1OCY


Conserved Protein Domain Family
Collar
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pfam07484: Collar 
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Phage Tail Collar Domain
This region is occasionally found in conjunction with pfam03335. Most of the family appear to be phage tail proteins; however some appear to be involved in other processes. For instance Swiss:Q03314 from Rhizobium leguminosarum may be involved in plant-microbe interactions. A related protein Swiss:Q9L3N1 is involved in the pathogenicity of Microcystis aeruginosa. The finding of this family in a structural component of the phage tail fibre baseplate suggests that its function is structural rather than enzymatic. Structural studies show this region consists of a helix and a loop and three beta-strands. This alignment does not catch the third strand as it is separated from the rest of the structure by around 100 residues. This strand is conserved in homologs but the intervening sequence is not. Much of the function of Swiss:P10930 appears to reside in this intervening region. In the tertiary structure of the phage baseplate this domain forms part of the 'collar'. The domain may bind SO4, however the residues accredited with this vary between the PDB file and the Swiss-Prot entry. The long unconserved region maybe due to domain swapping in and out of a loop or reflective of rapid evolution.
Links
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Statistics
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PSSM-Id: 429485
Aligned: 171 rows
Threshold Bit Score: 38.3085
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1OCY_A         15 GAIMMWAADSL--------P---------SDaWRFCHGGTVSASD--CPLYASRIGTRYGg----SSSNPGLPDMRGLFV 71  Escherichia vi...
WP_015924621    8 GMVIPFAGPLK--------Edql----ksSG-WVPCDGRVLDKTQ--YSELFDVIGTKYGg---dGIPNFNIPDLRGRFV 69  Ruminiclostrid...
jgi:Ccel_1105  10 GSVISFAGEIKsemvnrlyR---------MG-WLICDGSKLKIAE--YPDLFQAIGKAHGg----DNTYFYLPDTQSKFI 73 
Q7Y2B3        316 GGIILSGFNAD------------------RGdFLICNGRSLNKNQ--YPQLFSAIGYTFGg----SGDNFNLPDMRGLVA 371 Enterobacteria...
EDM38502      578 GGIVAFYGEKV--------P---------DH-WLLCDGKPVDHSL--YPDLYRLLG-----------GEKRLPDLRGRFL 626
Q03314         69 EAPISYVEA--------------------QG-WMLCDGRYLRAAV--YPELYAVLGGLYGernstADLEFRIPDYRGLFL 125 Rhizobium legu...
Q9L3N1         46 NIPITYPEA--------------------YG-WMLCDGRYLEIDA--YPELFAVIGTLYGk---qGDNKFRLPDYRGLFM 99  Microcystis ae...
Q55EP2         28 GSVNIFTGIEI--------P---------VG-WSLCDGAPLNKLT--YPELYRQIGDAFGs----SEHEFSKPDFRGKCP 83  Dictyostelium ...
WP_011927565   10 GFVCMFAGDLS--------VstvrsaliaAG-WLPCDGSSYATSQ--YAALYTAIGNAHGg---sG-GNFNVPNLTGRFV 74  Bradyrhizobium...
WP_011927565  387 GSVTAYGGDVT--------SidnltsllaDG-WLPCVGQKLKKNDptYAALYKVIGATFGq----DNLNFYLPDLRGYFV 453 Bradyrhizobium...
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