6NZ5


Conserved Protein Domain Family
DUF463
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pfam04317: DUF463 
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YcjX-like family, DUF463
This family represents a group of uncharacterized proteins including a bacterial stress protein YcjX. The crystal structure of YcjX from Shewanella oneidensis has now been solved, and shows it to be a Ras-like GTP-binding protein. However, YcjX utilizes a non-canonical switch 2' motif not found in any other G protein.
Links
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Statistics
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PSSM-Id: 427862
Aligned: 69 rows
Threshold Bit Score: 428.495
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6NZ5_A        27 LRLAVTGLSGAGKTAFITGLVNQLLnsgAvstvshsrQNGLPLWQVS----------REQRLLGVKRAMQPDLEIAS--- 93  Shewanella onei...
WP_013327078  22 VKIAITGLSRSGKTVFITSLIDQLLyqdKil----gvTASYPPFKTT----------IKPPLANAK----------R--- 74  Sulfurimonas au...
Q0BTK7        25 VRIGVTGLARSGKTAFLTSVAANLLaqgAg-------LAALPALQTA----------LQGRTLNVAIAPSGTDSIPR--- 84  Granulibacter b...
CDK97925      25 adIAVTGLRRAGKTVFVASLIRNLLarsRn-------PDVLPGFRP--------------EIIGVKEEPAGIADLPP--- 80 
WP_012824047  12 tRIGITGLSQAGKSALITSIINHL--------------EN------A----------RRGSLIQQAVLSDVTHGLWRrda 61  Halothiobacillu...
WP_015047773  41 rcIAITGFSGAGKSTLLTSLITQL--------------QHLPLQQAQgwypdighcwLSAKLLN------TDGSLPD--- 97  Simiduia agariv...
Q87NJ7        20 VRIAVTGLSRAGKTAFITSLVNQLLhtaT--------HDNLPLLTAA----------RDKRLIGAKREPQTNMMVPR--- 78  Vibrio parahaem...
Q9KSF0        20 VRLAVTGLSRAGKTAFITSLVNQLLhtsS--------HHNLPLLAAD----------REQRLIGAKRVPQSNMMVPR--- 78  Vibrio cholerae
WP_012604208  20 IRVAVTGLSRAGKTAFITSLVNQLLhtsT--------HKNLPLLASA----------RDGRIIGAKRIPQHNMMIPR--- 78  Vibrio atlanticus
Q5E0R2        20 VKLAVTGLSRAGKTAFITSLVNQCLhasT--------SDKLPLLSAS----------REGRMIGAKRVPQSNLSIPS--- 78  Aliivibrio fisc...

6NZ5_A        94 ---FDYQGAMLALTsNPPTWPESTRTISELRLAIKYRPEKGllAkfAd-AATLYLDIVDYPGEWLLDLPMLRQSYIEWCT 169 Shewanella onei...
WP_013327078  75 ---FDYYTLIHQLk-QEHRWTKGTDEITHTVLEIETKSRFAfl-----gNSTFEIELIDYPGEWLLDLALLEMNYKKWSQ 145 Sulfurimonas au...
Q0BTK7        85 ---FDYAAHMASLAmDPPAWPDRTDTVSMLALDLTISRS-GlaSml--pERRIRLECLDYPGEWLLDLPMLAQDYEEWSG 158 Granulibacter b...
CDK97925      81 ---FQTEKYFRDLQaDPPRWPKSTDSISRTELKIRYKRARSitNplGk-DGILTLGIIDYPGEWLNDVQLLHLSFEEWSR 156
WP_012824047  62 phaFDYDAGLQALThRPPYWPASTTDWSIARIELT-----MtrSwySpkPRKRIIELFDYPGEWLMDLALLDWDFAQFCQ 136 Halothiobacillu...
WP_015047773  98 ---YPYAQQQQRL--QTGEWPEPTRALSRALLEVRVKPGSRwrDlrNkgFVSTQVELWDYPGEWLMDLPLAVMTHQQWLQ 172 Simiduia agariv...
Q87NJ7        79 ---FAYDEAMSQIHaNPPQWPVPTRDVSEIRLALKYKPKKTtkKllSk-TAVLNVDIIDYPGEWLLDLPLLDMNFSSWSQ 154 Vibrio parahaem...
Q9KSF0        79 ---FAYDEALTELQsSPANWPVPTRDVSEIRLAIKYKPKKRskKllTs-SATLYLDIIDYPGEWLLDLPLLEMDYATWSA 154 Vibrio cholerae
WP_012604208  79 ---FSYDEAMESLNaQPPEWPVPTRDVSEIRLAIKYKPAKGakKllSk-NSTLYLDIVDYPGEWLLDLPLLDMDFDTWSQ 154 Vibrio atlanticus
Q5E0R2        79 ---FTYDDGMDSLLsDPPTWPEPTRDVSELRLAIKFKPKSGvlKhfQd-SATLFVDIVDYPGEWLLDLPLLDMDYLAWSK 154 Aliivibrio fisc...

