Conserved Protein Domain Family
ECM1

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pfam05782: ECM1 
Extracellular matrix protein 1 (ECM1)
This family consists of several eukaryotic extracellular matrix protein 1 (ECM1) sequences. ECM1 has been shown to regulate endochondral bone formation, stimulate the proliferation of endothelial cells and induce angiogenesis. Mutations in the ECM1 gene can cause lipoid proteinosis, a disorder which causes generalized thickening of skin, mucosae and certain viscera. Classical features include beaded eyelid papules and laryngeal infiltration leading to hoarseness.
Statistics
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PSSM-Id: 461739
Aligned: 11 rows
Threshold Bit Score: 786.34
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_012667220  45 VGYAAPPSPP--LSQSLPM-DHPDASQHGPL-LEGQSEVQ-PLPPQEAIPVQEEEMPPPQVPLEK-T---------DLPH 109
Q16610        41 VGYAAPPSPP--LSRSLPM-DHPDSSQHGPP-FEGQSQVQ-PPPSQEATPLQQEKLLPAQLPAEKeV---------GPPL 106 human
XP_003498694  45 VGYAAPPSPP--QTRGLRVdDHFETSLHDSL-FEGQREVE-PPASPEVPFVQEEEWPASPKSVKSeV---------GPPT 111
Q61508        45 VGYAAPPSPP--QTRRLRV-DHSVTSLHDPPlFEEQREVQ-PPSSPEDIPVYEEDWPTFLNPNVDkA---------GPAV 111 house mouse
XP_003478933  45 VGYAEPPSPPvsRSRGLPAgPH-DSSQRDPS-FEGQMEVNfPYVSQEEIPLQ-KEVPPLQHPNAKrV---------DTPG 112
XP_013216683  41 AGYAAPPSPP--QARGFPV-YHLDPSQYDLP-FEGQREVQ-SPPSPEAIPVQ-EELPPPHLSNGKkV---------DPPL 105
XP_001370788  46 VGYAAPPAPSspQKPDL---QDLVISHRA---FEGQTEaqd--------------------------------------- 80  gray short-tail...
XP_023359324  52 VGYAAPPAPP--RPQEPSL-QDPVTPQHI---FVGQETVD---YLFEDFPVQ-QAQSPQRIPLET-----------GKST 110 Tasmanian devil
XP_023403142   1 ---------------mgtvsraalvlaclavasaasegAQ-TPPSQEAIPVQTEELPPRQLPVERk----------DHPL 54  African savanna...
XP_006095273  41 VGYAAPPSPP--LTRARPR-DHPEISLHDPD-FEGQSEVQ-PFSSFD----QEEQLFSPQLLVRSgSlslsgsqaeDPTG 111 little brown bat
XP_012903466  45 VGYAAPPSPP--RTRALPM-DHPDTHQRGSD-FEGQGEVQ-PPRSLEAIPIQEEELPPPQLPVENkV---------DPHF 110 domestic ferret
XP_012667220 110 PQEAIPAQEEnLPPPQLSIEQKevepalsqa--------------------------------------------emifq 145
Q16610       107 PQEAVPLQKE-LPSLQHPNEQK---------------------------------------------------------- 127 human
XP_003498694 112 PQEAIPLQEK-QPPPQVSIEQKeidpyaqqq--------------------------------------------eefih 146
Q61508       112 PQEAIPLQKE-QPPPQVHIEQKeidppaqp-----------------------------------------------qee 143 house mouse
XP_003478933 113 PQEEIPLQQE-VTPLRHPTGQKqmgspvthq--------------------------------------------keifp 147
XP_013216683 106 PPEAIPLQEE-LPPPHPRTEQKeis------------------------------------------------------- 129
XP_001370788  81 ffEDFPLQQA-QSPQKLSLGKKepspsravpiqkevepprhlpmdqreaqssspaleseeiphqeqkevipsqfgelppa 159 gray short-tail...
XP_023359324 111 PNEAIPLQKE-VHAPQLPIEQKevespfhppkddgf-----------------------------------pqqeqkeid 154 Tasmanian devil
XP_023403142  55 PHGAIPIQEE-LPPPQLPVEQKevdppfpqqe-------------------------------------------eitfg 90  African savanna...
XP_006095273 112 PGRVVPVQEE-LLPPPGPIEQKeldapplpaq------------------------------------------eertsp 148 little brown bat
XP_012903466 111 PQEAIPLQEE-LPPPQDPVEQKeiepsflhqe-------------------------------------------emtfp 146 domestic ferret
XP_012667220 146 pkqrE-----GKPAALVSQSHPEPET--WNPAQHCQRGRSRGGWSHRLDGFPPGQPSSDNLNQICLPDRQHVLYGPWNLP 218
Q16610       128 ----E-----GTPAPFGDQSHPEPES--WNAAQHCQQDRSQGGWGHRLDGFPPGRPSPDNLNQICLPNRQHVVYGPWNLP 196 human
XP_003498694 147 tgqkE-----EKPAPSVVQGSPGPRS--WNPAQHCQQGR-RGGWGYRLDGFPPGRPSPDNLNQICLSERQHVVYGPWNLP 218
Q61508       144 ivqkE-----VKPHTLAGQLPPEPRT--WNPARHCQQGR-RGVWGHRLDGFPPGRPSPDNLKQICLPERQHVIYGPWNLP 215 house mouse
XP_003478933 148 sgqtE-----EKSGPLTGQGPSDPQS--WNPAQHCQRGRFRGGWGHRLEGFPPGRPSADNLNQICLPDRQPVLYGPWNLP 220
XP_013216683 130 --qsE-----EKPAPPMRQDPPEPHS--WNPAQHCQQGRFRGGWGYRLDGFPPGRPSPDNLNQICLPERQHVVYGPWNLP 200
XP_001370788 160 lgeeH-----QQP-------------------RRCRPEGRPVGWGHRLDSFPPGRPSPKNMHQICHPERKHVVYGPWNLP 215 gray short-tail...
XP_023359324 155 fsqdE-----EHPNGQREMEHPNPGSspYNQPRHCPQDPRFGGWGHRLDGFPPGRPSPDNIDQICLPDRKHVVYGPWNLP 229 Tasmanian devil
XP_023403142  91 skqrQ-----KKPAHSLGQGHPEPES--WNPAQHCQRGRPRGGWGHRLDGFPPGRPSPDNLNQICLPGRQHVVYGPWNLP 163 African savanna...
XP_006095273 149 pkqgEatqseEKPAPTSQHG----------PGQHCQQGGPQRCWGQRLDGFPPGRPSPDNLDQICLPTRQHVVYGPWDLP 218 little brown bat
XP_012903466 147 skqrE-----EKPAPFMDRSSPEPES--WNPALHCQQGRSRGGWGHRLDGFPPGRPSPDNLDQICLPNRQHVVYGPWNLP 219 domestic ferret
XP_012667220 219 QSGYSHLTRQGETLNFLETGYSRCCRCRSHTQRLDCAKLVWEDAMTRFCEAEFSVKTRAHWCCKQQGEARFSCFQKEAPQ 298
Q16610       197 QSSYSHLTRQGETLNFLEIGYSRCCHCRSHTNRLECAKLVWEEAMSRFCEAEFSVKTRPHWCCTRQGEARFSCFQEEAPQ 276 human
XP_003498694 219 QTGYSHLSRQGEALNLLETGYSRCCRCRSHTNRLDCAKLVWEDTMTRFCEAEFSVKTRPHRCCKQRGEERFSCFQEEAPQ 298
Q61508       216 QTGYSHLSRQGETLNVLETGYSRCCRCRSDTNRLDCLKLVWEDAMTQFCEAEFSVKTRPHLCCRLRGEERFSCFQKEAPR 295 house mouse
XP_003478933 221 QTGYSHLSRQGETLNLLETGYSRCCRCQSTTHRLECAKLVWENSMTQFCEAEFSVKTRPYSCCKQQGEARFTCFQEGALR 300
XP_013216683 201 QSGYSHLSRQGETLNLLETGYSRCCRCRSHTNRLDCARLVWEDAMTRFCEAEFSVKTRPHWCCRQQGEARYSCFQEAAPQ 280
XP_001370788 216 QTGYSHLSRQGNALNFLETGYTRCCHLP--KDQLDCAEFVWADALFRFCESEFSVKTRAYSCCWLRGEARLSCFQERAPQ 293 gray short-tail...
XP_023359324 230 QTGHSHLSRQGNALNFLETGYTRCCHLK--MGRLDCAASVWADALFRFCESEFSVKTRAYSCCWLRGEARLSCFQENAPL 307 Tasmanian devil
XP_023403142 164 QTGYSHLIRQGEALNLLETGYSRCCRCSSHTNRLDCAKLAWEDAMTQFCEAEFSVKTRAYGCCKQQGEARFSCFQEEAPW 243 African savanna...
