Conserved Protein Domain Family
PRK07726

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PRK07726: PRK07726 
DNA topoisomerase 3
Statistics
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PSSM-Id: 236078
Aligned: 346 rows
Threshold Bit Score: 795.138
Created: 9-Dec-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
120598390   1 MILYIAEKPSLGRAIADVLpkPHKKGDGFIEaANGDCVSWCVGHLLEQAEPDAYNPEFKAWKFEHLPIVPDKWQLTPKAA 80 
258515068   2 KQLVLAEKPSVARDLSNVLg-NFNKGNGYLE-SDAYIITWAIGHLVTLAEPDDYDAALKKWFLNTLPILPREFKLKPVSA 79 
224477225   2 KSLILAEKPSVARDIANALn-VTQQRNGYFE-NNQYIVTWALGHLVTNATPEQYDKKFKTWDLAELPIIPDHMKTVVIPK 79 
15896801    3 KILVISEKPSVGRDIANVLg-CKTRGEGCLI-GAKYIVTWAVGHLVTLWEPEEYNAIYKKWRFDTLPIIPEVMKIKPIDG 80 
29376573    4 KQLIIAEKPSVAKDLSRVLg-ANQKNKNYYE-GPNVIVTWALGHLLGLKMPEDLNKEWQTWQMETLPMIPKNLGIKPLPK 81 
73661968    2 KSLIIAEKPSVGRDIANTLn-INEKRNGYFE-NNKYIVTWALGHLVTNATPEQYDASYKEWKLNDLPIIPNKMKTIVISK 79 
81428375    3 KKLVITEKPSVAKELAKVLg-TNQKTKTYFE-GDQYVITWAFGHLLSLQLPEDIKKEWQQWRLEDLPIIPKHIGLKPLPK 80 
134299706   2 KQLILAEKPSVGRDIVNAIggHFEKRDGYYE-NSQYIISWAIGHLVELCEPEDYQPNLKKWTLSALPIIPECFKLKPNPK 80 
222150439   2 KSVVLAEKPSVARDIARVLk-CNQKKNGYME-NDKYIVTWALGHLVTNADPEQYDAKYKQWDLNMLPIIPERMKTVVIGK 79 
90962280    2 KKLILAEKPSVARDIGRILn-ANEKKKNYLE-GKNYIITWALGHLLGLKMPEDLNKKWEKWQLETLPMLPKFIGIKPLPK 79 
120598390  81 TRSQLTVLKRLV--KQASMLVNAGDPDREGQLLVDEVIAYLGVtgdkLHQTQRLLISDLNPQAVKRALTQLRSNREFIPL 158
258515068  80 TLKQFNIVKSLLhrNDVGDIICATDSGREGELIFRYIYKLTDC----QKPFKRLWLSETTPAAVRKGFDNLRPGNDLDRL 155
224477225  80 TKKQFNTVKSLMlkENVKEIIIATDAGREGELVARLILDKVHN----KKPIKRLWISSITAKAIRNGFKQLKDGKAYLSL 155
15896801   81 TKKQFNIIKKLMndNSVESLICATDAGREGELIFRYTYEAAEC----KKPFSRLWISSMTDEAIKEGFSTIKPGTEYDNL 156
29376573   82 TGHQLKAIKQLAnrKDVSEAVIATDAGREGELVARWILEYVRF----NKPVKRLWISSQTDKAIKDGFKKIRPAKDYDNL 157
73661968   80 TRKQFSTVQSLInnNKVKDIIIATDAGREGELVARLILDKAHN----KKPTKRLWISSVTNKAIKEGFNKLQDGRKFNNL 155
81428375   81 TGGQLKAISHLAhrQDISGAVIATDSGREGEAVARYILEWIKF----DKPVERLWISSQTTKAIKDGFANLKPAKQFDNL 156
134299706  81 TIKQYKVVKQLLnrPDV-ELIAGTDAGREGELILRYIMRLSGY----SRPFKRLWLSETTPESIRKGLANPLPGQAKDLL 155
222150439  80 TRKQFNTVKAQIerQDVNEIIIATDAGREGELVARLIIEKCKG----NKPMKRLWISSVTDKAILDGFKHLKPAQAYQGL 155
90962280   80 TRGQLKTIESLVkrKDINEIVIATDAGREGELVARWILQYVHA----NKKVTRLWISSQTDKAVKQGFKELKPAEKYDNL 155
120598390 159 STSALARSRADWLYGMNMTRAYTIQGkkvgYQG-VLSVGRVQTPLLGLVVRRDKEIANFQSKPFYEVL---AHL-AtDKq 233
258515068 156 AFAAEARSQADWLIGINATRAFTVKH-----NQ-LLSVGRVQTPTLALIVNREQEIRAFVPEKYWELF---------ALf 220
