7KMT


Conserved Protein Domain Family
TRAPPC-Trs85

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pfam12739: TRAPPC-Trs85 
ER-Golgi trafficking TRAPP I complex 85 kDa subunit
This family is one of the subunits of the TRAPP Golgi trafficking complex. TRAPP subunits are found in two different sized complexes, TRAPP I and TRAPP II, and this Trs85 is in the smaller complex. TRAPP I, but Not TRAPP II, functions in ER-Golgi transport. Trs85p was reported to function in the cytosol-to-vacuole targeting pathway, suggesting a role for this subunit in autophagy as well as in secretion. The overall architecture of TRAPP I shows the other components to be Bet3p (TRAPPC3), Bet5p (TRAPPC1), Trs20p (TRAPPC2), Trs23p (TRAPPC4), Trs31p (TRAPPC5), Trs33p (TRAPPC6a and b) and Trs85p.
Statistics
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PSSM-Id: 463688
Aligned: 72 rows
Threshold Bit Score: 162.427
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7KMT_B        244 YEDARDLLVNFKNLNHNTENf------------PIFMNT--NeM---LPVFLLCYNDDS----QEEFE--KCQALAKkLK 300 
XP_011612710  165 LEQFLKLSQEQHRIQHSGEYt-----------nPKWFIP--N-T---LKYYVLLHDMSE----GNEER--ANLSYED-MK 220 
3_pfamImport    4 SEQFLKLSQ-QHRIQHSGEYs-----------sPKWFIP--N-T---LKYYVLLHDVGE----GSEDR--ANVVYED-MK 58  
EFX86884      150 MEQFQQLNDQLTQLMSSNGTvd----------gPRWFNM--L-S---LRYHVLIHDACD----GETSK--AEELLQT-MR 206 
XP_002065801  160 VETAHKLTQRVQQMQSITPQk-----------lPKWFHPs-E-V---LNSYVVLHEARQ----GDLSK--AQQAFEM-LK 216 
EEY66454      176 RHSFEELTSPRNLP-------------------APFQMGlyD-AtlvPKFFVVLHDVLE----TEGTSidPDAILRS--- 228 
ESS31117      655 SSSSSSFSSFSSSSSSDLPCs--------------------S-S---AEPSAASYDVSE-----------IEALIAS--- 696 
EEA08301      255 ILDGLRTGISFTNIDGNSNYyhnqgyfrshylqETYLN---D-F---PLVFILISDSSL----EDNCNldVQSIISK-LK 322 
Q57ZE9        179 VEGILKEFNELKRGQEIGEIwrnmp------------cmeeE-M---HSHFLLLHDVTEgpgmDEVNR-----MFAA-VQ 236  Trypanosoma b...
XP_029285269  193 VEQFLKLSQEQHRIQHSGEYt-----------nPKWFIP--N-T---LKYYVLLHDMSE----GGEQR--ADSVYED-MK 248  Cottoperca gobio
7KMT_B        301 KQLFVE-SILLALwkdsfiydensv------------------------------------------------------- 324 
XP_011612710  221 QRYGPQgCALLKMntrsisadngeqipdpwcqylhanylsnqevledvapaaslpaen---------------------- 278 
3_pfamImport   59 QRYGPQgCALLRTntrpvsvdsgeqipdpwgqylhtnhpstqdapedvaaspgsgr------------------------ 114 
EFX86884      207 NAYGSHgCHLLVInskpkkgsmvepglpapdpwlrflprkasksdasiegetvvdgadagemelpgkvvegtnsqslgsl 286 
XP_002065801  217 STFGDSkCFLISInsneggqpaaqdmqdlwkdyikrqpkstlaqegssdpsapkspqeat-------------------- 276 
EEY66454      229 MNISTVnGAVLKInslpvesapvpsqfstvwtdnpy-------------------------------------------- 264 
ESS31117      697 -------DAPLPVasrlaccalgasppggssaavcppsssav-------------------------------------- 731 
EEA08301      323 QLFPENeFYLWNIkgiskcscsesifeeqkvdk----------------------------------------------- 355 
Q57ZE9        237 SSLGHAnCALVKLnsisnpqnvknmdpsvwtdanpsfmdvpsdtacravrys---------------------------- 288  Trypanosoma b...
XP_029285269  249 QRYGHQgCYLLKVnsrtfsaeedeqipdpwsqylhrntvqnqdvlddaavnsaave------------------------ 304  Cottoperca gobio
7KMT_B        325 ----------------------------------------iqlhqpvmssleEIL------------------------- 339 
XP_011612710  279 --------svsvaeedshhsgkdgvcnnreisplkldtlsslgslhsvstatDGMndakg-------------------- 330 
3_pfamImport  115 ---------rseqpeltvtllpdgacssldssplkpdtpaglgspqaatgdpRGPea----------------------- 162 
EFX86884      287 pkmpimdalqeamqeininsilapspstsalssltrdestnmknnlsqrsavEIKddplnaglgmttsglsvdeadgtgl 366 
XP_002065801  277 ------savgsmpamqmsvlqeqeqdvvgmlhplspmqesatdalstrlsisSESiasqninpn-------------vwa 337 
EEY66454      265 ------------------------------------------------------------------------vrpplfph 272 
ESS31117      732 ------------------------------------------------------------gahaadcgmptpaaqaaayv 751 
EEA08301      356 -----------------------------------------------------------------------pvsigsyah 364 
Q57ZE9        289 --------------qqlesrsgspasaggggdsassrvaaepllfprvqamfGKWp------------------------ 330  Trypanosoma b...
XP_029285269  305 ---------nnmsaaevdspekdsastspeshplqldtasssgslhaltaanTELkkaa--------------------- 354  Cottoperca gobio
7KMT_B        340 -----FFLQAPTQTTLSLALINSIYDMLDYLVYDLMIPFMKRKVSFWEETiLQPRKSLfNgaKFF------KKFMnknpv 408 
XP_011612710  331 -letrVGGPRSHGVCLTLNDHEHIRQFIQEFTFRGLLPHIEKNIRQLNDQlI-SRKGLsR--SLFta---tKKWFggska 403 
3_pfamImport  163 ---raPGGPRSHGACLTLKDHEHIRQFIQEFTFRGLLPHIEKNIRQLNDQlI-SRKGLsR--SLFta---tKKWFgggka 233 
EFX86884      367 ilapsIVESELHGGCLTTEDLDRIQGLVNDFCLKSLLPHMERQMRLLNESaS-ARKSThR--SLLsa---tKRWFgssrp 440 
XP_002065801  338 asddvAADNAPHGSCLGAKDLENLRHFVQDYAVRALIPYIEHLVAILSEGvT-QKKGVsK--SLLsa---tKRWFvtskp 411 
EEY66454      273 lsetfpqvtegmgtlLSRDDVAQIKTFVRDFGLRFMLSSLEGRIFQLNEVvSAMKKGV-K--NVFkswlrkPKDLrpsnt 349 
ESS31117      752 rcstlccldTSFCVGLSWSDLHSLSAFIQHLVNTGILPWMERKARQLDGSiATNRKGFrN--QLRyl---wRKPRgmtaa 826 
EEA08301      365 pyldttdyymNVNRFLTHSDMELLRSIIFSCVTKNFVLWIQNTMNRLYNTvNQSRKGIkS--HLRmfwrrpKPEVntsmn 442 
Q57ZE9        331 -----DGTAKVTGCYLSPENVRDLRAVMHHYLSQCLFTFIERKLRSLNTTvNERRTTTlG--KMAawfrnkNEvnkskte 403  Trypanosoma b...
XP_029285269  355 -repeVGVAGSHGACLTLNDHDHIRQFIQEFTFRGLLPHIEKNIRQLNDQlV-SRKGLsR--SLFta---tKKWFgggka 427  Cottoperca gobio
7KMT_B        409 ngnhq------------------------------------------------------------------------hns 416 
XP_011612710  404 peks---------------------------------------------------------------------------i 408 
3_pfamImport  234 pekg---------------------------------------------------------------------------a 238 
EFX86884      441 gglq---------------------------------------------------------------------------- 444 
XP_002065801  412 gag----------------------------------------------------------------------------- 414 
EEY66454      350 s------------------------------------------------------------------------------- 350 
ESS31117      827 sqnsvlssggagaggapsegsasssfspfasafpssatsvvanvaeqaggaaeallsavggaflgetassfsqsgssska 906 
EEA08301      443 sdsflstlgmtnaisn--------------------------------------------------lddksqlfesnipl 472 
Q57ZE9        404 s------------------------------------------------------------------------------w 405  Trypanosoma b...
