Conserved Protein Domain Family
LruC_dom
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TIGR04456: LruC_dom 
LruC domain
This domain is abundant in the Leptospira, in Bacteroides, and in Vibrio (three widely separated lineages). Most members have plausible lipoprotein signal peptides, including lipoprotein LruC from Leptospira interrogans and BACOVA_00967, from Bacteroides ovatus, with a solved crystal structure. Note that the C-terminal region of pfam13448 (length 83) matches the N-terminal region of some members of this domain (length 243).
Links
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Statistics
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PSSM-Id: 275249
Aligned: 94 rows
Threshold Bit Score: 194.769
Created: 9-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_009384488 445 TTFAYEDQFPKMGDYDMNDVLMNVKYTEYS--QNNEVIQLKIEGQIAALGGTYRSGFAIRLPGVDPSDVK-TDSTKLYIN 521 Vibrio sp. N418
WP_004411536 605 GTIAFEDEWPNRGDYDFNDAVFNYNIEEYK--INGLVKQINYKILPTARGATYTNSLRLLLN-VPISNIA---QVSITTM 678 Vibrio orientalis
WP_009133401 171 GTLMFEDLWPSYGDYDFNDLVVNYQVDLMMq-NKNQAREMFIALCVRAIGGKLPYDLYLSLRGVRPDQIA-DIKMDDLQN 248 Alistipes indis...
WP_009138062 165 GTLMFEDLWPEYGDYDLNDLVANFKVQLYId-KKNKVEAILVGVRINAVGGIFPYEFYLHLMGVKSTDID-EIVPYNSVN 242 Odoribacter laneus
WP_002773148 204 FTIAFEDLFPTPGDADFNDYVVRVKSEQDLd-AQGKVVRMRSEFTHVAKGAGYNHTFHMKLPGTGQYTLK-----RTAAD 277 Leptonema illini
WP_007463890 218 YIAAYEDNYPAKSDYDFNDLVVGYRVGYGM--QDDKVSSLIVYGYMIARGSGYTHDWYLHIG-LPAGTSG-SGTLNLFKP 293 Photobacterium ...
WP_008594340 201 YTTSYEDLFPKQGDADFNDYVIRSYFEEDLn-KFGEVVRVRGYFTHVAKGAGYNHTLRFGLPG---ASVTsYSLLRYAAD 276 Leptospira lice...
WP_010414351 204 YTIAFEDLFPNQGDADFNDYVVRTYFEEDLn-ATGGVARVRGYFTHVAKGAAYNHTLHFSLPN--AAAVGsYTLNRLGYD 280 Leptospira inadai
WP_008999777 157 GTVMFEDNYPQIGDYDFNDFVASYMVEIQTypGTTFIKSIQFYMAIHAIGASYSYIPHLRIQSFENSTVK---SMEVNKK 233 Bacteroides sp. D2
WP_014775212 158 GTLMFEDLWPAYGDFDFNDFVVNYKIQLYMq-NKNKVNAMLIGVRVKAVGGSIPYDLCLAMKGVKGGEID-QIEPYNSKN 235 Alistipes fineg...

WP_009384488 522 GELQ------SVDIVESGT--TDTVLIVHEDLWSITEsgedDGCNMFRTEAGC--G-TSYRPSWELIVPFSSPVASAQMP 590 Vibrio sp. N418
WP_004411536 679 GNAT------QVEPIADKN---QTLIVVIADLKDALPa--nSGSKLTNTLTGS--N-KVTGKLLRLSVTFNYPVSSEILG 744 Vibrio orientalis
WP_009133401 249 GVQSc-----DLVKVNSGN--SRPAILKFVDIKQNLNk--pGGTTFLNVRPGEemK-TGDLTVVSFNVTFRNAISTRDLA 318 Alistipes indis...
WP_009138062 243 ASPSc-----DFVAVKPAN--GDDALFLFKEVKNNanc-paG-GQYLNTEPGYemA-EKDLVEVAYMLYLKDPLPLNKVL 312 Odoribacter laneus
WP_002773148 278 GTVAf----dTTLPL------TDAGVEILPSSETTLA--------QSNTATGQ--I-FVTGMTAQFEAVFETP--LTGLA 334 Leptonema illini
WP_007463890 294 GSTVqes-gyPKSFSQTGS--FDQRLLQGTKSLMQIP-----GKEFVNTESDT--S-LAQGHKFSVAFDFDTPVALSDIA 362 Photobacterium ...
WP_008594340 277 GTTL------EENLSGTPT--SIADLEILGNSSTTIS--------KSNASRTD--TtFVKGKTAKLEVILSAPISKLVLG 338 Leptospira lice...
WP_010414351 281 GTTVe----qALSGT--GP--AISGLEILGNSSTTIQ--------SWNSRKTD--T-FHVGKSAHLEVILSSPISTTNLG 341 Leptospira inadai
WP_008999777 234 GMSNlnvdrfADGKVNDDN--TGKIVLAFNGAENKKG------QEFLNTEKGS--Q-YIPGDKFDITLTFEEGKADIAFI 302 Bacteroides sp. D2
WP_014775212 236 APEA------ELVALNSPNyvKEPAVLKFLNIRENANr--pAGAAYVNTEEGYemP-EDRLAEASFMVYFRNSIAIENVA 306 Alistipes fineg...

