1BX4,1DGM


Conserved Protein Domain Family
adenosine_kinase
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cd01168: adenosine_kinase 
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Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular adenosine levels and the preservation of intracellular adenylate pools. Adenosine kinase is involved in the purine salvage pathway.
Links
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Statistics
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PSSM-Id: 238573
Aligned: 59 rows
Threshold Bit Score: 153.153
Created: 10-Jan-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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substrateATP binding
Conserved site includes 17 residues -Click on image for an interactive view with Cn3D
Feature 1:substrate binding site [chemical binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1               # # #                    #                                ###  #        
1BX4_A        6 ENILFGMGNPLLDISAVV-DKDFLDKYSLKPNDQIlaed----khkELFDELvkkf----kveYHAGGSTQNSIKVAQWM 76  human
1DGM_A       12 PMRVFAIGNPILDLVAEV-PSSFLDEFFLKRGDATlatp----eqmRIYSTLdqf-----nptSLPGGSALNSVRVVQKL 81  Toxoplasma gondii
CAA11263     33 PGRILFIGHPMIDIYCKA-DQSVIDELGFRKGESNri-------tpDVFKKLgerv---kiesQNAGGSSACTARSYSFL 101 Babesia canis
AAM27498     28 PRKVICFGNVLLDRLVQLeDPQLLERFGLELGSKGel-------dmEKLNQLaaeasessrclTNPGGSALNTARILKQL 100 fruit fly
XP_319291    47 CPRMVAFGNILLDISVELkDGKILHDFDLKPDDQRevpadklaalvSVAVETcgn------piYNPGGSALNTCRILRAL 120 Anopheles gambia...
AAS47710      3 GKKIFGMCNPILDIVLKA-SPDRIKDLGLKIGSTTlgn------deEVFKLIgdiisnnedanFVAGGSLLNAFRVCKEL 75  Cryptosporidium ...
O93919        3 SYKLFCMGNPLLDLQVRD-GEKLLEKYGLKSNDAIlaee----khlLLYDEIvkeh----evtYVAGGAAQNAARGAAYC 73  Schizophyllum co...
AAA82876      1 MSNTTAFMSRQTDVLVLG-GAGVDTIVHVPELPLPfa-------dsYMIRPGi---------eTRAGQSGDFVSLGLLAL 63  Streptomyces sp.
NP_407400     4 RNGIIAAGNMLVDHVHQIeQWPQRGWLAEIVHSERst-------ggAPLNVLlt-------laKMYTGLPLQAVGLIGDD 69  Yersinia pestis ...
ZP_00133200   4 RKGILALGNLLVDRTLVI-SDYPKETMLATISEMGlh-------cgGGCTNVl---------fNLSKLDPELSLFLSGAI 66  Haemophilus somn...

Feature 1                                                                #           # # #      
1BX4_A       77 Iqqp------hkaATFFGCIGIDKFGE---ILKRKAAEAHVDAHYYEqne--qpTGTCAACIT-GDNRSLIANLAAANcy 144 human
1DGM_A       82 Lrkp-------gsAGYMGAIGDDPRGQ---VLKELCDKEGLATRFMVapg--qsTGVCAVLIN-EKERTLCTHLGACGsf 148 Toxoplasma gondii
CAA11263    102 Gg----------ySTFFGLCGDDKLCD---DYAQCLSDYGVNLMLKRqpg--qfTTQLYSLVTpDAERSMYFLGGASHgl 166 Babesia canis
AAM27498    101 Gt----------dALFFGAVGADKHAE---ELRQIIRDRGIEARLQTved--ahTGQCVCLMY-QDNPTLYANIGASAqf 164 fruit fly
XP_319291   121 Gek---------nIIFCGAVGVDENGQ---ILQQILKDCALNTCIQTlpd--emTGTCMCLIS-GDKRSLNANIGASLhf 185 Anopheles gambia...
AAS47710     76 SnkdeknkddsisVFFSGGISDDSGGI---LLQELLTEIGIEFEFHItnkanleTAKCVVFVT-EEERTLLAGLGAAKey 151 Cryptosporidium ...
O93919       74 Lpp--------ksVVYTGCVGDDDLAE---QLKAANKREGLDEAYLVkkg--ekTGACAVIIT-GHDRSLVTTLRAAEkf 139 Schizophyllum co...
AAA82876     64 Gl----------rTHHLDMIGDDHEGD---LVRALHRDRGIPLTAVPap---ggTKRAVNLVG-PDGRRLSLYDATRSre 126 Streptomyces sp.
NP_407400    70 Hd-----------GDYIMAMLDQYQVN---RQHVRRTTLAPTSMSQVm------TDPSGQRTF-FHSPGTNRLLDLPAfd 128 Yersinia pestis ...
ZP_00133200  67 Gkd--------seGQFILRQAKKHNVVltaMLESDLPTSFTDVMINSq------NGERTFFHYiGAMQQYDHQTVTSIdc 132 Haemophilus somn...

