6IEM


Conserved Protein Domain Family
ArgH

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COG0165: ArgH 
Argininosuccinate lyase [Amino acid transport and metabolism]
Argininosuccinate lyase is part of the Pathway/BioSystem: Arginine biosynthesis
Statistics
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PSSM-Id: 439935
Aligned: 697 rows
Threshold Bit Score: 303.175
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6IEM_A         4 Ne-----G---S--LW-GGR---F-----AGGPSD-A-LA-ALS--KSTHFD---WVLAPYDLTASRAHTMVLFRAGLLT 56 
WP_011581717   1 Mat--pfT---------KAR---L-----GKDARA-T-LI-NAAhlPVLKRE---LDMFDAYVRVDLAHITMLAEQGIIP 55 
WP_011751529   1 Mt-----TeipKgyLGaEAR---I-----KSGPAP-ElVStGYA--LEIADA---PLLHEGLGLADLAHVLALTEDGIMP 61 
WP_011751544   1 Ms-----IevpAgyLGaEAR---I-----TSGPAP-ElIAsGYT--LETADA---PLLHEGLGLADLAHVLALVEAGVVP 61 
WP_011992986   1 MtrlsdrSa--GavLEiGNR---L-----SAAPSP-RmVAvAFA--EEVSGQ---VPLSPHLVLVDLAHVITLAERDVIP 64 
WP_015803232   1 ------mT---Al----TGR---L-----SAAPST-L-LD-AEV--LRPQFEhevRRLLPHYVAVERVLALEYRRMGLLT 54 
WP_013594944 354 iaggrtassalrsalslRSRsqvLyappeVPPPDAaT-VR-RIAlgERCAFRp--GSLAGSLFPIEKSHLLMLRSQGILS 429
WP_013673791   1 Mt-----Tp-tRs----AGRa--Lgf--pQTGPAP-ElVEsGFA--LENADA---SFLHRGLNLADIAHVLDLRRRGIVP 60 
WP_013734191  10 Ta-----M---Pl----TGR---L-----GRAPSA-V-LH-EHV--LAPQFQfeaDHLLGWYRVVERVLLAEYARMGLVT 64 
WP_129894546   7 Mp-----A---Nl----TGR---I-----AAGPHT-S-LD-EDI--LTPQFHydlAYLLPWYIQIEKVLLLEYRRMDLLN 61 
6IEM_A        57 EEQRDGLLAGLDSLAQDva-dGSFGPLVTDEDVHAALERGLIDRVGpDLGGRLRAGRSRNDQVAALFRMWLRDAVRRVAT 135
WP_011581717  56 IKVAKALLGALQDLRRAg--pQGLDVKGELGSILLQVEHYLAERVGaESAGYLQLARSRIDQNATISRVHARDELLHVAE 133
WP_011751529  62 EVASCALTAELLEILATp--aDEFPYDVVYGDAYNSRERELERRLG-DTAGWLHAGRTRREAGRIAFRIALRRRLLDLHD 138
WP_011751544  62 ASAAKDLARELLQILSTp--pEEFPYDPVYGDAYNSRERELESRIG-DAAGWLHTGRTRREAGRIAFRIALRRKLLDLHD 138
WP_011992986  65 RGPARDLVGALLDLHDE----GGAEALAELGDLYTNHEARIAARt--AAAGWLGTARARREALTTAYHLLLRERLLVLGT 138
WP_015803232  55 EEQAADVLGLLARVRPDelaaDP---EANLSDIAFALERHVERGAA-RPVPNWHVDRSRNDLQACAQLMAARDRLAALAG 130
WP_013594944 430 AGQFSALREAVLAAEAEpe---lLRAHASGRGDYFDYEHYVIDRCGeATGGMVQAARSRNDINATHLLLTLRQAIAGTMD 506
WP_013673791  61 EDAARELLALLLEVTEVd--aDDFPYDPSHGEPYNSREHFFVSRIG-DVAGWLHAGRPRREAARVALRLHLRRQLTELVE 137
WP_013734191  65 EPEAAAIAALLDTATADritaDP---AANLSDICLALERHVLAGLA-TVPSAWHVDRSRNDIQATAQLLYARSELLDIAE 140
WP_129894546  62 LEEALSIGTILNSIRRDtlqpKR---EENMSDIAFAIERQVEQSLS-HLPGAWHVDRSRNDFQACAQLLSGREQLLAIID 137
6IEM_A       136 GVLDVVGALAEQAAAHPSAIMPGKTHLQSAQPILLAHHLLAHAHPLLRDLDRIVDFdKRAAVSPYGSGALAGSSLGLDPD 215
WP_011581717 134 RIVDFQKVILQRAEEWADVLMPGYTHLQHAQPWILGHYMIGQHDVFARDLQRVIQTyDRVNLSSLGGLALVGTSWPIDRE 213
WP_011751529 139 GVGDLALAFATAARLHADTLWADTTYLQPAQPSTFGHYLGAFAEETTRHLSRIQSAyDLANRSPTGSGGVGGSPLLVNRV 218
WP_011751544 139 AVGDLALALASAARLHAETLWADTTYLQPAQPSTFGHYLGAFAEETTRHFDRIQAAhRWANRSPAGSGGVGGSPVLVNRK 218
WP_011992986 139 ALTRLGRRLAAAALAHADQVMPDYTYLQAAQPTSLGHYLLGFAWPVLRDLGRLEALyVRTDLCPAGCGSMNGSVAFQDRA 218
WP_015803232 131 QVLGMAAAARRVAARHLDTPMPGCTHYQAAQVTTPGFHLAALGERLLHTSRRLLATfDGTDACPLGAGALTGQHLPWDRE 210
WP_013594944 507 RAQQLGEALLQRAEATVDTILPIHSQYQVAMPGTAGHYLAAQATVLLGTMEALASLqDGLDTSPLGACAGAGTSFRTVPH 586
WP_013673791 138 EAVAFARDAVATAETHASTLLPDQTYLQQAQPSTFGHYLLSFVYPAVRDARRLLDElDWVDSSPGGAGCVNGTRLLDDRG 217
WP_013734191 141 ALVEVTRVARRRAAAVTHLPMPGYTHLQAAQVSTPGFFLSALVEHCLRTLRRLLATyDEINLSPLGAGALTGQELPWDRD 220
WP_129894546 138 QMVSFAWAVHRRASAMTEMIMPGYTHYQAAQVISPGFYLTALIEEMLASTTALLNIyDGLNTCPLGAGAMAGQQLPWDRV 217
6IEM_A       216 AIAADLGFSAAADNSVDA-TAARDFAAEAAFVFAMIAVDLSRLAEDIIVWSSTEFGYVTLHDSWSTGSSIMPQKKNPDIA 294
WP_011581717 214 RTAFLLGHSAPIRHSKDCaGFAMDYLAEVGSSLSILMSGLGRLASEWYIWSTWEFNLIELDEGLCGTSSIMPQKKNPYVL 293
WP_011751529 219 RDAVALGFDEPGWHTRDV-MWSVDGLVDAVFCSAQAVTTVDRLAEDLEIFASPAFGYVRLDASLCRASVLLPQKRNPYAL 297
WP_011751544 219 RDAATLGFDEPGWHTRDI-MWSVDGLVDAVVSATQTAATVDRLAEDLEIFASPAFGYVRLDASLCRASVLMPQKRNPYAL 297
WP_011992986 219 ALSRRLGFSSPLAHGRDA-MWQADLAIEAMALSVTASVGLDRLAEDLMIFATAEFGLVRLADKHSRASKILPQKRNPYAL 297
WP_015803232 211 RMAALLGFTRPGGSALTD-VASRAFVAEITAELSLFGITASRFATDLITWAGAGHGFVDLPDELSGISSAMPQKKNFPVL 289
WP_013594944 587 ETARLLGCVRGPSNSLAA-ISDKTPALRCAYLFIELSGHLNRLAIDLQLWTMREAGFAQLPEAMYGGSSNMPQKRNPYLL 665
WP_013673791 218 PVASALGFRGVIPHTRDA-MWQVDGLVHILATAASLLSNFSKLAEDLEIFSSSEFDFVDLADAYTRSSILMPQKRNPYAL 296
WP_013734191 221 RMALLLGCAGPYPHALTA-VASRAWALEIAGELSHFGVGTSRFVTDLMAWASSAYGFVELPDELAGISAAMPQKKNYPVL 299
WP_129894546 218 RMASLLGFDRPQRHALVS-VASRDWRTRIAAELSTIGATLSRFITDLIAWGSGPYAFISLPDEFSGISSAMPQKKNFPVL 296
6IEM_A       295 ELARGKSGRLIGNLAGLLATLKAQPLAYNRDLQED-KEPVFDSVAQLELLLPAMAGLVASLTFNVQRMAELAPAGYTLAT 373
WP_011581717 294 ERVRALAGESIGWTAAQLGMLRT-PTTVDADRFF--STGNVEYFRVANWALDLMQDCAATVRINRERMRELAGANWNTAS 370
