1NCF,1EXT,1TNR


Conserved Protein Domain Family
TNFRSF1A

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cd10576: TNFRSF1A 
Click on image for an interactive view with Cn3D
Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A), also known as TNFR1
TNFRSF1A (also known as type I TNFR, TNFR1, DR1, TNFRSF1A, CD120a, p55) binds TNF-alpha, through the death domain (DD), and activates NF-kappaB, mediates apoptosis and activates signaling pathways controlling inflammatory, immune, and stress responses. It mediates signal transduction by interacting with antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRAF2 and TRADD that play regulatory roles. The human genetic disorder called tumor necrosis factor associated periodic syndrome (TRAPS), or periodic fever syndrome, is associated with germline mutations of the extracellular domains of this receptor, possibly due to impaired receptor clearance. TNFRSF1A polymorphisms rs1800693 and rs4149584 are associated with elevated risk of multiple sclerosis. Serum levels of TNFRSF1A are elevated in schizophrenia and bipolar disorder, and high levels are also associated with cognitive impairment and dementia. Patients with idiopathic recurrent acute pericarditis (IRAP), presumed to be an autoimmune process, have also been shown to carry rare mutations (R104Q and D12E) in the TNFRSF1A gene.
Statistics
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PSSM-Id: 276902
Aligned: 19 rows
Threshold Bit Score: 188.717
Created: 13-Jun-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 21 residues -Click on image for an interactive view with Cn3D
Feature 1:parallel homodimerization interface [polypeptide binding site]
Evidence:
  • Comment:parallel homodimerization proposed to aid in matrix formation of TNF-TNFR complexes
  • Structure:1NCF: Human Tumor necrosis factor receptor (TNFR) parallel homodimer; contacts at 4.0A
  • Citation:PMID 7768931

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1          ###           #######           #    #         #                         ##   
1NCF_A         5 CPQGKYIHPQNnsiCCTKCHKGTYLYNDCPgpgqDTDCRECESGSFTASENHLRHCLSCSKCRKEmGQVEISSCTVDRDT 84  human
CAG32132      61 CQLGQYLHPKGt-hCCMRCHAGTYKLKDCEwsgqAPVCLPCPNGTFTAVDNIMEKCFQCTRCRTElQQIEKTPCTQKQDT 139 chicken
BAF95748      58 CADDEYKHPELn-hCCKKCLAGFYRTVHCPeknqVTQCRPCRTGTFTEVSNSITRCRRCSPCTSQhGHVIVKNCTQDKDT 136 African clawed ...
XP_002187728  61 CQLGQYLHPRKt-hCCMRCHAGTYKAKDCDgpdqATVCLPCSNGTFTAVDNTMSKCFQCKRCRTAlQQIVETPCTPKQDT 139 zebra finch
AFJ51871      61 CQVGHYLHPNEt-hCCIKCHKGTYLSEHCSgsdkAPKCSVCPENAFMPTENNSPKCFACQSCRTSfQQIIKFSCTKWENT 139 eastern diamond...
EMP33636      39 CQVGEYLHSNRt-hCCMRCHAGTYLAEDCQsnslATRCTQCPKGTFTATDNILRKCISCRRCRSEfQQITLSECSEKKDT 117 green seaturtle
XP_007527905  36 CPPGKYLHPDNrtfCCTMCHKGTYLKDHCQgpglDTKCEVCKKGTFIAAQNHIKQCFSCARCRKEmQQVEISPCTVEQDT 115 western Europea...
XP_007503965  39 CPEGKYEHRTNasiCCLKCHKGTYLNADCGdsglAPDCKTCPNGTFTERENYVSKCLSCSICRKEmGQIEKTPCTISRNT 118 gray short-tail...
XP_008118687  66 CQRGYYYHTAGt-hCCMQCHKGTYVVEECLgperTTNCSECGSGSYMPENNYSPRCLGCSRCRATlGQIEISSCKPEQDT 144 green anole
EOB04756      48 CQLGQYLHPNEt-hCCMRCHAGTYKAKDCEradqAPVCLPCANGTFTAVDNTMSKCYQCKQCRTElSQIVVTPCTPKHDT 126 mallard
Feature 1                                              #  #  ###      # 
1NCF_A        85 VCGCRKNQYRHYWse---nlFQCFNCSLCLNGTVhlsCQEKQNTVCTCHAGFFLR 136 human
CAG32132     140 VCGCRKNQYQFGEad----fFQCKNCSSCANGIIt-nCSKNSDAVCRCKPMFFMT 189 chicken
BAF95748     137 VCGCHPGQFQFKVas----tFICKNCSHCLNGTVsvpCNGYNDTICTCHFGFYFD 187 African clawed frog
XP_002187728 140 VCGCQKNQYQIDSds---eyFQCRNCSSCADGTIa-sCSKNKDAICRCKPQFFLS 190 zebra finch
AFJ51871     140 VCGCDRNQYKTTGds----eFLCKNCSDCHNGKIrqdCTSDSDTICECHRGFFLQ 190 eastern diamondback rattlesnake
EMP33636     118 VCGCLPNQFQKTDsi----lFKCLNCSLCHNGTIrqkCTKNSDTICVCHAGYFLH 168 green seaturtle
XP_007527905 116 VCGCRENQYRHTWgd----lFQCRNCSACVNGTIthsCHGKLDTICFCHTGFYLK 166 western European hedgehog
XP_007503965 119 VCGCGENQYQQSQgkeenglFKCVPCNPCFNGTIqrpCQEKQDAVCLCNPDFFWN 173 gray short-tailed opossum
XP_008118687 145 ICGCGNNQYQASGgs----eFSCRNCSACENGKIrqhCTKFNDTICECHTNFFRR 195 green anole
EOB04756     127 VCGCRKNQYQDGDay----vFYCKNCSLCPNGIIa-nCSKNRNTICRCKPMFYLA 176 mallard

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