
XP_001325741              13 AVYIDLKNATPTNDvERKIVEDFQEKVlNPGKNLYDKFANYKDGQEFVKIAMRDTS--------QA-NKDAAWNAILPNV 83 
WGS:AAFB:cds.EHI_131000A   9 VAIPINFSATPSAA-EQEPFQTINEVA-SHINEMLQKMTNYKAKETEIRAAIATPS--------PE-TEEAAWKAIIPQV 77 
BAN39491                  16 QITIDFENVSPSEA-ELKIWNDIDIML-RRKDDVLNKVTNYHGQDDLIRKAISARTgsdnlsgmSQ-PEEEAWKVISSQA 92 
XP_003241353              34 DIFLDFENAQPTES-EMELFDEVQIVL-TEASDVLSDLKHYLGADQYIRAAINNPS--------AE-QNALTWEALMPRI 102
EPB83473                  20 EINFDIENARPSSE-ELGIYNQLHALLvQPNSNLLKILKEYKPASDEIRNAIATPN--------QE-NEDKAWNAILPTV 89 
7AJK_CCC                  88 GKLKKFYEFSQRLEAALRGLLGALTSTPYSPTQ-HLEREQALAKQFAEILHFTLRFDELKMTNPAIQNDFSYYRRTLS-R 165
EGF81405                  87 VKLKEFYDFSSSIEQLVPRIWQFFG--KGDVSA-SFEKYQATARRLAEILDFATQFDGLKMSNPNVQNDFSYYRRSVS-R 162
EPB90899                  89 DILRDIYDYSADLQEGLPKLLGVLC--QGDVSK-NLERNQGLAKLFAELLDFVFEFDHLKMRSPTLQNDFSYYRRMLQ-R 164
EIE80432                  89 NMLRTFYSYSAQLEKGIPTLLNVLC--KDGTTK-DLDRHPGLTKLFADLLDFVFEFDYIKIRSPAIQNDFSFYRRTLQ-R 164
Q8T2H0                    85 DQLQEFYDFSLELETCFPKLLVALC--KNDPKA-SLSNQQALAKQLADIFDFVLKFDDAKMVNPAIQNDFSYYRRTLN-R 160 Dic...
XP_001325741              84 YTQMDGYYFSSTIATEFVNVMSSVLEIAGAAKVdFFTQYPALTKCFADCFDVCLKFDQIPIKNPFLLNDLAYFRRNCReH 163
WGS:AAFB:cds.EHI_131000A  78 QTINSFFEYSRSMKTEVVKSLRLIC--KLNGND-SVTQYQAVTVKLMELIDFAVQFDNKKLANPGLQNDFSYYRRSVG-K 153
BAN39491                  93 DIINEFYQFAVLLETEFPKLVTELS--RDDAKA-TLTDKQALCKQLGVILDFVLAFDNKKVTNPGIQNDFSYYRRSFP-R 168
XP_003241353             103 RTLRRFYFFSQKIAFVVPQILTEICSDDITPSL-HLENQQALVKQFSEIIEFVLKFDEYKIRTPAIQNDFSYYRRVLM-R 180
EPB83473                  90 DALREFYSYSSELERGIPMLLNVLCKDGGGTTK-DLDRHPGLTRLFAEILDFVFEFDYLKIRNPTIQNDFSFYRRTLQ-R 167
7AJK_CCC                 166 -------MRINNVPAEGEn---------EVNNELANRMSLFYAEATPM-LKTLSDATTKFVS--ENKNl-pIENTTDCLS 225
EGF81405                 163 -------MKMNNAQLVA-----------VVSDDLANKMSLFFAHSSPV-TKALIDATALTIS---SRAi-sQDAASDILS 219
EPB90899                 165 g------RYSSQDGRDGDdssvsdlrsaMIEDDQANRISLFIAYPTPM-LKCIIDTTTKFVN--KNRL---QKSVGDWLA 232
EIE80432                 165 g-----------rSLEDSdpnksnlrtaMDEDDLANRISLFIAYSTPM-LKCLIDTTVKYVQ--SNQS---TKSVSEWLS 227
Q8T2H0                   161 -------MKLTKKDANI-----------KIRDELANRMSLFFAYPTPM-MKVLSETTVKFLS--QDTTv-pRDNVTTALA 218 Dic...
