Conserved Protein Domain Family
DUF445

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pfam04286: DUF445 
Protein of unknown function (DUF445)
Predicted to be a membrane protein.
Statistics
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PSSM-Id: 427840
Aligned: 70 rows
Threshold Bit Score: 150.854
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_011723139  11 IVGAIIGYITNWLAIKMLFRPheekrIFgIKIPfTPGLIPKEQKRIAKSVGNAVGEHLLTKDT---MIDALKNNEVDSKF 87  Clostridium novyi
Q5WHV2        12 VVGAIVGAATNALAIRMLFRPhraysIGkWQLPfTPGLLPRRQKELAVQLGNIVANHLLTAEG---LGKKFGSTAFAAEL 88  Alkalihalobacil...
Q5L2A6        12 AVGALIGGVTNFIAIVMLFRPyepmyVFgKRLPfTPGLIPKRRRELAEQLGKTVVEHLVTPEG---LRRKLMDPSFTAEM 88  Geobacillus kau...
Q81UK6        12 glGAIIGGFTNHLAIKMLFRPhrpmyIGkFQVPfTPGLIPKRRDELAVQLGKMVVEHLLTPEG---IGKKLTNEEFQKGL 88  Bacillus anthracis
Q7NNA7        30 IVGALIGFTSDTLAIKMLFRPykpkyFLgRQIPlTPGLFPKGQERFARKVAQMLTDKLLTPDEvhrIAQRLLTPERLEEG 109 Gloeobacter vio...
Q2JHS8        11 LAGLVIGYFTNDIAIKMLFRPyrpyrVFgWRIPfTPGLIPQNQPRLAKQIAKTIMGSLLTPEElhnLARKLLQTERMQAG 90  Synechococcus s...
Q10XM6        12 IAGGIIGYFTNDIAIKMLFRPyrpyyIFrRKLPfTPGLIPANQERLAKRVADTIMGSLLTPSElqnLARRLLQTERMEAA 91  Trichodesmium e...
Q8YLP3        21 ILGGIIGYFTNDIAIKMLFRPyraiyIGgRRVPfTPGLIPRNQERLAKNISDTIMGSLLTPDElqkLARRLLKTERVQGA 100 Nostoc sp. PCC ...
Q55115        21 IAGGIIGYFTNDLAIKMLFRPykplfLGpYQLPfTPGLIPRNQERLAKRVSDTIMGSLLTPEElqrLARKLLQRERVEGA 100 Synechocystis s...
B1WSD1        22 IAGSIIGYFTNDIAINMLFRPykaiyIGkRRLPfTPGLIPRNQERLAQKVSDTIMGSLLTPEElqkLAKRLLKTERVKGA 101 Crocosphaera su...
WP_011723139  88 KVWANkkvke-vikkNISVKEELrnllgnkiydfinsvrvklsniilTAIKKDEVKVQLEDMIVNSIKEELKKNPEdiin 166 Clostridium novyi
Q5WHV2        89 TNWLKkqlas-wlrsERTVESILkpl-------------------fqADIGREHLVVQSKSWLKDRLKRYLQKNKE---- 144 Alkalihalobacil...
Q5L2A6        89 AEWGRewlrk-wlarKETPAELLer--------------------lgIRSPAERLEAMAAEQAERAYERWSETWRL---- 143 Geobacillus kau...
Q81UK6        89 IHWAQvev-----dkVITNEQSLrhml----------------gkwdVAHVEKEATEKIEQVITEKIQAFLEEYYT---- 143 Bacillus anthracis
Q7NNA7       110 LRFALlyalgeysdgRKRARLA------------------------------VALGDILQEVFSESLPKWIDALSRs--- 156 Gloeobacter vio...
Q2JHS8        91 IRWLLgvaldrlqnpEQQQQTA------------------------------QVLARILADLFNESLPRLVKVLARq--- 137 Synechococcus s...
Q10XM6        92 ILWLLqmsld-qlklNTDTKST------------------------------KILANILRDLLGQSLPRLLKVWAKr--- 137 Trichodesmium e...
Q8YLP3       101 ILWLLqlaid-qiktDTDKKSA------------------------------KIVAGILRDLIGESLPRLLKVLARr--- 146 Nostoc sp. PCC ...
Q55115       101 LGWLLqlalk-qireDKQQKTA------------------------------QILANILRDLFSESLPRLLKALARq--- 146 Synechocystis s...
B1WSD1       102 ILWLLnl-------aLKQVKSDK------------------------QQKTAKILSGILEDLFSESLPRLLKALARr--- 147 Crocosphaera su...
WP_011723139 167 scfyqnitknlldmsigfknssefknylekgiqkkliklenidKPLDEVIPMGVISSL------KVYIYNKNYDIS---- 236 Clostridium novyi
Q5WHV2       145 -------------------------------------------VPIKSVVPQELQDRL------TDWLPEASALLL---- 171 Alkalihalobacil...