224477225 156 YRAALARSEADWIVGINATRALTTK-----YDA-QLSLGRVQTPTIQLVQMRQDEIKNFRPTEYYTLE---AKIaG---- 222
15896801  157 YHSAKCRSEADWLVGMNASRAYTLK-----YNV-LLSVGRVQTPTLAIIVKRQKEIDNFEPKDYWEVV---SKY------ 221
29376573  158 YYSALARAKADWLVGLNVTRALTVK-----YQD-NLSAGRVQTPTLAMVRQQEKTIEQFKPQTYFTIS------------ 219
73661968  156 YHAALARSEADWIVGINATRALTTK-----YDA-QLSLGRVQTPTIQLVQMRQNEINHFKPQTYYTMKlnaAGLtF---- 225
81428375  157 YASALARGHADWLIGLNVTRALTTK-----YED-NLSAGRVQTPTLAFVNETAQQISRFKPEKYYTIQ---LKV------ 221
134299706 156 AAAAECRSHADWLIGINATRAFTKK------HGdLFSIGRVQTPTLGLIVAREKEIKTFIPAHYWELY---ADFv----- 221
222150439 156 YEAAMARSEADWIVGINATRALTTK-----YDA-QLSTGRVQTPTLQMVKIRQDAVQKFQPKTYYSIE---LVS------ 220
90962280  156 YESALARATADWLVGLNVTRALTVK-----YQD-NLSAGRVQTPTLALVRRQEEKIEKFMPQKYYRIA---LRI-G---- 221
120598390 234 -----ET---FSAKWQPSEacqp---------------------------------------------ymdeEGRVLARG 260
258515068 221 tkengQT---YIGKWFKKEkkavenweipiqvgqkqtnqnpaasfeaaqggipsvmgeavpssngqdkpvamQTKFAARE 297
224477225 223 ----------QSFKLASQH-------------------------------------------------------RIKDKQ 237
15896801  222 -----EG---FNGTWFDKEt---------------------------------------------------kESKIMDKK 242
29376573  220 ----------LSVESEKAKmtq------------------------------------------------knPYALKERQ 241
73661968  226 ----------HCTKPQSHP----------------------------------------------------------DKT 237
81428375  222 -----GQ---EQATLQMAK-----------------------------------------------------PQGLKDRA 240
134299706 222 ----tTDgqvYRGKWFKNKn----------------------------------------------------KNRFNQEA 245
222150439 221 -----GS---DKFKWQSGS-------------------------------------------------------QIFDES 237
90962280  222 ----------KQTAYMKQKn----------------------------------------------------IYAIKERD 239
120598390 261 LAQNVVSRI-SDKPALVTQLVAKDKKQHPPLPYSLSALQIDAAKRFGMSAKDVLDTCQSLYERhKLITYPRSDSRYLPVE 339
258515068 298 AARDIQKKVtG-QPGQVVSVEKKDIIEHPPLLFNLNDLQKEANKKFGLSAAKTLSVAQELYESrKLITYPRTDSRCITVE 376
224477225 238 KLEKLVQRL-KGKQAEVVDIQSKHKKQYPAKLYSLTDLQQDAYQRYHMGAKETLNTLQNLYERhKLATYPRTDSNYLTDD 316
15896801  243 KADDLGAKI-LGQTGKVISIENKKKKQVPPLLYDLTELQRDCNKKFGFSAQKTLDIVQSLYEKrKMVTYPRTDSRYLSHD 321
29376573  242 EAEQLVKEL-SKQKGLVTDIQEKVKTENAPLPYDLTEIQREANQRFQFSAKKTLSLVQSLYEThKIVSYPRTDSKYLTTD 320
73661968  238 VLESIKKAI-DGQSGHIASISKTHKKAYPQQLYNLTDLQQDAYKRFHLGPKETLNTLQTLYERhKLVTYPRTDSNYLTDD 316
81428375  241 QAETLVAKL-KQAQGKVGSVKTSQKSQAAPLPYDLTELQQVANAMYGLSAKKTLSLIQSLYEIhKVVSYPRTDSKYLSTD 319
