1RW1


Conserved Protein Domain Family
ArsC_Yffb
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cd03035: ArsC_Yffb 
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Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine suggest that it is likely to function as a glutathione (GSH)-dependent thiol reductase. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from GSH via glutaredoxin, through a single catalytic cysteine.
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Statistics
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PSSM-Id: 239333
Aligned: 30 rows
Threshold Bit Score: 150.052
Created: 2-Mar-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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putative
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:putative catalytic residues [active site]
Evidence:
  • Comment:Based on the known function of arsenate reductase, ArsC.
  • Comment:The catalytic cysteine and the second arginine of the triad is conserved in this subfamily. The first arginine is replaced by an asparagine while the third arginine is replaced by a phenylalanine.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1               #                                              #                        
1RW1_A        2 YVLYGIKACDTXKKARTWLDEHKVAYDFHDYKAVGIDREHLRRWCAEHg-WQTVLNRAGTTFRKLDeaqkADLDE-AKAI 79  Pseudomonas aeru...
NP_883970     4 VTLYGLNKCSTCVKARDWLAARGVAHDFVDYRDHPVPAATLKQWAGKVggWEKLVNRTSMTWRALSderkAARSD-AEWT 82  Bordetella parap...
YP_155843     2 LRVYGIKNCDTVKKSLKWLDKNEVAYEFIDVRQQPLQKETVSGWLQKLp-AESLLNKRSTSWRNLSdeqkSVVDA-NAIA 79  Idiomarina loihi...
NP_636760     2 TTVYGLKNCDTCKKATKWLDRFGVAYTFVDYREHTPAPDTLLEWAGKAggFDALINKSSTTWRQLPdn-kKTPGSeAEWK 80  Xanthomonas camp...
BAB53506      3 ITIYGITTCDTVKKARVWLESHDVAYRFHDFRADGLDAKRLDGWVGKVg-WEKLLNKGSTTFRELAdkdkQDLDE-KKAK 80  Mesorhizobium lo...
P44515        2 ITVYGIKNCDTVKKALKWLADHNIEHKLHDYRVDGLDLNFLTQAETQFg-WDVLVNKRSTTWRNLDeqvkNSLDK-TTAL 79  Haemophilus infl...
ZP_00472943   2 ITLYGIKTCDSCRKARRALDTQGTAYRYHDLREDGLDAERLDAFLARSd-WKTLLNTRSTTWRGLDeadkRDLDA-ASAR 79  Chromohalobacter...
ZP_00582863  39 LTLYGIKNCDTVRKARKWIENHQLPVHFHDFRDDGLRQEDLEFWCKASg-WETVFNKRSTSFRALSdadkTDIDQ-AKAI 116 Shewanella balti...
ZP_00636218   3 VTLFGIKNCDTVRKARKWLEAENIKAQFHDFRDDGLSQEQLQHWVESLg-WETVLNKRSTSFRALTeqqkNELNQ-ASAM 80  Shewanella denit...
ZP_00586873   1 MTLFGIKNCDTVKKARKWLEANGHNVPFHDFRVDGLPAEQLNDWVARIg-FEPLLNKKSTSFRALTdeqkQDIDT-AKAI 78  Shewanella amazo...

Feature 1                  #             #  
1RW1_A       80 ELXLAQPSXIKRPVLELG-GRTLVGFKP 106 Pseudomonas aeruginosa PAO1
NP_883970    83 ALIAEYPALVRRPVTVTPdGEVTVGFSE 110 Bordetella parapertussis 12822
YP_155843    80 ELVAEQPTLFKRPLVESG-QAVHCGFNE 106 Idiomarina loihiensis L2TR
NP_636760    81 LLLREYPQLIRRPVVLTDdGTLSQGFSD 108 Xanthomonas campestris pv. campestris str. ATCC 33913
BAB53506     81 ALMLAKPTMVKRPVLELG-DRVLVGFKP 107 Mesorhizobium loti MAFF303099
P44515       80 SVLAENPTLIKRPIILQD-GKALIGFNE 106 Haemophilus influenzae
ZP_00472943  80 ALLLAHPTLLKRPVLETP-DRLLVGFQA 106 Chromohalobacter salexigens DSM 3043
ZP_00582863 117 QLMQAQPTLIKRPVLVVG-EHVLIGFDE 143 Shewanella baltica OS155
ZP_00636218  81 QLMLEMPTLIKRPVLVKD-DKVLLGFKL 107 Shewanella denitrificans OS-217
ZP_00586873  79 ALMLEYPTLIKRPVLVKG-DTVYTGFND 105 Shewanella amazonensis SB2B

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