1NBF,1NB8


Conserved Protein Domain Family
peptidase_C19C

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cd02659: peptidase_C19C 
Click on image for an interactive view with Cn3D
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Statistics
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PSSM-Id: 239124
Aligned: 39 rows
Threshold Bit Score: 378.524
Created: 22-Apr-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Active Site
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:Active Site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1            #    #                                                                    
1NBF_A       5 GYVGLKNQGATCYMNSLLQTLFFTNQLRkavymm---------------------------------------------- 38   human
Q9NVE5      39 NLSGIRNQGGTCYLNSLLQTLHFTPEFRealfslgpee------------------------------------------ 76   human
XP_421884  174 NLSGIKNQGGTCYLNSLLQTLLFTPEFRealfslgpee------------------------------------------ 211  chicken
AAH86278   171 GYVGLVNQAMTCYLNSLLQTLFMTPEFRnalykwe--------------------------------------------- 205  African clawed frog
NP_597569  109 GYVGLRNLGATCYINSLMQALFSIAKFRndv------------------------------------------------- 139  Encephalitozoon ...
Q24574      53 GYVGLVNQAMTCYLNSLLQALFMTPEFRnalyr----------------------------------------------- 85   fruit fly
CAF99624   104 GYVGLVNQAMTCYLNSLLQTLFMTPEFRnalynwe--------------------------------------------- 138  Tetraodon nigrov...
XP_420965  171 GYVGLVNQAMTCYLNSLLQTLFMTPEFRnalykwe--------------------------------------------- 205  chicken
NP_060414   98 GYVGLVNQAMTCYLNSLLQTLFMTPEFRnalykwe--------------------------------------------- 132  human
EAL36128   224 GYVGIRNLGATCYMNSLLQSLYHIGRFRkavytiplnpnritsgsscsntpisretrpeltpmsacipkiddfgevtpqs 303  Cryptosporidium ...
Feature 1                                                                                      
1NBF_A      39 ---------------------------ptegdDSSKSVPLALQRVFYELQhsdkpvgtkklt----------ksfgwetl 81   human
Q9NVE5      77 -----------------------lglfedkdkPDAKVRIIPLQLQRLFAQlllldqeaastad-------ltdsfgwtsn 126  human
XP_421884  212 -----------------------lgtlddvgkPDAKVRIIPLQLQRLFAQlllldqqaasttd-------ltesfgwnsn 261  chicken
AAH86278   206 --------------------------feeseeDPVSSIPYQLQRLFVLLQtskkraiettdv---------trsfgwdss 250  African clawed frog
NP_597569  140 ------------------------------fgLEPRGRVLLLQKLFKEMQtgehpvdttdf-----------vvnniwvd 178  Encephalitozoon ...
Q24574      86 ---------------------------wefdnDNEAKKSYQLQKLFLNLQtspkaavettdl---------trsfgwdst 129  fruit fly
CAF99624   139 --------------------------feeseeDPVTSIPYQLQRLFVLLQtskkraiettdv---------trsfgwdss 183  Tetraodon nigrov...
XP_420965  206 --------------------------feeseeDPVTSIPYQLQRLFVLLQtskkraiettdv---------trsfgwdss 250  chicken
NP_060414  133 --------------------------feeseeDPVTSIPYQLQRLFVLLQtskkraiettdv---------trsfgwdss 177  human
EAL36128   304 issesnslaisllgeasedaiewtsnvakslfEYESDGIASLESIMSSNAcqdygqntgvvsgnvsgpgstiggncsasd 383  Cryptosporidium ...
Feature 1                                                                                      
1NBF_A      82 dsfMQHDVQELCRVLLDNVEnkmkg----------------------------------------tcveGTIPKLFRGKM 121  human
Q9NVE5     127 eemRQHDVQELNRILFSALEtslvg----------------------------------------tsghDLIYRLYHGTI 166  human
XP_421884  262 eemRQHDVQELNRILFSALEtslvg----------------------------------------tsghDLINRLYHGTV 301  chicken
AAH86278   251 eawQQHDVQELCRVMFDALEqkwkq----------------------------------------teqaDLINQLYQGKL 290  African clawed frog
NP_597569  179 dvhVHQDIHEFSKVFFDSLEkds-------------------------------------------krkDVIEDMIQGEL 215  Encephalitozoon ...