134299706 246 DGISIKNKI-VGQDGSVIKVEEKAVSEPPPTLFNLNDLQKEANKKFGFTASQTLEIAQALYEKhKLLSYPRTEFKHLTNE 324
222150439 238 KVDGLLKDI-QGKQAVVQDVVSKEKKRYPGKLYDLTSLQQDAYKRFKYSAKETLNAMQSLYEThKYVTYPRTDSNYLTTD 316
90962280  240 EAEKKKRHL-DNFKGQIKDINSKIKREPAPLLYDLTELQREANKRYGYSAKKTLSLVQSLYEIhKVVSYPRTDSRYLSND 318
120598390 340 QHNLAPSVLKAISDGAAELLQGADAPDPRL---KSKAWDDKKVDAHHAIVPTEKTANLSSLSQRERQLYLHIARQYLAQF 416
258515068 377 MGKTIPQRLGALAVVAEYENFIHLIKERKAf-lNKRYINDSKVTDHTALIPTNVKPDLDKLSSDERRVYDLVVRRFLAAF 455
224477225 317 MVDTFKERLQALL-ATEYKAQVRPLVNQKFs-aKMNIINNQKVSDHHAIIPTEIRPDMNVLSQREQKLYLMIAERFIENL 394
15896801  322 MVNKIKKTIGRLN-INPYDKYVGEILKLSKlpmGKRIIDDSKVTDHHAIIPTDVKPNLSTLTKDELKVYDAIVRRFLCVF 400
29376573  321 MKGTMKERLQAIA---DFSPEVKGYLKNGAvvkQQKVFQNAKVTDHHGLIPTEQRPRYEKLSNDEQKIYQMIVQRFLGLF 397
73661968  317 MVDTLKDRLKAIM-ATSLKDMAKAQMSQTFs-sKQRFVNNNKVSDHHAIIPTEVRPDINQLSQRESKIYMMIAQRYLENL 394
81428375  320 IEGTLKERLSALVKFDPRAKQYLGQGAKVK---QPAVFNDRKVTDHYALIPTEEPVRAEKLSTDELRMYRLIVERFMGLF 396
134299706 325 LAKTIPSRLSALGSVSGYSKFVAYAQSAPKp--GKRFIDDAKVGDHHALIPTNVKPTA-ALSPNEAKIYNMVARRFLAMF 401
222150439 317 MESSLKERVASLG-ATPYKDQVVKLLKTHIk-gGSHFINNAKVSDHHAIVPTEIRANLEALGAREKNIYLLIAERFLSNL 394
90962280  319 IKATLMERLQAIRKYDSRAEEAIKNKAKVI---LKKVFNDSKVTDHHALIPTEQVPNYSKFSADEQKIYNLIVSRFLGIF 395
120598390 417 YPAYCYSETTVQVTIEGGLFNTKARQDKSLGWKQLFarqepngskasgnksteesaGKDDEEHDef-iGQLPPLKLGQAL 495
258515068 456 FPPARYEQTQVITEVKQETFLSRGRVELDKGWKTVYd------------------pVQDKLVDDe--qGILPVIENEESV 515
224477225 395 LPPYEYDAVKVVCKIDGESFEFQDKVTVQPGFKALK-------------------------SETt--pSQMPTFDKDKSY 447
15896801  401 YPNYEYTITKIVTEVVEENFLTQGKTILKLGWMEFYk------------------hDKKEKDDEnsepDELPKLKKNESV 462
29376573  398 AEPNQTKQTKVTVAFGKETFVFHQNKVVVAGWKTTAe------------------------------qPLSTVQWQKGMT 447
73661968  395 MPPHEYEAIAIELKVGQHTFTFKDKVTTKLGFKAIY-----------------------ENKESi--nTQIDQLQKGTKL 449
81428375  397 ADQYVTAVTKATVQFGDHTFTFKQTKVVQQGWHA---------------------------DSKe--tPTTSVDWQEGAV 447
134299706 402 FPAAEYKQTKIMTSVSDETFLTSGKIELSPGWKEVIpp----------------lkGENKEKSDe--eVLLPPLTKGENV 463
222150439 395 MEPHIYNEETITVQIGKEIFTLKTETTVKAGFKALY--------------------EQSSIERH-------KVYHKGEVL 447
90962280  396 AQPYTVEELRVVVTFDKDEFIFVGKKVLDYGW------------------------KNKDAAEE------VVLNLKKDTA 445
120598390 496 HCTRGELLEKNTQPPKAFTDATLLSAMTGISRYVT--DPEIRKILKETDGLGTEATRAGIIELLFKRGFLQRLGKSIVST 573
258515068 516 LTTKTDIKEKKTNPPKRYTEAALLSVMEGAGRLLN--DEELKEAMRGS-GLGTPATRAAIIERLLKVGYIERRKKTLLPT 592
224477225 448 TVQGFNIQAHETTPPAYFNEGTLLKAMENPQKFFDlkDSKHSQTLKQTGGIGTVATRAGIIDKLFNMNAIEARSGQIRVT 527