Q5L2A6       144 -------------------------------------------RPIRDVLPAELKQTM------EARVESLAGYLA---- 170 Geobacillus kau...
Q81UK6       144 -------------------------------------------YTWEQALPHSVHEKI------ENAIPNVSAFIL---- 170 Bacillus anthracis
Q7NNA7       157 -------------------------------------------SASNKIFEQIFDQVAgslrieEAQAVRLAEWIEknvf 193 Gloeobacter vio...
Q2JHS8       138 ------------------------------------------eTFLEGPINQLFDQVLlelrlsSEQAKQLSEWILkqal 175 Synechococcus s...
Q10XM6       138 ------------------------------------------eYFLEAQINQIFDQILlefqltEIQAAQLSDWLLkvvv 175 Trichodesmium e...
Q8YLP3       147 ------------------------------------------eDFLEAQINQIFDQILlelqlsEEQASRLADWFLevvl 184 Nostoc sp. PCC ...
Q55115       147 ------------------------------------------dNFLSDQINRIFDQILlefrlsELQSRQFADWLLgtvl 184 Synechocystis s...
B1WSD1       148 ------------------------------------------qDFLEGQINQIFDQILldfkltDTQARQFADWLLegvl 185 Crocosphaera su...
WP_011723139 237 --MGIKGILKDEKVQlkLQGVFSELISTN---------LNPMVAMFLNP-TTIYNKVYSVLDEYLDREETQK---EVAIF 301 Clostridium novyi
Q5WHV2       172 --KRATAYIDSEEGEqrIGAMVRQFLTTKg-------kVGSMVSMFFSA-DKLTEYVLPEIKKFLHDEQTKE---TVQSL 238 Alkalihalobacil...
Q5L2A6       171 --DRTLDYFRSEEGKqqISSMIERFFQERg-------mVGNMLQMLLGN-VNFVDKVQAELGKFLRHAGTRE---VLSRL 237 Geobacillus kau...
Q81UK6       171 --KRAIHFFESEEGKsrLSRMIDDFFASRg-------aLLNLVGMFLGN-VSVVDRVQPEVIKFLGQDGTKQ---LLTDV 237 Bacillus anthracis
Q7NNA7       194 tpDRLRLALINLLTNqtIDTLDKEARERAqgglwlvanVVGIKGPLSRFkSFCVEQPEAANELFTRFLAEAEvreRLTGA 273 Gloeobacter vio...
Q2JHS8       176 ppKVLRQNLVDFLTDrnIESLDEEFRERAtgsywvvanLFGLKNALLRLrTYCLEEPEGAEAILEDLLKDINasrRLTEI 255 Synechococcus s...
Q10XM6       176 ppDVLRKTLIDFLTDqnISIIDEGFREKAsgtywvvanLFGLRNTLTRLrTFCLDERDLTNQRLMELITALAvkeRITEW 255 Trichodesmium e...
Q8YLP3       185 ppDVIRQAIVDFLTDrtIQIIDESFREKTsgtywvvanLFGLRNTLTRLrTFCLDEKEATNNRLTELIQDLQmrdRFRKI 264 Nostoc sp. PCC ...
Q55115       185 ppDTIRLALVDFLSDrnIQVIDEGFREKTsgtywvvanLFGVRNSLTRLrAFCLEEKETANLRLKELLLSLEirnRLKDW 264 Synechocystis s...
B1WSD1       186 ppDILRQALVDFLTErnIQVIDEGVREKTsgtywvvanLFGVRNTLLRLrSFCLEEKEVANTRLKEILLSLEvrsRLREW 265 Crocosphaera su...
WP_011723139 302 IN-DIIDKLLKLKLSNIMSQISEDAkikNTEAISDLILKNVVEdE--------LFHEILLKLEEKFKEhesieellskan 372 Clostridium novyi
Q5WHV2       239 LQ-TEWHRMLNRPLASFQAENYVDQ---FVDKAAEELEGKIPVlN--------WYNAPLSTWTTPYAE------------ 294 Alkalihalobacil...
Q5L2A6       238 LW-TEWNKWLDYPLATVEEMIGRRR---IDEAVRSAARRLVQSgS--------WLHRPLDELIAPYEQ------------ 293 Geobacillus kau...
Q81UK6       238 LQ-KEWEKLKGRDVKELETFVEKEM---IVSSILSAVKVEETVsK--------FLNQSVQQVCEPVRE------------ 293 Bacillus anthracis
Q7NNA7       274 LNgLSVQTLSMATVQDLKRQFVTSLtaaLSAQGPGLSQRLGESiDwsrwaaevLDRVVTSEKTLGWID------------ 341 Gloeobacter vio...