XP_006095273 219 QSGYSHLSRQGETLNMLETGYSRCCRCHYYAKRMDCAKLVWENAMNQYCEAEFSVKTRPHWCCKQQGEARFSCFQEEAPR 298 little brown bat
XP_012903466 220 QSGFSHLTRQGETLNLLETGYSRCCRCHSHTNRLDCAKLVWEDAMTRFCEAEFSVKTRPHWCCKQQGEARFSCFQEEAPR 299 domestic ferret
XP_012667220 299 PHYRL--RACPNHQSGISSGLELPFPPGVPTLDNVKNICHLRRFRSVPRNLPATDPIQRQLQVLTWLEGEFQRCCRQGDN 376
Q16610       277 PHYQL--RACPSHQPDISSGLELPFPPGVPTLDNIKNICHLRRFRSVPRNLPATDPLQRELLALIQLEREFQRCCRQGNN 354 human
XP_003498694 299 PHYLR--QPCPTHQTGMSSGPQLPFPPGLPTLDNVKNICLLRRFRSVPRNLPATDPIQRQLQALTRLEMAFQRCCRQSHN 376
Q61508       296 PDYLL--RPCPVHQNGMSSGPQLPFPPGLPTPDNVKNICLLRRFRAVPRNLPATDAIQRQLQALTRLETEFQRCCRQGHN 373 house mouse
XP_003478933 301 PHYQL--QAYPSHQPGISVGLEVPFPPGLPTLDNVNNICHLKRLRYMPRNLPATDTIERQLQVLMQLEVEFQRCCRQGND 378
XP_013216683 281 PHYQL--RACPTHQPGISLGLELPFPPGMPTLDNFKNICHLRRFRSVPRNLPATDPIQRQLHALTQLEMEFQRCCRQGNN 358
XP_001370788 294 ADYERlhEPCPPPTPRPAPGLELSFPPGVPSPDNVRNICRLRRFRSVPRGLPTMDHVQRQLRALTQLEGKFRRCCHQGDN 373 gray short-tail...
XP_023359324 308 PDYKLlqGPCPGHPPRPSSGLAVSFPPGVPTQGNIRNICRFRRYRAVPRGLQILDHLVPQLRAVAQLEGKFKRCCHQGDN 387 Tasmanian devil
XP_023403142 244 PQYQP--RACPSQQPGISSGPELPFPPGVPTLDNVRNICLLRRFHSVPRNLQATGHIERQLQALTQLERAFQRCCRQEHN 321 African savanna...
XP_006095273 299 PHYQL--QAGPSPQPVISTGLELPFPPGLPTLDNIKNICHARRFRSVPRNLPPTDGLQRQLQALTRLEGELQRCCRRGSN 376 little brown bat
XP_012903466 300 PHYQL--RACPSHQPGISSGPELPFPPGVPTLDNVKNICHLRRFRSVPRNLPATDPIQRQLQALTRLEGEFQRCCRQGNN 377 domestic ferret
XP_012667220 377 HTCTWKAWEDSLDRYCDQEHAVKTHPYSCCHYPPSPARDECFARRAPYPNYDRDILTVDISRVTPNLMGYLCGKQRVLTK 456
Q16610       355 HTCTWKAWEDTLDKYCDREYAVKTHHHLCCRHPPSPTRDECFARRAPYPNYDRDILTIDIGRVTPNLMGHLCGNQRVLTK 434 human
XP_003498694 377 HTCLRNAWEDTLDEYCDRELAIKTHPHSCCHYPPSPARDECFSRRAPYPNYDRDILTLDLSRVTPNLMGHLCGNRRVLTK 456
Q61508       374 HTCTWKAWEGTLDGYCERELAIKTHPHSCCHYPPSPARDECFAHLAPYPNYDRDILTLDLSRVTPNLMGQLCGSGRVLSK 453 house mouse
XP_003478933 379 HTCARKAWEDALDRYCDQEQAVKTHHHMCCHYPPSPIRDECFAQRAPYPNYDRDILTLDLSRVTPNLMGHLCGNGRIITK 458
XP_013216683 359 LTCIWKAWEDTLDGYCDKEQATKTHHHSCCHYPPSPARDECFAHQAPYPNYDRDILTLDLGRVTPNLMGHLCGNRRVLTK 438
XP_001370788 374 YTCARQAWEEALDSYCDEELAIKTHHHVCCQHPASPARDICFARHAPYPNYDRDILTVDLSRITPDTMAQLCGHRKVLTk 453 gray short-tail...
