5Z0Q,1C7N,3L8A,1D2F


Conserved Protein Domain Family
MalY

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COG1168: MalY 
Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism, General function prediction only]
Statistics
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PSSM-Id: 440782
Aligned: 519 rows
Threshold Bit Score: 318.574
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5Z0Q_A         9 MPFNFDQRIDRRHSDSLKW----K-K--YA------DRDILPLWIADTDFRAADCIIDALQQRVQQGVFGYGVTSEALAE 75 
WP_015778541   1 MKFEFDKMLERHGMDAIAVdglgT-VpgMSpdkpkeGFDVIPMWVADMNFATAPSIQEAIIKRAKHPAFGYFAPTDEYYQ 79 
WP_014488694   1 MI-NFDELIDRRKTNSIKWt----kA--FGek--plKENQIPMWVADMDFKAAPEIIEAIKKEADFGIFGYFT-YDEYYE 70 
WP_014079173   1 MKFDFTTIMDRKGKDALAVdkipCk--dVTvq---eGFSTIPMWVADMNFATVPSVQKAMTDRIAHPAFGYFEPREEYFD 75 
WP_014080057   1 MKYDFTSILNRDGMDAIAVnppmN-AswISfapikeGFDLIPMWVADMNFPTVPTIQDAIIERTKHPAFGYFRPRPEYFE 79 
WP_014119169   1 MQYDFTSIIDRHGKDSIAVdpemTn--fVSfaatkpGFSRIPMWVADMNFATVPTVQKAIIDRAEHPAFGYFAPREEYYR 78 
WP_007491704   1 MKYDFTSILDRRGKDAAAYdnvgAh--vIAparpkeGFDIIPMWVADMNFPVVPTITEAIIARAQHPSFGYFFPTDKYYD 78 
WP_014016309   1 MKYDFTTIIDRAGKDATAFdgigKtVwgFEpdkakpGFDEIPMWVADMSFATCPAVVQAMEQRLKHPLFGYFLPSDAYYQ 80 
WP_124786445   1 MKYDFTSIIDRHGMDSIAVdswgK-IpdMApnapdeGFDRIPMWVADMNFATVPTVQEHIIQRAQHPMFGYFNPRPEYFD 79 
WP_079536038   1 MKYDFTTIWDRSGKDAMAVdaieK-FpiFQpd---eGFDSIPMWVADMNFATAPSIVEAMQKRLEHPLFGYFITSDEYFD 76 
5Z0Q_A        76 VAIERMESRFGWKI-QPEWLVFLPGVVTGINIAVRAFTEAHQSTVSATPIYPPFFLAPKLAGRQHLSAALRL-EQQ--RW 151
WP_015778541  80 AIIDWHRDRKGIGDiKKEHIGYENGVLGGVISALNVFCSRGDKVLVHSPTYIGFTNSLTNNGYEIIHSDLIKdKDG--RW 157
WP_014488694  71 SVIKWHKERYNWDI-KKEWLNFTQGLVQGFNIAISALTRPGESVLVLTPTYYPMFAGIKNQGCQIVESDLIY-DDNtcRY 148
WP_014079173  76 AIIRWHAKRNGVQGlTRECIGYENGVLGGVLSALNVFCSRGDKVLVHSPTYIGFTFSLKNNGYEIVHSPLVLdENG--VW 153
WP_014080057  80 SIINWHKLRNGVTGlSEEHIGYENGVLGGVISALSVLCSKGDSVLFHSPTYIGFTASLTNNGYNMVLSPLVRdENG--VW 157