Q2JHS8       256 LQnLSLQNLPVSAVRQLRRALRDGIqdyLRSQGPEVIKGLGETiDwekvaslvLGRLRNSKALITSID------------ 323 Synechococcus s...
Q10XM6       256 LHsLSMQNLPVSTVRELRNTMQNSVrlyLQENGTDLIQALSLSvAwehiadliINRLQASSIMNSSLE------------ 323 Trichodesmium e...
Q8YLP3       265 LQnLTLQNLPIGTVRQLRKTTRETVrqyVQTSGSDLLQGLTDSiNweniaellLNRLSNSPVVISSLE------------ 332 Nostoc sp. PCC ...
Q55115       265 LQqLSLENLPVSTVRQLRRTTGEVVrtyIRERGEPLLKDFGSSvDwdnvavliVNRLQSSTAVTGSLG------------ 332 Synechocystis s...
B1WSD1       266 LQsLSLQNLPVSTVRQLRKTTRETVqlyVQQSGEKFIQDFGKTvDweqlsiliINRLQNSAALTTSLE------------ 333 Crocosphaera su...
WP_011723139 373 insdkilrdlignklekilksketeekvkVYTDSivNKILESKIcditkgkeeeilnvcdnlaetgfnKFIENEASEFLE 452 Clostridium novyi
Q5WHV2       295 -----------------------------PLVERgvPVIVGMVT------------------------VYMEQHIADILS 321 Alkalihalobacil...
Q5L2A6       294 -----------------------------PLFDRliPQAAATVS------------------------CLLSDKIEAIVA 320 Geobacillus kau...
Q81UK6       294 -----------------------------TIIEKvvPNAVTKGL------------------------KWGGENVESILN 320 Bacillus anthracis
Q7NNA7       342 -----------------------------RIAEGssRLLDRYLT------------------------RELEPLVMKFLP 368 Gloeobacter vio...
Q2JHS8       324 -----------------------------QISADlaLVLERYLE------------------------RDLESLMMQVIP 350 Synechococcus s...
Q10XM6       324 -----------------------------LVSRElaLILERYLE------------------------RDLENIVALAIP 350 Trichodesmium e...
Q8YLP3       333 -----------------------------VVSQElaLILERYLE------------------------KDLEAIVAQVIP 359 Nostoc sp. PCC ...
Q55115       333 -----------------------------LVSEElaSILERYLE------------------------DDLEKIVKQIIP 359 Synechocystis s...
B1WSD1       334 -----------------------------TISEElaLILERYLE------------------------EDLEKIVAQAIP 360 Crocosphaera su...
WP_011723139 453 VFDISKIVEDKINTFEVSFAEQIILEIASKELSAITWLGALLGFIMG-----LVSSII 505 Clostridium novyi
Q5WHV2       322 KLRLEEVIEEQVASFSMAHLEKLIMNITRRELHMITLLGGLIGGIVGli-qaVIVHFF 378 Alkalihalobacillus clausii KSM-K16
Q5L2A6       321 QLGLADIVRDQVESFSLRRLEAIILSIARRELKMITYLGALLGGLIGav-qgVIGLWL 377 Geobacillus kaustophilus HTA426
Q81UK6       321 NLHLAEIVQQEVSTFSTERLEDLVLSITKNELKMITYLGALLGGMIGiv-qgLLLLFl 377 Bacillus anthracis
Q7NNA7       369 ALGLEQMVITKICNTSPQELEAAIEQVARNELRAIPYVGMVLGFCVGlfevfLITVVI 426 Gloeobacter violaceus PCC 7421
Q2JHS8       351 VLNLDQVIADKVNATSPADLEQAIQQIVRQELQAIVNLGGLLGFLVGcv---qVLFLL 405 Synechococcus sp. JA-2-3B'a(2-13)
Q10XM6       351 ILNIDQVIIDRIKGTSAEELEVAVNVIVKNELQAIVNLGGVLGVVVGsf-qtILLVLQ 407 Trichodesmium erythraeum IMS101
Q8YLP3       360 ILSIDQVIVDRVKSTSPADLEAAIEGIVKNELQAIVSLGGILGLIVGlf-qtAFFIFS 416 Nostoc sp. PCC 7120 = FACHB-418
Q55115       360 ILAIDQVIINRINETPAAELETAVQAIVRSELQAIVNLGGVLGLIIGgl-qtGFFLVS 416 Synechocystis sp. PCC 6803 substr. Ka...
B1WSD1       361 ILSIDKVIIDRVNATSPQNLEMAVQGIVKSELQAIVNLGGILGFLVGvf-qtLLFLlr 417 Crocosphaera subtropica ATCC 51142
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