Conserved Protein Domain Family
MutL

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COG0323: MutL 
DNA mismatch repair ATPase MutL [Replication, recombination and repair]
Statistics
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PSSM-Id: 440092
Aligned: 726 rows
Threshold Bit Score: 452.576
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_012944342   8 ET--------------------------------E-IRQLDEDTVARIAAGEVVERPASAVKELVENSLDANADSVDVTV 54 
WP_011451995   1 ---------------------------------mK-IHILPIEIINKIAAGEILEKPANAVKELVENAIDAGSTSIKVEL 46 
WP_014268846   1 M---------------------------------K-IHVLDSIVAQRIAAGEVIERPSSVMRELLDNALDAHSTSIIASV 46 
WP_013906969   1 MA--------------------------------R-IKILPENIARKIAAGEVIERPASVVKELCENAFDAQAKQIEVEL 47 
WP_010881752   1 MAcakratgaalrqnagagclrsgkgfsmhetsyKpIHRLSPDTAKKIAAGEVIERPASVVRELLENALDAGATKIHLEI 80 
NP_212345      1 MN--------------------------------K-IRFLDKYLVQKIAAGESIDRPCSILRELLDNSIDSGATKIEVFL 47 
WP_013254939   1 MErtqq------------------------drsrS-IHLLRDQVARKIAAGEVIDRPFSLLRELMDNAVDAGADTIDVHL 55 
WP_024267954   1 MKttq--------------------------ssrR-ISILRDSVARKIAAGEVIDRPFSVLRELVDNSIDAQAATIDVSI 53 
WP_108673268   2 NR--------------------------------K-IRILSPQSISKIAAGEVIENSLSVIKELVENSIDSKATEIVVTV 48 
WP_012421984   1 MN--------------------------------K-IKFLDKSLVQKIAAGEAIDRPCSILRELLDNAIDSGADKIEVFI 47 
WP_012944342  55 EAGGTELIRVADDGRGMGEADVRAAVREHTTSKIEGLEDLeSGVATLGFRGEALHTIGSVSRVTIESRPRdGDes----- 129
WP_011451995  47 EEVGRNLIRVTDNGVGISREDLPLAIEKHATSKL-NTKDL-YDISYLGFRGEALHSIAITSEMKIASCFN-GE------- 116
WP_014268846  47 TEGGLEEITVIDNGEGIASEDLPLCCESHATSKVTSFEDL-YHLDTMGFRGEALYSIAAVSSITISSRFL-QNd------ 118
WP_013906969  48 ADGGLSLIRVRDNGLGMSPEDLKVCYLPHATSKIETEEDL-LRIRTWGFRGEALSSIAAVSELTITSREK-EA------- 118
WP_010881752  81 NAGGCALIRVSDNGHGMSPQDLLLCAEAHTTSKISSADDL-LQLRTLGFRGEALASIAAVSRLHLTSTRS-GPlawhyqp 158
NP_212345     48 EEGGIQKILIIDNGSGISKEDLKICYLPHTTSKISSEEDL-RKIETLGFRGEALSSIAICSNISITSSTT-SNe------ 119
WP_013254939  56 AGGGTRSVRVVDNGCGMEREDLELCFLPHATSKISEVEDL-DRITSLGFRGEALSSIAACSRLRITSAVA-EG------- 126
WP_024267954  54 EKGGISLLEVTDDGWGMSREDIQLCWLSHATSKISHEDDL-MHVHSLGFRGEALSSIAAVSRLEIVSRSG-EM------- 124
WP_108673268  49 KDAGKSFISVSDNGCGIEKDELHMAFIRHATSKLQD-DSI-YDIQYLGFRGEALASILAVSDITIITKTE-EE------- 118
WP_012421984  48 EEGGIRRILITDNGSGISREDLKICYLPHTTSKINEEQDL-EKIQTLGFRGEALSSIAICSNLTITSSTT-GEd------ 119
WP_012944342 130 gGAGTKLTY----EG-G-E-------------V----TG-VEPTGCPEGTIVEIEDLFYNTPARRKFLKTTATEFAHVNR 185
WP_011451995 117 ---GYVIDA---------Q-------------T----KE-VKPHHIKCGTLVEVRKLFHNIPNKLRFLRSEKTELSSIIE 166
WP_014268846 119 ---AFSITI----DN-G-R-------------K----QA-VVPGGPSEGTKVTVSGLFKEVPARRQFLKRPSTEATMCKN 171
