Conserved Protein Domain Family
TGF_beta_SF

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cl40434: TGF_beta_SF Superfamily 
transforming growth factor beta (TGF-beta) like domain found in TGF-beta superfamily
TGF-beta superfamily consists of a large group of cell regulatory proteins, such as TFG-betas, Nodal, Activins/Inhibins, glial cell-line-derived neurotrophic factor (GDNF) family of ligands, bone morphogenetic proteins (BMPs), and growth and differentiation factors (GDFs). They play important roles in developmental and physiological processes in a variety of species, including invertebrates as well as vertebrates, through specific receptor complexes that are composed of type I and type II serine/threonine receptor kinases. The receptor kinases subsequently activate Smad proteins, which then propagate the signals into the nucleus to regulate target gene expression. Proteins from the TGF-beta superfamily are only active as homo- or heterodimer.
Links
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Taxonomy: root
PubMed: 346 links
Protein: Related Protein
Related Structure
Statistics
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Accession: cl40434
PSSM Id: 477357
Name: TGF_beta_SF
Created: 8-Jan-2020
Updated: 4-Oct-2023
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