Feature 1                                           #                                           
1BX4_A      145 kkekhldl-----------eknwmlvekARVCYIAGFFLTVSp----------ESVLKVAHHASen---nRIFTLNLSAP 200 human
1DGM_A      149 rlped----------------wttfasgALIFYATAYTLTATp----------KNAFEVAGYAHgi--pnAIFTLNLSAP 200 Toxoplasma gondii
CAA11263    167 nmdsl----------------pgsimddYDFFGVNGYTFATP-----------QMVDFMHNMIEetlkrgKRVLTMLANA 219 Babesia canis
AAM27498    165 evqtlshavs------hegqsflrpverKQILYVEGFFVPQRs----------DVCDYIVQHLVre---rRRLALNLSAP 225 fruit fly
XP_319291   186 kkefvssrwcqskigvcksaahtnidedVRIFYIEGYFVPEKf---------hICTYIYEQYCKgt---aNLLVTNLNAS 253 Anopheles gambia...
AAS47710    152 sittfes------------eniqhalktANIFATSGFFVEVCf----------QAILKSAQYIHqfrsneCSFVFGLSAT 209 Cryptosporidium ...
O93919      140 eqshlss------------eavaplvdaVQFYYMEGYFVTHGl----------ASALELAGKSAak---sKCFVLNFSAP 194 Schizophyllum co...
AAA82876    127 td----------------------rfdePAVRQLAGAARHAHvv-------itQPCALALPVLRea---gVTISTDLHNW 174 Streptomyces sp.
NP_407400   129 g------------------------ldtSFKIFHLGYLLLLDsldvedteygtRSARLLALMSQl----gYETSLDLVSR 180 Yersinia pestis ...
ZP_00133200 133 na----------------------kiahIAYLPLLPALLDVS-----------KLVKTLTVLKEk----gFLISIDLVSC 175 Haemophilus somn...

Feature 1       #                                                                               
1BX4_A      201 FISQFYKESLMKVMPYVDILFGNETEAATfareqg-----------fetkdIKEIAKKTQalpkm--------nskrqRI 261 human
1DGM_A      201 FCVELYKDAMQSLLLHTNILFGNEEEFAHlakvhnlvaaektalstankehAVEVCTGALrlltag------qntgatKL 274 Toxoplasma gondii
CAA11263    220 ICIRRNGKYLKPIAEKSAYITGNLEEYLLlye-----------------leDREEVLRMFeqrtsg-------pnpqhTA 275 Babesia canis
AAM27498    226 YIVRKNHQAMMKLARAAFFLFGNRQEFEAlaeaa------------ggfrnVDELADHLLqsg-------------gtKV 280 fruit fly
XP_319291   254 YILQEFTTEMRFLVEHADLVFGNLAEFIAlaqi--------------yncdDVDALARLLikpyr--------khnrnKI 311 Anopheles gambia...
AAS47710    210 YIPEKYMNELFQLLPMIDYIIGNQEEFVSlyksinnilq---iedddqlllSQDNINQPEndalerilteihkhlkptCI 286 Cryptosporidium ...
O93919      195 FIPQFFMPAIQQLLPYVDIVIANESEAEAwasasg----------hpaptdLAAVAKSLAmqpkt--------nparpRV 256 Schizophyllum co...
AAA82876    175 DGADPYHEAFALQADLVFLSAMDLDDPERi--------------------lRNIAARGRA------------------RT 216 Streptomyces sp.
NP_407400   181 EGDPRYHLLVTPTLCWLDYLTINELEAGElsglemrla-----dgtpdvhhIAQAAKQLLea--------------gvRQ 241 Yersinia pestis ...
ZP_00133200 176 ENKQIFKNVIRPILSYVDFVIINDVEAKIlteqvni---------astekeLVTTAKAIMql--------------gvKK 232 Haemophilus somn...