XP_023359324 388 YTCARQAWEDVLDNYCDEELAIKTHHHVCCHRSPISARDECFARHAPYPNYDRDILTVDLSRITPDVMNQLCGHQKVLTK 467 Tasmanian devil
XP_023403142 322 HTCAQKAWEDALDRYCDKEQAIKTHQHSCCRHPLSPARDECFARWAPYPNYDRDILTLDVSQVTPNLMGHLCGNQRVFTK 401 African savanna...
XP_006095273 377 HTCAWKAWEDSLDGYCERELAIKTHHHSCCRYPPSPQRDECFAQKAPYPNYDRDLLTIDLSRITPNLMDYLCGNQRVISK 456 little brown bat
XP_012903466 378 HTCTWKAWEDALDGYCDQEQSVKTHHHSCCHYPPSPVRDECFARRAPYPNYDRDILTLDLSRVTPNLMGHLCGNGRVLSK 457 domestic ferret
XP_012667220 457 HKQIPGLIQNMTASCCELPFPEQACCAEEEKLAFISDLCGPRRNFWRDPAFCCDLNPGDEQVNCFNTNYLRNVALVAGDT 536
Q16610       435 HKHIPGLIHNMTARCCDLPFPEQACCAEEEKLTFINDLCGPRRNIWRDPALCCYLSPGDEQVNCFNINYLRNVALVSGDT 514 human
XP_003498694 457 HKQIPGLIQNMTARCCVLPFPEQACCGEEEKLAFIEDLCGPRKNSWKDPALCCNLSPGDEQANCFNTNYLRNVALVSGDT 536
Q61508       454 HKQIPGLIQNMTIRCCELPYPEQACCGEEEKLAFIENLCGPRRNSWKDPALCCDLSPEDKQINCFNTNYLRNVALVAGDT 533 house mouse
XP_003478933 459 YQHIPGLIRNMTARCCELPFPEQACCAEEEKLAFIEDLCGPRRNFWRDSASCCDRKPEDEQTKCFNLNYLRSVALVTGDT 538
XP_013216683 439 HKQIPGLIQNMTARCCNLPFPEQACCAEEEKSAFVEDLCGPRRNFWRDSAFCCDLSPGDEQTNCFNINYLRNVALVAGDT 518
XP_001370788 454 HKHIPGLIRNMTARCCELAPPEQGFCAEEEKSAFIRDLCGSRRDSWRDTESCCDHSPGDEQTCCFNTHYLRNVALVAGVP 533 gray short-tail...
XP_023359324 468 HKQIPGLIRNMTARCCKLPAAEQGACAEEEKSAFIEDLCGSRRDSWRDSDYCCDEKPGDEQTNCFNIHYLRNVALVAGVA 547 Tasmanian devil
XP_023403142 402 HKQIPGLIQNMTARCCDLPFPEQACCAEEEKSAFIENLCGPRHNSWQDPARCCDLSPGDKQTNCFNIQYLRNVAVVAGDT 481 African savanna...
XP_006095273 457 YKQIPGLIRNITARCCDLPLPEQACCAEEEKTSFISYLCGPQRNIWRDPAFCCRMNPGDEQTNCFNINYLKNVALVAADS 536 little brown bat
XP_012903466 458 HKQIPGLIRNMTAHCCNLPFPEQACCAEEEKLAFIEDLCGPRHNFWRDSALCCNLNPGDEQTNCFNTYYLRNVALVAGDS 537 domestic ferret
XP_012667220 537 ENAKGQGEQGPT-GGTKIGSTLEPKAE 562
Q16610       515 ENAKGQGEQGST-GGTNISSTSEPKEE 540 human
XP_003498694 537 GDATGQREQDPT-GETNVNPAPGSKEE 562
Q61508       534 GNATGLGEQGPT-RGTDANPAPGSKEE 559 house mouse
XP_003478933 539 GDARG--EQVPT-RGTNVSPAPESKEE 562
XP_013216683 519 GDARGQGEQVPT-GGTNISPTPESKEE 544
XP_001370788 534 QKPRGQQGTGTT-ELPLVTPTPEHKGE 559 gray short-tailed opossum
XP_023359324 548 QKPKDQQETGTT-ELPPASPTPEHKGE 573 Tasmanian devil
XP_023403142 482 GDAKDPGEQDPN-QETNISPTQKPSEE 507 African savanna elephant
XP_006095273 537 GDAKGQGKHDPT-QATNTSPPSEPQEK 562 little brown bat
XP_012903466 538 GDDKGQGKQGQVxGRSisptpepkee- 563 domestic ferret
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