1NIJ,4IXM,4IXN


Conserved Protein Domain Family
CobW-like

?
cd03112: CobW-like 
Click on image for an interactive view with Cn3D
cobalamin synthesis protein CobW
The function of this protein family is unknown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage caused by mitomycin. YijA gene is a homologue of the CobW gene which encodes the cobalamin synthesis protein/P47K.
Statistics
?
PSSM-Id: 349766
Aligned: 106 rows
Threshold Bit Score: 158.839
Created: 1-Sep-2005
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
 
Zn binding siteputative active
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Structure:4IXM; Escherichia coli YjiA with bound Zn2+

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                          #    #                                       #
1NIJ_A         5 AVTLLTGFLGAGKTTLLRHILneq--hgyKIAVIENEFGEVSvDDQLIgdr----------------atQIKTLtNGCIC 66  Escherichia coli
4IXM_A         5 AVTLLTGFLGAGKTTLLRHILneq--hgyKIAVIENEFGEVSvDDQLIgdr----------------atQIKTLtNGCIC 66  Escherichia col...
NP_603676      2 RILLVSGFLGAGKTTFIKELAkni---nlEFVVLENEYADIGiDRDFLdek----------------nlNVWEMsEGCIC 62  Fusobacterium n...
NP_764014     10 KITIVSGFLGSGKTTFLTHYInellkideKITVIMNEFGSFDvDGNHLse-----------------lvKVYPLlNGCVC 72  Staphylococcus ...
AAQ55475       5 KIDVISGYLGCGKTTFIQKLIkat--eneRIVIIENEFGDIGiDGDILrdk----------------glDVVELeKGCIC 66  Methanococcus v...
YP_001254004   3 KVNLISGFLGAGKTTLIKKVLenv--keeKIVIIENEFGEVAiDGDLIkke----------------gfDVFELrSGCIC 64  Clostridium bot...
XP_002503677   4 PVNIITGVLGVGKTTAIRHLIsqrp-aneRWAIVVNEFGALGiDGAILdtagglskgdgggsskgdggiIVREVaGGCLC 82  Micromonas sp. ...
EFN55957      12 PVTIVTGALAAGKTTMVASLLrckp-aneVWACLLNEFGAAGlDAALLegeaaav--------sgggsiIIHQLaGGCLC 82  Chlorella varia...
EGA96330      10 RISIINGFLGSGKTTLLTHYIsellkndeKIKIIMNEFGTFDiDSNSIsn-----------------eiEVHSLiNGCVC 72  Staphylococcus ...
ADX77296       7 SLILIHGFLGSGKTTFLNHYMtqilkkdeKVALIVNEFGDFDvDSHLLsq-----------------yhVQQSAlQGCIC 69  Staphylococcus ...
Feature 1                                                                                        
1NIJ_A        67 CSrsnELEDALLDLLDnldkgniqFDRLVIECTGMADPgPIIQTFFshevl--cqrylLDGVIALVDAvhADEQMNqf-- 142 Escherichia coli
4IXM_A        67 CSrsnELEDALLDLLDnldkgniqFDRLVIECTGMADPgPIIQTFFshevl--cqrylLDGVIALVDAvhADEQMNqf-- 142 Escherichia col...
NP_603676     63 CSmkgDFKSSIKRIYSei-----nPEYLIIEPTGVGMLsSIIENIReinn----ndieILSPLTLIDItsFNEYLKtf-- 131 Fusobacterium n...
NP_764014     73 CDmksDLVQQIEMLSHnh-----eTDHIIIEATGIAHPiELIMACQdpriv---qfveRPHVVSIVDAlrFLQRQQytds 144 Staphylococcus ...
AAQ55475      67 CTlklNFLKSLKDIVEym-----kPTRIIVEPTGMALLsQILGIVLdennkeiqdnckLNSVITVVDGenYLDQVElf-- 139 Methanococcus v...
YP_001254004  65 CMmkqDFEDSLQKVIEey-----kPDRIIIEPTGISSLsQLLDILEkdnfk---dkinINRVITVVDStsYLEEKDaf-- 134 Clostridium bot...
XP_002503677  83 CAvaaPFTVAVTQLLRra-----kPDRLIIEPSGMGHPgGLHDALQdehlg---kvlrIAATIALVDMtqVARGGAlve- 153 Micromonas sp. ...
EFN55957      83 CVlsnVTPLAIAQLLRrv-----kPDRLIIEPSGLAHPaTLLDMLQgeh------lgsSLAVQPVVDAtqFVGGTGqpac 151 Chlorella varia...
EGA96330      73 CDlkqELVYELKAIALkg-----dVNHVIIEATGIAHPlELLVACQdpqiv---nffeKPIIYGVLDAtrFLERHQyten 144 Staphylococcus ...
ADX77296      70 CDiqhDLIAHLYQLTRda-----eVDYIIVEATGVANPiDILVACQdpllv---dafsSIETIGLVDSvrFIKRHDntaq 141 Staphylococcus ...
Feature 1                                                                        
1NIJ_A       143 ---tIAQSQVGYADRILLTKTDVage---aeKLHERLARINar-aPVYTvtHGDIDLGLLFNTN 199 Escherichia coli
4IXM_A       143 ---tIAQSQVGYADRILLTKTDVage---aeKLHERLARINar-aPVYTvtHGDIDLGLLFNTN 199 Escherichia coli K-12
NP_603676    132 --ndFFYDNLKNTGKVILTKLESfnsf-dveSIKSEILKTNsn-lEIITtdYRYFPKEWFGEIL 191 Fusobacterium nucleatum subsp. ...
NP_764014    145 -tkrLMEEQLEVSDVLVVNKLDLisve-drdALKNQLNEVNkyssKIYTt-YGQVNIEELSQFR 205 Staphylococcus epidermidis ATCC...
AAQ55475     140 --gdFFNDQIRNADKLIISKSQYitqn-eldNIVNSLKELNdn-aILISenWDSIDSDKFLKII 199 Methanococcus voltae PS
YP_001254004 135 --geFYMDQVENAEILIVSKTQMvdks-tlkKVKESLRECNkk-aSIKTlaFEEFNKEYILNFL 194 Clostridium botulinum A str. AT...
XP_002503677 154 --seAFRDQVQCADVVVGAKGDVatva-dqcRFTDWAQTLYppklAVHViaRGELRLDVLNTPL 214 Micromonas sp. RCC299
EFN55957     152 lssqLLANQISVADVLVGSKADMcnsd-tlrAFQRWAEQLFppkqLVTTarHGCLADAVTAAMF 214 Chlorella variabilis
EGA96330     145 -tvsLMEDQLKLSDMIIINKIDLvtdd-sleKIDKQLSRICas-iPTYKttYGQVSLEELDLPG 205 Staphylococcus aureus O11
ADX77296     142 -tkaLMEDQVRASQTILVNKVDLieddaqlqMVIEDIKALSpk-sRIVLtqYGETLKTIEKGAN 203 Staphylococcus pseudintermedius...

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap