Conserved Protein Domain Family
Dicty_REP

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pfam05086: Dicty_REP 
Dictyostelium (Slime Mold) REP protein
This family consists of REP proteins from Dictyostelium (Slime molds). REP protein is likely involved in transcription regulation and control of DNA replication, specifically amplification of plasmid at low copy numbers. The formation of homomultimers may be required for their regulatory activity.
Statistics
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PSSM-Id: 252996
Aligned: 5 rows
Threshold Bit Score: 1099.11
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
O60983    4 NKLISPHDFTQHFVNILELFSMPERVQ--TIKTPRIMPYSFSIEHLLFFEFFKSLSTKIk------NDSFQISLDIKSIF 75   Dictyostelium disco...
Q23895    2 DELISWDRFFKFFVILLEEFKGCKRNDvrLSVDYDILSGIYSPRTFVLKEVFRAVAVSY-------DESEIDLFRLGSVF 74   Dictyostelium disco...
O15924    5 KQLIPWNTYIFDYIKILEYFSPIERVP-----GNEIIPHMYSMHILVLKEVFREALDRSeayqntgSPYIINPLDIKTIF 79   Dictyostelium disco...
P10511    2 QNLAPWESFFMFVNILLRDYEPVKRRQq-GSESNEVMKYSFTVDTLICRELFRSILKEKt------lGILGDYLNRECIF 74   Dictyostelium sp. (...
Q26257    5 NKLLPWYNYVFFYKKILKEYLPSKRYH-----DTDIMRHYYSPHVLIMKEIFRTIINKHyypkegpLRRPEDCYDPTVIF 79   Dictyostelium gigan...
O60983   76 DKLPLKNLsyhitLDLDVSFKKTICGDK---NKKISISDCDQSIFIVDHFSRLFDRFIFSKPEIISYKRISALVSKQ-YQ 151  Dictyostelium disco...
Q23895   75 PGTSLYSY-----IPGIFSLKDFLLISKt-kSGKIRVSDVDQAILIFDHFSRISDKQVFRKDIIPGYRTFEKSLSSE-YK 147  Dictyostelium disco...
O15924   80 KGTS---FpiqltNGTKDDLDHLFSIKNd-eKGRILVKDCDQAIFIIDHLSRCSDTQVFNKKNITGFRNLEKMVSENgYK 155  Dictyostelium disco...
P10511   75 ERTKKLVKlnyndDEYDYDLDDILKIRKn-sSGKLIVDDIDQAIFIIDHLSRKVDCKVFTKKSLVGFRHIEKTITEAgYK 153  Dictyostelium sp. (...
Q26257   80 PKFSLEFDm----ESPFTDLDDVFRMKKtknNAKFIVTDGDQTIFIIDHFSRIADPQIFCKKALASFRNAEKIVTSAgYK 155  Dictyostelium gigan...
O60983  152 LVDYRMFGTKWFMFLRKVRRCCADMKGF------EGFLKNLDFVSLYSSIQPIKV-SQGHDEYIVSEIYKLYPSFNIEnd 224  Dictyostelium disco...
Q23895  148 ISDGRAAGVSWFNLVSKISTYCKNHPLFa----eNPTYKHVDFISMLSLVHGIIVdSQNEDENNVSAMYSLNPFVDLE-- 221  Dictyostelium disco...
O15924  156 IKDHRQFGLHWFSFLNILRSSLQYYQF--------NFFKNFDLISTLTTFHCVMVdDQNREEEKLSDFYTLYPFIDLE-- 225  Dictyostelium disco...
P10511  154 IRERRSIGLDWYTLLNDIRTSCAKHRTFv----aFSKYRYVDFIAMLTAFHQVKAaKSN-EEEHLSTIYSLYPFVE---- 224  Dictyostelium sp. (...
Q26257  156 LEDYRQIGIDWYGFINKLHTACVQEEYLndrelfSGIFQYPDFIAMLALVHDIAIdEQNRNEEDLSLLYTLYPYTNLE-- 233  Dictyostelium gigan...
O60983  225 plpvqegVNESDIEQIAINSENIQKINSQPNKRPNNQIYSRSQLSLVDFHARKLQKISIDPHKLSLnqakekfknntgsd 304  Dictyostelium disco...
Q23895  222 -------KSDIPGAVQSRVTTNRTRGSRSNSNLNNPTTTTTTTTTTTTTAPITTRSKRKSDDSVQE-------------- 280  Dictyostelium disco...
O15924  226 ---------------EDIEADNTSRERIKPSSSKNKTTTTTTTTTTTVQQPVTRKRK-----NIVQplqpiqpqqskkps 285  Dictyostelium disco...
P10511  225 -------------------------HNFDEDKEDAATTKQTTTTTTTTPQTRTRKRQATGDNTPTPtpapapkpt----- 274  Dictyostelium sp. (...
Q26257  234 -------EESNTPTPTSVGSKRGRRTTPQPQTPTTTTTTTTTTTTTTTSTEPLKKRRIIN-------------------- 286  Dictyostelium gigan...
O60983  305 d----------dtfnrfqnfsidsedGNDFSDTGDDDDDDDDDVDNDVDNddddddddnddefkeihnicsvshngVSIS 374  Dictyostelium disco...
Q23895  281 --------------------------QSSRQPKTSRKSGSLKDVRINNIS--------------------------VDSS 308  Dictyostelium disco...
O15924  286 tqpiqpiqpkktktqpiqpiqpiqppQSKYPHKITRKSGSLKKVRIDQISsqsydn---------------emgdvENQE 350  Dictyostelium disco...
P10511  275 ----------------------tpkptpapRKISSRKNGGLTNVRVDHISvnnip-----------------tpsdTNES 315  Dictyostelium sp. (...
Q26257  287 ----------------------------------SRSSGNLKEVRVNNITld----------------------ppSGDE 310  Dictyostelium gigan...
O60983  375 NKVTEKIISVSNVIKLTLIEISKNKKEVNSEVVLSIFKNLQEGSFNSQLVDSFFGINKCDKVITFPNSILTYLASTDLNK 454  Dictyostelium disco...
Q23895  309 SSESDVIMSVSNRLKCYLLEAVVNKGEIGLEVVKEVLKDLQDKNYSTGLLENIFNHNKSERVITLSSSFFEIASKINYDE 388  Dictyostelium disco...
O15924  351 IIPVEEVSSNPNKIRNCLSEVMNSKGEIKTNLVKAIFDSLQSKNYTIDLLDSIFSQNKSERVVTLPSRLFELANSINFEE 430  Dictyostelium disco...
P10511  316 LSPPSTIISSSNSIKQCLVEVLESKGEISIDKIKSIFNCLQNKQYTGDLIDSMFQQNKSEKVITISSKLFNMSNKVDYDE 395  Dictyostelium sp. (...
Q26257  311 IDPESTIVSISSKIKDCILETIYSKGELDTRTVKAIFSSLQNKDYSLDLVDTIFHQNKSDKVITVSNKMYNLVSKLDFDE 390  Dictyostelium gigan...
O60983  455 IKINEISNEVFDLTKNLFLDESVNVLIPTISEQNKIGFIWVPIKDDNINTTINLIPMD-IDPCHSQIKSISRFIQFCILI 533  Dictyostelium disco...
Q23895  389 VKFSELSIDVLESAKRLTFEKNTNILIPTNNFKEGFEFLWVPIVNGIASTSVFVSPNNySSGSFANVESALKLIHLCISL 468  Dictyostelium disco...
O15924  431 INFGKIPEDLFSMFESISFEKNTNIIIPTQE-ENSFAFLWIPIINGVTSTSIFLTPNN-SPVNLIKVKSVIKFIQLCIVM 508  Dictyostelium disco...
P10511  396 INFAKLKDDILYLSRRLIYEKNTNLLIPTEEGEGIIGFLWLPVVNGALTASVYVSQLG-ADVDFKKISATVRFVQLCISM 474  Dictyostelium sp. (...
Q26257  391 IRISDFSDELFELSKRISFEKSTNILLATQDGENRFGFLWIPIVDNHTSTSIYLSPTN-SKVDHDRIRLILKFVHLCIVL 469  Dictyostelium gigan...
O60983  534 KKINQFIVNINISFDLFKKISMNLIGLSQNLLLMEAEVERLKSGRCSNdlfHSKR--------ANDNEQRKFSLMVNEFl 605  Dictyostelium disco...
Q23895  469 GNINGFLSIRSITFDTFKSITKDLIPMSKRMLDLEQGFRKLRDAWNNS---NKKSkvqdsdisGIDTEDTKLISFVHEF- 544  Dictyostelium disco...
O15924  509 KELLDFMTIRSINYETFKSIISELLGMSERVLNLEQDVKKLKDLLLKKs--KKSTiddesellSRVSNHREFATFLYEF- 585  Dictyostelium disco...
P10511  475 SDIIGFMELRSLSLDAFRSIANELLYMSDRILNLEADLRTLKDIVMKPtnlKKHVnvdnlfsrLSPEGSNGFANYLYDF- 553  Dictyostelium sp. (...
Q26257  470 GDINRFISSRSITFERFKQVSNELLGMSQRLLSLETDVHKLKQLLSKK---KSKMdiesveftNNVISETELAVYVNEF- 545  Dictyostelium gigan...
O60983  606 IENSNIIKMSILNNCLELRSLPLTNLNVEYDPVTLLHKLGFIFHCRQEISKFNYN-HfISIDEVIKLFKPNNVTAKSCEI 684  Dictyostelium disco...
Q23895  545 INDNLYLKLSKEEDGLMLVDFPTSTLFMRYNPNSIDNKVGFMFHCRSEISKFQSCkN-HSIDNLVLSFTPNNIKNISQDN 623  Dictyostelium disco...
O15924  586 INKNKHLSLSKSDNYLKFVDSITSTLCVEYDSNSIEHKIGFINHCRSEISRFQPTgDiIKMNSLFSSFTPSNINTVSQQS 665  Dictyostelium disco...
P10511  554 ISNHPYIKIDKSQNSIKLKETPNPVLVLTYDPKVVEHKVGFLFHCRSEISRFNAGgNkFILNNIQHSFTPNNIGVLSQDR 633  Dictyostelium sp. (...
Q26257  546 INNNIYIKLSKLDNALKLSNPPVSSLVVEYDPDNIDHKVGFLYHCRSEISKFDTNkNsYSINKLLTSFTPNNIRNVSLVN 625  Dictyostelium gigan...
O60983  685 ENNIKQYYALKSSDCSKHKQTEESFVPLNFIRFLNISITIAPYNVNNTFSFRNIKKGFSITNLELFSLLKSERpEKQFKD 764  Dictyostelium disco...
Q23895  624 ENELKKKYSLMVSDFRNVPKVTPKFIPSEFKRFTIITFTNNSYNANRVFAFDDISSGISITNVKNIHAKGQRN-FEIYET 702  Dictyostelium disco...
O15924  666 EEDLKRKYSLMSSDLSGLLKDKSRFNPSNFDRYVLISFNNNVSGHCKVFSFGDVSNGFSITNLRNVYVQDSNL-YNRYEE 744  Dictyostelium disco...
P10511  634 ENDLKRNYSMLTSNTSKLITGTGS-GEHNLERFISITINNTAYDLIRVVLFRDISNGISISNLRDIFRENSDN-RNRYLE 711  Dictyostelium sp. (...
Q26257  626 EEDIKRKYHLMSSELSEILKDPTPFIPSNFQRFMNVTITNTAYNYNSVNVFEDISDGLSITNLRDIFAEDSPE-ENRYLE 704  Dictyostelium gigan...
O60983  765 YVGDTRRIKLSFVSPCLIKITDITYCFSFSKSNEYNYRKIKSFKIHNLSIVPIDIKSNNKLIKTIEPISVENVDINHSSF 844  Dictyostelium disco...
Q23895  703 LLGSTRIIRAFFCAPCLIQINNFKFATDKLIDDQSVNHQIASLEIKNLSYLPLDIKVRGSTVGTIKGGETAPIIINSEDF 782  Dictyostelium disco...
O15924  745 YMGKTRVITAFFFAPCLIQLTNFIFQTDKITNDKNISRQIKSIKIYNRSYINIEVKVGGNTIDSVKSGFSKVVQINSSEF 824  Dictyostelium disco...
P10511  712 YLGKSRLIRVFFIAPCLIQILEVNFAATQLTADKNFNRAIKSIKIRNLSYITIDIIVGGNVIDSIRGDATQVVQINASEF 791  Dictyostelium sp. (...
Q26257  705 YMGDSRVIRAFFFAPCLIKITNIVFVSEQLINNRSISRQIKSIKIKNHSYIPIEIKVGNCIIDTVKSDETREVFINSSEF 784  Dictyostelium gigan...
O60983  845 NFSISCYDIIFSTIIISKARLDELKNY----KIALPKNLSTVQDQFVKIVTNFASKINELK-DLTDLEKHIISQYlltQE 919  Dictyostelium disco...
Q23895  783 TFSISCLDIRFSASLISKTKLSQLPTFapdeRYNKETNILKVLDQCDELTRTFLNNYKIAN-KLSTIENYLYNNF---MG 858  Dictyostelium disco...
O15924  825 SFTISCLNISFSSVLISKNKLNNLSSLva-dYYVKSTELLRKADKLEQLLKKYIENFQKLN-TITETEEDIIEAFdfeSS 902  Dictyostelium disco...
P10511  792 SFSVSCLKFSVSATLVSKKNLQNISTIvl-nKYNEEKSYLQCVKKFSKLSKSFIRKFTGMNiNINALEELLLSEA---GA 867  Dictyostelium sp. (...
Q26257  785 NFSISCLKFTFSTTLISKSKLKNIKTLip-eKYEQMTDYENCTNKINNLAENFFVELKRTN-ILTKLDTYLCALF----- 857  Dictyostelium gigan...
O60983  920 NKNKKAQERERQKIQEQQEQQEQQ 943  Dictyostelium discoideum
Q23895  859 LEDEDEDEDEDEDEDEDEDEDEDE 882  Dictyostelium discoideum
O15924  903 AGDDIRNEDED-DEDEDEDDDDDE 925  Dictyostelium discoideum
P10511  868 YEDDDDDEGEGNEDDEDNDENEDE 891  Dictyostelium sp. (STRAIN GA11)
Q26257  858 ---------DQSNGKEDTDESSDE 872  Dictyostelium giganteum
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