Feature 1                                                        ##  #                          
1BX4_A      262 VIFTQGRDDTIMAte-------sEVTAFAVLDqdq--------keIIDTNGAGDAFVGGFLSQLVSDK--PLTECIRAGH 324 human
1DGM_A      275 VVMTRGHNPVIAAeqta--dgtvVVHEVGVPVvaa--------ekIVDTNGAGDAFVGGFLYALSQGK--TVKQCIMCGN 342 Toxoplasma gondii
CAA11263    276 VIITMGGDGAYIVy---------QGRRHHVKApk---------veVVDTTGAGDFFCGGVFYGLFNGY--TVRQAGIFGA 335 Babesia canis
AAM27498    281 IFVTNGSAGVQVItn-------yVEELAPPGPvsfedfraqrveqLVDATGAGDAFVAGFLHAWLEKR--SLGECIRMAS 351 fruit fly
XP_319291   312 LIATDGCRSVRLYygag---skfVAECYPVPViqg--------nlVIDTTGAGDSFVAGFLYKFMNDEspTLVDCIRYGC 380 Anopheles gambia...
AAS47710    287 ILCTRAHLPVISFnpkdpnscikYHECIHVPKe-----------rLIDVNGCGDAFKGGLIYGISNSY--PLDASIYMGH 353 Cryptosporidium ...
O93919      257 VIFTHGAEETVVVnsa----epgRVRTFKVDKlae--------geIVDTNGAGDAFAGGFLGALVAGR--ELDDSVEAGH 322 Schizophyllum co...
AAA82876    217 VVATAGADGSYLLy---------DDELTHTPAvtp-------papVVDSNGAGDAFAAAFLLGTLNGE--HPRRCALYGT 278 Streptomyces sp.
NP_407400   242 RVVIHCPEGAWGVe--------hGQEGAWVPSwkla------qeeIVGSVGAGDAFCAGILYGYHERW--PLNDCIQLAH 305 Yersinia pestis ...
ZP_00133200 233 AVIVHSPKYAVACd--------lLGNIVTVPSywve------kdkILSTLGAGDAFCSGILYGLHQNL--PLQKTLQLGH 296 Haemophilus somn...

Feature 1                      
1BX4_A      325 YAASIIIRRTGCTFP 339 human
1DGM_A      343 ACAQDVIQHVGFSLS 357 Toxoplasma gondii
CAA11263    336 AMAGEIINHFGTLVR 350 Babesia canis
AAM27498    352 SVAAKVVTQVGCNLP 366 fruit fly
XP_319291   381 KVAGKVIRQVGCNLP 395 Anopheles gambiae str. PEST
AAS47710    354 YAASNVAQNVGCDFD 368 Cryptosporidium parvum
O93919      323 KLAKISIQQIGPQFK 337 Schizophyllum commune
AAA82876    279 VAGAYACTVPSTRTG 293 Streptomyces sp.
NP_407400   306 ACARANLLCANAIDG 320 Yersinia pestis CO92
ZP_00133200 297 GLAYFNLFSLSATEG 311 Haemophilus somnus 2336

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