Conserved Protein Domain Family
CobS

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COG0368: CobS 
Cobalamin synthase CobS (adenosylcobinamide-GDP ribazoletransferase) [Coenzyme transport and metabolism]
Cobalamin synthase CobS (adenosylcobinamide-GDP ribazoletransferase) is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis
Statistics
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PSSM-Id: 440137
Aligned: 691 rows
Threshold Bit Score: 78.2687
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_130537148   1 M-IfktsskKTFWLSLQFFSQLPTPNFQS--V-TVREMAA-SMVWSPVIGLILGGGLAVSFS-IALwlamqgVPagVLAV 74 
ADM27173       3 L-L------KGIKSLLSLLTTIPIGEE------DIESGAR-VFYLVPLIGLLEGCIAGAILS-LMKil---qLSidIIAV 64 
AFH42023       1 --M------KDFFSLLSFLTPIPVPRK----Y-REGGLSFgSVYLLPIIGLLRGGIAIIPAA-VLLslk-ikLv-pLIAF 64 
WP_083755277  13 FsM-------GFRGLISFLTIIPAGG-------KFEYAPR-YFYLVPLIGLIEGLIAASPLL-I---------SkpIGAA 67 
WP_013135635   4 FiL-------GFKFALSYFTILPVKFKEDddLsKKEILSF-MLFSLPLLGLILGFITLVLYH-LLAdl------swFGAT 68 
WP_013325862   4 L-F------KGFALALSMLSILPFFKVHD--F-YKGINGY-AVMFYPLVGFLLGLILYGAFI-LLTp----yLPplHVSI 67 
WP_013458886   4 IiL-------GVKFALSYFTLLPIRFNADddLsHPRVLKS-MLLSLPFVGVLLASLSIGVFS-VLEsl------gwLGAI 68 
WP_014770279   4 FyL-------GLKFSLSYFTILPMHFKASddVgHPPVLSS-MLFFFPLVGVLLSAITLILYHfLLApl------qgVGAF 69 
WP_015232742   4 A-I------KGFLSLLSFLTTIPTNQN------NIKEASE-YFYLSPLIGLIEGIIIGLIFF-LLr------FNfiINGS 62 
WP_025391992   4 F-Fi------GFAIAWNMLTNIPLfRIYT--F-KEGYNAY-ACVNYGVVGFVLGLIVYLLCK-IACi-----ePyiLVKV 66 
WP_130537148  75 FILVIWIAFSKGLHLDGLADVGDAWMGSlGSTERALNIMKDSRLGTGGVTTLVLMILIKWQLITHLLtefsridtgltpt 154
ADM27173      65 LYIAIHIAITGGIHIDGYADYLDAIGSH-RRGEEALKIMKDPRKGTFSIAILTLSLITSYISMKELItld---------- 133
AFH42023      65 SIVALHFIMQGFLHADGFIDFTEALLAG-RFGVDAKKVLKDKYRGSYAIASFSVFTLWLYSSLSSFQepg---------- 133
WP_083755277  68 LSTALTYLINGFQHMDGFLDFGEALLTG-RRGEEAVRVLKDPHRGSFALTLGLIDVLLVYSSLLSMGke----------- 135
WP_013135635  69 ICAVSYMILYGFIHTEAIIDVVDAIYAK-HSGKDAYEVIKEPTIGAMGVLYAFAFFTLKIAGIVYLFln----------- 136
WP_013325862  68 IIFSLWVVLTGALHLDGFADTVDGLFVD---KKRALEVMKDPHNGGMGITFSIVFLLLKASSLAALDa------------ 132
WP_013458886  69 IAAVIYMVLYGFIHTEAVIDVADAVHAA-HSGKDPYEIIKDPTVGAMGVLYGVSFTLLKIAALSTLLmh----------- 136
WP_014770279  70 IAAVVYMLLYGFIHTEAISDCVDALYAK-HSGKDAYKVIKEAHIGAMGMLYTLAFVLIKVALLGYMLsh----------- 137
WP_015232742  63 ILLASHLLLTGGLNLDGFSDYSDVIGSR-KIGEEAEKILKDPRKGSFAIIFTSLIIIIRFASFSNIKn------------ 129
WP_025391992  67 LIFSFYTFSYGALHLDGLFDSLDAIFLK-APKEKLLSILKDPHLGSFSVIFGTLFIITKLSAFVYLKn------------ 133
WP_130537148 155 vfagvFILI--LLIPAFARFTAWRLMALSRYAGQTayhrklfhywSSGNL--SKTSN-R--MyrLS-AALL--TfVmLIA 224
ADM27173     134 --lyeLIPLl-ISIYVSATESMYIVAAIGREEPYM----------GLGYMfsRYAKPlKn-I--IM-NIAIyvL-L-ILL 194
AFH42023     134 ---yaLI-LfpISAEVWSPSSMILTSLLS-GEPPE----------GMGREfkRSSSP-Ss-L--AA-SLLI--S-F-PFT 189
WP_083755277 136 ----tLITLp--ITEAAAAYVMFTTAYLG-KPSEG----------GLGRLfiIEAKG-N--Vk-LTsSTLLyaA-I-IVA 192
WP_013135635 137 ---gyLLEF--VSIIVISRLMLLFVIKNF-EFK-S----------SFVNQlkDSLST-Ni-F--LS-AIIV--F-T-LAN 190
WP_013325862 133 -----VYLL--PVILMLSRLSAVLEIYLYPYISQN----------GMGSLakAEFNR-Wq-L--FV-ALAY--S-F-MV- 185
WP_013458886 137 ---hlFLPF--IAIALISRLSLLVLIRTY-EFR-S----------SFVTRlhENLRV-Vp-L--IL-LILL--C-G-ALG 190
WP_014770279 138 ---alYSEF--IAVTLCSRFALVVLMKTL-HFR-S----------SFVTSlqEALVP-Km-L--FL-SFMV--T-L-LVG 191
WP_015232742 130 -----IFSI--VLSYVTGIESGYLISYFSNAPKYQ----------GLGSMfiESSKN-KkkL--LY-NLIIylI-I-III 186
WP_025391992 134 -----MSLF--IVAASASRFSVIFPMRFFPYIS-S----------GMAQKakNELKS-Yh-L--II-ASII----M-VV- 184
WP_130537148 225 LyglVaeLfcpqiSqMncsS----Si-iLL--VtIf---LtVgALLIfgmqMLWLRKQSENLIGGINGDMVGAQIEVSET 294
ADM27173     195 Ll--A--I-----N-M---KillhL---LA--I-V----V-L-TIAI----SLLSYRDSRYRIGFITGDVMGFTYELLRI 245
AFH42023     190 Lm--Ls-F-----S-L---Kl---S---LIitA-Ls---L-S-SLLLs---SLLSYYMGKKALGYANGDVLGFSNELCYA 242
WP_083755277 193 Vp-lL--Y-----H-W---G----AliiLI--T-ItvnaL-I-SELV----ALLTVKLSHSRLGFVNGDVLGFSFELSKV 247
WP_013135635 191 Ii--L--I-----G-F---S----A---IT--L-T----F-F-AFIF----SYLIALFIKKNVGFLNGDALGTILELSEL 237
WP_013325862 186 Lv--L----------F---E----S---YI--L-M----F-V-SLLV----MFVLKSFFIKRYDGFTGDIYGFSIEMTEL 230
WP_013458886 191 Fy--L--L-----S-V---N----F---LP--L-F----V-A-GVLT----ALLLSFLTKRSLGFINGDVLGMSLEGSEL 237
WP_014770279 192 If--L--L-----K-G---D----F---LL--L-L----T-C-TLVF----AFIVATRLAKGLGFLNGDGLGATLELCEA 238
WP_015232742 187 Ll--F--V-----SkT---K----Yy--LI--S------I-F-SLLL----VPIIVFDSNKRLGYANGDVIGFTIEIIET 234
WP_025391992 185 FlspI--Y-----R-F--------S---IL--I-L----I-F-SVCC----SLFIGNLLTKKFGGLNGDFYGLLIETNEL 232
WP_130537148 295 VGLILLLL---L 303
ADM27173     246 LSLLILSI---T 254
AFH42023     243 LLLTVYAAgayL 254
WP_083755277 248 TLLTIYSA---L 256
WP_013135635 238 FLIIIILN---- 245
WP_013325862 231 VLLNAVIVglq- 241
WP_013458886 238 VLIITALL---T 246
WP_014770279 239 LLFLGIAL---W 247
WP_015232742 235 ASLLISVI---I 243
WP_025391992 233 LLILVFVF---L 241
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