1FM0,1JWB,1NVI,1VJK,2Q5W,3BII,3RPF,1JWA


Conserved Protein Domain Family
Ubl_MoaD
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cd00754: Ubl_MoaD 
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ubiquitin-like (Ubl) domain found in molybdenum cofactor biosynthesis protein D (MoaD) and similar proteins
MoaD, also termed molybdopterin synthase sulfur carrier subunit, or MPT synthase subunit 1, or MPT synthase small subunit, or molybdopterin-converting factor small subunit, or molybdopterin-converting factor subunit 1, is a conserved small sulfur carrier protein that has beta-grasp ubiquitin-like (Ubl) fold involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor of a diverse group of redox enzymes. MoaD is activated in an ATP-dependent manner by sulfurtransferases similar to the activation mechanism of ubiquitin-activating enzyme E1.
Links
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Statistics
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PSSM-Id: 340452
Aligned: 64 rows
Threshold Bit Score: 55.6624
Created: 7-Oct-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Comment:the alpha-phosphate of the ATP contacts the terminal Gly of the carboxy-terminal Gly-Gly motif of MoaD
  • Structure:1JWA; Escherichia coli MoeD-MoaB binds ATP, contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
1FM0_D         2 IKVLFFAqvre-lvgtDATEVAAdf--pTVEALRQHMAAQSDrwal-aledGKLLAAVNQTLVSfd--hpLTDGDEVAFF 75  Escherichia coli
1JWA_D         2 IKVLFFAqvre-lvgtDATEVAAdf--pTVEALRQHMAAQSDrwal-aledGKLLAAVNQTLVSfd--hpLTDGDEVAFF 75  Escherichia coli
NP_636375      5 ITVLYFAslre-aagiASEQVHSga--aDLRGVYAELDARHGlrw----tpAQLRVAVDGAFARwd--dpLRDGSEVVFI 75  Xanthomonas cam...
NP_682151     11 IYLRYFAqlreqsereQEERVTTa---qTYGELYQELKIQYGftl----dlAQIKVAANDRFVAld--qpLRAGDEVVFI 81  Thermosynechoco...
NP_774112      1 MKVKYFAwvre-rvgkAEETIEPpatvrTVEELIAWLSGRSEayayafekpKVIRAAIDHAHVKsd--aaIAGAREIAFF 77  Bradyrhizobium ...
NP_354145      2 TRIVYFAwvre-kigtDEEELDIpssvtTAGELIAYLATRGEnyeaafefpNVIRVAVNQEHVEhd--esIVGAREIGIF 78  Agrobacterium f...
BAM06192      27 FFMVYFGpire-kagrLEEEILTna--rTPESLYEEIRKKYDley----pfSLLRVAVNGTFTNpd--dsLVHGDTVVFL 97  Leptospirillum ...
WP_007280994   4 YKLQYFSllgd-ftgkPSEELQSia--sTPKELYTELQQLYSfeh----csSKLRVAINDEFGDwq--sqLKDGDNIVFI 74  Lentisphaera ar...
WP_013943266   5 IHIIYYAllrq-ergvPEETVEFek--nTVRELFNMLKALHSfrl----seSQIKVAVNSKVATwd--tlLSEGDSVIFI 75  Simkania negeve...
CDF78367       2 ITIKYFGmlae-qtqcSEEQLEFkp--lTLSELVQDLKVKYQfn------sASFHVALNHKLIQgseeitLQFQDEIALL 72  Formosa agariph...

Feature 1             #
1FM0_D        76 PPVTGG 81  Escherichia coli
1JWA_D        76 PPVTGG 81  Escherichia coli
NP_636375     76 PPVSGG 81  Xanthomonas campestris pv. campestris str. ATCC 33913
NP_682151     82 PPVAGG 87  Thermosynechococcus elongatus BP-1
NP_774112     78 PPMTGG 83  Bradyrhizobium diazoefficiens USDA 110
NP_354145     79 PPMTGG 84  Agrobacterium fabrum str. C58
BAM06192      98 PPFGGG 103 Leptospirillum ferrooxidans C2-3
WP_007280994  75 PPVAGG 80  Lentisphaera araneosa
WP_013943266  76 PPVAGG 81  Simkania negevensis
CDF78367      73 PPFAGG 78  Formosa agariphila KMM 3901

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