5H1B,1SZP,3LDA,5JZC,1N0W,5H1B


Conserved Protein Domain Family
Rad51
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cd19513: Rad51 
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RAD51D recombinase
RAD51 recombinase plays an essential role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. RAD51 is recruited to the break site with the help of its paralogs, RAD51D, RAD51B, RAD51C, XRCC3, and XRCC2, where it forms long helical polymers which wrap around the ssDNA tail at the break which leads to pairing and strand invasion.
Links
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Statistics
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PSSM-Id: 410921
Aligned: 40 rows
Threshold Bit Score: 454.083
Created: 16-May-2012
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Comment:contains the Walker A and Walker B motifs
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                   #######                           #      #           
5H1B_B       102 ITTGSKELDKLLQGGIETGSITEMFGEFRTGKTQICHTLAVTCQlpidrgggeGKAMYIDTEGTFRPERLLAVAErygls 181 human
1SZP_A        81 LTTGSKNLDTLLGGGVETGSITELFGEFRTGKSQLCHTLAVTCQipldigggeGKCLYIDTEGTFRPVRLVSIAQrfgld 160 baker's yeast
3LDA_A       160 LTTGSKNLDTLLGGGVETGSITELFGEFRTGKSQLCHTLAVTCQipldigggeGKCLYIDTEGTFRPVRLVSIAQrfgld 239 baker's yeast
1N0W_A         6 ITTGSKELDKLLQGGIETGSITEXFGEFRTGKTQICHTLAVTCQlpidrgggeGKAXYIDTEGTFRPERLLAVAErygls 85  human
EGY18462     109 ISTGSKQLDTLLAGGIETGSITELFGEFRTGKSQICHTLAVTCQlpfdmgggeGKCLYIDTEGTFRPVRLLAVANrfgls 188 Verticillium da...
ABI97150     104 ITTGSKQLDTLLAGGIETGSITEIFGEFRTGKSQICHTLAVTCQlpidmgggeGKCLYIDTEGTFRPTRLLAVADrygln 183 Pneumocystis ca...
P36601       124 ITTGSKQLDTLLQGGVETGSITELFGEFRTGKSQICHTLAVTCQlpidmgggeGKCLYIDTEGTFRPVRLLAVADrygln 203 Schizosaccharom...
XP_001692733 105 ITTGCKELDTILEGGIETGSITEIYGEYRCGKTQLCHTLCVTCQlpvemgggeGKAMYIDTEGTFRPQRLSQIAErygla 184 Chlamydomonas r...
Q99133       102 ITTGSKNLDAILGGGMETGSITELYGEFRTGKSQLCHTLAVTCQlpvdmgggeGKCLYIDTENTFRPTRLLAVAErfgln 181 Ustilago maydis...
ABO97415     106 ITTGSAKVDELLQGGIESGSVTEIYGEFRTGKTQLMHTLAVTSQmpiehgggeGKCLYIDTEGTFRPQRLIQIAErfnmd 185 Ostreococcus lu...

Feature 1                                                                                        
5H1B_B       182 gsDVLDNVAYARAFNTDHQTQLLYQASAMMVesRYALLIVDSATALYRtdYSGRGELSARQMHLARFLRMLLRLADEFGV 261 human
1SZP_A       161 pdDALNNVAYARAYNADHQLRLLDAAAQMMSesRFSLIVVDSVMALYRtdFSGRGELSARQMHLAKFMRALQRLADQFGV 240 baker's yeast
3LDA_A       240 pdDALNNVAYARAYNADHQLRLLDAAAQMMSesRFSLIVVDSVMALYRtdFSGRGELSARQMHLAKFMRALQRLADQFGV 319 baker's yeast
1N0W_A        86 gsDVLDNVAYARAFNTDHQTQLLYQASAXXVesRYALLIVDSATALYRtdYSGRGELSARQXHLARFLRXLLRLADEFGV 165 human
EGY18462     189 geEVLDNVAYARAYNSDHQLQLLQQASAMMCetRFSLLIVDSATALYRtdFVGRGELSSRQTHLAKFLRTLQRLADEFGI 268 Verticillium da...
ABI97150     184 geEVLDNVAYARAYNADHQLQLLGQAANMMAesRFSLLIVDSATSLYRtdFAGRGELSARQMHLAKFLRTLQRLADEYGI 263 Pneumocystis ca...
P36601       204 geEVLDNVAYARAYNADHQLELLQQAANMMSesRFSLLVVDSCTALYRtdFSGRGELSARQMHLARFMRTLQRLADEFGI 283 Schizosaccharom...
XP_001692733 185 peDVLNNVAYARAHNTEHQMRLLQEAAGMMAdsRFSLVVVDSATALYRteFNGRGELSIRQILLGRFLRALQNIADEYGV 264 Chlamydomonas r...
Q99133       182 geEVLDNVAYARAYNADHQLQLLMQASAMMAesRFSLLIVDSLTSLYRtdFSGRGELSARQMHLAKFLRGLMRLADEFGV 261 Ustilago maydis...
ABO97415     186 psAVLDNVAYAKAHNVEHQSELLLAAAGMMAetRFSLMIIDSVTNLYRteYEGRGELSARQMHLGKFLRQLARLADEFGV 265 Ostreococcus lu...

Feature 1                                                          #                  ###     
5H1B_B       262 AVVITNQVVAQVDgaam--faaDPKKPIGGNIIAHASTTRLYLRKGRGETRICQIYDSPCLPEAEAMFAINADGVGD 336 human
1SZP_A       241 AVVVTNQVVAQVDggma--fnpDPKKPTGGNIMAHSSTTRLGFKKGKGCQRLCKVVDSPCLPEAECVFAIYEDGVGD 315 baker's yeast
3LDA_A       320 AVVVTNQVVAQVDggma--fnpDPKKPIGGNIMAYSSTTRLGFKKGKGCQRLCKVVDSPCLPEAECVFAIYEDGVGD 394 baker's yeast
1N0W_A       166 AVVITNQVVAQVDgaax--faaDPKKPIGGNIIAHASTTRLYLRKGRGETRICKIYDSPCLPEAEAXFAINADGVGD 240 human
EGY18462     269 AVVITNQVVAQVDggpsamfnpDPKKPIGGNIIAHASTTRISLKKGRGETRIAKIYDSPCLPESDCLFAINEDGIGD 345 Verticillium dahli...
ABI97150     264 AVVITNQVVAQVDgnas-mfnpDPKKPIGGNIIAHSSTTRLSLRKGRGEQRICKIYDSPCLAEADAVFAITNGGVDD 339 Pneumocystis carinii
P36601       284 AVVITNQVVAQVDgis---fnpDPKKPIGGNILAHSSTTRLSLRKGRGEQRICKIYDSPCLPESEAIFAINSDGVGD 357 Schizosaccharomyce...
XP_001692733 265 AVVVTNQVVANPDgaga-mfagPQTKPIGGNIMAHATTTRLSVRKGRGENRVVKIIASPSLPEREANFAIGQEGVTD 340 Chlamydomonas rein...
Q99133       262 AVVITNQVVAQVDgata--ftaDAKKPIGGNIVAHASTTRLSLRKGRGNQRICRIADSPCLPEADAVFAIGPEGIID 336 Ustilago maydis 521
ABO97415     266 AVIVSNQVVANPEggpf--agaNALKPIGGNIMAHASTTRLALRKGRGENRVMKVVCSPVLPESEAQFSISEFGIED 340 Ostreococcus lucim...

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