Conserved Protein Domain Family
SRC-1

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pfam08832: SRC-1 
Steroid receptor coactivator
This domain is found in steroid/nuclear receptor coactivators and contains two LXXLL motifs that are involved in receptor binding. The family includes SRC-1/NcoA-1, NcoA-2/TIF2, pCIP/ACTR/GRIP-1/AIB1.
Statistics
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PSSM-Id: 462615
Aligned: 32 rows
Threshold Bit Score: 73.9658
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_019205506  675 KGHKKLLQLLTSPTEELGIggsgptgppvppPPTSSNTPAGSDSKDTTGGMTSPSStGVTssssasgnsgqatgpggVSA 754 
KFW05013      586 TSH-KLVQLLATTAEQQ----------------LR-HADADTSCKDSLACAGTAGTlASG-----------------NPP 630 
XP_016152527  532 TSH-RLVQLLASTAEQQ----------------LRHHADADTSSKDSLACAGIAG----------------------NSA 572 
NP_001106383  641 SSN-KLVQLLATTAEQQ----------------LR---DVDTNCRDPLTCHVVTNT-SCG-----------------SSS 682 
XP_024098234  629 TSH-KLVQLLTTTAEQQ----------------LR-HADIDTSCKDVLSCTGTSNS-ASA-----------------NSS 672 
XP_004081302  644 KCHTKLLQLLTTKPEPLE-------------TPLSP--GADGECKD-QAGSGV------------------------RAG 683 
3_pfamImport    1 KGHTKLLQLLTTKSESADPc-----------SSPSP--EDEQTCKD-QPG---------------------------GVG 39  
CAF97770      584 KGHTKLLQLLTTKADPSDPc-----------SPSGP-LGDDQDFKD-QLGVIG------------------------GVD 626 
XP_004565576  621 KGHTKLLQLLTTKLEPSDPc-----------SPTGA-FGDDQICKDQLGGVGG--------------------------- 661 
XP_011484481  624 KGHTKLLQLLTTKLEHSDSc-----------SSPG---PLGDDCKDQLGGVAG-------------------------VG 664 
XP_019205506  755 SMSSAHYTGSLQEKHKILHKLLQNGNTPDEVAKITAE 791 
KFW05013      631 NSTCPSSHSSLTERHKILHRLLQEG-SPSDITTLAME 666 
XP_016152527  573 GNSCPSSHSSLTERHKILHRLLQEG-SPSDVPGLAPE 608 
NP_001106383  683 SGTCPSSHSSLTERHKILHRLLQEG-SPSDISSLSID 718 
XP_024098234  673 GGSCPSSHSSLTERHKILHRLLQEG-SPSDITTLSVE 708 
XP_004081302  684 HTGGSTHATSLKEKHKILHQLLQNSTSPVDLAKLTAK 720 
3_pfamImport   40 GSGHNNHPTSLKEKHKILHKLLQNGASPVELAKLTAE 76  
CAF97770      627 GAGHNNNPTSLKEKHKILHRLLQTSTSPVELAKLTAE 663 
XP_004565576  662 -VGHNNHSTSLKEKHKILHRLLQNSTSPVELAKLTAE 697 
XP_011484481  665 GLGHSNQSTSLKEKHKILHRLLQNSTSPVELAKLTAE 701 
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