Conserved Protein Domain Family
TMEM132D_N
?
pfam15705: TMEM132D_N 
Mature oligodendrocyte transmembrane protein, TMEM132D, N-term
TMEM132D_N is the N-terminal family of chordate proteins implicated in panic disorder. TMEM132D is a single-pass transmembrane protein that is highly expressed in the cortical regions of the human and mouse brain. The function is still unknown. It may act as a cell-surface marker for oligodendrocyte differentiation. Additionally, as it may be most strongly expressed in neurons and it colocalizes with actin filaments TMEM132D may be implicated in neuronal sprouting and connectivity in brain regions important for anxiety-related behaviour.
Links
?
Statistics
?
PSSM-Id: 464813
Aligned: 44 rows
Threshold Bit Score: 131.575
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
XP_022522224   41 VQYQVLNADLSFFLKEANQDIMRNSSLQARTELFFIQQA-------RRVPTVNASYGPLSVQQPVPMEFLgpgllnnpss 113 
XP_015221339   51 VSFQIQNAVSSFFLKEAGQEVMRNSSLQARTEPFFIHMA-------EGIPSVNCSYGNLSAEATVPLELLq--------- 114 
XP_005801069   61 VQCQLSGTDSAFFLREANQEVMRNGSLSSRTEPFFLHQLepg-valQSQPSVNCSYGNLSIEQMIPTELLr--------- 130 
3_pfamImport    1 VTYRILNAEAAFFLQEANQDVMRNASLQARTEAFFIQQA-------WQTPVLAVSYGPRSLQH-LPPELLra-------- 64  
XP_002594816    7 AHLTYEHADSAYFLQDDFSSLFSNGSETVQIDQFALLRP-------REPAVVRASYGPFKVQQSVPHEFL---------- 69  
BAC33373       44 VALELLDAPEHFRVQQVGHYPPANSSLASRSETFLLMQPw-----pRAQPLLRASYPPFATQQVVPPRVT---------- 108 
XP_005451400   44 IKFQVLNVD-HMFVRQDSPQPSGNSSLKAQTQTFLITGPga----gLLEPSVNASFGPLALDASIPLDLL---------- 108 
XP_015221913   49 VSYQITNANSFFFLKEISQDIMRNSSMQIHTEPFVILKT-------SQPPVISASYGPLSVEQTVPLHFM---------- 111 
XP_010709076  316 VEMELQEVPEHYRLQRADGVLPANTSLHARSDTFLLLPRhp---taGPSPLLRASYPPFSTHQ----------------- 375  turkey
TNN74918      190 VQCQLSGADSAFFLRESNQDVMRNGSLSSRSEPFFLHQLeaavaapHSLPSVNCSYGNLSAEQPIPVELLq--------- 260  Tanaka's snai...

XP_022522224  114 sssssSSSSSSSsvtsststtpSPQLFTFNWKVQTFIISERIHPSWPKVQVLFYVV------------------GRDWDD 175 
XP_015221339  115 -----SMPRLLS----------SPSQATVNWKIRAHIVNDRVHLQRPRVQTLFYLA------------------GRSWDE 161 
XP_005801069  131 ----gPQPHLLT----------SVSQVTMNWRIKGQVVVHKVASTRRWIQVLFYLI------------------GRRWDE 178 
3_pfamImport   65 ----aPGPGSAA----------TPPVLTPSWKLQAFIIRQRVHPSWPRVQVLFYLA------------------GRRWG- 111 
XP_002594816   70 -----FPGLNRT----------SPGQF-YKLDIRAHLLDKSLTPEKSRLGVLFHIV------------------ESDLSR 115 
BAC33373      109 ----------------------EPHRRPVPWDVRAVSVEAAVTPAEPYARVLFHLK------------------GQDWPP 148 
XP_005451400  109 -----LSGR----------------------KILPVILSRQVRSSSPVVKILFHMPtesnitawqetmgslednGRKSNG 161 
XP_015221913  112 -----QTADLFR----------TSTKFTFDWKIQSYILTQKVYSSTPKMRILFYIS------------------GRDWEA 158 
XP_010709076  376 ----------------------EVPTKSPTWAIRAVPLHSTVSPDEPNARVLFHLH------------------GPDWRG 415  turkey
TNN74918      261 ----gPPPHLLL----------STNQVTLNWKVKGQVVVPKVGSTRPWIQVLFYLS------------------GRRWDE 308  Tanaka's snai...

XP_022522224  176 YSTv---DRLPCVRMFAFHETQ 194 
XP_015221339  162 ASPp---ENLPCIKVFAFQETQ 180 
XP_005801069  179 PDPlp-rSILPCVRALAVRDIN 199 
3_pfamImport  112 -------HNLPCVALVAFHETQ 126 
XP_002594816  116 NEGs---GPLPCIVLHVTMDGK 134 
BAC33373      149 GPGs-----LPCARLHATHPAG 165 
XP_005451400  162 AKAk---DGAHCVTAYAFWETR 180 
XP_015221913  159 QGTegamDDLPCVIVYAFWQTQ 180 
XP_010709076  416 RRDppgdHSLPCIVLQAQQRSQ 437  turkey
TNN74918      309 PDPpp-qALLPCVRAVVVRDTS 329  Tanaka's snailfish
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap