Conserved Protein Domain Family
Lbh

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pfam15317: Lbh 
Cardiac transcription factor regulator, Developmental protein
The family of proteins are cardiac transcription regulators, named Lbh, short for Limb, bud and heart. They regulate embryological development in the heart. More specifically, in humans, they may act as transcriptional activators in MAPK signaling pathway to mediate cellular functions. This family of proteins is found in eukaryotes. Proteins in this family are typically between 92 and 116 amino acids in length.
Statistics
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PSSM-Id: 434627
Aligned: 10 rows
Threshold Bit Score: 94.2267
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_014964224   1 MALVPGSSE-DGPWP-KDSPGSSQHAESPRLTTPLWK------DRGEIDRVEGHQDvqvstlppcvlllahpllwpsspv 72 
XP_023374203   1 MALVPGSSEeDGPWT-RDSPGSSKHPESPRLMNSLWK------DRGEISRVQGYQD------------------------ 49 
XP_009244516   1 MALVPGRSKvDGLWT-RNSPGSSQHPESPRLPNPLW-------DRGKIGKVEGHQH------------------------ 48 
XP_008272594   1 MALVPGNSEeDGPWP-RDSAGSSRCPEGPRLTSSLWK------DTGAIGRAEGPQD------------------------ 49 
NP_001273032   1 MALVPESSK-DGSWS-GDNPDSPWHPESPQLANPLSK------NREETGRCEDHQD------------------------ 48 
2_pfamImport   1 MALVPGNSE-DGPWP-RDRPGSSQHPESSRLMNPLRM------DRGEIVRVEGHQDaqvstsppcalla-ppptwskrpa 71 
XP_003442986  19 MTEVMINST-----P-MEDMRLSPSKD--RLSFQIFP------DPSDFDRCCKLKD------------------------ 60 
EGV98321       1 MTEVMMNTP-----S-MEEIGLSPRKD--GLSYQIFP------DPSDFDRCCKLKD------------------------ 42 
ELK13441       1 MDLVPESSE-DGPWP-RDSPGSFQHPESARLTNPLWK------DRGEIDRVEDHQD------------------------ 48 
XP_014344014  83 MAEVMSTCE-----PvMEDFILNQAPE---ERELPFQvfpdsqET--YEKHPKLFK------------------------ 128 coelacanth
XP_014964224  73 vpIQvTCPQTRLPSIVVEASEVN-EESGELRWPHQELLLLTDDeEEEAEVFFQDQSE 128
XP_023374203  50 --FQvVSQKSHLPSIVVEASEVNeEESGDLQWPHEELLLLTDGeEEEAEAFFQDENE 104
XP_009244516  49 --IQdFSQKSHLPSVVVEANEVN-EESGDLHLPHEELLLLTDGeEEDAEAFFQDQSE 102
XP_008272594  50 --VQaVSQKPRLPSIVVETSEVN-EDGAGLQWPCEDLLLLTDG-EEEAEAFFQDQSE 102
NP_001273032  49 --VE-VSQKPRLPSIVVEASEGSeEDQEDHQWPHEELLVLTDG-EEDAEAFFQDQSE 101
2_pfamImport  72 ipIQaVSQKTPLPSIVVEASEVS-EDSGELGWPHDELLLLTDE-EEEAEVFFQDQSE 126
XP_003442986  61 ----------RLPSIVVEPTE-GeVESGELRWPPEEFLVSEEE-EEDEEEEEEEQNS 105
EGV98321      43 ----------RLPSIVVEPTE-GeVESGELRWPPEEFLVQEDE-QDNCEETAKEKKE 87 
ELK13441      49 --IQvVSQKTHLPSIVVEASEIS-EESGELRWPHEELLVLTDD-EEEAEGFFQDQSE 101
XP_014344014 129 ----------RLPSIVVEPTDTGeVESGELRWPPDDMKSIEDK-ATAVDQYCQKESM 174 coelacanth
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