1LOP


Conserved Protein Domain Family
cyclophilin_EcCYP_like
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cd01920: cyclophilin_EcCYP_like 
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cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these have reduced affinity for cyclosporin A. E. coli cyclophilin A has a similar peptidylprolyl cis- trans isomerase activity to the human cyclophilin A. Most members of this subfamily contain a phenylalanine residue at the position equivalent to Human cyclophilin W121, where a tyrptophan has been shown to be important for cyclophilin binding.
Links
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Statistics
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PSSM-Id: 238901
Aligned: 7 rows
Threshold Bit Score: 222.318
Created: 30-Sep-2004
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved Features/SitesClick to see Conserved Features Help
 
substrate
Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1:substrate binding site [chemical binding site]
Evidence:
  • Structure:1LOP_A, Escherichia coli cyclophilin A bound with tripeptide, contacts 3.5 A
  • Citation:PMID 8601841
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                         # #  ## #                     
1LOP_A        3 TFHTN--HGDIVIKTf--------DDKAPETVKNFLDYCREGFYNNTIFHRVINGFMIQGGGFEpgmkq---------ka 63  Escherichia coli
P83221        5 ELNTS--AGRIVLELn--------DAEAPKTVENFLAYVRSGHYDGTIFHRVISDFMIQGGGFTpdmqq---------ks 65  Streptomyces ant...
NP_988248    41 TIQTN--YGNMTFELy--------PDKAPITVENFKKYAESGFYEGTIFHRVISDFMIQGGGFTangtk---------ke 101 Methanococcus ma...
NP_719348    33 EFDTS--LGKIVVELd--------RTRAPITVDNFLTYVVKGEYNNTIFHRVISDFVVQGGGLNpqlee---------lp 93  Shewanella oneid...
NP_274283    27 LMETD--MGNIRLVLd--------ESKAPKTVANFVRYARKGFYDDTVFHRVIDGFVIQGGGLTedlaq---------ka 87  Neisseria mening...
ZP_00318202   2 QFQTS--LGDFEVNLy--------DEHTPITVENFLAYVNAGSYTDSIIHRSVDNFIVQGGGYTweqdenp-----arie 66  Microbulbifer de...
NP_896852    33 ELTTNnqLGDRSIFLelfnkkgsaDFLTKKTVKNFFKYLNKGVYDNSIFHRSVPGFVLQGGGFSaplapadeggsidpvd 112 Synechococcus sp...

Feature 1                             ######        #       ##           #                      
1LOP_A       64 tkePIKNEannglkntrgTLAMARTQAP-HSATAQFFINVVDNDFLNFSGeslqgwGYCVFAEVVDg-MDEVDKIKgvat 141 Escherichia coli
P83221       66 tlaPIQNEadnglrndnyTVAMARTNDP-HSATAQFFINVKDNAFLNHTSktpngwGYAVFGRVTEg-QDVVDAIKgvkt 143 Streptomyces ant...
NP_988248   102 tldPIKNEadnglsnkrgTIAMARTNIV-DSATSQFFINTVDNSYLDYQNdq--nyGYAVFGELTDg-FDVLDKIEnvat 177 Methanococcus ma...
NP_719348    94 agkPIVNEsgnglsnsmgTIAMARDNEP-HSATRQFYFNVADNTKLDPSKrr---wGYAVFGEVIEg-KQVLEAMAvvet 168 Shewanella oneid...
NP_274283    88 sdkAVANEsgnglkntagTIAMARTTAP-DSATSQFFINLADNASLDYKNgq---yGYTVFGRVESg-MNTVSKIArvkt 162 Neisseria mening...
ZP_00318202  67 tnpAILNEpvys--nvagTIAMAKTGNNvNSATSQWFFNLKDNGANLDIQn----gGFTVFGHTDAagLAILESISdlpv 140 Microbulbifer de...
NP_896852   113 tfnPIKNEpgns--nrrgTIAMAKLAGDpDSATSQWFVNLEDNLSLDTQNe-----GFTVFGKVLGngMEVVDYLAsvev 185 Synechococcus sp...

Feature 1                            
1LOP_A      142 grs--gmhqdvPKEDVIIESV 160 Escherichia coli
P83221      144 gss--rghqdvPVQPVVIESA 162 Streptomyces antibioticus
NP_988248   178 ann--gqyqnwPVEDVIIEKV 196 Methanococcus maripaludis S2
NP_719348   169 ttnaklnwpdvPVTPIILKTA 189 Shewanella oneidensis MR-1
NP_274283   163 atr--gfyqnvPVQPVKIRRV 181 Neisseria meningitidis MC58
ZP_00318202 141 ysf-qnsfesmPLMDYTTDDA 160 Microbulbifer degradans 2-40
NP_896852   186 ynf-ggpytelPLWQLVQKPD 205 Synechococcus sp. WH 8102

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