XP_029285269  428 peks---------------------------------------------------------------------------v 432  Cottoperca gobio
7KMT_B        417 ltrdsqgNEy---------------FASSSSEFLMRKLADWSMMLSDFKTAYSTYESLMDDL--DAFPKYL-----ASCI 474 
XP_011612710  409 sepkstcGLl---------------YPPEAPELQIRKMADLCFLVQHYELAYSCYHTAKKDFlsDQAMLYA-----AGAL 468 
3_pfamImport  239 qeprstsGLl---------------YPPEAPELQIRKMADLCFLVQHYELAYSCYHTAKKDFlsDQAMLYA-----AGAL 298 
EFX86884      445 -----------------ttqtvavsYHPESVQLQLRRLGDLAFLLGHYELAYHSYHSAKKDFeaDQAWLHY-----AGAM 502 
XP_002065801  415 -----------------annqnaviYTNESAELQTRKLGDLYFMFGHYNLAFQAYHQAKRDFnaDSAWQYY-----AGAL 472 
EEY66454      351 -------------------ssggvlYKSDSIESQTRLLADTAFLVRDYELALQMYRLVRDDFksDKSVFHC-----ANVN 406 
ESS31117      907 apsrseaPGsprrnglstqafvqsaYQLHAIEWQYRLLGDLQLFFGLHEAALQSFRSCAADFkqDKRWKQL-----GGAC 981 
EEA08301      473 ftsykdtSAkkqlr-------spiiYSASTIEGQTRILADLCFLIGDFSSATQYYKQILSDYklDKSYMCM-----GSTY 540 
Q57ZE9        406 vaargnsRAm---------------YLAGSLEMQMRRAADLSLALADYDAAANFYRLCRAEAlaTVETRAFnkpliAAAQ 470  Trypanosoma b...
XP_029285269  433 sepkstcGLl---------------YPPEAPELQIRKMADLCLLVQHYELAYSCYHTAKKDFlsDQAMLYA-----AGAL 492  Cottoperca gobio
7KMT_B        475 EWCAVSLLMGA--QSIVTvKMik--------nDiNPLIERALATYENCSriqrgkgke----snsldvtePVRSYETRCM 540 
XP_011612710  469 EMAAVAAFLQAg-AARPY-PT--------------HYMDTAIQTYRDTC---------------------KNMVLAERCA 511 
3_pfamImport  299 EMAAVAAFLQPg-APRPY-PA--------------HYMDTAIQTYRDTC---------------------KNMVLAERCA 341 
EFX86884      503 EMAALSVFLQNg-HNRTI-PF--------------HYFDKALT---------------------------TMPYWATRCA 539 
XP_002065801  473 EMAALSAFQLGtaHRKTY-----------------DYMEDAIVCYLTVC---------------------KLQQFATRAT 514 
EEY66454      407 EMIAVCLLLTKgsPMQMT-NA----------------LDAANAIYAKTPs-------------------pLTQRMAIRTA 450 
ESS31117      982 EMSAICLHLSGap-----------------rrEvEACIEQAYNAYVKA----------------------SAGRLALRCV 1022
EEA08301      541 EILAVCQVATG--MDLEA-VS--------------NLLLNACNSYQRSSdyysyslymrsiiflvislfnSPDLYSVDSE 603 
Q57ZE9        471 EGIGICHFLQG--RLLPssltpwraggtssknNsDCRLEVAMNDYDAC----------------------EMNVYSLRVA 526  Trypanosoma b...
XP_029285269  493 EMAAVSAFLQAg-APRPY-PA--------------HYMDTAIQTYRDVC---------------------KNMVLAERCA 535  Cottoperca gobio
7KMT_B        541 ILASELflslsn------------------twtstpYAIQYLEtilde-------------------------------- 570 
XP_011612710  512 LLSAEIlks------------------------qgkYSDTATLlikmt-------------------------------- 535 
3_pfamImport  342 LLSAEIlks------------------------qgkYSETATLlikmt-------------------------------- 365 
EFX86884      540 VLASEClka------------------------tnqYSDAALQlirlt-------------------------------- 563 
XP_002065801  515 LLSMEClkt------------------------arlYSEVAKQlirmt-------------------------------- 538 
EEY66454      451 VIAGEIyhalsk------------------sglftdYMDNASAalirg-------------------------------- 480 
ESS31117     1023 LLGTRLtmdlltavplpfsppfspflalqqssspslLSTAEAAveaarrllaanaelpaldpraklptsllrrsegsaka 1102
EEA08301      604 FSISDLsgsfrvkystiydsiidkvksviidmqnldMNSKYFSwilpndkgnysteynst-------------------- 663 
Q57ZE9        527 LLLYEFcrtrtpplvdrtta------------------------------------------------------------ 546  Trypanosoma b...
XP_029285269  536 LLSAEIlks------------------------qskYSEAATLlikmt-------------------------------- 559  Cottoperca gobio
7KMT_B        571 ------------------------------------------------cklgPCSQIMVWERLsdcynlrvdprikhrvg 602 
XP_011612710  536 ------------------------------------------------sedsdLRSALLLEQAahc-------------- 553 
3_pfamImport  366 ------------------------------------------------sedsdLRSALLLEQAahc-------------- 383 
EFX86884      564 ------------------------------------------------sedadLRSAVLLEQAalcflrsavkp------ 589 
XP_002065801  539 ------------------------------------------------seesdLRSALLLEQAaycf------------- 557 
EEY66454      481 -----------------------------------------------stmeqGICAAVLMERAalc-------------- 499 
ESS31117     1103 aarpdgstgdsrdlrevketrdareskearegrdeetkelesavaasfaqsqAVRSAMLLEQAalc-------------- 1168
EEA08301      664 ------------------------------------srneqivrstniskqsILNFAIMNDLFtrllall---------- 697 
Q57ZE9        547 --------------------------------------lllhvqhrgmvgrsKLQIAVLQELLaanalflnppqca---- 584  Trypanosoma b...
XP_029285269  560 ------------------------------------------------sedsdLRSALLLEQAahc-------------- 577  Cottoperca gobio
7KMT_B        603 amkkdakdtedlrgehkystdhftdedilsEGLTRRR-----KAAFFRLIAAKKWAEQKQWRQVSWCLKDIESTY----S 673 
XP_011612710  554 ---------------------------fihMRNPMVR-----KFAFHMILAGHRYSKAGQRRHALRCYCQAMQVY----K 597 
3_pfamImport  384 ---------------------------fihMRNPMVR-----KFAFHMILAGHRYSKAGQRRHALRCYCQAMQVY----R 427 
EFX86884      590 --------------------nsssgdaakpNMVPLIR-----KYAFHMILAGHRFGKSGQKRHASRAYQLALQVY----K 640 
XP_002065801  558 --------------------------lispQPRAMHR-----KYAFHIVLAGNRYSRAGQRRHAYRCYRQAYQVF----E 602 
EEY66454      500 ---------------------------dlrARLPKFR-----KYGFRMVMAGHVYDSLGHEQHSARCYSLARAIY----D 543 
ESS31117     1169 ---------------------------feqAGILHRR-----KRNFQLVMAGHTYYKAGFKRLALRCYTSVVSHY----E 1212
EEA08301      698 ------------------------pndahpSGSISRRnlychKWYYHSILAAQAFQYIGFKAISLQSFLNVLLQE----D 749 
Q57ZE9        585 ------------------gmrikaslpnnfPVHAHVR-----TYMKYCIAAGDAYCSEDMFQSALRCYLRALFVYgsvgR 641  Trypanosoma b...
XP_029285269  578 ---------------------------finMRNPMVR-----KFAFHMILAGHRFSKAGQRRHALRCYCQAMQVY----K 621  Cottoperca gobio
7KMT_B        674 EIKFLHGNGLIL 685 
XP_011612710  598 ERDWSLAEDHIN 609 
3_pfamImport  428 ARGWSLAEDHIN 439 
EFX86884      641 GHGWSLAEDHIH 652 
XP_002065801  603 KREWSLAEDHIQ 614 
EEY66454      544 CSGWFLVEDHIN 555 
ESS31117     1213 WSGWQHVSQHLR 1224
EEA08301      750 TIKWPDIDTYLR 761 
Q57ZE9        642 CGSWPHICEHLF 653  Trypanosoma brucei
XP_029285269  622 ERGWSLAEDHIN 633  Cottoperca gobio
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