Conserved Protein Domain Family
DUF444
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pfam04285: DUF444 
Protein of unknown function (DUF444)
Bacterial protein of unknown function. One family member is predicted to contain a von Willebrand factor (vWF) type A domain (Smart:VWA). Another family member YeaH is predicted to be part of a conserved signalling pathway with the kinase YeaG and the SpoVR protein YcgB. The pathway may be involved in nitrogen metabolism (see Supplementary note 5 in.)
Links
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Statistics
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PSSM-Id: 427839
Aligned: 91 rows
Threshold Bit Score: 364.533
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q18G01           1 MGLREDLERF-REVGEDRRQDLESFIRYGDLSN-SDADNIEIPIKVVDLPEFEYDqLDRGGVGQGQGDTpDVGQPVGQPE 78  Haloquadratum...
WP_014256096    13 DRSAEDRRRHrELVEEAIKKNIGNIIAEESIIGqSKDKKIKIPIKGIKEYQFIYG-NNGTFAGSGDGSE-KRGDRIGQDK 90  Acetivibrio c...
jgi:Cthe_1204   31 DRAAEDRRRHrELVEESIKKNIGNIIAEESIIGqSKDKKIKIPIRSIKEYQFVYG-KNGPSVGSGDGTE-KRGEKIGEEK 108
WP_013624315    13 DRSVEDRRRHrRLVENSIKKNLADIISEESIIGeSKNKKIKIPVRGVKEYEFIYG-KNSGGVGSGDGSE-KRGDKIGSAR 90  Syntrophobotu...
A5N5W4          14 DRSLEDRRRHrQLVEKSIKDNLADIISEESIIGqSKNKKVKIPIKGIKEYQFIYG-DNSSGVGSGDGSQ-KKGDRIGKAI 91  Clostridium k...
JLU:CLAU_2438   14 DRSLEDRRRHkQLVEKSIKDNLADIISEESIIGqSKDKKIKIPIKGIKEYHFIYG-GNSPQVGSGNGSQ-KRGDKIGRSL 91 
jgi:Clopa_4105  15 DRAVEDRRRHrQLVEKSIKDNLGDILSEESIIGqSKDKKIKIPIRGIKEYQFIYG-KNVPGVGSGDGSE-KRGQVIGKDK 92 
Q97LI1          15 DRTIGDRRRHrELVEKAIKDNLADIVSEESIIGeSKSKKIKIPIRGLKEYKFLYG-NNSSSVGSGTGNE-KKGDIIGKEQ 92  Clostridium a...
WP_044035791    15 DRSIEDRRRHrQLVEKSIKDNLGDILSEESIIGeTKNKKFKIPIRGLKEYQFIYG-KNSGGVASGTGEE-KRGDKIGSE- 91  Clostridium b...
WP_022749637    15 DRSIEDRRRHrQLVEKSIKENLGDILSEESIVGeSKNKKFKIPIKGIKEYQFVYG-SNSKGVATGVGDE-ERGDKLGNG- 91  Clostridium s...

Q18G01          79 PGEADgDgdeDGdEeGEPG--DgSDDHGYYEMDPEEFATELDEALGL-DLEPKG-KEVVEEIEGDFTDVTRTGPNSTLDF 154 Haloquadratum...
WP_014256096    91 TGKNGnG------E-GQAGnqE-GEDIYETEVTIEELINYLFEDLNLpDIDRKKmAEIESVKSFKNLGYQRKGIPPRLAK 162 Acetivibrio c...
jgi:Cthe_1204  109 TANGGqG------V-GQAGnqE-GEEIYETEITIEELINYLFDDLNLpDIDKKRiAEQESIRSYKNLGYQRKGIPPRLAK 180
WP_013624315    91 ERRQGgD--------GGAGnqE-GEDIYETEVTIEDVINYLFEDLDLpDLNKAKaSEEIRASARKKSGYQRKGIPPRLAK 161 Syntrophobotu...
A5N5W4          92 KDRDGkG------N-QGAGnqE-GEDMYEIEVTIEDVLDYLMEDLELpLMDKKKfSQILSNNSPKKSGYQRKGINPRLAK 163 Clostridium k...
JLU:CLAU_2438   92 EENGSkG------K-GGAGneE-GEDMYETEITLEELMNYLLEDMELpLMDKKKfSELLSKKSLKKSGYQRNGINPRLAK 163
jgi:Clopa_4105  93 SQNGGkG------N-QGAGndE-GEDIYETEITLEDVMNYIMNDLELpKMDKKKfAEVLTENGTKKAGYQRHGINPRLAK 164
Q97LI1          93 MGNGSkGk-----G-KGAGnsE-GEDIYETEVTIEEVFSYLLEDLNLpNLDKKKySEIVTDSSKKKAGYQKYGIRPRLAK 165 Clostridium a...
WP_044035791    92 KGGKGkG---PGkG-QGAGndE-GEDYYETEITLDEVFDYLAEDLELpHMDRKKySEIITESSFKKKGYQKHGINPRLAK 166 Clostridium b...
WP_022749637    92 KKQLAnG------N-KGAGnqE-GDDVYETEITLEELMDYISEDLDLpNLDQKKySEIVTETTGRKRGYQTHGIRPRLAK 163 Clostridium s...

