4HHB,1FDH,1CG5,1SPG,1PBX,1HBR,2R1H,3MKB,1SI4,1GCW,3W4U,5JNZ


Conserved Protein Domain Family
Hb-alpha-like

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cd08927: Hb-alpha-like 
Click on image for an interactive view with Cn3D
Hemoglobin alpha, zeta, mu, theta, and related Hb subunits
Hb is the oxygen transport protein of erythrocytes. It is an allosterically modulated heterotetramer. Hemoglobin A (HbA) is the most common Hb in adult humans, and is formed from two alpha-chains and two beta-chains (alpha2beta2). An equilibrium exists between deoxygenated/unliganded/T(tense state) Hb having low oxygen affinity, and oxygenated /liganded/R(relaxed state) Hb having a high oxygen affinity. Various endogenous heterotropic effectors bind Hb to modulate its oxygen affinity and cooperative behavior, e.g. hydrogen ions, chloride ions, carbon dioxide and 2,3-bisphosphoglycerate. Hb is also an allosterically regulated nitrite reductase; the plasma nitrite anion may be activated by hemoglobin in areas of hypoxia to bring about vasodilation. Other Hb types are: HbA2 (alpha2delta2) which in normal individuals, is naturally expressed at a low level; Hb Portland-1 (zeta2gamma2), Hb Gower-1 (zeta2epsilon2), and Hb Gower-2 (alpha2epsilon2), which are Hbs present during the embryonic period; and fetal hemoglobin (HbF, alpha2gamma2), the primary hemoglobin throughout most of gestation. These Hbs types have differences in O2 affinity and in their interactions with allosteric effectors.
Statistics
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PSSM-Id: 381263
Aligned: 38 rows
Threshold Bit Score: 185.466
Created: 14-Jun-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
heme bindingtetramer
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:heme binding site [chemical binding site]
Evidence:
  • Structure:1SI4: Human HbA2, alpha subunit binds cyanide ion/heme; contacts at 4A
  • Structure:1FDH: Human HbF, alpha subunit binds heme; contacts at 4A
  • Citation:PMID 881729
  • Structure:4HHB: Human deoxyhemoglobin alpha subunit binds heme; contacts at 4A
  • Citation:PMID 5528692
  • Structure:1CG5: Dasyatis akajei deoxyhemoglobin alpha subunit binds heme, contacts at 4A
  • Structure:1HBR: Gallus gallus R-State form of hemoglobin D alpha subunit binds heme; contacts at 4A
  • Citation:PMID 6644819

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                   #         ##                #  ##  #              
4HHB_A      2 LSPADKTNVKAAWGKvgAHAGEYGAEALERMFLSFPTTKTYFPHFd--LSHGSAQVKGHGKKVADALTNAVAHVDDMPNA 79  human
1CG5_A      2 LSSQNKKAIEELGNLikANAEAWGADALARLFELHPQTKTYFSKFs-gFEACNEQVKKHGKRVMNALADATHHLDNLHLH 80  red stingray
3MKB_A      2 FTGVERSTIGAIAKIlaSTPEAYGAEALARLFATHPGAKSYFDYAd--YSAAGAKVQLHGGKVIRAVVSAAEHDDDLHAH 79  Isurus oxyrinchus
1SI4_A      2 LSPADKTNVKAAWGKvgAHAGEYGAEALERMFLSFPTTKTYFPHFd--LSHGSAQVKGHGKKVADALTNAVAHVDDMPNA 79  human
1GCW_A      2 FTACEKQTIGKIAQVlaKSPEAYGAECLARLFVTHPGSKSYFEYKd--YSAAGAKVQVHGGKVIRAVVKAAEHVDDLHSH 79  Mustelus griseus
P84216      3 LSDANKQEIHHVAELikPHAEAVGADALARLFELHPQTKTYFPNFs-gYHATDAPVKAHGAKVINAVLKAAEHLDDLPKH 81  Eaton's skate
P02020      3 FSQDDEVLIKEAWGLl-HQIPNAGGEALARMFSCYPGTKSYFPHFghdFSANNEKVKHHGKKVVDAIGQGVQHLHDLSSC 81  South American lun...
P20244      2 LSEGNKKAIKNLLQKihSQTEVLGAEALARLFECHPQTKSYFPKFs-gFSANDKRVKHHGALVLKALVDTNKHLDDLPHH 80  marbled electric ray
P07408      2 LSAADKTAIKHLTGSlrTNAEAWGAESLARMFATTPSTKTYFSKFt-dFSANGKRVKAHGGKVLNAVADATDHLDNVAGH 80  spiny dogfish
P02021      9 YSAADRAELAALSKVlaQNAEAFGAEALARMFTVYAATKSYFKDYk-dFTAAAPSIKAHGAKVVTALAKACDHLDDLKTH 87  Port Jackson shark
Feature 1        #   #         ##  #                                  #     
4HHB_A     80 LSALSDLHAHkLRVDPVNFKLLSHCLLVTLAAHLPaeFTPAVHASLDKFLASVSTVLTSKYR 141 human
1CG5_A     81 LEDLARKHGEnLLVDPHNFHLFADCIVVTLAVNLQa-FTPVTHCAVDKFLELVAYELSSCYR 141 red stingray
3MKB_A     80 LMVLAVTHGKkLLVDPSNFPMLSECILVTLATHLAe-FSPATHCAVDKLLSAISSELSSKYR 140 Isurus oxyrinchus
1SI4_A     80 LSALSDLHAHkLRVDPVNFKLLSHCLLVTLAAHLPaeFTPAVHASLDKFLASVSTVLTSKYR 141 human
1GCW_A     80 LETLALTHGKkLLVDPQNFPMLSECIIVTLATHLTe-FSPDTHCAVDKLLSAICQELSSRYR 140 Mustelus griseus
P84216     82 LEKLATKHGHeLLVDPHNFVLFSDIIVVTLATKLPt-FSPATHRAIDKFLEELVHQLSSKYR 142 Eaton's skate
P02020     82 LHTLSEKHAReLMVDPCNFQYLIEAIMTTIAAHYGekFTPEINCAAEKCLGQIVHVLISLYR 143 South American lungfish
P20244     81 LNKLAEKHGKgLLVDPHNFKLFSDCIAVTLAAHLQe-FSPETHCAVDKFLEEVTYQLSSLYR 141 marbled electric ray
P07408     81 LDPLAVLHGTtLCVDPHNFPLLTQCILVTLAAHLTe-LKPETHCALDKFLCEVATALGSHYR 141 spiny dogfish
P02021     88 LHKLATFHGSeLKVDPANFQYLSYCLEVALAVHLTe-FSPETHCALDKFLTNVCHELSSRYR 148 Port Jackson shark

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