WP_013906969 119 -LIGARIKI----KF-G-K-------------E----VS-FVEKGLAPGTIVEVVNLFANVPARRAFLKSPRAETARVNE 173
WP_010881752 159 kAAGTAAHVppvpQG-T-E-------------A----GV-LEPASLERGTVVRVEQLFENFPARKRFLGRQSAETTLCRS 218
NP_212345    120 ---SYQIEV----EN-G-I-------------E----KC-FKKQPAINGTIVDVTKIFHNFPARKRFLKQEPIETKMCLK 172
WP_013254939 127 -E-AFTIEV----DN-G-K-------------L----LS-LQPSKGRKGTVVEASDLFYSIPARKRFLKSDQAELSACRK 180
WP_024267954 125 -DASARLII----EG-G-G-------------E----AR-YGKVTGRRGTRVSVRDLFYNLPARRKFMKSSRSESVLCRN 179
WP_108673268 119 -DHAWELSL----SSlSdEknallndntitteIqekiSNlITPKNRAKGTTIEVKGLFAPTPNKLRFLKNNNAELHSILQ 193
WP_012421984 120 ---SYQIEV----EN-G-T-------------E----KY-FKKQSAINGTIVDVTNLFHNFPARKRFLKKDSIETKMCLK 172
WP_012944342 186 VVTRYALANPDVAVSLTHDGREVFATT--Gq---GD-LQAAVMAV--Y-GRE---VASAMI-AV-EAD--GddlppgPLE 249
WP_011451995 167 LLNRLALVNPNIAFELISNGRQVFDYQ--Ta---TQ-L-KRMEQLkvL-GKE---FVENMI-HV-KHT--N------DGI 225
WP_014268846 172 LLIEKSLAFPDRSFKFYSDGQLKLDLR--At---DK--KQRILDA--L-STSqniVPSEML-ELfD-N--A------GRF 231
WP_013906969 174 IVKLMALENPQTNLSLKTKGKILFEYN--Yk---LG-RLGLLAEF--S-GLK----AENFL-TE-EVE--V------RDI 230
WP_010881752 219 ALIDVSLAHHPVEFRFTVDGTHKLTLL--Sq---QT-RKDRCLETqmLkGDPa------LFhTI-EGG--D------CSF 277
NP_212345    173 VLEEKIITHPEINFEINLNQKLRKIYFk------ES-LIDRVQNV--Y-GNV---IENNKF-RVlKKE--H------DNI 230
WP_013254939 181 LFAEKALAFPEISFRLFSEGELKLFLPa------SS-LIDRVTAS--Y-PGQ---VHASMIhTI-QGA--G------EGF 238
WP_024267954 180 AFLEKALPHPERSFRLFADGKPRLLLPetGt---SG-YISRISAA--Y-PEQ---CPSELLqHI-HGS--G------DGF 240
WP_108673268 194 FMHSIALAYQNCNFKLFSESKLLFDTT--RdqfdDDiLKQRIIDI--F-GNE---FTNNIA-KV-SYtgfS------REI 257
WP_012421984 173 VFEEKAVTHPGIDFKLNINNELRKVYFk------ES-LIDRVQSV--Y-GEI---IDNNKFgKI-EAE--Y------ENI 230
WP_012944342 250 SVSGLVSHPETNRSSPE-YLATYVNGRSVTADAVREGIMGAYGAQLGGDRYPFVTLFLEVPGEAVDVNVHPRKREVRFDD 328
WP_011451995 226 FGELFLGLPTLTQ-KRN-NCLIFVNGRPVKDSVISSVMRHAYNDYIPKNTYPIAVIFIRVHNNEVDVNIHPNKSEVKFRD 303
WP_014268846 232 SLYALASSPAIFRSDRS-HIKIYVNERPVEEYSLVQAVSYGYGELLPGGSFPYCYLFITVDPTLVDFNIHPTKREVKLRN 310
WP_013906969 231 RLTIILSKSEHFFPTAR-YLYFLVNNRVVKDKLISAAAFEGLKSVYPKGRYPALLLALTLPPEQVDVNVHPAKWEVRFRE 309
WP_010881752 278 HFHLVLSEPAICRRERR-GIFTFVNGRRIFDYGLVQALVLGSEGYFPNGTFPVACLFLTVNSERIDFNIHPAKKEVHLQD 356
NP_212345    231 KIEIFLAPDNFSKKSKR-HIKTFVNRRPIDQKDLLEAITNGHSRILSPGNFPICYLFLEINPEYIDFNVHPQKKEVRFYN 309
WP_013254939 239 HFTALGSGLSLYRKDRR-YIHIYVNKRKIDEFSLVQAVSYGYGEYLPGGTFPVCFLFLEVDPERVDFNIHPAKKEVRFRG 317
WP_024267954 241 TLDIVLGIPPLFRQDRK-YIQIYCNRRRINEFSLIHAVEYAFDSILPGGNHPVAFVFLEIDPELVDFNIHPAKREVRFAR 319
WP_108673268 258 KINGYVTIPTYTPSIRKqKSIIFVNGRLIHDYSIICFIKAAYSGLIANNLKPLAILFIEIPLQDVDVNIHPHKTEVKFSD 337
WP_012421984 231 QMKIFFAPPNFSRKDKR-NIKIFVNRRPVEEKNLSEAIIDGHSRILTNRNFPVCYLFLEIDPRYIDFNIHPQKKEVRFFN 309
