3D9Y,1F2K,1PNE,1D1J


Conserved Protein Domain Family
PROF

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smart00392: PROF 
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Profilin
Binds actin monomers, membrane polyphosphoinositides and poly-L-proline.
Statistics
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PSSM-Id: 214646
Aligned: 23 rows
Threshold Bit Score: 103.943
Created: 13-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3D9Y_A      1 MSWQAYVDTSLLGTG---------KIDRAAIVS-R-AGd---SVWAASAgf-----nL---Sp-QEIQGLAAGFQDP--- 54  fission yeast
AAB22843    1 MSWDSYVDNLIAQSKdas---gttHCDKACIIG-K-DG----SAWTTMPtsd--tsnNlklTp-EEMANIAKCFKSKd-- 66  Strongylocentrotus...
AAA03022    2 AGWQSYVDNLMCDGC---------CQEAAIVGY-C-DAk---YVWAATAgg-----vFqsiTp-IEIDMIVGKDREG--- 58  human
Q20025      2 SGWDDYIKLLFGKSP---------AIKRAAIIG-S-DG----SVWARSGda-----nAfraTe-VELKRFAALFNDI--- 57  Caenorhabditis ele...
CAA65655    2 AGWNAYIDSLMADGT---------CQDAAIVGY-K-DSp---SVWAAVPgk-----tFvsiTp-AEVGVLVGKDRSS--- 58  Norway rat
Q03777     18 QAWDTSVKEWLVDTGkvyaggiasIADGCRLFG-A-AIdngeDAWSQLVkt-----gYqieVlqEDGSSTQEDCDEAetl 90  Eimeria acervulina
NP_493258   2 SGWNAYIDTMTAAAP---------SIKRCAIVG-AaDG----SVWARTEad-----nVfkaSe-EELKTFVALFNDV--- 58  nematode
1D1J_A      1 AGWQSYVDNLMCDGC---------CQEAAIVGY-C-DAk---YVWAATAgg-----vFqsiTp-IEIDMIVGKDRE---- 56  human
XP_829434   1 MSWQSYVDDSLVGSG---------FMHSAAIVGlA-DG----SYWAYgg-------tYvp--qpEEVTHILKCLENF--- 54  Trypanosoma brucei...
P23412      2 SGWDQYVQYLTANQQ---------VEYGLILGK-T-DG----TIWASNVglttlynnYqidVe-GQKANVNETANLL--- 62  Tetrahymena pyrifo...
3D9Y_A     55 -----PSM--------FGTGIILAGQKYITIR----A----------E-GRSIYG-KL-------QKEGIICVATKLCIL 98  fission yeast
AAB22843   67 ----fAAF--------MSSGIYVNGTKYQFLR----Ee---------D-SKLVLG-KKk------GEGSLTLQSSKTAIV 113 Strongylocentrotus...
AAA03022   59 -------F--------FTNGLTLGAKKCSVIR----Dsl------yvD-GDCTMD-IRtksqggePTYNVAVGRAGRALV 111 human
Q20025     58 -----NSV--------PGTGADLEEIHYIVPR----V----------E-EKLIFG-KK-------EQTGFFAAKTNQAIV 101 Caenorhabditis ele...
CAA65655   59 -------F--------FVNGLTLGGQKCSVIR----Dsl------lqD-GEFTMD-LRtkstggaPTFNVTVTMTAKTLV 111 Norway rat
Q03777     91 rqaivDGR--------APNGVYIGGIKYKLAE----VkrdftyndqnY-DVAILG-KN-------KGGGFLIKTPNDNVV 149 Eimeria acervulina
NP_493258  59 -----TQV--------PAKGADIEGVHYVVPR----T----------E-ESLIFG-KK-------ENTGFFAVKTKSAVL 102 nematode
1D1J_A     57 ------GF--------FTNGLTLGAKKCSVIRdslyV----------D-GDCTMD-IRtksqggePTYNVAVGRAGRALV 110 human
XP_829434  55 -----SLV--------QSSGVTICGVKFFGLQsgseG----------Q-MKYIFF-KK-------GAAGGCIYTSKQTAI 102 Trypanosoma brucei...
P23412     63 -----AAMnnngvptdPLCGIRIMNQKYYTVK----Y----------DaDSQVWYlKK-------DHGGACIAITNQALV 116 Tetrahymena pyrifo...
3D9Y_A     99 VSHYPET-------------------TLPGEAAKITEALADYLVGVGY 127 fission yeast
AAB22843  114 IGHCPEG-------------------GQQGNLNKAVGVIAEYLESLSM 142 Strongylocentrotus purpuratus
AAA03022  112 IVMGKEG-------------------VHGGTLNKKAYELALYLRRSDV 140 human
Q20025    102 IAMYEGDn------------------AQSASVRAGVEYIAQYLASSGY 131 Caenorhabditis elegans
CAA65655  112 LLMGKES-------------------VHGGLINKKCYEMASHLRRSQY 140 Norway rat
Q03777    150 IALYDEEk-----------------eQNKADALTTALAFAEYLYQGGF 180 Eimeria acervulina
NP_493258 103 IAVYEGPn------------------EVAAQVRKAVESMQTYLNNAGY 132 nematode
1D1J_A    111 IVMGKEG-------------------VHGGTLNKKAYELALYLRRSDv 139 human
XP_829434 103 IAVYGNPgdasalqqdlqkteatyvaVNPADCNTTVKRIAEYLISLDY 150 Trypanosoma brucei TREU927
P23412    117 IGTFDITkkqq-----------ngvaQNPGQVNKVVESLAATLKQAGY 153 Tetrahymena pyriformis
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