Conserved Protein Domain Family
Tam41_Mmp37

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pfam09139: Tam41_Mmp37 
Phosphatidate cytidylyltransferase, mitochondrial
Tam41 also known as MMp37 is a mitochondrial phosphatidate cytidylyltransferase (CDP-DAG synthase)(EC:2.7.7.41) that catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. It is required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane. It is suggested that the N-terminal portion of Tam41 may possess the NTase (Nucleotide Transferase) fold, which is consistent with the CDP-DAG synthase function of Tam41. Furthermore, it has been shown that Tam41/MMP37 proteins possess the NTase fold but they have only one active site carboxylate and thus probably are not able to carry out enzymatic reaction. These potentially non-active members of NTase fold superfamily may bind ATP, hydrolysis of which is necessary for the translocation of proteins through the membrane.
Statistics
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PSSM-Id: 462690
Aligned: 114 rows
Threshold Bit Score: 237.809
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_007672357      36 LRQILW-RFRApIRYAFAYGSGVFAQQSSksmtetsmsphpnppkavedwQKGGAKIIDFIFGVSHTQHWHSLNLMEHPD 114
Q9SN75             9 LSSFLS-VLPP-VDFCCVYGSTLHPNN------------------------QDKSKMVDYILGVSDPIKWHSANLKMNSD 62  thale cress
CBI27230           9 LASLLK-FLPP-VEFCCVYGSALHPNN------------------------YNKSTMVDYILGVSDPMQWHSQNLKMNRD 62 
XP_003524826       6 FRSFLQ-VLPP-VEFACVYGSSLHPSN------------------------HDKTTMTDYILGVSDPKQWHSENLKLNKH 59 
XP_002299388       9 LKSFLK-VLPP-VGFCCVYGSSLHPNN------------------------NDKSTMVDYIIGVSDPKQWHSKNMELNED 62 
XP_002528146       9 LKNFLE-VLPS-VEFCCVYGSALHPNN------------------------QDKSSMVDFILGVSDPRQWHSENLKLNRD 62 
jgi:MICPUN_79022  10 LRAVLE-DVPP-VNHAFGYGSGVLPQPlrddegp----------sasardHAATGSVVDFVFAVDDPRAWHRRNMAMNPS 77 
EEH57855           9 LGVVLN-DLPP-VVHAFAYGSAVFPQP------------------------ASSGSVVDYVLAVDAPDEWHAANMAANPS 62 
A0ECV7             9 LKQFIQ-TLPQ-SELSFAYGSAVQPQFNYd--------------------YTKNKPMIDLIIAVDNVEEWHMQNIQINST 66  Paramecium ...
XP_001018527      17 LDSIIQrDFPK-IDFAFGYGSGVFRQIGYd--------------------YSKDSPMIDLIFGVQDADEWHRMNLIKNPS 75 
XP_007672357     115 HYSFLRHLpySSAAISHIQDD-FGAGVYFNPYITVN----------GTMIKYGVVNLDTLSRDLSEWNTLYLAGRLQKPV 183
Q9SN75            63 HYASWMVHlgGARLITNVADK-VGVGVHFNPFVNWN----------DRKLKYGVVRMHDLVQDILDWKRFYLSGRLQKPV 131 thale cress
CBI27230          63 HYASSMVYlgGAKLITQVADE-IGVGVHFNPFVSVN----------DEMFKYGVVRMHDLVEDVLNWETFYLSGRLQKPV 131
XP_003524826      60 HYASWMVHlgGESLITGVADR-IGVGVHFNPFVTWN----------GKLFKYGVIQMHDLLQDVQYWEKFYLCGRLQKPV 128
XP_002299388      63 HYASWMVPlgGAKLITQVADK-IGVGVHFNPFVTWN----------DKMLKYGVVRMHDLVQDVLHWERFYLCGRLQKPV 131
XP_002528146      63 HYASWMVHlgGAKLITEVADE-IGVGVHFNPFITWN----------DKMLKYGVVRMHDLVQDILNWERFYLSGRLQKPV 131
jgi:MICPUN_79022  78 HYAPHLRAl-GGGTVAALADR-VGAGVHYNTLIPWTktihpsarlaPTTFKYGVVSVNAMCDDLVNWRHMFVAGRMQKPV 155
EEH57855          63 HYAAHLRLl-GARSPGWIADR-VGVGVHYNTLLPWPctttr-phdgARLYKYGVVSVEALTRDLTRWSDLFVAGRMQKPT 139
A0ECV7            67 HYSGLSYYl-GSRFIQRMNVEiF--PIHFSPFVQYQ----------DLKLKYGVVSTKELIKDLENWKWLSIAGRMQKPI 133 Paramecium ...
XP_001018527      76 HYSGLGYYl-GSSYLHFLQQYiT--PVHFNPSIQVDsfd----qkrKLNIKYGVVDVKQLSKDLLKWNILTCSGRLHKPV 148
XP_007672357     184 KIL--RD-------DPRIRLANQVNLISALRTALLMLPEKF-S---ERQLYERIAGLSYTGDPRMNplFaSENPNKISNI 250
Q9SN75           132 HML--VD-------NLDIEDVNSVNKRAAISAALLLLPSKF-T---EEDLYAKICSLSYMGDLRMF--F-AEDTNKVNKI 195 thale cress
CBI27230         132 QVL--VD-------NLDIGNLNSVNLKGAISAALLLLPAKF-T---EEHLYAKICSLSYMGDLRML--F-AEDRNKVKKI 195
XP_003524826     129 HIV--VD-------NLDVNSTNSVNLRAAVSAALLLLPSEF-T---EEDLYAKVCSLSYTGDIRML--F-AEDKNKVKKI 192
XP_002299388     132 HIL--VD-------NLDIGDVNSVNLRAAVSAALLLLPSKF-T---EEDLYSKICSLSYMGDLRML--F-AEDKNKVKRI 195
XP_002528146     132 HIL--VD-------NLDIGNVNSANLRAALSAALLLLPSKF-T---EEDLYSKICSLSYMGDLRML--F-AEDKNKVKKI 195
jgi:MICPUN_79022 156 VALggAI-------DPRVTAAQSINARSALAAALLLLPEEF-S---REDLLGSLCGLSYAGDVRVA--LgAEDVDKVRRI 222
EEH57855         140 TTL--TTttaafaaDASLRAASEANLRAALAAALLMLPETF-S---TRELHETLCGLSYEGDVRTA--FgAEDVGKIPRV 211
A0ECV7           134 VTIqeFE-------DLRFQRAFIANLQSALAVAILMD---FkSsmsLQELLYSVISLSYYGDIRFT--LgGENQNKVFNI 201 Paramecium ...
XP_001018527     149 KIIqlDQv-----qNPTLNSDLRVNLIQATAISLLLN---FkPyieMKEFLMTIASLSYIGDVRFL--FgAENKNKIQNL 218
XP_007672357     251 VGAQLPGFRQLYVPLIENLPNvhfsdprtprdhAWekedairhtgtnpqldnvlggadGLELE--QNMDPVPRGNMVRRL 328
Q9SN75           196 VKGQFDLFQSMYKPFLEECETknllrfssaeasH-------------------------TKLV--QDSSLSATRSLVSSL 248 thale cress
CBI27230         196 VQVQFDLFQTMYKPLLEEYGAkgllrfsssdghQ-------------------------AIIS--QDCGLSVARSLVSSL 248
XP_003524826     193 VTGQFDLFHSMYKPFLEEYEAkkllrlsstannQ-------------------------IHAT--QDCDLSVACALVSAL 245
XP_002299388     196 VEGQFGLFQSMYKPFLKEYEAkelltfslpnshQ-------------------------ATIS--QDCSLSMTHSLVHSL 248
XP_002528146     196 VQGQFGLFHSMYRPILQDYEAkellrf--------------------------sssdyqSNIS--QDCGLSVTRSLVRAL 247
jgi:MICPUN_79022 223 ATGSERGLMEMYRDAVKVVGSdlagltmgrggeVW-----------------------S------RDGSPAARSALFATL 273
EEH57855         212 AAGSRAGLREMYADAIARFRSnpaigltavgtsVD-----------------------RGDCDwgQDKSAAARSALLETL 268
A0ECV7           202 LKGNYKNITDLYLSNLGDLNNvik---------------------------------iqKDGEvlIDNSIKSLEFLCSKI 248 Paramecium ...
XP_001018527     219 VEGNYDRFTHLYKDVIEQNNPinslaqvvgnraE------------------------HIKLE----TNSETVYQLVNCL 270
XP_007672357     329 PKAFRRKLYFQYKKKFgipgaaftdvleasededatsMRkREGGDFERRIAAEA-D---LPETVGRCVRNTVGWPSTTQS 404
Q9SN75           249 PASVRSQMGKSLGEKK---------------------FVsETGRVMGEVCISSReE---AAKCMEKVMRRRVMVSSGRQA 304 thale cress
CBI27230         249 PSKVRSQMGMKLGEKT---------------------KLsESGRVLREVVVGSReE---AAECMRGVLRRKVMVSSARQA 304
XP_003524826     246 PPSIRSQISKN-GE------------------------LtETGRFIHDTKVSAReV---AANCLQRILRQRVMVSSARQA 297
XP_002299388     249 PPLVRRKMGMKLGEMQ---------------------VLkDSGRVLHEVVIGSReE---AARSMQRIIRRTVMVSSARQA 304
XP_002528146     248 PPLVRSKMGMKLGEEK---------------------LWsDSGRFLHEVIIGSReE---AAKCMHKVLRRTVMISSARQA 303
jgi:MICPUN_79022 274 PRETLHKTMSA-----------------------------------RMLVKFEDaGgrsAVESLRECLRGTVRKSSLRQL 318
EEH57855         269 PRKALALAAVS---------------------------AgAGAEAAAAAIASRA-SperTRDVVRRAIDAIVFRSSARQL 320
A0ECV7           249 PGQLLSIVLGE-----------------------------KDNMGTLKMMSQDR-----IKDLIKESVKRKNQFSSKRML 294 Paramecium ...
XP_001018527     271 PDGL---GLFA-----------------------------RTNEINVKIINLED-----VQRQIIERIRKINMGSSQKLI 313
XP_007672357     405 IKGVFTSGFAKSWKYLGEKRSK 426
Q9SN75           305 VSGFLAAGAINATMYLSQKMRK 326 thale cress
CBI27230         305 VSGLVAVGGVNAIRYLANKMEK 326
XP_003524826     298 ISGLLAVGGVNATRYLSKKVSK 319
XP_002299388     305 VSGFLAAGGINATRYLANKVRK 326
XP_002528146     304 ISGLLAAGGINATRYLASKVCK 325
jgi:MICPUN_79022 319 LAGLLATSPSKSARYAASKLFK 340
EEH57855         321 MSGILSTSPRKSLTYALGKAVK 342
A0ECV7           295 FYNLAMISPFLSVKYGISKLSK 316 Paramecium tetraurelia
XP_001018527     314 LYNTLATSPTKNIYYVFKKLQK 335
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