6NZ5_A       170 TQQQRiAVLKSSPLYAGFETSLNALNLAAMAD-ESELKRLADQYQQLLHDLVHVq-GYYQAQPGRMLL------PGE-WQ 240 Shewanella onei...
WP_013327078 146 KTMLWlHS-VDDDKARAYLATLDSLTAKINTQ-EVE-LKLHNKYKELLIHLKKN--HYSQLTPGRFIM------PSD-LA 213 Sulfurimonas au...
Q0BTK7       159 AVLTRlEGQAE---AAGFLGFVKALPVSASAD-EAIAEEGARLYRAMLHRLREQ--GLTFLQPGRMLM------PPP-GL 225 Granulibacter b...
CDK97925     157 QTLSRlRTGAISIVATDFLGFLSTANGNSRADiDLISRRGHELYKDALFKMRDEl-GLSFLQPGRFIM------PDG-GG 228
WP_012824047 137 ALWGWcSQSPRLELGNALIQELSVIDPMAPVD-REYLSQLQQRWADFLADCRLPphQLSRNLPGRFLLsgtdykPGD--- 212 Halothiobacillu...
WP_015047773 173 DCFTQfNNEPRNAMAPALYSALLDLDPGAPFE-PSVFESLFADYRAFLLACKAR--GLHIINPGRYALd-----EGDlPA 244 Simiduia agariv...
Q87NJ7       155 TQFDAlKG-KRKELAQAWLAELEQIELNADAD-EKQLEKVAHAYTDYLHACKDA--GLHWVQPGRFVL------PGE-LA 223 Vibrio parahaem...
Q9KSF0       155 QQFHAlHG-LRKELAKPWCDAVEQLDLHQEAN-EQTLAAIAASYTDYLHQCKAS--GLHWVQPGRFVL------PGE-LE 223 Vibrio cholerae
WP_012604208 155 SQFAAlKG-DRETYSQQWNAMRGDIDLLAEAD-EKKLVAIADSYTQYLHTCKSN--GLHWVQPGRFVL------PGE-LE 223 Vibrio atlanticus
Q5E0R2       155 QQQANlTG-HRKVLSEAWLQEAKQLDPLAPVD-EKKLARIADAFTDYLHTCKNEk-GLHWVQPGRFVL------PGE-LA 224 Aliivibrio fisc...