Q24574     130 eawQQHDIQELCRVMFDALEhkfkn----------------------------------------tkqaNLISNLYEGKM 169  fruit fly
CAF99624   184 eawQQHDVQELCRVMFDALEqkwkq----------------------------------------tvqaDLINQLYQGKL 223  Tetraodon nigrov...
XP_420965  251 eawQQHDVQELCRVMFDALEqkwkq----------------------------------------teqaDLINQLYQGKL 290  chicken
NP_060414  178 eawQQHDVQELCRVMFDALEqkwkq----------------------------------------teqaDLINELYQGKL 217  human
EAL36128   384 agnDQTKISSALQTLFYELQtcsepvncrelmrsfgwdasdaftqhdaqelnrllcdrleeemkntavdGSIKALFEGEY 463  Cryptosporidium ...
Feature 1                                                                                      
1NBF_A     122 VSYiqckevdyrsdrreDYYDIQLSIKgk--------kNIFESFVDYVAVEQLDGDNKYDAGEhglq--eaeKGVKFLTL 191  human
Q9NVE5     167 VNQivckec--knvserQEDFLDLTVAvkn------vsGLEDALWNMYVEEEVFDCDNLYHCGtcdrlvkaaKSAKLRKL 238  human
XP_421884  302 VNQivckec--kniserQEDFLDLTVAvkg------vaGLEEALWNMYVEEEYFENENLYRCGacdklveasKSAKLHKL 373  chicken
AAH86278   291 KDYvkclec--gyeswrIDTFLDIPLVirpygsntafgSMEEALHAFIQPETLDGPNQYFCERckrk-cdarKGLKFLHF 367  African clawed frog
NP_597569  216 VTYingkcg---cvrriKEKFQDIQVEirdffnnklssNLQESLKRYVKSEILDGNNRYNCEKhglv--dakKGVMFSSL 290  Encephalitozoon ...
Q24574     170 NAYvkclgcn-tekndcEDTFLDIPLPvrpfgsssaygSIEEALRAFVQPETLDGNNQYLCEKckkk-cdahKGLHFKSF 247  fruit fly
CAF99624   224 KDYvrclec--gyeswrIDTYLDIPLVirpfgasqaygSVEEALQAFIQPETLDGPNQYFCERcqkk-cdarKGLRFLHF 300  Tetraodon nigrov...
XP_420965  291 KDYvrclec--gyegwrIDTYLDIPLVirpygsnqafaSVEEALHAFIQPEILDGPNQYFCERckkk-cdarKGLRFLHF 367  chicken
NP_060414  218 KDYvrclec--gyegwrIDTYLDIPLVirpygssqafaSVEEALHAFIQPEILDGPNQYFCERckkk-cdarKGLRFLHF 294  human
EAL36128   464 ENYiecldv--dctsrrRENFYDIQVDveg------vkSLEESLQRFVEEEILDGENLYEAEGfgkq--rakKGVRFQRF 533  Cryptosporidium ...
Feature 1                                                                                      
1NBF_A     192 PPVLHLQLMRFMYDPQtdqniKINDRFEFPEQLPLDEFLqkt-------------------------------------- 233  human
Q9NVE5     239 PPFLTVSLLRFNFDFVkceryKETSCYTFPLRINLKPFCeqse------------------------------------- 281  human
XP_421884  374 PPFLTISLLRFNFDFEkceryKETSCYTFPIQINLRPFCeqte------------------------------------- 416  chicken
AAH86278   368 PYLLTLQLKRFDFDYTsmhriKLNDRMTFPDELDMSPFIdmedekspqtdsctdsgaenegschsdqms----------- 436  African clawed frog
NP_597569  291 PPVMFILLKRFNVDFEtgngyKINDYFEFPDSIDMLPFLdrdsk------------------------------------ 334  Encephalitozoon ...
Q24574     248 PYILTLHLKRFDFDYQtmhriKLNDRVTFPQTLNLNTFInrsgnsgeqnsqlngtvddcstadsgsameddnlssgvvtt 327  fruit fly
CAF99624   301 PYLLTLQLKRFDFDYTtmhriKLNDRMTFPEELDMSPFIdvedekspqtesctdsgaenegschsdqm------------ 368  Tetraodon nigrov...