WP_009384488 591 -EFPYDPFIFAtP-GYyhgetglqvsgghPGRGLEVHLKNKTPTSKFN-YGYVGKQDDATDT-G-AG--TYFHTSN-GLP 662 Vibrio sp. N418
WP_004411536 745 -APPYNTFIARqL-AT-------------SEWV-EVHFPGKPATSKAS-KRQFGRGDDDTQQ-Q-GD--RFFFSKN-NLP 802 Vibrio orientalis
WP_009133401 319 -FDTFDFFIAR------------------DDQQQEIHLAGFEPVLFGA-DRYRALRTQPTSN-A-NTqsEYYYSND-NLV 375 Alistipes indis...
WP_009138062 313 -YDSFDFFIGN----S-------------SVRK-EIHINGYKPV-LFDqVTYVKYRNESSNTdK-SN--DFYTSNT-HLI 368 Odoribacter laneus
WP_002773148 335 --FPYDMYLYV------------------KNTKKEIHFPGK------------YTNSDGSDP---------YMDAN-GFP 372 Leptonema illini
WP_007463890 363 -LPPYDPYLYV------------------NNTGYEIHLPEH--------SSRMGSSVNNSET-A-GG----FKNAQ-GYP 408 Photobacterium ...
WP_008594340 339 -PAPYDTFIRV------------------INTGKDIHAAGK----------YF----DSEGK-------DIYRDAT-GFP 377 Leptospira lice...
WP_010414351 342 -PPPFDTYLHV------------------INTNKDIHAAGK----------FF----DAKGA-------DLYRDST-GFP 380 Leptospira inadai
WP_008999777 303 yADKFDIFLAD------------------KNRTKEIHMLGYGPA--------FASGKDYGNT-------NYYKQAGtNLV 349 Bacteroides sp. D2
WP_014775212 307 -FDTFDFFLTR-DrES-------------DGRRIEIHRGGFEPTPAAT-ADYNALAGQSAYT-DrAG--RFYYSND-GLV 366 Alistipes fineg...

WP_009384488 663 WGIELPLDWQHPLETISILDTYPKFADFSQdPSGLTEQSWYV 704 Vibrio sp. N418
WP_004411536 803 WAMHIPEKWHHPKERVDLSNGYPDILNWAQ-SNGKKHKGWYK 843 Vibrio orientalis
WP_009133401 376 WGICIPAEIPHAYETRDFLTAYPNFAKWAQ-SGGVSNTDWYT 416 Alistipes indistinctus
WP_009138062 369 WGIKVPAAIPHAYEKVEFTLAYPNFAAWAQ-SGGKQCQNWYE 409 Odoribacter laneus
WP_002773148 373 WALLIPGDWSWPLERNNIHQAYPLFQSWYE-TAGQQAAEWYK 413 Leptonema illini
WP_007463890 409 FAVIIPDDWEPPLERVDLGEAYTTFLGYVG-SEGDEQTSWYT 449 Photobacterium sp. AK15
WP_008594340 378 WVLLVPGNFQWPYEATDIRKSYPTFKTWYE-SLGTADTDWFR 418 Leptospira licerasiae
WP_010414351 381 WYLLIPGNFLWPYEGENIRIPYSQFKPWYE-SLGTTDVDWYR 421 Leptospira inadai
WP_008999777 350 WGINVPSIIGHAYEKSNFLDAYPNFAKWVE--GDMNANEWYK 389 Bacteroides sp. D2
WP_014775212 367 WAINIPFDIQHAYEKTDFLKAYPQMLEWAQ-SGGAVAQEWYL 407 Alistipes finegoldii
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