4LV7


Conserved Protein Domain Family
Ins_P5_2-kin

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pfam06090: Ins_P5_2-kin 
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Inositol-pentakisphosphate 2-kinase
This is a family of inositol-pentakisphosphate 2-kinases (EC 2.7.1.158) (also known as inositol 1,3,4,5,6-pentakisphosphate 2-kinase, Ins(1,3,4,5,6)P5 2-kinase) and InsP5 2-kinase). This enzyme phosphorylates Ins(1,3,4,5,6)P5 to form Ins(1,2,3,4,5,6)P6 (also known as InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, nonhomologous end-joining, endocytosis and ion channel regulation.
Statistics
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PSSM-Id: 461826
Aligned: 81 rows
Threshold Bit Score: 126.745
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4LV7_A        49 YRGEGGANLVLAYAGsspl------------------------------------------------------------- 67  thale cress
EPE10016      63 YIGEGSANAVFCVTPkkknlskssskssapgs-----------------------------------------------h 95 
EGS20648      27 FVGEGASNVVFEVRVppskrgsis-------------------------------------------------------- 50 
XP_003344264  21 FIGEGAANIVFEVIFphedvtitqddg----------------------------------------------------- 47 
EKG15189       7 FRTEGNANVIFRIAAldpaaldaprpdvrandvhgalepdwrysddprkqrlynremrarrrellapyaragqlpaaadf 86 
XP_002149285  15 YLAEGGVNIVYRMIlpaaedqvllqhqpseiphygsstpp-----------------------------pteiddidnle 65 
XP_002835291  42 YLAEGAANIIYRLSAppgappa---------------------------------------------------------- 63 
CAZ85836      23 YFGEGAANVLYRYIGadpf------------------------------------------------------------- 41 
EPS38329      28 YFTEGAANVLYRYVgkeeq------------------------------------------------------------- 46 
XP_957829     21 FIGEGAANIVFEVVFpeedittqddg------------------------------------------------------ 46  Neurospora cras...
4LV7_A        68 -----------fvgkVIRIQKARRndkaiknsngvvsvltsdeqhlwrennelISSPNKCVLEQRYVQNVIIPLLG--PK 134 thale cress
EPE10016      96 nipsndsdagslsthLLRIPKAGP-----------------------------GVGAGTCLDHHAYYSSVLRPLIG--TE 144
EGS20648      51 ------sklfegtgnLLRVPKAGT-------------------------------KAYSYEDLHAYWETVVKPLFE--PQ 91 
XP_003344264  48 ----dskilnilqgkLLRVPKANT-------------------------------KAFPHPQILQYWESSISPLFDnpQE 92 
EKG15189      87 vrdvnqhnltsardtLLRLKKQMP-------------------------------FYQDDETTYSFYINTVADWIP--PR 133
XP_002149285  66 pdiatdtdtnitsrkLLRLRKNVR-------------------------------YGLPYRETAHDFRTQIRPLFG--DE 112
XP_002835291  64 ---------deyvnrLLRLRKALP-------------------------------SAQPNLLAYSHLLHTFHPLFP--SH 101
CAZ85836      42 -----------fgpyLLRLRKRLP-------------------------------GAPTTQQLYADLHSRWGPLLD---N 76 
EPS38329      47 -----------fkphLIRLRKYLP-------------------------------NFPTTLQLYTHLHKVFVPLLP---T 81 
XP_957829     47 ----dsqildilhgkLLRVPKANT-------------------------------KAFPHPEILQYWESSISPLFDnpQE 91  Neurospora cras...
