6CB2


Conserved Protein Domain Family
BacA

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pfam02673: BacA 
Bacitracin resistance protein BacA
Bacitracin resistance protein (BacA) is a putative undecaprenol kinase. BacA confers resistance to bacitracin, probably by phosphorylation of undecaprenol. More recent studies show that BacA has undecaprenyl pyrophosphate phosphatase activity. Undecaprenyl phosphate is a key lipid intermediate involved in the synthesis of various bacterial cell wall polymers. Bacitracin, a mixture of related cyclic polypeptide antibiotics, is used to treat surface tissue infections. Its primary mode of action is the inhibition of bacterial cell wall synthesis through sequestration of the essential carrier lipid undecaprenyl pyrophosphate, C55-PP, resulting in the loss of cell integrity and lysis. The characteriztic phosphatase sequence-motif in this family is likely to be the PGxSRSGG, compared with the PSGH of the PAP family of phosphatases.
Statistics
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PSSM-Id: 460646
Aligned: 816 rows
Threshold Bit Score: 53.224
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6CB2_A              30 AAILGVVEGLTEFLPVSSTGHM--IIVGHL-L----GFeg----------dTAKtFEVVIQLGSILAVVVMFWRRLFG-- 90 
Q5JGF5               8 ALLSGILAALTSWLPMSPEGSFgrLIDGVIsY---------------------TaFLVPAYAGIMFSVLYRYRERLSKep 66  Thermococ...
CCX93837             8 SFLYGLFSGLTDILPVSAEAHR--ILMLKC-FgiqsST---------------ElMKLFAHLGVFGAMYFSCRKQIVRih 69 
CDA12453             6 AIFQAIGQVLTYIFPLSESGHS--AIFHDF-SgrftGScse--------------ltgLIHIGIALGIIAAFWKVFLK-- 66 
CDC33691             6 AIFQAIGQAFTWVFPVSESGHS--VIFHNF-SgrftNAcsq--------------ltgVIHIGIAIGLFIAFYKLFIS-- 66 
WP_022355310        10 AFFLGIIQGITEWLPISSTGHL--IIFDTI-W----PLtp---------aaFFEvFKVVIQFGSILAVLFLYFRKLNPf- 72  Faecalita...
WP_022092516        10 TIFLGIIQGITEWLPISSTGHL--LIFNSI-W----PMlp---------neFFDvFKVVIQFGSILAVIFLYWHRLNPw- 72  unclassif...
CDE05606             8 ALLYGIIEGITEWLPVSSTGHL--IIINAI-P----ALelgsslpgefraeFCEmFEVVIQLGAIMAVVVFFFDRLYPfg 80 
jgi:SpiGrapes_3206   7 ALLLGIVQGITEWLPISSTGHL--LLLDEL-I----QLqis--------paCKElFMVIIQLASILAVIILYFSTLNPf- 70 
jgi:SpiBuddy_1793    7 SLVLGIVQGITEWLPISSTGHL--LLLDEV-L----HLrlg--------enAKElFMVIIQLASILAVVVLYFSTLNPf- 70 
6CB2_A              91 ---LIgihfgrPLQHeg-------esKGRLTLI-------HI---LLGMIPAVVLGLLFH--DTI-----KS-------- 135
Q5JGF5              67 lmaLRgae------------------------------tseLqyfVLGFLLTLLLGLP------LakpltAHnaafdvfn 110 Thermococ...
CCX93837            70 rarRLarvpkhRRRRpld------trSLMDFS---------L---LRTMLIPVILGFLLN--RYVeplkeKL-------- 121
CDA12453            67 ---LIfefvltGKELftkkldlkktaNSRKFMYytfipyiFM---LAYLIPVGSTNIY----GVLhayayDG-------- 128
CDC33691            67 ---LFknffatWNDIfhkrldlknipPQREFMFmtilsfvFF---IVYAIPAGKYG---NvyMLFnrtshNK-------- 129
WP_022355310        73 ----------dPEKSskk------krETFHLWK-------LV---IIGCIPAAVIGFFLD--DII-----EQ-------- 111 Faecalita...
WP_022092516        73 ----------dGRKNekq------kkRTFNLWL-------KV---LIGCIPAGVFGLILN--DLI-----DS-------- 111 unclassif...
CDE05606            81 r-------kshPKTAae-------srASLMLLA-------KI---AVASLPAAAAGLAAD--RLL-----EHftgcglha 129
jgi:SpiGrapes_3206  71 ----------sTKKGqle------kkQTWNLWG-------KV---LVATLPAGVAGVLLN--DFM-----DT-------- 109
jgi:SpiBuddy_1793   71 ----------sAKKSkqe------rsATYLLWV-------KV---LIATIPAGIAGVLLD--DFM-----DE-------- 109
6CB2_A             136 LF--NPINVMYALVVGGLLL----IAAEc-------LKPK----EPRapGL-D--D--MTYRQAFMIGCFQCLA-LWP-- 190
Q5JGF5             111 LI------LAFLITFFGLTWpgltVLKG----------------------AeDriPskPSFLDAVLAGVFQSFS-STG-- 159 Thermococ...