Q18G01         155 ERLFKQGLKRKLAMDF---DESFVREamrvadqtpesvyrwcreqnvlvsfswieaewkdipddergrWADfEELEANVE 231 Haloquadratum...
WP_014256096   163 RRSVIEKIKRKQAFLRtqkEIGVEDE------------------------------------------PDEnIVTGDIEQ 200 Acetivibrio c...
jgi:Cthe_1204  181 KRSVIEKIKRKQAYLRnsrELGDLDE------------------------------------------SAEe----DIAA 214
WP_013624315   162 KRSMAEKIKRRQGLKK---ALREENP-------------------------------------------------AEDDR 189 Syntrophobotu...
A5N5W4         164 KRTVVEKLKRQQGTKR---ALREIHG----------------------------------------------ELESDPKN 194 Clostridium k...
JLU:CLAU_2438  164 KRTVIEKLKRQQNSKR---AIREASK-----------------------------------------------------D 187
jgi:Clopa_4105 165 KRTTVEKLKRQQGKKR---ALREEDI------------------------------------------------------ 187
Q97LI1         166 KRTVIEKIKREQSRKR---AIKELGK------------------------------------------------------ 188 Clostridium a...
WP_044035791   167 KKTVMTKIERLQSKKR---ALKEANI------------------------------------------------------ 189 Clostridium b...
WP_022749637   164 KKTVMSKIARKQGKKR---ALREMEE------------------------------------------------------ 186 Clostridium s...

Q18G01         232 HTPVGQRIRRnglkeIPLRKDDERYRQPEIEETRQKNVVVVNIRDVSGSMRETKRELVERTFTPLDWYLTGTYDNAEFVY 311 Haloquadratum...
WP_014256096   201 E------RKR-----FPFMEDDLRYRRVREDHKKDFNAVVICIMDVSGSMDQTKKYLARSFYFLLYQFVRLKYSNVEVAF 269 Acetivibrio c...
jgi:Cthe_1204  215 QETLDGVRKR-----FPFSEDDLRYRRVREDRKKDFNAVVICIMDVSGSMDQTKKYLARSFYFLLYQFIRLKYANVDVVF 289
WP_013624315   190 EGRENAEAER-----FPFIEEDLRYQRMKETVRKKSNAVVFCLMDVSGSMDQTRKYLARSFFFLLCQFIQMKYDGVDVVF 264 Syntrophobotu...
A5N5W4         195 KLPENTTIKSr----FPFKQDDLRYFRVKRKPKLELNAAIICVMDTSGSMDSTRKFLARSFFFVLYRFIKMKYNNVEVKF 270 Clostridium k...
JLU:CLAU_2438  188 PLFQNKTISKdidsrFPFRQEDLRYFRIKEKKKRELNAAVICVMDTSGSMDSTRKFLARSFFFILYQFVKAKYNNVEIKF 267
jgi:Clopa_4105 188 ----DEEIER-----FPFKNEDLRYYRIKKTMKRECNAVIICVMDVSGSMDNTKKYLARSFFFILSQFIRTKYSNVEIAF 258
Q97LI1         189 ----DDKVER-----LPFSEEDLRYHRIKEKPKKECNAAIMCVMDCSGSMDSTKKYLARSFFFILSKFIRMKYVNVEIAF 259 Clostridium a...
WP_044035791   190 ----NEEIDR-----FPFIEDDLRYYRVKVQPKRESNAAIIFVMDVSGSMDNTKKYLARSYFYVLSRFIKNKYNNVEVAF 260 Clostridium b...
WP_022749637   187 ----EQELDR-----FPFREEDLRYYRVKLKPRKDSNAVMIFIMDASGSMDITKKYLARSYFFVLATFLKRKYNNIAFEF 257 Clostridium s...