15896801  463 QVKDSEIKAKKTKAPSSYTEASLLSAMENAGRFVE--DEQLKEQLKD-GGLGTPATRASIIERLIQVGYIQRKGKSLHPT 539
29376573  448 VAPNFTINKELTSPPKPLTEGTLLGKM-------------------EKHSLGTPATRAEIIEKLIKSELMERTNSGLSVS 508
73661968  450 NVTKILIEEHETTAPPYFNEGSLLKAMESPQKFFDlsDKKHDKTLKDTGGIGTVATRADIIEKLFNMNAIEARDGKIKVT 529
81428375  448 VPADFSIKEQLTSAPKPLTEGTLLGKMEHY-------------------GLGTPATRAEIIEKLVRSELLERRGHSLAVT 508
134299706 464 AVTKAKLQQKKTEPPKRYTEGTLLAVMEGAGKFVD--DKALKDAMKG-HGLGTSATRAAIIERLIKVGYVERKSKTLIPT 540
222150439 448 SSVSLKKTTGETQPPAYLNEGTLLKAMENPASIFNi-DKESTTTLKSAGGIGTVATRADIIEKLYNLNAIENNNGNIKVT 526
90962280  446 VSPNFTVEEKLTTPPAPLTEAGLLAQMEKF-------------------GLGTPATRAEIIEKLVKSELMERTGHALRVT 506
120598390 574 DVGKGLINSLPLSATTPDMTALWEASLNGICHKETSYQGFMQPLLGTLSTLIQNAGAQL----PTALNGLKGQGYRktas 649
258515068 593 EKGENLIKLVPEQVKSPEMTARWEKALADIEDGQLNPGEFMSGIIEQTRQVVELARRQKtegePLRNNRDIIGKCP---- 668
224477225 528 SKGRQILDLAPQELTSPLLTAEWEEKLTQIEKGKYDSCAFMKEMKNFTKDIVNEIKNSEq---KYKHDNLTSTECP---- 600
15896801  540 DKGMKLIEIVPYELRSPETTGKWEKGLSSISKGKMASERFMQSIKRYVQYIIQESVKVNr---SVVFQ------------ 604
29376573  509 AKGKQLLDLVNPSLVTPELTEKWEKSLEAIASGQQKSQLFLKDIEEDTKKLVREIKQSEk---KYQDFSITQKKCP---- 581
73661968  530 SKGKQILELAPQKLTSPLLTAEWEEKLLLIEQGKYNASQFISEMKAFTNQVVNEIKESEq---NYKHDNLTTTECP---- 602
81428375  509 PKGQQLLKLVNKTLVSPELTGKWENSLEAIARGQENQKAFITEIEAATKTLVSEIKKSEt---EYHDFAITNKKCP---- 581
134299706 541 QKGETLISLVPEVVSSPQMTGEWEKALADIEAGQVNPKRFMSEIISLTKKIVNLAKEQKtngyMPESTKEVVGKCP---- 616
222150439 527 NKGRQLLELAPDALKSPELTADWEHKLTRIEKNKYGRKQFMREMIDFTKEIIDEIKSSDe---KFKHDNLTSTECP---- 599
90962280  507 PKGKQLLNLVNKELVSPKLTAKWEKQLEDIAHGKMKSQKFIGDIKNDTKRLVSEVKNSKe---DYKDFSLTKKRCP---- 579
120598390 650 hksgyrksyskKSSSAKGIGTTK-NDVSNKYGSQKtsskssvTRSTSRSASNSRKS 704
258515068 669 -----------LCGRPVVEYPKS----YSCSDYRAgcqfviwKVILGKNITVEMAR 709
224477225 601 -----------TCGKFMIRVKTKnGQMLVCQDPSCktk-knvQRKTNARCPNCHKK 644
15896801  605 -----------NNDSKFPQKNKQ-------------------LPEAIGECPFCKRG 630
29376573  582 -----------DCGSNLREKNTKdGKIYVCTNQECsyrrrkdPKVSNHRCPQCHKK 626
73661968  603 -----------TCGKFMIKVKTKnGQMLVCQDPQCktk-knvQRKTNARCPNCHKK 646
81428375  582 -----------ECDHPLKERNTRdGKVYVCTNCHYrrr--kdPKVSNHRCPQCHKK 624
134299706 617 -----------LCGREVVEYAKK----FGCGGFREgcafsfgKQILKKKITVKQAK 657
222150439 600 -----------TCGKFMLEKKTRnGKMLVCQDPTCgtk-knvQRKTNVRCPECKKK 643
90962280  580 -----------ECNSFLKVRKTRdGEIYVCSNPECnyrrrkdAKVSNHRCPQCHRK 624
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