3PYP,1DRM,1EW0


Conserved Protein Domain Family
PAS
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cd00130: PAS 
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PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.
Links
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Statistics
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PSSM-Id: 238075
Aligned: 183 rows
Threshold Bit Score: 31.4496
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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putative activeheme pocket
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:putative active site [active site]
Evidence:
  • Comment:putative active site of photoactive yellow protein (PYP)
  • Citation:PMID 9600888
  • Structure:chromophore covalently bound to the side chain of Cys .
  • Structure:hydrophobic pocket formed by three aromatic side chains and the aromatic ring of the chromophore.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                      #   #      #             ####                                   
3PYP        26 LAFGAIQLDGDGNILQYNAAEGd-iTGRDPKQVIGKNFfkDVAPCTDsp---eFYGKFKEGvas---------gnlNTMF 92   Halorhodospira h...
2499558     29 HGLVVVLQEPDLTISQISANCTg-iLGRSPEDLLGRTLg-EVFDSFQid---pIQSRLTAGqi-----------ssLNPS 92   Synechocystis PC...
1240049     24 DGADILIHRFDGTITHWSIGCEn-mYGWAREEAVGEKVh-DLLATQFpe---pVENIRDQLks-----------rgSWQG 87   Rhizobium legumi...
7470857    173 VRNPQTGDIEDFRCLVINPILSk-aFNRSREDLIGRVLlkRFLQRLDp----qLFDQFVNLvet----------gtFLTQ 237  Synechocystis sp.
1075570    153 LPAPWILVASDGRVLMMNHPARqvvAGLPEPLLEGQPVa-SLHHDLArawpdrTGRTMSLAiggrqyqvtrapvgaTGAE 231  Rhodobacter spha...
2494692    704 DSEIWTKVSTSGMFLFVSSNVRs-lLDLLPENLQGTSMq-DLMRKESra---eFGRTIEKArk------------gKIVV 766  Neurospora crassa
282166      74 VSDALIVVSRAGEVLGTSASVEa-lTGQGAGVWQGRPLa-ALFDPASgp---rLDRVLAEAanr----------raPVTV 138  Rhodobacter caps...
1145263     35 LPDPSYVLDDTGRVLVCSQAGAr-tVGRLPEELVGRHWg-ELGFPPEel--arLETARARVmli----------qdTCEL 100  Myxococcus xanthus
7340817     63 VSDILIVVSRAGLIEEVSASVPa-rTRLPRAALCGRPAs-DLFAEADrp---aLQEAMRRAtda----------rsALTL 127  Rhodobacter spha...
481880     450 ASDWFWETGPDHRITKISEHSDp--ASAAPTALIGLTRw-DIPPDAEle--pgKWEQHRATlda---------hlpFRDL 515  Bradyrhizobium j...

Feature 1         #    #                                 
3PYP        93 EYTFDYQ-MTPTKVKVHMKKals--------gdsYWVFVKRV 125  Halorhodospira halophila
2499558     93 KLWARVM-GDDFVIFDGVFHrns--------dglLVCELEPA 125  Synechocystis PCC6803
1240049     88 EIIHRHKsGHDIHIASRCVLvnlpegdfaviqtnIDVSALRR 129  Rhizobium leguminosarum
7470857    238 DIYFPIA-NSDWYHFVAVKLgdgfavtvrditdrKRMELELQ 278  Synechocystis sp.
1075570    232 VLSFTDR-TEETQLDLLLQGvi----------reAIAATYDI 262  Rhodobacter sphaeroides
2494692    767 AASMRCK-TSVARCSRPIQHst----------peMVVRVKGQ 797  Neurospora crassa
282166     139 EAALLGP-GGPAPLELSVSPrlderdr-ligyvlTGRPLGEL 178  Rhodobacter capsulatus
1145263    101 EAPWTTQtGLRRHALMLSPLpsedgg--accvlvTARPLTDA 140  Myxococcus xanthus
7340817    128 EAGLETPeGPSAVELSLSPRfdergr--aaglvlTGRSVAEL 167  Rhodobacter sphaeroides
481880     516 VYRGRDRnGSPIYVRTSGKPlhd--------adgHFLGYRGV 549  Bradyrhizobium japonicum

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