WP_012944342 329 DDSVRRQVDAAVESALLEHgllrsraprgrsapgeasvapgdaprgtsdgepttedlpaalegdgesesgsespseptad 408
WP_011451995 304 PQVIRRFLLSVSSRSLLQCgrststtvadraveqfnqllkkqtafrketvskttesgffqspkakkaidqsqeyakqfeg 383
WP_014268846 311 KAEIHHQVVAMISTQIKRTiprlvkereetfqsdlaenleipyrapvqrnsfsqipaqrekp------------------ 372
WP_013906969 310 ERRLFELIKKSLENLFKPTvsfeiktkieedlpisydrkttseediw--------------------------------- 356
WP_010881752 357 YAHIRHTLSRSVAHFYRQCtiahyvraepahapatqgnapthssppctgvreepaapcahtpryeslf------------ 424
NP_212345    310 LPFLFKLISDNINNFFDKNinnyqdiiikrqlteddhliemtnqpenfnkintydipqnnnletedvnepnk-------- 381
WP_013254939 318 LKEIHHQVSSGIRDFLRSKwptplpyeipaaddrphlsegekndfgssgfpkpsydkapfskssmsprs----------- 386
WP_024267954 320 PEIIHRRVRELIEEFIGFQirnkpqnlrtpdnlspvsgdlpltdseppspqgpasrhnhaggnlhtapa----------- 388
WP_108673268 338 ITSIKNAVVNAVREALSSPyiaqsltenqlysgfdtsynlsneyeardsykhsnqdkhe--------------------- 396
WP_012421984 310 LPFLPKQIASNINEFFDRGqkeilqdyhniiikrqltnddhllhteddptnsdfqaykitqnealtldkpqnn------- 382
WP_012944342 409 dtaaassrspstvdaesadsgsttgsagsppaggassgpsgtassgpsgsdssgtsetpsgtassestrrassdapttes 488
WP_011451995 384 krnldfdqmqnn---------------------------------------------------ngpfhfstdqseealpl 412
WP_014268846     --------------------------------------------------------------------------------    
WP_013906969     --------------------------------------------------------------------------------    
WP_010881752     --------------------------------------------------------------------------------    
NP_212345        --------------------------------------------------------------------------------    
WP_013254939     --------------------------------------------------------------------------------    
WP_024267954     --------------------------------------------------------------------------------    
WP_108673268     --------------------------------------------------------------------------------    
WP_012421984     --------------------------------------------------------------------------------    
WP_012944342 489 tasrgdssvdhrdddsdrsdrqperkfaaateqrtlsgepatgdetdfdslpalrVLG----QLDDTYLVC-E-TDDGLV 562
WP_011451995 413 mshkktsedysnklplekqqspsiflhdnrdtsflqqqlrkinhcehlqnekhfeTFGkfkcQVHGTFIIT-E-TENEMI 490
WP_014268846 373 -------------sdplwfskarevlsqvdtsmqatrtteqediwasqavendytYIG----QAFNLFLIA-Q-KGEELF 433
WP_013906969 357 ----------------------------stskvaepaenifkkpstlfskntsyqVLS----RFGKEFFLI-L-ADDELY 402
WP_010881752 425 -------plpvqhahllppspphiscehardcthpapaaegdapvhnhthtgafkVLG----QVAGTFIAV-E-RNNALY 491
NP_212345    382 ---nttqsnidlrrynsiiqnrptlrenignifsdnflefeeppnknekeeikfnYIG----QIFSEFLIV-E-KINEIY 452
WP_013254939 387 -----knsfsfppsstvapvksnaeqnrqfydrfeqtrsqqeqqaaeesqayafrYLG----QVFGLFLAA-E-KEGTFY 455