XP_420965  368 PYLLTLQLKRFDFDYTtmhriKLNDRMTFPEELDMSIFIdvedekspqtesctdsgaenegschsdqmsn---------- 437  chicken
NP_060414  295 PYLLTLQLKRFDFDYTtmhriKLNDRMTFPEELDMSTFIdvedekspqtesctdsgaenegschsdqmsn---------- 364  human
EAL36128   534 PPVVQFHLKRFQFNIQsmdmvKLNDYFTFPEKLDLSSFVnhnnkget--------------------------------- 580  Cryptosporidium ...
Feature 1                                                         #                  #         
1NBF_A     234 ----------------------------dpkDPANYILHAVLVHSGDnhGGHYVVYLNpkg-dgkWCKFDDDVVSRCTKe 284  human
Q9NVE5     282 ----------------------------lddLEYIYDLFSVIIHKGGcyGGHYHVYIKdvd-hlgNWQFQEEKSKPDVNl 332  human
XP_421884  417 ----------------------------mddSEYMYELFSVIIHKGGcyGGHYHVYIRdvdelgnWQLQEDEDRLIEDQp 468  chicken
AAH86278   437 -ndfstddavdegicletnsnieklnksvaeKNSLYELFSVMVHSGSaaGGHYYACIKsfa-dgqWYSFNDQHVSRITQe 514  African clawed frog
NP_597569  335 ---------------------------rkeeSDATYDLYSVIVHRGDhdEGHFYAYLKin---grWLKFNDTVVTEAGEm 384  Encephalitozoon ...
Q24574     328 asssqhendlndedegidmssstsksakqgsGPYLYELFAIMIHSGSasGGHYYAYIKdfd-nneWFCFNDQNVTSITQe 406  fruit fly
CAF99624   369 --sndfstddcvdegicldstnnadrmlkpkSLLTFELFSVMVHSGSaaGGHYYAHIKsfs-dgqWYSFNDQHVSKITQe 445  Tetraodon nigrov...
XP_420965  438 -dfsnddgvdegiclesnsaaeriakvgsekNSLLYELFSVMVHSGSaaGGHYYACIKsfs-ddqWYSFNDQHVSKITQe 515  chicken
NP_060414  365 -dfsnddgvdegicletnsgtekisksglekNSLIYELFSVMAHSGSaaGGHYYACIKsfs-deqWYSFDDQHVSRITQe 442  human
EAL36128   581 ------------------------dtgniveGTEKYILHTVVIHQGDvhSGHYYAYIRpkp-dsdWFRFDDEKVTLVSSs 635  Cryptosporidium ...
Feature 1                                                                      
1NBF_A     285 ea--------------------iehNYGGHDddlsv------------rhctNAYMLVYIRESK 316  human
Q9NVE5     333 ------------------------kDLQSEEeidh-------------plmiLKAILLEENNLI 359  human
XP_421884  469 srdsentketenplavlkgilseeeCKQIPVdqlgqkfl-----ekikvswnKKYRKQYGALRK 527  chicken
AAH86278   515 di--------------------kktYGGATGnrgyyss--------afasstNAYMLMYRLKNP 550  African clawed frog
NP_597569  385 ea--------------------lehNFGGRHpykdr------------irdhSGYYLIYLRKSM 416  Encephalitozoon cuniculi GB-M1
Q24574     407 di---------------------qrSFGGPNgsyyss---------aytsstNAYMLMYRQVDA 440  fruit fly
CAF99624   446 di--------------------rktYGGSSGsrgyyss--------afasstNAYMLIYRLKDP 481  Tetraodon nigroviridis
XP_420965  516 di--------------------kktYGGSSGsrgyyss--------afasstNAYMLIYRLKDP 551  chicken
NP_060414  443 di--------------------kktHGGSSGsrgyyss--------afasstNAYMLIYRLKDP 478  human
EAL36128   636 ta--------------------iedNFGGHEyevwdylgnpesdipkrskthSAYILVYVREDQ 679  Cryptosporidium hominis

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