WP_011751529 298 AVIRSGANVLVGRAAGMLATQRT-PSARTDNWLHA-YGEVAGSVDLASRLVRLGTAVVSSLEVDRDALTREAAAHFTGAA 375
WP_011751544 298 AVIRAGAGVLLGRTSGLMATQRT-PSARTDNWLHA-YGEVASSVDLATRLVRLGTAVVRSLEVDEEALARAAGAHFTGAA 375
WP_011992986 298 AFIRGLANRLIGAQAGVAASART-PTGQMDNRMLA-YGAVPEALGSCAEATDLMAEIIGALSFDGARAEALLADGACFAS 375
WP_015803232 290 ERIRGRTAHLTSCHVDVALAQRGTPYTNLVEVSKEaGAQFHDALDTAGSVVRLFTAVLDGLVFRADRMRAACEREYLGGF 369
WP_013594944 666 EWLRLHHDRHAGQFAGLLSSLSHLPTGNSYQASRCaVESIADLSGSLGDMCTVATYAIAGMRFDEAAIRRALGSGDAHAT 745
WP_013673791 297 SIIRGANGVVIGRLTGFLAVTKS-PSARSDNLIFA-YGEVPRALDLSLRITRLTSGVVRTLKVNPVRMREELDRGYTQAT 374
WP_013734191 300 ERIRGRTAHLTSLALDLATAQRATPYSNMVEVSKEgGAHLHDLFRSARGVLALLRTVLENLDWRPEAMRAACDREFLGGF 379
WP_129894546 297 ERLRARTAHLTAYYQDFIMGQRNTSYTNLVEVSKEaGSQLSSMFTTMASLLRIFTLVIDQMEFQSETMRHACTQEYFGGF 376
6IEM_A       374 DLAEWLVRQ-GVPFRSAHEAAGAAVRAAEQRGV-GLQELTDDELAA-----I--S-PEL-TPQVREVLTIEGSVSaRDCR 442
WP_011581717 371 NLADAIVREcGLDFRSAHQIVGALVKASIESGT-HSRDVGLAEVNAaaratIgrE-ISMtDQQIHDSLDPEQFVAtRVSQ 448
WP_011751529 376 DLAESIMVNlGLDYRSAYRVVGHAVGVAIDAGR---TALLASDVDLaakelLgeAlSPRp--DVESITDPGRIVAtRDVA 450
WP_011751544 376 DLAESMVLHqGLDYRSAYRVVGRAVAAAVEGER---TVLDRSHLDIaawdlFghGlSDLp--DVESITDPATIVStRDVL 450
WP_011992986 376 DLAERLCLAlGLDFRRAHGLVGRLVTRLEGEER-ALSTLTQDELSAacha-fdaAlPPVpDGLLAAAFDPKTCLEaRRDV 453
WP_015803232 370 ALATLLTLRaGVPWRRAQVLAGRYVVAALERGL-PPTRPDGDLLAAvaea-dgvT-APSpGALLAEAFDVDASLRaTRTT 446
WP_013594944 746 LAAEALVQEgQASFREAHTTVGRLLAQAPTEDSsPLAARASGLL-------T----------QLRTELEHGQPFDrLRSG 808
WP_013673791 375 DLAEHLVQRlGVDYRTAYVVVGNTVRAASRAGV-PGAQITGAMIDEaavahTgrS-WGLaGEDLSGVLDPVSIVAsRRAE 452
WP_013734191 380 TLANRLTLDeKVPWRTAQVIVGRYVRAKLAAGD-PLDRPDASLLAGlaea-agyR-LTDpAARLR-GLDSGGQLAvKCSA 455
WP_129894546 377 ALANHLTLQaGISTRQGQVAAGKYIVQAIQQGF-TPGQGSAHLLHAicqa-qgyS-ADIaYHTLQELFDPEHNLQeKHTS 453
6IEM_A       443 GGTAPGRVAEQLNAIGEAAERL--RR 466
WP_011581717 449 GSLSKAELQKLFDMARTDIAAS--EK 472
WP_011751529 451 GGSAAGRVREHALRVEGLAAQA--YA 474
WP_011751544 451 GGSAPNRVREHAERIEQLAGHA--QQ 474
WP_011992986 454 GGAAPQEVRRQARELDDTFRHR--AE 477
WP_015803232 447 GSAHPDEVAAQLRAQDGEHAEL--ER 470
WP_013594944 809 GGPTASSTREAIAELHGRLRRCglRq 834
WP_013673791 453 GGAAQAAVADMVSRLRAELDEL--AA 476
WP_013734191 456 GSARPDHVRDLLDRQGVALDAL--AG 479
WP_129894546 454 GSTGTQAVEQMLREQTNDLQHV--QT 477
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