CCX93837           122 IW------IAVLLFLNGIILyipqFFPT----------------------S-NrdSrmLSRVEGLLVGLGGALG-ILP-- 169
CDA12453           129 NLvsE----GICFLVDAVLL----LFAYfrlkknekG---------T--Q--------LSLPAVLVVGCAVFF--ALPvs 179
CDC33691           130 TIlgE----GVCIALLGVLL----IVTNs--------------------lInSnrNklPNWANAVILGLIGFL--ALPtg 179
WP_022355310       112 FLs-ANFVIAVALITYGIIF----IITAk-------HPKKv---TIE--SL-N--E--LDVLTSLKIGFFQCLAlI-P-- 166 Faecalita...
WP_022092516       112 VLs-ANFVIAVTLIAYGIIF----IVVEk-------HPKKa---TIK--NI-E--S--MDYLTALKIGFFQCLAlI-P-- 166 unclassif...
CDE05606           130 LLy-TPPVVASALIIYGIFF----IAVEr-------LRRGka-pAVE--SV-N--D--ITFANALLIGAFQALA-IIP-- 186
jgi:SpiGrapes_3206 110 YLy-IWPVIVVALASYGLVY----ILLEk-------KGRGtrkpRIT--TL-S--E--ISYADAAKMGAFQMLAlV-P-- 167
jgi:SpiBuddy_1793  110 HLy-RWPVIAIALFSYGVLY----LFLEk-------SSIGraqkRVK--NL-S--S--LTHKDALFLGLFQMLAlV-P-- 167
6CB2_A             191 GFSRSGATISGGMLMGVSRYAASEFSFLLAVP-MMM---GAT---A------LDlYKSWG------FLTsgdi------- 244
Q5JGF5             160 GASRTGLVTLALVLPGHKAENVLEWGFLIAPAyHLI---RLLylgAyegdtlLG-------------------------- 210 Thermococ...
CCX93837           170 GVSAVGSALSVASICGVERSYGLNMALLM----NMFiqvGLI---V------LD----VLa-----LISvgagtlsflil 227
CDA12453           180 GLSLCAIVIAILALFGTNPKIAFRYFISLSAP-ILL---VHG---IieiatcVS-------------------------- 226
CDC33691           180 GCSFMGAIFAFMILLGMSQKYAIRYAVTMSVP-TLI---VMG---IielcvaVT-------------------------- 226
WP_022355310       167 GTSRSGATILGGLYCGCSRYVASEFSFFIAIP-VMA---GAS---L------LK-IVKYFm----eTGMftldq-----w 223 Faecalita...
WP_022092516       167 GTSRSGATILGGLYSGCTRTLSSEYSFFIAIP-TMA---GAS---L------LK-IVKYVh----vNGMfpmsq-----l 223 unclassif...
CDE05606           187 GTSRSGSTVLGACCLGISRTAAAEFSFFMAIP-AML---GAS---L------IK-GAKFCrflaasGETlpaae-----t 247
jgi:SpiGrapes_3206 168 GTSRSGSTILGGIIIGIDRPIAAQFSFFMAIP-IMA---GAS---L------LK-LLKIG-------FSftnse-----y 221
jgi:SpiBuddy_1793  168 GTSRSGSTILGGIIIGLERQVAAQFSFFMAIP-IMA---GAS---L------LK-LLKLG-------FSytree-----y 221
6CB2_A             245 pmfAV-------GFITAFVVALIAIKTFLQLIKRIS----FIPFAIYRFIVAAA 287
Q5JGF5             211 ---FI-------TAVTAFFVSLGIMEVLVRTAQHLGtrrfLTLFGLIGVLLNLG 254 Thermococcus kodakarensis KOD1
CCX93837           228 vryLV-------TAAVSFGAALLGVKLMRLLAANNG----YALLAVYCWGVSLF 270
CDA12453           227 ---YVnifagiiGVVIAIALTFIASKFLLQIVKSNS----LNYFSYYGFTVGGL 273
CDC33691           227 ---KInilsaiiGLVISIIASFFAIKLFIFVLKKRA----LNYIAYYDISIGVI 273
WP_022355310       224 allFV-------GTFVSFVVSVFAIQGLLNYVKKHD----FTSFGWYRIALGIF 266 Faecalitalea cylindroides
WP_022092516       224 fllLL-------GTFISFVVSLFAIRSLINYVKKHD----FTVFGYYRIVLGIL 266 unclassified Firmicutes sensu stricto
CDE05606           248 aalAA-------AFVTAFAVSVATVRFLLDFVKRHT----FSAFGVYRILLGIA 290
jgi:SpiGrapes_3206 222 lilAV-------GFITSFVVSLFCIKALVAYVRKHD----FSIFGFYRIALALV 264
jgi:SpiBuddy_1793  222 illII-------GFVSSFLVSLVCIKALIAYVRKHD----FSVFGLYRIVLAVV 264
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