WP_024267954 389 ------mvrdrafqyhsgfderpspvqppgggasgpaaapasiqstagkempayrYLG----QIFSVFLLV-E-MEQTLY 456
WP_108673268 397 ---------------stllplsarypiedftamnkaieeritesqlddklyyfgnPIC----QISNLFIISyNsNTDDLF 457
WP_012421984 383 --kitniiedkvkfesqpptqkdkpsfknyiqniflktstmlndlqkpiekhefkYIG----QLFSEFLIV-E-SDNEVY 454
WP_012944342 563 LIDQHAADERVNYERLQQAf-A-DDPAAQALAEPVELELT-AAE-AEAFEGYREALSRLGFYAD-RTDD-RTVAVTTVPA 636
WP_011451995 491 IIDQHAAHERILYEQMKKSi-Ts---PGQNLLTAEFVPLS-EKA-VEILSFNVEKLKEIGLVVE-RVSH-CAVMVNSLPE 562
WP_014268846 434 LVDQHAAHERILFDEIRGK-----K-EVQALMIPVEFEVD-RDV-DNYLGENTDVYLNLGIKLE-KSAD-LFWKLYSIPA 503
WP_013906969 403 IFDYHAAHERLLFEQWKKEl-K-DNLKIQALLVPQVFSLT-GKS-LERVEILLPVLNSLGFEID-FFGE-EKIILRSVPA 476
WP_010881752 492 LIDQHAAHERIIFDTLQRNl-G----TAQILLIPYHIHPRsDEE-ARIMHRACTELSPAGFRFH-EEPD-GSWHVTAVPL 563
NP_212345    453 FIDQHAVHEKIIYEKLRNS-----KKNVQKLLVPIEFTVV-DKNiEEIIDSEIEEYKQMDIIIS-KIGP-KKYQLESIPN 524
WP_013254939 456 LIDQHAAHERILYEQFVAG-----ASRKQQLLIPKRLQLD-DEG-KTLLQGQIDYYRGLGIVIEaEKEG-DNLLLTALPE 527
WP_024267954 457 IIDMHAAHERILYDRFRSSs------AVERLLIPFTVENDdPAL-AERMSLQAEKLRAMGFDIR-LKGSgNSLEIHAIPA 528
WP_108673268 458 VIEQHAAHERVMLEKMKDAllHkKKLKMQNLLLPISTEIS-GTE-AMIILEQHDTLLKYGIKIK-MMQ--DKIHIVGIPI 532
WP_012421984 455 FIDQHALHEKIIYQILIKS-----EKIIQKLLVPIEFQVD-CEDkDKILASELEEYKKIDITVN-KIKE-QTYQLESIPN 526
WP_012944342 637 VLEE--TiA-PERLRDVL-ASFVEGdreagaetVDALADEFLGDLACYPSiTGNTSLTEGSVVDLLEALDDCENPYACPH 712
WP_011451995 563 AFKN--V-PtNELIEDIA-SLLEEEi------ePKTLLERIHANIACKRAiKANHNLTREEIEELLTLMEDIPHTGQCNH 632
WP_014268846 504 MFR-----DiEQEVVAFI-Q---NHtg-----dTAEVEKGLYAIVSCHAAiKSGDVLDKITAKAILDKVFAMEDP-CCPH 568
WP_013906969 477 LLGD--Fs--REVLEKFLaEEL-Sf-------sAENLLEEVMARISCKAArKAGEKLSFEEVLNLFIEVKN-TGLSNCPH 543
WP_010881752 564 HWRG--Se--EQLAHDIL---Y-Sgk------nAHDILRHVLATCACRSAcKDGTILDDATLHSLVEQAFALPQ-SRCPH 628
NP_212345    525 ICSQy-----ENTLINFF-Q---Srrs----rtINSLESDLYATIACRKAvKRNDMLSAEFSKFLINEFFKLEI-KHCPH 590
WP_013254939 528 SCVHl-----EKEITTFI-E---SQet-----gsDGFSERIFANLACKAAiKEGEFLPPETAKKIIAGTFALKQ-HRCPH 592
WP_024267954 529 ALKGk-----ERLLRSTL-AELERD--------SRDLEVSLYEKMACRTAvKDGDVVDSSTARSIIEASWRLPE-KRCPH 593
WP_108673268 533 ILQilpSvSpHEKVIQIL-NHVIQNsalv-keiSETAIiEIYNEVACHSSiLKGKSLSKEEMCILLREMERYNFTAQCNH 610
WP_012421984 527 ICNKy-----ESVIIQFL-K---Trks----ktIDSLEADLYATIACRQAiKRNDTISSEFSQFLINEFFNLKL-KHCPH 592
WP_012944342 713 GRPVIVRFDEREIEDRFE 730
WP_011451995 633 GRPTHIRLPRKEIEKLFL 650
WP_014268846 569 GRTFVVRLNKQELSEAVG 586
WP_013906969 544 GRPLYWRIGLDEVRRKLG 561
WP_010881752 629 GRPIWIVIGRDELFKRIK 646
NP_212345    591 GRKIYYKISKFELEKKVD 608
WP_013254939 593 GRPLYFSVTEKELYKAVG 610
WP_024267954 594 GRPIWFTLSKEELYQIVG 611
WP_108673268 611 GRPTYIKITHDFLLKIFQ 628
WP_012421984 593 GRKIYHKISKFELEKNVN 610
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