Conserved Protein Domain Family
DUF4495

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pfam14906: DUF4495 
Domain of unknown function (DUF4495)
This domain family is found in eukaryotes, and is typically between 322 and 336 amino acids in length. There are two conserved sequence motifs: QMW and DLW. Proteins in this family vary in length from 793 to 1184 amino acids.
Statistics
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PSSM-Id: 464363
Aligned: 23 rows
Threshold Bit Score: 402.404
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_005457551  532 SFIESCGRAAFAMLGRLQERALEVPSSAPLKNL-----HALLATCIYVHQRLEHYSARLKds---stAAAKI-TLTPLPV 602 
EKC39102      556 AFVDAINLCLQNFHIHLTKLSSDVPRNAPMKTL-----YILLSSSVYIKNHLQHYEMVLTg------DDSSK-KNFSSLH 623 
EEN62441      522 AFVEKTAAACDQVLAMLTKVAADCPHQAPIQNM-----YICLASAGFLRNQVFHFNSVLV-------TKGER-GPLHPSY 588 
XP_002110311  460 KFLPILTNDYGKIYTSLKVVIVDVICQKAIADMspspaYLAIATAAFIKNRLLTFDQILS--------TDTR-LSFFTSY 530 
XP_002429007  101 EFLKVIEDTAAQLLEHLHILSQEALDHADLTVL-----TGTLGASALVKNTLWCYNEHLN--------LKEG-LSLHESY 166 
XP_002042673   99 KFVQLVTKSADLLLEHIHRLSQESLDHADLSVL-----TATIGAASLVKNSLSVYMQAATtticppkGDEKG-GALKLSF 172 
XP_015832883  103 KFVSLINKSAEQLLEHLHVLTQEALDHADLTVL-----TGTIGASALLKNCLWFYLQSINe-----iKGSQV-ELLHESY 171 
XP_019696545  100 DFILLVVDTAEQLLEHLHMLIQESLDHADLTVL-----TATLGAAALVRNCLWCYNQHAKgv----iSSQSS-EKINKLY 169 
XP_022523295  520 CYVEVCGRVISALLTRLEERSGQVPNTAPLKNL-----PTLLASSLYIQQRLMHYESQLR--------DSTRtPLTLLPV 586  Mexican tetra
XP_015215744  427 AFVDACSKAAAALLARLGERSREVPRTAPTRNL-----HTSLSTAVYVLQRLAQYETLLKds---arQ-----PVFLLTL 493  spotted gar
XP_005457551  603 QKYKDTVEAMREQLTSYCIQACYTCILQDAESHHWADPKPFYEGERCSFSVQMWFYFLCGLRSDLWAVLPAELARDVLGQ 682 
EKC39102      624 KNYQELVDALFKLTVEIHNNYMATSVLHDMESYNWKDSKEFQEGERCSFPVQMWNYHLRGLCHDLWTICSPRLSQDIYSQ 703 
EEN62441      589 QSVRDFVDSLEEQVIGYHTNVIATSVLQDSDSHYWQDPRAFYEGERCSFAVQMWSYHLSALRRDLWVYAPPRLGQHVLAC 668 
XP_002110311  531 EHYADLVESLCELIVEHHNTTISTTVLQDSDSNNYSNPRTFYEGKRCSFSIQMWNYYLHSIRHDLWQYCPLKQAQRIFIS 610 
XP_002429007  167 KNYKEMSEALAERLLDLHCRLLSLYVLQDADSLSWDYPHPFFEGERGSFVIQMWWLYMQGTRQDLWNTVPPKTAQRVLAG 246 
XP_002042673  173 KQYSQMSEALAERLLDLHCRLLLLYIMQDADCLHWEDTQPFFESERGSYTVQMWWHYMRGTQTDLWNSVPPKMAQKIFAG 252 
XP_015832883  172 KKYQEMGEALAERLLDLHCRLLSLYILQEAESLDWENQKPFCESERGSYVIQMWWLYMQGTREDLWNTVPPKMAQRVFSG 251 
XP_019696545  170 KEFHEMAEAVAERLLDLHCRLISLYILNEADSLSWHSNKPFFERERCSYVIQMWWLYMQGTKADLWNTVSPKMAQRVFAG 249 
XP_022523295  587 QRSQDVTAALNEHLTSYCVHVCATSILQDAESHYWADPKPFYEGERCSFSIQMWHYFLSGLRSDLWGSVSPVLAQQTLAQ 666  Mexican tetra
XP_015215744  494 QQYRELVGALQVQLTGHCVRTCATSILQDAESHFWCDPKPFYEGERCSFSIQMWHYFLSALRWDLWNVLPPSLAQDVLAQ 573  spotted gar
XP_005457551  683 VLTDTLQLLVRRYARARASYRRHLQIRCDITAMLLYVEHLMWSLCESPETLVRYnpssvitiIAGG-SDWPYQIHNLCEQ 761 