XP_001325741             164 nhdgsfdNLLTD----------------------SNFSTVFWGSRMPFtMKVVSEVQDKYKS--NATQ---YANVINLIG 216
WGS:AAFB:cds.EHI_131000A 154 -------MKQKHREDV------------VLRDEVTNQISMFFAFAAPM-ILCLCEALNE-----DIKNglsLDNLGDWLR 208
BAN39491                 169 -------MKQFKREDEL-----------KIPDEVANRISMFIANPSPM-MAHLVTIIKGVQNgaINPS------FSEILI 223
XP_003241353             181 ega--svHSFTDQDEDS-----------NSNLNVANKVSLFYAEATPM-LRTLSNVTSQFLN--KDKRl--VDYAIDMLS 242
EPB83473                 168 gra-tefTQTTPSSPEKEqrsqsdlrlaMNEDDLANRISLFIAYPTPM-LKCVIDTTTKYVQ--SNQL---SKCTSEWLA 240
7AJK_CCC                 226 TMASVCRVMLETPeyRSRFTNEETVSFCLRVMVGVIILYDHVHPVGAFAKTSKIDMKGCIKVLKDQPPN------SVEGL 299
EGF81405                 220 TLAGIAYSTVAKNr------aGNDTGFYLRVMVISIVLYDHVDLAGAFIKTSKISIKSSVKVIQTYGGS------ACDTL 287
EPB90899                 233 ALWATCFNTVSK----KRNQNPEISAFCMKVMVVSIILYDHIDPNGAFYKNSPINIKHSVKIIQTITTVksn-eySATNL 307
EIE80432                 228 SIWAVCYQTLSK----KKTNNDSISSFCFKVMVVTIILYDHVDPQGAFSKYSPINVKNSLKIIQTSNNnnn-eqsSTANL 302
Q8T2H0                   219 TMANVCHDMVEKK----KFTQDDLNMFCLRAMVGSIILFDHIHPQGAFVKKSPVNIKPCIVTLKDSNTQ------SSPGL 288 Dic...
XP_001325741             217 LVADCCTSICTKSdnPS----QEICIIALRCLTAAIIIYDSLNPLGAFHHEVRYHYREAVDLLLNYTP-------KQQDL 285
WGS:AAFB:cds.EHI_131000A 209 TVAYSCCVEAQKH--------GSNGIQLLRIMTGCILLYDTVVPTGAFSTKGKFNVLECVRTLQTYQEE------EVALL 274
BAN39491                 224 LFANVCNDMVQKG----IFENNETNLFCLRVMTGCIILNDNISELGSFHKKSPIKVKDCIMQLKNFADNvdy-teAINSL 298
XP_003241353             243 TMVKVCIRMLETP--TVQFRKQETHLFMLRVLVGLIILYDHVHPNGAFVKTSNIDIKGCVRLLKDQPEEf-----QTENL 315
EPB83473                 241 SIWAVCYQTLNAN--YKKSSSSSVDTFCLKVMVVSIILYDHIDPSGAFAKNSPINVKSSLKTIQNVNQInrqeqsSTSNL 318
7AJK_CCC                 300 LNALRYTTKHLNDETTSKQIK 320
EGF81405                 288 LNSLRYSTRHLNDETTPKVTK 308
EPB90899                 308 LSALRYNSKHLNDDTTPKNVK 328
EIE80432                 303 ISALRYNSKHLNDESTPKAIK 323
Q8T2H0                   289 LNALRFTTIHLNDVDTPGAIK 309 Dictyostelium discoideum
XP_001325741             286 IDIVKYCTTSLSKPTTDSKIK 306
WGS:AAFB:cds.EHI_131000A 275 ANSLKYSTKHFNDEDTPKNIK 295
BAN39491                 299 LDTIRYTCLHVGDPDTPGYIK 319
XP_003241353             316 LNALRYTTAHLNDPSTSKTVR 336
EPB83473                 319 ICALRYNSKHLNDESTPKGIK 339
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