Conserved Protein Domain Family
DEXHc_HrpB
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cd17990: DEXHc_HrpB 
DEXH-box helicase domain of ATP-dependent helicase HrpB
HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Links
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Statistics
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PSSM-Id: 438711
Aligned: 14 rows
Threshold Bit Score: 179.45
Created: 11-Aug-2017
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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ATP bindingDEAD box
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Comment:based on the structure of human RNA helicase A (DHX9) with bound Mn.ADP
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1     #                         #######                                      #        
EGH38505   19 LPVAAVLPELLAALDg-ASQVLLSAPTGAGKSTWLPLQLLAHPgi-------ngKIILLEPRRLAARNVAQRLAELlnek 90   Escherichia coli ...
NP_599394  17 LPVENIIPHLQEAFSagPKNLVIQAPPGTGKTTLLPPLVANILcnegagnatptKVLVTAPRRVAVRAAARRLAQLddsq 96   Corynebacterium g...
YP_427452  25 LPIDPVLPALLEALAs-HGRAVLIAPPGAGKTTRVPPALLGALwlg------gqKVVMLEPRRLATRAAARRMAFEagea 97   Rhodospirillum ru...
AAT81912   21 LPVAAYRDEITTALH--GGRAVIVAPPGTGKTTFVPPLVASRCs---------gRVIVTQPRRVAARAAARRLATLtgtr 89   Propionibacterium...
ACS29998   25 LTFAAALPDLEAALDa-RGVAVVEAPPGTGKTTVVPPALVVRLadr-----gggRVLVTQPRRVAVRAAWRRLRTAvlaa 98   Micrococcus luteu...
NP_716265   4 LPIHSLLPSLRDAFAt-HAQVILEAPTGAGKSTALPLAMLDWAei-------sgRILMLEPRRVAARSVAQFIASCrqqa 75   Shewanella oneide...
NP_294143   3 LPIQTVVPEVKAALAq-HPLVVLQAPPGAGKSTALPLDLLHEEwla------gqSIIMLQPRRVAARAVAARLAEGlgea 75   Deinococcus radio...
NP_252650   4 LPIDAVVPALRQALGa-QHQAVLEAPPGAGKTTRVPLALLDEPwla------gqRILMLEPRRLAARAAAERLAAElgek 76   Pseudomonas
ABG39018    5 LPVEDTLPALHDGLN--NNDVILVAPPGAGKSTRVPLALLQHStfa------trKIIMLQPRRIAARNIAHYLAKQlgee 76   Pseudoalteromonas...
NP_626261  10 LPVRGALPALHDALEe-HGTAVLVAPPGTGKTTLVPLALAGLLggeg---vparRVVVAEPRRIAARAAARRMAWLlger 85   Streptomyces coel...

Feature 1                                                                    ##               
EGH38505   91 ----------------pgdTVGYRMRAQNCVGpntRLEVVTEGVLTRMIlrdpelsgvGLVILDEFHERSlqaDLALALL 154  Escherichia coli ...
NP_599394  97 ----------------lgtKVGFSVRGEHISGs--HVQFMTPGVLIRQLlnnpelpgiGAVIIDEVHERQldsDLLLGML 158  Corynebacterium g...
YP_427452  98 ----------------vgqRFGFRVRGESRSGpltRVEVMTEGILTRRIqddpelagvGCVILDEFHERGlqgDLAFALL 161  Rhodospirillum ru...
AAT81912   90 ----------------pgeFASHTVHGESTTTrdtKVEFVTTGVLLRRLlsdpdltgvDAVVLDEVHERHldaDLVVAMV 153  Propionibacterium...
ACS29998   99 aadvqpgadpdaqarlgdaAVGYAVRGDAAGGgasAVEFVTPGLLLRRLladpgldgvDAVVLDEVHERDldtDVLFALL 178  Micrococcus luteu...
NP_716265  76 ----------------vgqEVGFRVRGEAKVSrdtRLEIVTEGILTRMIqqdpeltgiDMIIFDEIHERHlttDLGLALA 139  Shewanella oneide...
NP_294143  76 ----------------vgeTVGSRVRFESRVSdrtRLEVVTEGILTRRLqrdpelsgvGLVILDEFHERSlnaDLALALL 139  Deinococcus radio...
NP_252650  77 ----------------vgeTVGYRIRLESRVGpktRIEVVTEGILARRLqddpaldgvGLVIFDEFHERSldaDLALALT 140  Pseudomonas
ABG39018   77 ----------------vgqTVGYRIRGDSRVSkatRLEIVTEGILTRMLqndpelssvSLVIFDEFHERSmhaDFSLALC 140  Pseudoalteromonas...
NP_626261  86 ----------------pgaSVGYTVRGERVVGrraRVEVVTTGVLLQRLqrdqelagvDAVVLDECHERHldaDTSAAFL 149  Streptomyces coel...

Feature 1                                                   
EGH38505  155 LDVQQglr--ddLKLLIMSATldNDRLQQMLpe-------aPVVIS 191  Escherichia coli AA86
NP_599394 159 AELSQlr---ddFSLIAMSATldSDKFANLLdaqvl-sveaPIFPL 200  Corynebacterium glutamicum ATCC 13032
YP_427452 162 REIQGalr--pdLRLLVMSATldGAAIAALMdd-------aPVIES 198  Rhodospirillum rubrum ATCC 11170
AAT81912  154 CEVAQlr---ddLTIVAMSATvdSSGWAAFLggv----epaPVVEV 192  Propionibacterium acnes KPA171202
ACS29998  179 ADLRQlr---peLALVAMSATvdAAALAARWargmgedaplPVVST 221  Micrococcus luteus NCTC 2665
NP_716265 140 LEVQSslr--ddLKILAMSATlsGLALSELMpy-------aALLKS 176  Shewanella oneidensis
NP_294143 140 REVQGalr--ddLRVLVMSATldPDLPARLGa---------PLVES 174  Deinococcus radiodurans R1
NP_252650 141 LNGREllrdeppLKVLVMSATleGERLAALLge-------aPVVRS 179  Pseudomonas
ABG39018  141 LEVKDalr--ddLRLLVMSATldVSSLEKLLpn-------aDSIAC 177  Pseudoalteromonas atlantica T6c
NP_626261 150 WDVRQalr--peLRLVAASATtdAEGWSRLLgg-------aPVVEA 186  Streptomyces coelicolor A3(2)

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