Conserved Protein Domain Family
FH_FOXJ2
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cd20051: FH_FOXJ2 
Forkhead (FH) domain found in Forkhead box protein J2 (FOXJ2) and similar proteins
FOXJ2, also called Fork head homologous X (FHX), plays an important role in tumorigenesis, progression, and metastasis of certain cancers. It acts as a transcriptional activator that can bind to two different type of DNA binding sites. It is specifically expressed in meiotic spermatocytes in adult mouse testes and appears to promote meiotic progression during spermatogenesis. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.
Links
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Statistics
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PSSM-Id: 410825
Aligned: 4 rows
Threshold Bit Score: 179.806
Created: 18-Dec-2018
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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putative DNA
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              #                 ##  #                  ## ##  #      #         ### #    
Q9P0K8        65 GKPRYSYATLITYAINSSPaKKMTLSEIYRWICDNFPYYKNAGIGWKNSIRHNLSLNKCFRKVPRPRdDPGKGSYWTIDT 144 human
KYO44661      99 GKPRYSYATLITYAINSSPaKKMTLSEIYRWICDNFPYYKNAGIGWKNSIRHNLSLNKCFRKVPRPRdDPGKGSYWTIDT 178 American alligator
Q68EZ2        58 GKPPYSYANLIQYAINSAPaKRMTLSEIYRWICDNFPYYRSAGVGWKNSIRHNLSLNKCFRKVPRPRdDPGKGSYWMIDS 137 African clawed ...
XP_006006289  63 GKPPYSYATLITFAINSSAnKKMTLSEIYQWICDSFPYYRNAGVGWKNSIRHNLSLNKSFWKVPRPRnDPGKGSYWMIDS 142 coelacanth

Feature 1          
Q9P0K8       145 CP 146 human
KYO44661     179 CP 180 American alligator
Q68EZ2       138 CP 139 African clawed frog
XP_006006289 143 CP 144 coelacanth

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