Conserved Protein Domain Family
Wnt_Wnt2b
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cd19346: Wnt_Wnt2b 
Wnt domain found in protein Wnt-2b and similar proteins
Wnt-2b, also called protein Wnt-13, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a redundant role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.
Links
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Statistics
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PSSM-Id: 381720
Aligned: 6 rows
Threshold Bit Score: 614.237
Created: 23-Jan-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Frizzled
Feature 1:Frizzled receptor binding site [polypeptide binding site]
Evidence:
  • Comment:The structure of Xenopus Wnt8 (XWnt8) in complex with mouse Frizzled-8 (Fz8) cysteine-rich domain (CRD) reveals an unusual two-domain Wnt structure, not obviously related to known protein folds, resembling a "hand" with "thumb" and "index" fingers extended to grasp the Fz8-CRD at two distinct binding sites.
  • Comment:Based on the structure of Xenopus laevis Wnt8 (4F0A) in complex with the cysteine-rich domain of frizzled 8.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
Q93097        67 GARVICDnIPGLVSRQRQLCQRYPDIMRSVGEGAREWIRECQHQFRhHRWNCTTLDRdhTVFGRVMLRSsREAAFVYAIS 146 human
Q98SN7        61 GARVICDnIPGLVNKQRQLCQRYPDIMQSVGEGAKEWIRECQYQFRhHRWNCSTLDRdhTVFGRVMLRSsREAAFVYAIS 140 chicken
XP_007897604  67 GARVICNnIPGLVNKQRQLCQRHADIMQSIGEGAKEWIRECQHQFRhHRWNCSTLARdhTVFGKVMLRSsPEAAFVYAIS 146 elephant shark
NP_001079279  27 GARVICDnIPGLVNKQRQLCQKHPDIMQAIGEGAKEWIRECQHQFRhHRWNCSTLDRdhTVFGRVMLRSsRETAFVYAIS 106 African clawed ...
XP_005987699  72 GARVICDnIPGLVNKQRQLCQKHPDIMQSIGEGSKEWIRECQHQFRhHRWNCSTLDRdhTVFGRVMLRSsREAAFVYAIS 151 coelacanth
Q4SSA4         7 GARVICDnIPGLVNKQRQLCQGHPDLMRSIGEGAKEWIKECQHQFRhHRWNCSTLDRdhTVFGRVMLRSsREAAFVYAIS 86  spotted green p...

Feature 1                                                                                        
Q93097       147 SAGVVHAITRACSQGELsvCSCDPytrgrhhDQRGDFDWGGCSDNIHYGVRFAKAFVDAKEkrlKDARALMNLHNNRCGR 226 human
Q98SN7       141 SAGVVYAITRACSQGELkaCGCDPlkrgrakDERGEFDWGGCSDNINYGIRFAKAFVDAKEkkvKDARALMNLHNNRCGR 220 chicken
XP_007897604 147 SAGVVHAITRACSQGELhnCSCDThegdkkhNTKREYDWGGCSDNIKYAINFSKVFVDAKEkkeKDARAHMNLHNNRCGR 226 elephant shark
NP_001079279 107 YAGVVYAITRACSQGELksCNCDPkkrgrskDERGEFDWGGCSDHIDFGIKFPKDFVDAKEkrlKDARALMNLHNNRCGR 186 African clawed ...
XP_005987699 152 SAGVVYAITRACSQGELktCSCDPhkrgrsrDDRGKFDWGGCSENINYGIKFAKAFVDAKEkkeKDARALMNLHNNKCGR 231 coelacanth
Q4SSA4        87 SAGVVYAITRACSQGELksCNCDGqkrgrssDATGSFDWGGCSDNINYGIKFAKAFVDAREkmmKDARALMNLHNNRCGR 166 spotted green p...

Feature 1                   ##  ###       #                                                      
Q93097       227 TAVRRfLKLECKCHGVSGSCtLRTCWRALSDFRRTGDYLRRRYDGAVQVMATQDGANFtaarqgyRRATRTDLVYFDnSP 306 human
Q98SN7       221 MAVKRfLKLECKCHGVSGSCtLRTCWLAMSDFRKTGDYLQKKYNGAIQVIMNQDGTGFtvanknfRKPTKTDLVYFEnSP 300 chicken
XP_007897604 227 TAVKRfMKLECKCHGISGTCtVRTCWNAMSDFRKTGDYLRKRYHLAVQVTMNQDGTGFtvanrrtAQLMKTELVYFEnSP 306 elephant shark
NP_001079279 187 MAVKRfMNLECKCHGVSGSCtLRTCWRAMSDFRKTGDFLRRRYNGAIQVTMNQDGSGFavanqnfRKATKKDLVYFEnSP 266 African clawed ...
XP_005987699 232 AAVKRfMKLECKCHGVSGSCaLRTCWLAMADFRKTGDYLRKKYNGAIQVTMNQDGTGFtvanknfRKATKNDLVYFEnSP 311 coelacanth
Q4SSA4       167 MAVKRfMKLECKCHGVSGSCsLRTCWLAMSDFRRTGDYLRKKYNSAVEVTMNQDGTGFlvadknfKGNTKNELVYVEnSP 246 spotted green p...

Feature 1                                                            # # # #               
Q93097       307 DYCVLDKaaGSLGTAGRVCSKTSKGtDGCEIMCCGRGYDTTRVTRvtQCECKFHWCCAVRCKeCRNTVDVHTCK 380 human
Q98SN7       301 DYCVMDKsaGSLGTAGRVCNKVSRGtDGCEVMCCGRGYDTTRVTRvtKCECKFHWCCAVRCKeCEDTVDVHTCK 374 chicken
XP_007897604 307 DYCVLDKaiGSLGTAGRVCNKSSRGtDGCEVMCCGRGYDTRRATRvsQCECKFHWCCTVRCRdCQEMVDVHTCK 380 elephant shark
NP_001079279 267 DYCVMDKtaGSLGTAGRVCDKVSRGtDGCEVMCCGRGYDTTRVTRitKCECKFHWCCAVRCKeCEETVDVHTCK 340 African clawed frog
XP_005987699 312 DYCVMDKsaGSLGTAGRVCNKTSKGtDGCEVMCCGRGYDTTRVSRiiKCECKFHWCCAVKCKeCQETVDVHTCK 385 coelacanth
Q4SSA4       247 DYCLMDRsaGSLGTAGRVCNKSSRGtDGCEIMCCGRGYDTMRVKRvtKCECKFKWCCAVECSdCEDIVDVHTCK 320 spotted green pufferfish

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