WP_014119169  79 AIIEWQERHNGVKGlTKEHIGYENGVLGGVVSALNVLCSKGDHVLLHSPTYVGFTGCITNNGWEIVHSPLKLdDQG--IW 156
WP_007491704  79 SIVQWHEKRNGVTGlTKEHIGYENGVLGGVVSALNVLCSRGDNVLVHSPTYSGFTSCLTNAGYSIVLSPLVQdEQG--IW 156
WP_014016309  81 RIIDWQTTRHDWPElTRDMIGYENGVHGGITSTIQVLTEPGDAVLVHSPTYPGFIGDLSNTGRHVVFSPLRK-EQG--IW 157
WP_124786445  80 RIIEWQSRRNGVEGlAPEHIGYENGVLGGVVSTLRAYVQPGDAVLVHSPTYIGFTKSIEAAGYRIVHSPLKLdDQG--VW 157
WP_079536038  77 AIINWQENRNGVQElEKEHIGYENGVLGGVMSALGAVCCQGDAVLVHSPTYIGFSGSIKNAGYKLVTSPLKPdRLG--IP 154
5Z0Q_A       152 VLDLDSHEDRMs-gNEKLLLLCNPHNPGGTVYRRKELEAQLRFAQRHDLLVCSDEIHCDLVLePGVqHIPFASLSDDAAQ 230
WP_015778541 158 VMDYQNMEELIvreKISATIMCNPHNPTGRVWSKEELKRACDIFEKHGVKIISDEIWSDIIL-DGNrQTPTQNVSDYAHE 236
WP_014488694 149 TIDYEDVAKKVkdnNLTAALIGNPHNPTGRLYSIEELSKLADILIENNVKMICDDIHCDIIVdPSKkYTPLASI-EKYAN 227
WP_014079173 154 RMDYEDMEKKIrenHIHAAIFCSPHNPCGRVWERWEIERAMEIYEKYQVEVVADEIWSDIIL-GDHqFVPTQSVSEYARM 232
WP_014080057 158 RMDYEDMERKIkenHIHAAVFCTPHNPTGRVWERWEIERAMELFQKYDVFVISDEIWSDLIL-NGHkHIPTQSVSEDAKN 236
WP_014119169 157 RMDFEDMEKKIveyKIHATVFCSPHNPCGRVWERWEIERAMELFQKYDVYVVDDEIWSDLIL-NGHrHIPTQSVSEDARN 235
WP_007491704 157 RMDFEDMEKKIvanHIHTALFCSPHNPTGRVWERWELEKAMEIFQRHGVYVISDEIWSDIIR-PGQkHIPTQMVNSYAKE 235
WP_014016309 158 RMDFADMEEKIkkhHVHLAIFCSPQNPTGRVWERWEIEQAMALFKKYDVLVISDEIWSDIIF-QGHcHIPTAAVSEDARQ 236
WP_124786445 158 RMDFEDMERKLaqnHIHAAVFCSPHNPCGRVWERDEIERAMDIYRQHDCVVISDEIWSDIIL-PGHrHIPTQSVSEDARM 236
WP_079536038 155 RMDFYDMETKIkrnDIRAVVFCSPHNPTGRVWEREELEQFMDMCRRYELTVISDEIWSDIIL-KGHkHIPLQSISEDARM 233
5Z0Q_A       231 RSITLMSPSKSFNIAGLGASLAVIPNPELRARFNRMRKGm-vPDVDVLAYVAASAAWR-EGQPWLDAQLDYLRANRDMLA 308
WP_015778541 237 NTVALYAPSKTFNLAGLVGSYHIIYNGYLRNRINKESSLshyNSMNVLSMHGLIGAYSkTGREWTDELNQTLTQNVNYAC 316
WP_014488694 228 HIISMNAPSKTFNLAGAKVSNIIIQNEEIMRAFKFQMERfc-vSVSILSLVACKTAYS-KCAYWVDEMKKYVWDNYNYIK 305
WP_014079173 233 HTVAMYAPSKTFNLAGLVGSYHIIYNPVIRDRVKKESSLshyNEMNVLSMYALIGAYQqEGYEWTDELCKVLTKNAEYAY 312
WP_014080057 237 RTIALYAPSKTFNLAGLIGSYHIIYNSWLKDRIDKESSLchyNDMNVLSMHALIGAYKpEGHEWVDELCEVLTENVNIAY 316
WP_014119169 236 RTVSLYAPSKTFNLAGLVGSYHIIYNQYLRDRIDKESSLshyNEMNLLSMYALIGAYQpEGYEWLKQLMCVLNENVEYAY 315
WP_007491704 236 HTVALYAPSKTFNLAGLIGSYHIIYSKWLRDRVDKESSLchyNEINVLSMHALIGAYKpEGYEWVDELNQVLANNVDFAC 315
WP_014016309 237 RTVAFYAPSKTFNLAGLIGSYHIIANPLLREKITQHGQRtcyNEMNVLSMHALIGAYSqDGHEWTDELNQVLESNCRYAV 316
WP_124786445 237 RTVALYAPSKTFNLAGLVGSYHIIYNETLCDRVCAVSNKthyNEMNVLSMHALIGAYQpQGYEWVDELNEVIEGNVDYFC 316
WP_079536038 234 RTVGLYAPSKTFNLAGLVGSYHIIYNEFLRRKVKKQASLahyNSMNVLSMHALIGAYSdEGAEWVDELRQVITENVKYAC 313
5Z0Q_A       309 QHVN-RlP-G-LSMVTPEASFLGWIDASGL----GV-ADP-AL---FFE--KHGLGFSSGRDFGN--DRFVRFNFGCPRQ 372
WP_015778541 317 DFIEeNfK-G-VSVNKPEGTYMLFVDFSKY-----CkDKGvDIgeiLKRgwDCGVAWQDGRAFNg--KYAIRMNLALPLD 387
WP_014488694 306 EYIEnSiLkDyIKAVPLEGSYLMFADNKNLmkefNM-NQE-DLnnfYYD--SCNLSLDEGNAFGKagIGFMRFNLATQRY 381
WP_014079173 313 DYIRsHfK-G-VQVAMPQGTYMLLLDCTEW-----CrKHGiTIdelQKRgvGVGVIWQDGRPFHs--PCGIRMNLALPFS 383
WP_014080057 317 DFFs-NiD-G-IDTAKPEGTYMLFLDCKGW-----CtAHNqTLedlYKKgqSVGVYWQDGRPFHn--EYGIRVNLALPKS 386
WP_014119169 316 QFVKtHfQ-G-VELARPQGTYMLFLDCTEW-----CrKQGkTIddlLRAgqEVGVLWQDGRMFQa--PCAIRMNLALPKS 386
WP_007491704 316 EHIWeQyK-G-IQVTKPQGTYMLFLDCTKW-----CeAHGkTIeelQKAgsDVGVAWQDGRRFHg--PCHIRMNLALPLS 386
WP_014016309 317 QYIQdHfP-G-CQVSLPQGTYMLFVECGEY-----LkANQmTLpelLKKawDVGVAWQDGRKFAw--KDAMRLNLALPRT 387
WP_124786445 317 NYVDeHfE-G-VGYSRPQGTYMVFLDCTEW-----CrEHGrDIqwlLDEgaRVGVGYQDGRPFHg--PCHIRVNLALPLS 387
WP_079536038 314 KFIRkElP-G-VSVHQPEGTYMLFLDCEEY-----CnSHHrELedvKIAgyKCGVVWQDGRQFYg--PNHLRMNLALPKE 384
5Z0Q_A       373 LLEEALQRMTRAL 385
WP_015778541 388 KVKEAFDKLKKYV 400
WP_014488694 382 YVEKAMNNISEAV 394
WP_014079173 384 LVEEAMDRLRKYV 396
WP_014080057 387 RVEEALNRLRNYV 399
WP_014119169 387 LVVEAFDRLEQYV 399
WP_007491704 387 RVQEAFARLDKYV 399
WP_014016309 388 RLEEAMRRLSEYV 400
WP_124786445 388 RVREACDRLDRYV 400
WP_079536038 385 RVIDAFNRLRDYV 397
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