4LV7_A       135 HVDAGVRVS--VSKEFLecvDKKVTKQ--RPL------------WRVNAanvd------tshdCALILNDHSLFSQGI-- 190 thale cress
EPE10016     145 WLVGQHLVQgiISRGVQstlNDLLENLd---------------rSGRRRpdwvgtr-ispdvdVALLVEDMTLACNKS-- 206
EGS20648      92 NLVQHQLILl-gGEAVIrrlNSILEKEd-----------------aTRRadfrgs--rvamakYGMLIEDMRQRHP---- 147
XP_003344264  93 DLVQQYLVR--LDNSIVsqlNEVLGTEd-----------------vQRRadfqgt--kvaeaeYGMLVEDMRKKSP---- 147
EKG15189     134 HLVQQDLIE--LGQDIIqecNKELRLQe---------------kAGKRDvnrhgk--ylhttsKALILRDMESHDPD--- 191
XP_002149285 113 ELVDQIMVR--VPPSIIhrcNADLQEKe---------------rLGQRPaircgvy-laedepLGMLVTDMTTVTTTTtt 174
XP_002835291 102 LLVPTTLIR--VPKSVIlreNVNLVQLe---------------nAGKRPakrrglyleeetedYGFVILDMSPRPVEDlp 164
CAZ85836      77 CLLKTEIVK--LGINIIpdlNSMFAMGdgEEAtdwsgrpikppkQRRLLddt---------esWGLIVEDMSCGNYLYne 145
EPS38329      82 SILDTKLVE--VSPNVLkalNVRLQQDdrGNSgleeglppklggKKKGKlde--------sekWGLIVEDMTPGVYQKyi 151
XP_957829     92 DLVQQYLIR--LNNSVVsqlNAILENEd-----------------aQRRadfqgt--kvaeaeYGMLVEDMRKKSP---- 146 Neurospora cras...
4LV7_A       191 ---------------------------------------------------TSG-GDCISVEIKPKCgF--LPTSRFIGk 216 thale cress
EPE10016     207 ----------------------------------------------------LHpSTTTTVQFKPKW-LvqSPSAPAGA- 232
EGS20648     148 --------------------------------------------------------DDLTFEFKPKW-LaqSPSAPPTA- 169
XP_003344264 148 --------------------------------------------------------TDLLLEFKPKW-LtpSPTAPSTA- 169
EKG15189     192 --------------------------------------------------------KSLTLEFKPKW-LwqSPHAPEGA- 213
XP_002149285 175 tttt------------------------------------------tppttSA---GVNIVELKPKW-LvqSPSAPAKA- 207
XP_002835291 165 ptppdtddtttpp------------------------iagvtaegfqrkdfST---RQILVEFKPKW-VvqSPSAPANW- 215
CAZ85836     146 metqldsmqe------------------------------geeiddgrdegSDEwKDMAMIEFKPKW-LaqSPNAPANW- 193
EPS38329     152 tananleqkkknssrdifslsllreslkqaqgsqkddtstcastmdakalaKDGwRDLLTVEFKPKY-LtqSADAPRDW- 229
XP_957829    147 --------------------------------------------------------LDFLLEFKPKW-LtpSPSAPSTA- 168 Neurospora cras...
4LV7_A       217 enilktSVSRFKMHQLLK-------------LEYIEISE----ES----------EYDPLD-L------F-SGSKERVLE 261 thale cress
EPE10016     233 ------RRCRTCALSAASaspstssstkgngRKNSNGPKttqgRSssgpekshkiKPCPIV-LvadppkT-AAEEADLDA 304
EGS20648     170 ------TRCRNCAREALKrhanpdr------------------------qpkssaILCPLDfR------TcATSPISLAN 213
XP_003344264 170 ------TRCRNCAREAYRlhkslrsasssrpSSDQGSAAltenS-----------IFCPLEyL------AaQSSPSSLAR 226
EKG15189     214 ------TRCRTCALRAKRnsegma-------------------------eskthgVQCPLSiA--------TGEPSLVKD 254
XP_002149285 208 ------RRCRTCALRDMKradsplnpqnpttLATAVAVQpg------------kaQFCPLD-L------T-SDNENDMQR 261
XP_002835291 216 ------RRCRTCALLLQKngg--------------------------------kpSFCPLD-L------S-SREESRVRD 249
CAZ85836     194 ------LLCRTCAVRLMQsakrqtndllcvpGEEGHDLEee------------alDFCPLDlS--------SGDPTRIEK 247
EPS38329     230 ------KLCRTCALRSMRsrsmsgrstasanSDGDDRHHsi------------ppDYCPLD-L------V-STNKDRVRR 283
XP_957829    169 ------TRCRNCAREAYRlhkslrsassdqnS----SCAlsheP-----------PFCPLEyL------AaQSSPCSLAR 221 Neurospora cras...
