Conserved Protein Domain Family
PV-1

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pfam06637: PV-1 
PV-1 protein (PLVAP)
This family consists of several PV-1 (PLVAP) proteins which seem to be specific to mammals. PV-1 is a novel protein component of the endothelial fenestral and stomatal diaphragms. The function of this family is unknown.
Statistics
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PSSM-Id: 461970
Aligned: 6 rows
Threshold Bit Score: 679.336
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9BX97         2 GLAMEHGGSYARAGGSSRGCWYYLRYFFLFVSLIQFLIILGLVLFMVYGNVHVSTESNLQATERRAEGLYSQLLGLTASQ 81  human
ELW67180       2 GLPMEHGGAYARAGGSPRGCWYYLRYFFLFVSLIQFLIILGLVLFMVYGNVHVSTEDNLQATERRAEGLFSQVVGLTASQ 81 
XP_005333070   2 GLAMEHRGAYSRAGDSPRGCWYYLRYFFLFVSLIQFLIILGLVLFMVYGNVHLSTESNLQATERRAESLYSQVVGLSAAQ 81 
Q91VC4         2 GLSMDR-SPYARTGDQQRGCWYYLRYFFLFVSLIQFLIILGLVLFMIYGNVHATTESSLRATEIRADSLYSQVVGLSASQ 80  house mouse
Q3ZC85         2 GLAMEHGSPYSRAGSSSRGCWYYLRYFFLFVSLIQFLIILGLVLFMVYGNVHVSTESNLQATERRADGLYGQVVGLTASQ 81  cattle
XP_012664866   1 ---MDRGGAYSRAGGSPRGCWYYLRYFFLFVSLIQFLIILGLVLFMVYGNVHVSTESNLQATERRAGDLYSQVLGLMASQ 77  small-eared galago
Q9BX97        82 SNLTKELNFTTRAKDAIMQMWLNARRDLDRINASFRQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFML 161 human
ELW67180      82 TNLSKELNLTSRAKDAIMQMLLSARRDLDRINASFRQCQGDRIIHANNQRFMAAIILSEKQCQEQLRESNKTCDALLLML 161
XP_005333070  82 VNLSKELNITARTKDNIMQMLLSARRELERINASFRQCQSERAVYISREKYIVAIILSEQECQEQLKQANKSCNALLYVW 161
Q91VC4        81 ANLSKQLNISLLVKETVMQQLLTTRREMERINASFRQCQGDLITYINYNRFIAAIILSEKQCQEQLKEVNKTCEALLFKL 160 house mouse
Q3ZC85        82 ANLTKELNLTARAKEAINQMMLSARRDLDRINASFRQCQADRVIYMNNQRYMAAIILSEKQCQEHLKEANKSCDALALTL 161 cattle
XP_012664866  78 TNLSKELNLTSRAKDSIMQMLLSARRDLDRINASFRQCQSERVIHTNNERYVAAIIVSEKLCQDQLKEMNKSCEALHLRS 157 small-eared galago
Q9BX97       162 NQKVKTLEVEIAKEKTICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLW 241 human
ELW67180     162 GQKAKTLEVELAKEKAVCTKDKESSSLSKRVVEDQLAECGKAREQLRLERQLVEGRLQKVQSVCLPFDKEKFETDLQNLW 241
XP_005333070 162 DQKAKALEMELAKEKVVCAQDKEGLLASKRAAEQQLVACNQVREQQQQERQLAQDRLQKVQALCLPLDKDKFEMDLRNLW 241
Q91VC4       161 GEKVKTLEMEVAKEKAVCSKDKESLLAGKRQTEEQLEACGKARERQQQEQQVTEENLRKVQSLCIPLDQEKFQADVLSAW 240 house mouse
Q3ZC85       162 TQKAKTLEVELAKEKLVCTKDKDGLTVGKRVAEEQLAECGKTRDQQQQERQLAEDRLRKVQAFCIPLDRNKFETDLRNLW 241 cattle
XP_012664866 158 GEMAKKLEVELVKEKVVCTKDKEGLLLSKNVMEEQLTQCSKAQEQHQQERQLAEDKLQKVQSLCFQLDKDKFENDLRNLW 237 small-eared galago
Q9BX97       242 RDSIIPRSLDNLGYNLYHPL--GSELASIRRACDHMPSLMSSKVEELARSLRADIERVARENSDLQRQKLEAQQGLRASQ 319 human
ELW67180     242 RDSIIPRTLDTFGYGLYSHI--NPELNSIRRTCDHMPTLMASKVDELARSLRSGIERVARENSDLQRQKLEAEQNLQASQ 319
XP_005333070 242 KDSIVSRSLETLGYNMGYPMisHSDVISIRRTCDQMPSIMSTKVEELARSLRAGIERVARENSDLQRQKLEAEQSLRASQ 321
Q91VC4       241 RDSLIYRTLETLPY--HYQL--MPEYASLRRTCESLPGIMTTKIEELARGLRAGIERVTRENAELRRQKLELERAAQAAQ 316 house mouse
Q3ZC85       242 RDSIIPRTLSTLSFNLYHPL--GSELPSIQRACDSLPSIMTSKVEELARSLRAGIDSVTLENEKLQRQKLEVEQSLRASQ 319 cattle
XP_012664866 238 RDSIIPRTLDSLSYGVYHPL--GSDILSIQRMCNQLPSLMSTKVEELARSLRASIESVARENSDLQRQKLQAEQSLRASQ 315 small-eared galago
Q9BX97       320 EAKQKVEKEAQAREAKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAIRNSALDTCIKTKSqpmmp 399 human
ELW67180     320 AAKEKVEKEAQGREAKLHAECARQTQLALEEKAVLRKERDNLAKELEEKKKEVEHLKMQLAVANSALDTCIKAKG----- 394
XP_005333070 322 EAKEQAEKEARAREAKIQAGCTQQVQLALEEKAVLRRERDNLAKELAEKKREVEQLKMQMDVRISALDTCLKAKSqsipl 401
Q91VC4       317 EARARAGTEAQARETQLRAECARQTQLALEEKAALRAQRDNLERELEARKRELEQLRTEVDVRISALDTCVKAKSlpavp 396 house mouse
Q3ZC85       320 EAKEKVEKEAQAQAVKLQAECARQTQLALEEKVALQKERDRLVKELEEKKREAEHLKLQLAVSNSALDTCIKAKSqltip 399 cattle
XP_012664866 316 EAKEKVEKEAQAREAKLQAECSRQTQLALEEKATLRKERDNMAKELEEKKREVEQLKMQLAVSNTALDTCIRAKSqpipl 395 small-eared galago
Q9BX97       400 vsrpmgpV--PNPQPIDPASLEEFKRKILESQRPPAGIPVAPS 440 human
ELW67180     395 -------A--GSRCPVDPASLEEFKKRILESQRPPAGNLPASP 428
XP_005333070 402 p-rpvgpVpqPQPQPIDPASLEEFKKRILESQRSPAGNPAVLS 443
Q91VC4       397 p-rvsgpP--PNPPPIDPASLEEFKKRILESQRLPVVNPAAQP 436 house mouse
Q3ZC85       400 gprpavpV--PNPPPIDPASLEEFKRRILDSQRAPASNVLVSA 440 cattle
XP_012664866 396 p-rpvgpA--PNPPPIDPVSLEEFKKRILESQRTSIGNPAAPS 435 small-eared galago
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