6NZ5_A       241 GAPLLAFFPLLSVTNAQWSnlkqsdKHSAFHVLEKRYQEYVAKVVKPFYKQHFAGFDRQVVLVDCFSALNRGKSQFEDMG 320 Shewanella onei...
WP_013327078 214 NDPILVFAPLPPNA-----------AKELFKSYEKRYNRYVKEIVKDIQLEHFKGFERQVVLVDVLEALQNGYDCYSDMK 282 Sulfurimonas au...
Q0BTK7       226 EPPWMGFFPSLA-------------RGGLGGLLSGRYDRYRQAIRDELMAPSFGHVDRLVVMADLLSALHAGPDAYADAA 292 Granulibacter b...
CDK97925     229 DKPLLWFFPMEPPPEADKSg-----KDTLWATLAQRYKAYCDKIVTGFLRETFDRCNQQVVLVDLLTALNGGQVVFDDAC 303
WP_012824047 213 -KP---FVPLFSTNLAGGSvpdsfpAQSWGAVCADHYKAYRDHEARPFFERHFQNLDAQVILIDLLGAMTAGQEALKDMR 288 Halothiobacillu...
WP_015047773 245 SLP--RFIPLLSMVNADGSew---pAGSWGAQMAMRYRAYVQDWVKPFLTDVFEQVDHQLVLVDLLGALGDGKLAMEELR 319 Simiduia agariv...
Q87NJ7       224 GAPVLQFFPCRFESEsk------apKGSNLAMLEARFHEYQQKVVKAFYKHHFATFDRQIVLVDCLQPLNAGDEAFYDMR 297 Vibrio parahaem...
Q9KSF0       224 GAPVLQFFPCHAPQgs-------vsKQSYYALLQARYQEYQNKVVKAFYKDYFATFDRQIVLVDCLSPLNVGHESFLDMR 296 Vibrio cholerae
WP_012604208 224 GAPVLQFFPCNAPEgk-------fsKTSNYAVLKARYEEYQQKVVKAFYKNHFATFDRQIVLVDCLQPLNAGYDSFMDMR 296 Vibrio atlanticus
Q5E0R2       225 GAPVLQFFPFMFLHKYTEEelakakKGSNIAVLKQRYKHYQQNVVKKFYNDHFRHFDRQIVLVDCLQPLNAGENSFNDMR 304 Aliivibrio fisc...

6NZ5_A       321 AALNAIMESFQYGQS-S---------------YLRRL-FA-PRIDRLLFAASKVDHVTRDQQ---SHVLSLLTDMLKHSQ 379 Shewanella onei...
WP_013327078 283 NGLKSMLALYEHKNK-N---------------FLSQW-FS-PSIKKVLFCATKADQVAASQH---ANFSALLVDMIDDLQ 341 Sulfurimonas au...
Q0BTK7       293 SALGAVASALRWRGSwAdsipllreagrflpeWLRSA-LLpGAIARAAFVASKADHVAERQRgnlAALMGLLTDSVPERF 371 Granulibacter b...
CDK97925     304 EAIGTALDALGLGRS-R---------------WWKLLrMQhRKFDRVLFAVTKADHVPQSQR---HALERLLENIIGDRI 364
WP_012824047 289 AALDSVLQPFRYGQD-H---------------WLGRL-FR-RRIRRVAVCATKIDHLLPEDQ---KRMQSLLESYLYETV 347 Halothiobacillu...
WP_015047773 320 RSLARVLQLFHYGHN-S---------------WIDRL-LA-PKIEQLTFVATKLDCVLPSQR---KALSELMRALVAESV 378 Simiduia agariv...
Q87NJ7       298 QALEQIMHSFRYGRS-S---------------FLRRL-FS-PKIDKVLFAATKADHVTPDQH---PHLVSLLQQMVHPAW 356 Vibrio parahaem...
Q9KSF0       297 SALEQIMHSFRYGRS-G---------------LLSRL-FA-PKIDKVVFAATKADHVTPEQH---VNMVSLLQQMIHPAW 355 Vibrio cholerae
WP_012604208 297 GALEQLLKSFKYGRS-N---------------ILRRL-FA-PKIDKILFAATKADHVTPDQH---PNLVSLLQQMVHPAW 355 Vibrio atlanticus
Q5E0R2       305 QAIDQLMHSFQYGKS-S---------------LLKRL-FS-PKIDKVLFAATKADHVTPEQH---PNMVSLLQQMIYQTW 363 Aliivibrio fisc...