EKC39102      704 ILHNSLQIFSQRYSHSKPSYRRTSQYRSDIISILLCASELLFPACSSVSMYLDP----------GSsQLPHYSIHNFCSV 773 
EEN62441      669 VLRDSLAVLAARYSQASPSYNRTPQFRSDITAVLLITCSYLWSVCDSLHCLLDT---------TNPpSHPVTSIHNHCTT 739 
XP_002110311  611 VLENSLLTLSFRYGQIKPSLRRLCQFRADINAIILISLSFIWFTGQTVNSLVNPdfhalstaDFNP-QSEIPKIYNYCNL 689 
XP_002429007  247 MLNETLTILASRYCQAEPSPARLSLLVTDIGNLLLCVNEILPSICSNASEFLGF----------SN-SKILRDIHCKCHQ 315 
XP_002042673  253 MLNETLSVLTVRYTQIVTSVARSTLHLVDICNMLLCIAELLPHICESGEAYVGLq-------LSNQ-SVIIRDIHAKCKE 324 
XP_015832883  252 MLNESLTILTVRYTQSCPSEARSKLLVVDISNLLLCIAQLLPSICDKAEELIGLn-------LNNK-SKILRDIHTKCQE 323 
XP_019696545  250 MLNESLSIITTRFTHGRPTLARSEQFWSDAFNVLCCTGYLALAACIDSDEMIGAr-------PSNL-STAVRDMHAKCNE 321 
XP_022523295  667 VLAQTLELLLQRYSRAQPSYKRLPQIrMDITAILLCVEELMWSVCGSVEELVRP--------CLSS-GSWVSCIHSLCNQ 737  Mexican tetra
XP_015215744  574 VLTQTLEILVQRYSQACPTYSRTLQIRADITAVLLCAESLLWGLCSSPGKLLWP--------DRDP-CPRLFSIHSLCNQ 644  spotted gar
XP_005457551  762 LLTVLVIVTAPLSLLHRTFMIDA--AK---------ETSPDPPTIPVIRWLNAINPdvFTEQAI-------R------DG 817 
EKC39102      774 LLADMAIVASPLEMLYKMYKKGF--HElpelqptggSTPTAEVIGTNTHWLSWIQPtiFQTGHK-------Hy-----FD 839 
EEN62441      740 LMAALTVVSSPLADIYKVFKKGFhhKKkk------kGEETESAGRQNTQWLHFLYPglFGQLGS-------F------HD 800 
XP_002110311  690 LLMIVVAESCPIDVYPKAISRFQ--DG---------SKISGSNNICGTFWLSNYLPdmFSSIEL-------S-------D 744 
XP_002429007  316 LLLCLSLRGCPLSILYKLFKNGF--DD---------VIAFENRAKSIAPWLIFVSPelLQLSLG-------Er----lTS 373 
XP_002042673  325 LFYCLLLRGSPLGVLSKVFRKGL--DN---------MEMFSSRHGLPSAWIIFALPryFPKEQS-------CqwvtefSD 386 
XP_015832883  324 LLNCLVLRGASLDTLQKVFRKGL--ET---------VDLFKSRNTGPASWITFSLPniFKVQPK-------Nit--rmSD 383 
XP_019696545  322 LLVCLLLRGTPLKELYQVFRHGL--EN---------LTILRPRRG-PAPWLLICVPnlLGSIDN-------Pad---iVT 379 
XP_022523295  738 FLNVCVILTAPLPLIHstfqkels--------egitstpaEPSSSQAPFWLNVINPtlFPQELLreqeageG-------- 801  Mexican tetra
XP_015215744  645 LLAVLAVVTSPLRALFETFRRGP--EDls------sLSAAGPSGCPPLQWLRFVKPslFSRQEI-------L-------- 701  spotted gar
XP_005457551  818 LMGQASLACQLRLLTSDPGCNPKLLLQMLLYRDCHLPRILLENS 861 
EKC39102      840 MRTTTAVYFHCKLLLSQPDIDWSKVLQAYIMKDFTLPILFLTQS 883 
EEN62441      801 LTTKQAVYVQLKLLCSQPAPDWAMLLHLLMMGGCQAPVLLLTQT 844 
XP_002110311  745 IPPQVSLKIAIKLLRHRTGIDLKLILQILLSNKFSALKLIITET 788 
XP_002429007  374 ISDEYAIMLELKVLIAQPQPCYPLLLHVLTMREYKVITLLLKKI 417 
XP_002042673  387 LSTNTAISLDLRVLLAFPEADWSYLLKILLMRDAYLTGIIMRHL 430 
XP_015832883  384 LPPDAAIALELTVLLAQPQPNWSLLLKVLGMKNCKLLKLILDLS 427 
XP_019696545  380 LSEDKAVVLELNVMRHQPQPNWPQLMKVMSMSNHVVARMLLRSL 423 
XP_022523295  802 -----SALWLLKLMGSGPGCCPALVLQAALHSDCLLLRLLLSRS 840  Mexican tetra
XP_015215744  702 AADEISSQLQLKLMLSQPSCNPRLLLQTLLQSDCLLLRVLLNTY 745  spotted gar
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