Q18G01         312 IAHDAEAWEVEREDFFGIRSGGGTRISSAYELAKEILEDEYPWSEWNRYVFAAGDSENAANDTTQNVVpLMESI--PANQ 389 Haloquadratum...
WP_014256096   270 IAHTTSAKEVNEDEFFHKGESGGTYISSGYEKALEIIEQRYNPASWNIYAFHCSDGDNWSEDNKKAVE-YAQKLceVCNL 348 Acetivibrio c...
jgi:Cthe_1204  290 IAHTTTAKEVSEDEFFHRGESGGTYISSGYEKALEIIEQRYNPNSWNIYAFHCSDGDNWSEDNKKAVE-LGLKLcdVCNL 368
WP_013624315   265 IAHTTTAAEVSEREFFHKAESGGTNISSAYAKALEIIEKRYPVEQWNIYAFHVSDGENWEQDNEKAVR-YAQELclLCNL 343 Syntrophobotu...
A5N5W4         271 ISHSTSAKVVTENEFFHKVESGGTYISSGLKKALEVIEENYNPAYWNVYTFYVSDGDNWSEDNSLALK-CAKDLckVCNL 349 Clostridium k...
JLU:CLAU_2438  268 ISHSTKAKVVTENEFFHKVESGGTYISSGLNKALEVIEENYNPAYWNVYTFYVSDGDNWDEDNERALK-AAKDLceVCNL 346
jgi:Clopa_4105 259 VAHSTVGREVNEFEFFHKVESGGTYISSGLNTALEIIEKRYNPVYWNIYTFYVSDGDNWTEDNNRAVA-SAKKLceVCNM 337
Q97LI1         260 ISHSTVGREVTETEFFHKVESGGTYISSGLNTAMDIIKERFNPATWNIYGFYVSDGDNFTEDDERAIK-SMRKFceIANM 338 Clostridium a...
WP_044035791   261 VAHSTTAKEVGENEFFHKGQSGGTYISSGLNKALEIIEERYDPAMWNLYTFCVSDGDNWSEDNDKTIK-AVKDLceVCNL 339 Clostridium b...
WP_022749637   258 IYHTTVAKRVDEYEFFHKSESGGTYISSGINEALNVIKEKYPPSAWNIYSIYASDGDNWSEDNERAIA-AVKNIceISNM 336 Clostridium s...

Q18G01         390 HAYVETQPgg-tAINATHAEEVDRALGddGNVVVVSVTGPEDVTGAIESILSTD 442 Haloquadratum walsbyi DSM 16790
WP_014256096   349 FGYGEIVPgy-ySSSSTIKSEFQKNINn-KNFAVITMTKKEDILPGLKKLLDKE 400 Acetivibrio clariflavus
jgi:Cthe_1204  369 FGYGEIVPgy-ySTGSTIKDEFQKSIKr-DNFSVITITNKDDVLPGLKKLLEKE 420
WP_013624315   344 FAFAEVLPsayyT--DTIIKVFRARIKa-DHYLTASIQEKEDLWPALKKILKKE 394 Syntrophobotulus glycolicus
A5N5W4         350 FSYAEIIPs---PYGSSIKHIFQNKITd-NNFTVVTIHEKQDLWKSLKKILNKE 399 Clostridium kluyveri DSM 555
JLU:CLAU_2438  347 FSYAEIIPs---YFGSNIKNIFRRGIDk-NNFSTVTINEKQDLWISLKKILKKE 396
jgi:Clopa_4105 338 FGYSEIMSg---YYSTNIKDKLVKEVQn-KNFIAVSIKQKNDLWNALKDMLKKE 387
Q97LI1         339 IGYAEILPy---SYSGTMKYKFDNYVKd-KNFISSTIRNKEDLWPVLKKMLIKE 388 Clostridium acetobutylicum ATCC 824
WP_044035791   340 FGYTEILPi---TYATTMKYKLNNEIKn-KNYLSASIKQKSDLWVALKTMLKKE 389 Clostridium bornimense
WP_022749637   337 FGYAELLPs---TYTTTMYHKFKKEITd-EKFVPVIIKEKKDLWDALKIMLRKE 386 Clostridium saccharobutylicum
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