6NZ5_A       380 HFAGFEGCKVETMAISAIKATRHGMVT-TQEGDVEVVQGTGLn-GQALTLFPGEVPTRlPEPDFWREQGFNFIGFAPPd- 456 Shewanella onei...
WP_013327078 342 KELDISHIKTNTQIVAALKSTVTIEKK-YEGQTLSFIRGILEedGEMHDLYPGKMPIRfPSKAEFDTSKYGYKNFLPP-- 418 Sulfurimonas au...
Q0BTK7       372 RQETARGGRTRAFAMASVRCTEDFVWT-LDGHPVSAVRGRLNgsDRITRSYPGEVPDRpPEPSFWAHRFLAPPDFEPMr- 449 Granulibacter b...
CDK97925     365 SRDLTDGSRVQSMALASVLCTKDDKVL-VDVGEVDVVVGKPIdsDKGLKIYPGVIPSDrPRPDYWSRTAIRYPIFSPPr- 442
WP_012824047 348 QRLAAEDIDVNVMAIAAVQSAKLHETP----DHTQSLIGRDKrtGERIRFTPPHLPDNlPHALNLKI--EDLPQLSPPe- 420 Halothiobacillu...
WP_015047773 379 QAARFESVQVDHLELSAIAGTHLGERDgERALWVETPAG-------PAWLKHPHLPRGwPTDNDW----TRLADWAPPrl 447 Simiduia agariv...
Q87NJ7       357 QTAAYENIEMSCMSIASIQATTSGFIT-SGDKTISALQGTTLn-GEAMTMFPGEVPKKlPNAAYWQNSGFDFTSFRPM-- 432 Vibrio parahaem...
Q9KSF0       356 QHAAYENIEMNCISMASVRATQSGYIM-QGEQKVAAIQGITLe-GESITLFPGEVPRKlPDPDYWQRQAFDFTAFRPL-- 431 Vibrio cholerae
WP_012604208 356 QQAAFEHIDMSCMSIASIQATSAGYIS-SGSDNVPALQGVTLd-NVPQTMYPGEVPRKlPNKQYWETNQFDFTSFRPM-- 431 Vibrio atlanticus
Q5E0R2       364 QETAYEGIKMECMSIASIQATTAGMID-EDGEIFAAISGINTa-QQPMMMFPGEVPKRiPSKAYWETEPFNFMSFQPL-- 439 Aliivibrio fisc...

6NZ5_A       457 -nTnvDPSSv-HFDHIRLDHLLQYLVGDKL 484 Shewanella oneidensis MR-1
WP_013327078 419 --KkpYRENe-SLAHINMDRVIRKLIGDLL 445 Sulfurimonas autotrophica
Q0BTK7       450 -lP--AGGRa-GIPHLGLDTLLAWLLEDVL 475 Granulibacter bethesdensis CGDNIH1
CDK97925     443 -lD--AGAFg-GIPNINLDRAIDFILKDIL 468
WP_012824047 421 ----gLDRVq-AFPARRIDQLLAFLLAe-- 443 Halothiobacillus neapolitanus
WP_015047773 448 dpPplADPShsTWPSIHMDHLCQLLLKelm 477 Simiduia agarivorans
Q87NJ7       433 --P--SASDe-PMKHIRLDKALDYLLGDKL 457 Vibrio parahaemolyticus
Q9KSF0       432 --P--TAMDe-PCQHIRVDKALDILIGDKL 456 Vibrio cholerae
WP_012604208 432 --E--QHSDe-PCQHLRVDKVLEYLIGDKL 456 Vibrio atlanticus
Q5E0R2       440 --K--NENDr-PLQHIRMDKAIQFLLGDKL 464 Aliivibrio fischeri ES114
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