4LV7_A       262 AIKALY----------------------------S--TPQNNFRVFLNGSLILGgsgestgrtspeigyafedalkgfiq 311 thale cress
EPE10016     305 ALWEYVyqhlgsavssqssspnsstplspsttflLl-------------------------------------------- 340
EGS20648     214 VLNHLTprvhkptanahppsvslnghspasprptP--------------------------------------------- 248
XP_003344264 227 VIESMNlsatsvseetapatkenpvgaqpavsldGd----eGIEEVDE-------------------------------- 270
EKG15189     255 AIEKLVdnhenyvgcrppwlqksrrsstfplrkpA----------------P---------------------------- 290
XP_002149285 262 TIRQIFpyl----------------------------------------------------------------------- 270
XP_002835291 250 TLQHILp-----------------------------sIPPKNLQLRLGETWEDA-------------------------- 274
CAZ85836     248 ATFAILnmensvmiad--------ptptsddegdSdtPTPPTLNQRLAKCLE---------------------------- 291
EPS38329     284 AAEAIVnredgvlvvnede-----------------------------------------------------------vl 304
XP_957829    222 VIASMNlsaisasldtkpatrenpvgvqpavsldGedDGRPGMDQVDE-------------------------------- 269 Neurospora cras...
4LV7_A       312 sedghrTECFLQLVSDAVYGS-------------GVLDRLLEIQkldkldiegaihcyydiinqpcpickegrpleaels 378 thale cress
EPE10016     341 --------KTRPAIIRWMRTT-------------NLFRRIAAIQaehdphgalavd------------------------ 375
EGS20648     249 --------SQSARLRHWLQTn-------------TLLPRLRQAQlandglgpl--------------------------- 280
XP_003344264 271 --------RYRVALVRWLQTn-------------SLLPKLRDAQerldpape---------------------------- 301
EKG15189     291 --------RSREDLIALLQNHfqvrpdgskgegyRVLEGLRNLQkmldprgils-------------------------- 336
XP_002149285 271 ------lpKKIDTIASALYQh-------------PILQKLLSLQrihnevgln--------------------------- 304
XP_002835291 275 ------KKVIEDRTVDFLVSs-------------ELMPLLKRLQlemdplgpikaa------------------------ 311
CAZ85836     292 -------NSLVTLLTNFFRTS-------------PIIPLLTALQsrfgsrgvftsatlalmgekdvlps--edeirrtcl 349
EPS38329     305 vtdtalgedgISAWLDILDTSivdlltsyfsdpaCVTHALADLQqhfggkfgvlapptptlevsa-----------eels 373
XP_957829    270 --------RYRVALVHWLQSn-------------SLLPKLRDAQesldpape---------------------------- 300 Neurospora cras...
4LV7_A       379 lhalpldeslkivkeyLIAATAKDCSIMISFqsrnawdsePSGDYVSLKPTNQTFDYKVHFIDLSLKPLK--RMESYY 454 thale cress
EPE10016     376 -----laddvtsldrlQTAMTLRDCTCFLRV---------------TVSESSSEVSISAKLGDLDRKDGRr-KLARWQ 432
EGS20648     281 -------gadasdphfQLAMTLRDCTCFVRV------------------PANPELPIEAKLADLDKKNWMa-KMEYWR 332
XP_003344264 302 --------gttdreelALAMTLRDCTCFVRI----------------SEDSQGEVKVEAKLADLDKKNWKa-KLEYWK 354
EKG15189     337 -------hpgepsddfLLAMTLRDCSLYVQV-------------------HWDTRQVESRLGDLDPKVAKggKLEQWV 388
XP_002149285 305 -------gpspgsketSMSMTLRDCSVFLKI----------PSSTHLSSGTDLPAGIDIRLGDLDLKSAAngKAEYWL 365
XP_002835291 312 -----regsqycqerfITAMTVRDLTIFLRI--------------------DLDGSVEARIGDLDLKTGEagKWDYWS 364
CAZ85836     350 atgekyepavsdeddiWTAMTLRDCSLFLKV------------WVRKRRGRGMEAKIDAKVGDLDVKGGEggRAVYWR 415
EPS38329     374 rmlaghpttakigediCTAMSLRDCTVYVRI---------WVKAKSC-GGNGIDVHIECKVGDLDMKTGEggKGLYWR 441
XP_957829    301 --------gtsdqeklALAMTLRDCTCFVRI----------------SEDSKAGLKVEAKLADLDKKNWEa-KLEYWK 353 Neurospora crassa...
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